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C1orf21 Gene

protein-coding   GIFtS: 42
GCID: GC01P184356

Chromosome 1 Open Reading Frame 21

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 1 Open Reading Frame 211 2
Proliferation-Inducing Protein 131 2
Cell Proliferation-Inducing Gene 13 Protein2 3
PIG132
Uncharacterized Protein C1orf212

External Ids:    HGNC: 154941   Entrez Gene: 815632   Ensembl: ENSG000001166677   UniProtKB: Q9H2463   

Export aliases for C1orf21 gene to outside databases

Previous GC identifers: GC01P181882 GC01P179784 GC01P180876 GC01P181595 GC01P181087 GC01P182622 GC01P155591


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1orf21 Gene:
C1orf21 (chromosome 1 open reading frame 21) is a protein-coding gene.

Gene Wiki entry for C1orf21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1orf21 gene promoter:
         HOXA9   HOXA9B   AP-1   Meis-1b   MEF-2A   RORalpha1   HFH-1   aMEF-2   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC1orf21 promoter sequence
   Search Chromatin IP Primers for C1orf21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1orf21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

C1orf21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf21 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P184356:  view genomic region     (about GC identifiers)

Start:
184,356,150 bp from pter      End:
184,598,155 bp from pter
Size:
242,006 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CA021_HUMAN, Q9H246 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf21  
Size: 121 amino acids; 13865 Da
Secondary accessions: B2R551

Explore the universe of human proteins at neXtProt for C1orf21: NX_Q9H246

Explore proteomics data for C1orf21 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C1orf21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110433.1  
    ENSEMBL proteins: 
     ENSP00000235307  

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    Search antibodies-online for peptides for C1orf21

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    antibodies-online antibodies for C1orf21 (12 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027967 DUF4612

    Graphical View of Domain Structure for InterPro Entry Q9H246

    ProtoNet protein and cluster: Q9H246


    Find genes that share domains with C1orf21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for C1orf21

    miRNA
    Products:
        
    miRTarBase miRNAs that target C1orf21:
    hsa-mir-7-5p (MIRT025859), hsa-mir-103a-3p (MIRT027208), hsa-mir-484 (MIRT041632), hsa-mir-93-3p (MIRT038732), hsa-mir-16-5p (MIRT031863), hsa-mir-146a-5p (MIRT021273), hsa-mir-186-5p (MIRT021202)

    Block miRNA regulation of human, mouse, rat C1orf21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C1orf21 (see all 183):
    hsa-miR-411* hsa-miR-520f hsa-miR-199a-3p hsa-miR-128 hsa-miR-134 hsa-miR-3653 hsa-miR-138-2* hsa-miR-298
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1orf21
    Interactions:

        Search GeneGlobe Interaction Network for C1orf21

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1orf21 (CA021)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C1orf21 gene: 
    NM_030806.3  

    Unigene Cluster for C1orf21:

    Chromosome 1 open reading frame 21
    Hs.497159  [show with all ESTs]
    Unigene Representative Sequence: BX648959
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000235307(uc001gqv.1) ENST00000489143 ENST00000367514 ENST00000477517

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    Selected qRT-PCR Assays for microRNAs that regulate C1orf21 (see all 183):
    hsa-miR-411* hsa-miR-520f hsa-miR-199a-3p hsa-miR-128 hsa-miR-134 hsa-miR-3653 hsa-miR-138-2* hsa-miR-298
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    OriGene qPCR primer pairs and template standards for C1orf21
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      QuantiTect SYBR Green Assays in human, mouse, rat C1orf21
      QuantiFast Probe-based Assays in human, mouse, rat C1orf21

    Additional mRNA sequence: BX648959.1 

    2 DOTS entries:

    DT.447095  DT.97845465 

    Selected AceView cDNA sequences (see all 243):

    BM713345 AA360610 BU189106 CD518514 AA614150 F13369 AI420613 BQ721971 
    AI359474 AI359524 N55376 BM424135 BQ669478 AW292053 BU619279 AI808684 
    BX489282 BI819015 CA435797 AA872887 F02686 AA676234 F09276 CA435737 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C1orf21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGATGTG
    C1orf21 Expression
    About this image


    C1orf21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Natural Killer Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Colon (Gastrointestinal Tract)
     
     Ovary (Reproductive System)
    C1orf21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1orf21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497159

    UniProtKB/Swiss-Prot: CA021_HUMAN, Q9H246
    Tissue specificity: Expressed in spleen, prostate, testis and uterus

        Custom PCR Arrays for C1orf21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C1orf21 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700025G04Rik1 , 5 RIKEN cDNA 1700025G04 gene1, 5 93.94(n)1
    96.69(a)1
      1 (64.43 cM)5
    693991  NM_197990.31  NP_932107.11 
     1518908485 
    chicken
    (Gallus gallus)
    Aves C8H1ORF211 chromosome 8 open reading frame, human C1orf21 92.84(n)
    93.39(a)
      424449  XM_422292.3  XP_422292.1 
    lizard
    (Anolis carolinensis)
    Reptilia C1orf216
    chromosome 1 open reading frame 21
    93(a)
    1 ↔ 1
    GL343203.1(3438756-3586752)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691152 hypothetical protein MGC69115 80.09(n)    BC056102.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.209742 Danio rerio cDNA clone MGC55943 IMAGE3819290, complete more 79.47(n)    BC044550.1 


    ENSEMBL Gene Tree for C1orf21 (if available)
    TreeFam Gene Tree for C1orf21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C1orf21 (see all 4406)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127464991,2
    C,F,H--184354199(+) ATTTAT/CTTCAT 1 -- us2k118Minor allele frequency- C:0.04NS EA WA NA 2478
    rs168230651,2
    C,F,H--184354234(+) CAGGGC/AGTAAA 1 -- us2k129Minor allele frequency- A:0.13NA NS EA WA 3100
    rs127262041,2
    C,F,H--184354245(+) AACCCA/GAGGGA 1 -- us2k1 tfbs3 trp321Minor allele frequency- G:0.04NS EA NA WA 2750
    rs1883456211,2
    --184354440(+) CATTGA/CCACCT 1 -- us2k10--------
    rs755936681,2
    F--184354447(+) ACCTCG/ATTTTA 1 -- us2k12Minor allele frequency- A:0.08CSA WA 120
    rs1923711831,2
    --184354557(+) TGAAAC/GGGATG 1 -- us2k10--------
    rs1849171391,2
    --184354670(+) TGAACA/CAGAAT 1 -- us2k10--------
    rs1469570671,2
    --184354702(+) AATGTA/GAGTTG 1 -- us2k10--------
    rs569999001,2
    C--184354908(+) TAATTC/TGAAAA 1 -- us2k11Minor allele frequency- T:0.00WA 2
    rs355079781,2
    C--184354909(+) ATTTG-/AAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C1orf21 (184356150 - 184598155 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for C1orf21:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668015CNV Deletion23128226
    esv2674731CNV Deletion23128226
    esv2720162CNV Deletion23290073
    dgv20n21CNV Loss19592680
    nsv3821CNV Loss18451855
    nsv832037CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C1orf21
    DNA2.0 Custom Variant and Variant Library Synthesis for C1orf21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with C1orf21           About GenesLikeMe

    Genetic Association Database (GAD): C1orf21

    Export disorders for C1orf21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C1orf21 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with C1orf21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PubMed id 11318611)1, 2, 3 Sood R....Carpten J.D. (Genomics 2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81563 HGNC: 15494 AceView: C1orf21 Ensembl:ENSG00000116667 euGenes: HUgn81563
    ECgene: C1orf21 H-InvDB: C1orf21

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C1orf21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C1orf21 gene:
    Search GeneIP for patents involving C1orf21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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