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Aliases for C1orf210 Gene

Aliases for C1orf210 Gene

  • Chromosome 1 Open Reading Frame 210 2 3 5
  • TEMP 3 4
  • Type III Endosome Membrane Protein TEMP 3
  • Type III Endosome Membrane Protein 2

External Ids for C1orf210 Gene

Previous GeneCards Identifiers for C1orf210 Gene

  • GC01M043520
  • GC01M043747
  • GC01M041867

Summaries for C1orf210 Gene

GeneCards Summary for C1orf210 Gene

C1orf210 (Chromosome 1 Open Reading Frame 210) is a Protein Coding gene. Diseases associated with C1orf210 include Prostate Calculus and Lower Urinary Tract Calculus.

UniProtKB/Swiss-Prot for C1orf210 Gene

  • May be involved in membrane trafficking between endosomes and plasma membrane.

Additional gene information for C1orf210 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf210 Gene

Genomics for C1orf210 Gene

Regulatory Elements for C1orf210 Gene

Enhancers for C1orf210 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H042929 2 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +346.5 346478 18 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF766 ZNF143 FOS SLC2A1-AS1 HYI SZT2 ARTN RNU6-880P FOXJ3 C1orf210 ERMAP CCDC30 YBX1
GH01H043283 1.3 Ensembl ENCODE dbSUPER 8.7 +0.5 544 3 CTCF TFAP4 SIN3A RAD21 RARA ZNF121 POLR2A EGR1 HNF4G NR2F6 CFAP57 SZT2 MPL ENSG00000229431 MED8 LOC105378687 CDC20 ELOVL1 TMEM125 C1orf210
GH01H043270 1 ENCODE dbSUPER 8 +15.2 15162 2 BCOR PKNOX1 KLF1 MAX ZMYM3 RFX5 ZNF316 CTBP1 EGR1 POLR2A CFAP57 C1orf210 KDM4A-AS1 TMEM125 EBNA1BP2
GH01H043281 0.9 dbSUPER 7.8 +3.2 3234 1 ELF3 FOXA2 MLX ARID4B DMAP1 RAD21 RARA YY1 CREM MIXL1 MPL ENSG00000229431 MED8 SZT2 C1orf210 CFAP57 CCDC24 EBNA1BP2
GH01H043255 0.7 ENCODE dbSUPER 8.5 +29.0 29004 1 STAT1 HNF4A RAD21 CFAP57 C1orf210 LOC101929592 LOC105378685 TMEM125
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf210 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf210 Gene

Chromosome:
1
Start:
43,281,865 bp from pter
End:
43,285,840 bp from pter
Size:
3,976 bases
Orientation:
Minus strand

Genomic View for C1orf210 Gene

Genes around C1orf210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf210 Gene

Proteins for C1orf210 Gene

  • Protein details for C1orf210 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVY1-CA210_HUMAN
    Recommended name:
    Type III endosome membrane protein TEMP
    Protein Accession:
    Q8IVY1
    Secondary Accessions:
    • D3DPX2

    Protein attributes for C1orf210 Gene

    Size:
    113 amino acids
    Molecular mass:
    12024 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf210 Gene

Post-translational modifications for C1orf210 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for C1orf210 Gene

No data available for DME Specific Peptides for C1orf210 Gene

Domains & Families for C1orf210 Gene

Gene Families for C1orf210 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C1orf210 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf210: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf210 Gene

Function for C1orf210 Gene

Molecular function for C1orf210 Gene

UniProtKB/Swiss-Prot Function:
May be involved in membrane trafficking between endosomes and plasma membrane.
genes like me logo Genes that share phenotypes with C1orf210: view

Animal Model Products

CRISPR Products

miRNA for C1orf210 Gene

miRTarBase miRNAs that target C1orf210

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf210
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf210 Gene

Localization for C1orf210 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf210 Gene

Membrane; Single-pass type III membrane protein. Early endosome. Recycling endosome. Cell membrane. Note=Also localizes to tubular endosome structures. {ECO:0000250 UniProtKB:Q9CQM1}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf210 gene
Compartment Confidence
plasma membrane 4
endosome 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C1orf210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with C1orf210: view

Pathways & Interactions for C1orf210 Gene

SuperPathways for C1orf210 Gene

No Data Available

Interacting Proteins for C1orf210 Gene

Gene Ontology (GO) - Biological Process for C1orf210 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf210 Gene

Drugs & Compounds for C1orf210 Gene

No Compound Related Data Available

Transcripts for C1orf210 Gene

mRNA/cDNA for C1orf210 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf210 Gene

Chromosome 1 open reading frame 210:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf210
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf210 Gene

No ASD Table

Relevant External Links for C1orf210 Gene

GeneLoc Exon Structure for
C1orf210
ECgene alternative splicing isoforms for
C1orf210

Expression for C1orf210 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf210 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf210 Gene

This gene is overexpressed in Colon - Transverse (x7.8), Kidney - Cortex (x5.0), Pancreas (x4.7), and Stomach (x4.6).

Protein differential expression in normal tissues from HIPED for C1orf210 Gene

This gene is overexpressed in Fetal Liver (27.0), Pancreas (16.7), Colon (15.5), and Rectum (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf210 Gene



Protein tissue co-expression partners for C1orf210 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf210 Gene:

C1orf210

SOURCE GeneReport for Unigene cluster for C1orf210 Gene:

Hs.158963

Evidence on tissue expression from TISSUES for C1orf210 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with C1orf210: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf210 Gene

Orthologs for C1orf210 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf210 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf210 34
  • 100 (a)
OneToOne
C1H1orf210 33
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia C3H1orf210 33
  • 81.12 (n)
C3H1ORF210 34
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1305347 33
  • 80.67 (n)
dog
(Canis familiaris)
Mammalia C15H1orf210 33
  • 80.56 (n)
C1orf210 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2610528J11Rik 33 16 34
  • 80.06 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf210 34
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C6H1orf210 34
  • 15 (a)
OneToOne
Species where no ortholog for C1orf210 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf210 Gene

ENSEMBL:
Gene Tree for C1orf210 (if available)
TreeFam:
Gene Tree for C1orf210 (if available)

Paralogs for C1orf210 Gene

No data available for Paralogs for C1orf210 Gene

Variants for C1orf210 Gene

Sequence variations from dbSNP and Humsavar for C1orf210 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000224638 -- 43,285,788(+) ACCCC(C/G)CAATG upstream-variant-2KB, utr-variant-5-prime
rs1000250240 -- 43,286,602(+) GAGAC(C/G)CCATC upstream-variant-2KB
rs1000607020 -- 43,286,791(+) AAGGG(A/G)GGTAC upstream-variant-2KB
rs1000671601 -- 43,287,171(+) TGTTG(C/G)CCAGG upstream-variant-2KB
rs1001261896 -- 43,281,465(+) ACCTG(C/T)AATCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C1orf210 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV loss 17160897

Variation tolerance for C1orf210 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf210 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf210

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf210 Gene

Disorders for C1orf210 Gene

MalaCards: The human disease database

(3) MalaCards diseases for C1orf210 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prostate calculus
  • calculus of prostate
lower urinary tract calculus
  • calculus of lower urinary tract
osteogenesis imperfecta, type ii
  • osteogenesis imperfecta type 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C1orf210

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf210
genes like me logo Genes that share disorders with C1orf210: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf210 Gene

Publications for C1orf210 Gene

  1. A Novel Type III Endosome Transmembrane Protein, TEMP. (PMID: 24710541) Aturaliya RN … Teasdale RD (Cells 2012) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A … Levine B (Nature 2011) 3 60
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60

Products for C1orf210 Gene

Sources for C1orf210 Gene

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