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Aliases for C1orf210 Gene

Aliases for C1orf210 Gene

  • Chromosome 1 Open Reading Frame 210 2 3 5
  • TEMP 3 4
  • Type III Endosome Membrane Protein TEMP 3

External Ids for C1orf210 Gene

Previous GeneCards Identifiers for C1orf210 Gene

  • GC01M043520
  • GC01M043747
  • GC01M041867

Summaries for C1orf210 Gene

GeneCards Summary for C1orf210 Gene

C1orf210 (Chromosome 1 Open Reading Frame 210) is a Protein Coding gene. Diseases associated with C1orf210 include Prostate Calculus and Lower Urinary Tract Calculus.

UniProtKB/Swiss-Prot for C1orf210 Gene

  • May be involved in membrane trafficking between endosomes and plasma membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf210 Gene

Genomics for C1orf210 Gene

Regulatory Elements for C1orf210 Gene

Enhancers for C1orf210 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F043283 0.8 Ensembl ENCODE 8.8 +0.5 544 3.2 RARA ZNF121 SP5 CEBPB SMARCA4 ETV4 IRF1 HNF4A ZBTB26 CTCF CFAP57 SZT2 MPL ENSG00000229431 MED8 CDC20 LOC105378687 ELOVL1 MIR6734 TMEM125
GH01F043255 0.7 ENCODE 8.5 +29.0 29004 2.0 STAT1 GLIS1 RAD21 CFAP57 C1orf210 LOC101929592 LOC105378685 TMEM125
GH01F043239 0.7 Ensembl ENCODE 8.3 +46.3 46256 1.1 HDGF CTCF PKNOX1 MTA2 TBX21 ZFHX2 POLR2A IKZF1 KLF9 NBN TMEM125 CDC20 LOC105378687 MIR6734 ELOVL1 MPL ENSG00000229431 MED8 SZT2 HYI
GH01F043269 0.5 ENCODE 8 +15.2 15162 2.1 BCOR KLF1 PKNOX1 CREB3L1 TEAD4 MAX ZMYM3 ZNF316 ZBTB48 POLR2A CFAP57 C1orf210 KDM4A-AS1 EBNA1BP2 MIR6733 TMEM125
GH01F042926 1.3 FANTOM5 Ensembl ENCODE 6.7 +348.0 347971 22.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF766 ZNF143 SLC2A1-AS1 SZT2 SLC2A1 PPIH RNU6-880P FOXJ3 KDM4A LOC105378682 ZNF691 LOC105378687
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C1orf210 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf210 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001744300 440 801 CTCF TFAP4 ZNF792 ZNF644 RAD21 RARA HNF4G NR2F6 SOX5 SP5

Genomic Location for C1orf210 Gene

Chromosome:
1
Start:
43,281,865 bp from pter
End:
43,285,840 bp from pter
Size:
3,976 bases
Orientation:
Minus strand

Genomic View for C1orf210 Gene

Genes around C1orf210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf210 Gene

Proteins for C1orf210 Gene

  • Protein details for C1orf210 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVY1-CA210_HUMAN
    Recommended name:
    Type III endosome membrane protein TEMP
    Protein Accession:
    Q8IVY1
    Secondary Accessions:
    • D3DPX2

    Protein attributes for C1orf210 Gene

    Size:
    113 amino acids
    Molecular mass:
    12024 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf210 Gene

Post-translational modifications for C1orf210 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for C1orf210 Gene

No data available for DME Specific Peptides for C1orf210 Gene

Domains & Families for C1orf210 Gene

Protein Domains for C1orf210 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf210: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf210 Gene

Function for C1orf210 Gene

Molecular function for C1orf210 Gene

UniProtKB/Swiss-Prot Function:
May be involved in membrane trafficking between endosomes and plasma membrane.
genes like me logo Genes that share phenotypes with C1orf210: view

Animal Model Products

miRNA for C1orf210 Gene

miRTarBase miRNAs that target C1orf210

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf210 Gene

Localization for C1orf210 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf210 Gene

Membrane; Single-pass type III membrane protein. Early endosome. Recycling endosome. Cell membrane. Note=Also localizes to tubular endosome structures. {ECO:0000250 UniProtKB:Q9CQM1}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf210 Gene COMPARTMENTS Subcellular localization image for C1orf210 gene
Compartment Confidence
endosome 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for C1orf210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with C1orf210: view

Pathways & Interactions for C1orf210 Gene

SuperPathways for C1orf210 Gene

No Data Available

Interacting Proteins for C1orf210 Gene

Gene Ontology (GO) - Biological Process for C1orf210 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf210 Gene

Transcripts for C1orf210 Gene

mRNA/cDNA for C1orf210 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf210 Gene

Chromosome 1 open reading frame 210:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf210 Gene

No ASD Table

Relevant External Links for C1orf210 Gene

GeneLoc Exon Structure for
C1orf210
ECgene alternative splicing isoforms for
C1orf210

Expression for C1orf210 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf210 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf210 Gene

This gene is overexpressed in Colon - Transverse (x7.8), Kidney - Cortex (x5.0), Pancreas (x4.7), and Stomach (x4.6).

Protein differential expression in normal tissues from HIPED for C1orf210 Gene

This gene is overexpressed in Fetal Liver (27.0), Pancreas (16.7), Colon (15.5), and Rectum (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf210 Gene



Protein tissue co-expression partners for C1orf210 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf210 Gene:

C1orf210

SOURCE GeneReport for Unigene cluster for C1orf210 Gene:

Hs.158963
genes like me logo Genes that share expression patterns with C1orf210: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for C1orf210 Gene

Orthologs for C1orf210 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf210 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf210 35
  • 100 (a)
OneToOne
C1H1orf210 34
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia C3H1orf210 34
  • 81.12 (n)
C3H1ORF210 35
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1305347 34
  • 80.67 (n)
dog
(Canis familiaris)
Mammalia C15H1orf210 34
  • 80.56 (n)
C1orf210 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2610528J11Rik 34 16 35
  • 80.06 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf210 35
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C6H1orf210 35
  • 15 (a)
OneToOne
Species where no ortholog for C1orf210 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf210 Gene

ENSEMBL:
Gene Tree for C1orf210 (if available)
TreeFam:
Gene Tree for C1orf210 (if available)

Paralogs for C1orf210 Gene

No data available for Paralogs for C1orf210 Gene

Variants for C1orf210 Gene

Sequence variations from dbSNP and Humsavar for C1orf210 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111305387 -- 43,283,266(+) TCTCA(C/T)TCATG reference, missense
rs111551978 -- 43,286,969(+) TCTTT(C/T)TTTTT upstream-variant-2KB
rs111918624 -- 43,282,761(+) GGGAG(A/T)GGGGA utr-variant-3-prime
rs11210828 -- 43,282,012(+) gtaat(C/G)ccagc utr-variant-3-prime
rs11210829 -- 43,283,721(+) ctcaa(C/G)taaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf210 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV loss 17160897

Variation tolerance for C1orf210 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf210 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf210

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf210 Gene

Disorders for C1orf210 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C1orf210 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prostate calculus
  • calculus of prostate
lower urinary tract calculus
  • calculus of lower urinary tract
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C1orf210

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf210
genes like me logo Genes that share disorders with C1orf210: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf210 Gene

Publications for C1orf210 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3 64

Products for C1orf210 Gene

Sources for C1orf210 Gene

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