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C1orf210 Gene

protein-coding   GIFtS: 37
GCID: GC01M043747

Chromosome 1 Open Reading Frame 210

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 1 Open Reading Frame 2101 2
Putative Uncharacterized Protein C1orf2102

External Ids:    HGNC: 287551   Entrez Gene: 1494662   Ensembl: ENSG000002533137   UniProtKB: Q8IVY13   

Export aliases for C1orf210 gene to outside databases

Previous GC identifers: GC01M043520 GC01M041867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1orf210 Gene:
C1orf210 (chromosome 1 open reading frame 210) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1orf210 gene promoter:
         Egr-1   CUTL1   LCR-F1   POU2F1   POU2F1a   POU2F1b   STAT3   ZIC2/Zic2   POU2F1c   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC1orf210 promoter sequence
   Search Chromatin IP Primers for C1orf210

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1orf210


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

C1orf210 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf210 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M043747:  view genomic region     (about GC identifiers)

Start:
43,747,554 bp from pter      End:
43,751,288 bp from pter
Size:
3,735 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CA210_HUMAN, Q8IVY1 (See protein sequence)
Recommended Name: Putative uncharacterized protein C1orf210  
Size: 113 amino acids; 12024 Da
Caution: Product of a dubious CDS prediction
Secondary accessions: D3DPX2

Explore the universe of human proteins at neXtProt for C1orf210: NX_Q8IVY1

Explore proteomics data for C1orf210 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus

  • See C1orf210 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158301.1  NP_872323.1  

    ENSEMBL proteins: 
     ENSP00000430918   ENSP00000429399  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8IVY1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf210
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CA210_HUMAN, Q8IVY1: Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with C1orf210           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1orf210
    Interactions:

        Search GeneGlobe Interaction Network for C1orf210

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1orf210 (CA210)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C1orf210 gene (2 alternative transcripts): 
    NM_001164829.1  NM_182517.2  

    Unigene Cluster for C1orf210:

    Chromosome 1 open reading frame 210
    Hs.158963  [show with all ESTs]
    Unigene Representative Sequence: NM_182517
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523677(uc001cit.4 uc021omn.1) ENST00000423420
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidC1orf210 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat C1orf210

    Additional mRNA sequence: BC041633.1 

    1 DOTS entry:

    DT.95312287 

    20 AceView cDNA sequences:

    BM784450 AI380209 BE871001 BX088833 BG824594 NM_182517 BF917437 AI346561 
    BU149476 BU191347 BM273035 AW135850 AL696898 BC041633 BQ687573 BM845139 
    BM020260 AW607355 BM020183 BE617097 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C1orf210 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGGCCAGC
    C1orf210 Expression
    About this image


    C1orf210 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
     
     Epidermis (Integumentary System)
    C1orf210 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1orf210 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158963
        Custom PCR Arrays for C1orf210
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf210

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C1orf210 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2610528J11Rik1 , 5 RIKEN cDNA 2610528J11 gene1, 5 80.06(n)1
    77.57(a)1
      4 (54.78 cM)5
    664511  NM_025572.21  NP_079848.11 
     1185269995 
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ635468.12   -- 78.96(n)    BJ635468.1 
    zebrafish
    (Danio rerio)
    Actinopterygii C6H1orf2106
    chromosome 1 open reading frame 210
    15(a)
    1 ↔ 1
    6(33726177-33733876) ENSDARG00000096908


    ENSEMBL Gene Tree for C1orf210 (if available)
    TreeFam Gene Tree for C1orf210 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C1orf210 (see all 122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901075281,2
    C--43747122(+) GTGTGA/GTGGCT 2 -- int10--------
    rs125643951,2
    H--43747306(+) taggaA/Gaattg 2 -- int10--------
    rs1421240811,2
    --43747321(+) AACCCA/GGGAGG 2 -- int10--------
    rs617690271,2
    C,F--43747361(+) ATTGCG/ACTCCA 2 -- int11Minor allele frequency- A:0.00CSA 1
    rs1502562311,2
    C--43747398(+) CCTGA-/AAAC  
            
    AAACA
    2 -- int10--------
    rs1382116951,2
    --43747472(+) TGGAGA/GGGGGA 2 -- int10--------
    rs121267771,2
    H--43747546(+) TGACAG/CCTTTT 2 -- int14Minor allele frequency- C:0.00NS EA 404
    rs121275131,2
    H--43747575(+) aaataG/Cattta 2 -- ut314Minor allele frequency- C:0.00NS EA 384
    rs1495626981,2
    C--43747655(+) AGCTGG/TCCGGG 2 -- ut310--------
    rs112108281,2
    C,F,A,H--43747683(+) gtaatC/Gccagc 2 -- ut313Minor allele frequency- G:0.40NA WA CSA 10

    HapMap Linkage Disequilibrium report for C1orf210 (43747554 - 43751288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C1orf210:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829693CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C1orf210 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C1orf210)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    4. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 149466 HGNC: 28755 AceView: MGC52423 Ensembl:ENSG00000253313 euGenes: HUgn149466
    ECgene: C1orf210 H-InvDB: C1orf210

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C1orf210 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C1orf210 gene:
    Search GeneIP for patents involving C1orf210

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf210
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf210
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