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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1orf21 Gene

protein-coding   GIFtS: 39
GCID: GC01P184356

chromosome 1 open reading frame 21
 Explore 3 diseases affiliated with
C1orf21 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C1orf21    

Aliases
for C1orf21 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 1 Open Reading Frame 211 2
PIG131 2
Cell Proliferation-Inducing Gene 13 Protein2 3
Proliferation-Inducing Protein 132
Uncharacterized Protein C1orf212

External Ids:    HGNC: 154941   Entrez Gene: 815632   Ensembl: ENSG000001166677   UniProtKB: Q9H2463   

Export aliases for C1orf21 gene to outside databases

Previous GC identifers: GC01P181882 GC01P179784 GC01P180876 GC01P181595 GC01P181087 GC01P182622 GC01P155591


Summaries
for C1orf21 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for C1orf21


Genomic Views
for C1orf21 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1orf21 gene promoter:
         HOXA9   HOXA9B   AP-1   Meis-1b   MEF-2A   RORalpha1   HFH-1   aMEF-2   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C1orf21 promoter sequence
   Search SABiosciences Chromatin IP Primers for C1orf21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

C1orf21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf21 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P184356:  view genomic region     (about GC identifiers)

Start:
 184,356,150 bp from pter      End:
 184,598,155 bp from pter
Size:
 242,006 bases      Orientation:
 plus strand

Proteins
for C1orf21 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CA021_HUMAN, Q9H246 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf21  
Size: 121 amino acids; 13865 Da
Secondary accessions: B2R551

Explore the universe of human proteins at neXtProt for C1orf21: NX_Q9H246

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H246

    • C1orf21 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_110433.1  
    ENSEMBL proteins: 
     ENSP00000235307   ENSP00000356484  

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    Protein Domains /
    Families
    for C1orf21 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9H246


    Function
    for C1orf21 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C1orf21
    8/183 QIAGEN miScript miRNA Assays for microRNAs that regulate C1orf21 (see all 183):
    hsa-miR-411* hsa-miR-520f hsa-miR-199a-3p hsa-miR-128 hsa-miR-134 hsa-miR-3653 hsa-miR-138-2* hsa-miR-298
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    Gene Editing
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    Clone
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    Pathways & Interactions
    for C1orf21 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf21

    Drugs & Compounds
    for C1orf21 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1orf21
    Search CenterWatch for drugs/clinical trials and news about C1orf21 / CA021 

    Transcripts
    for C1orf21 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for C1orf21 gene: 
    NM_030806.3  

    Unigene Clusters for C1orf21:

    Chromosome 1 open reading frame 21
    Hs.497159  [show with all ESTs], Hs.743658  [show with all ESTs]
    Unigene Representative Sequences: NM_030806, BX648959
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000235307(uc001gqv.1) ENST00000489143 ENST00000367514 ENST00000477517


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    8/183 QIAGEN miScript miRNA Assays for microRNAs that regulate C1orf21 (see all 183):
    hsa-miR-411* hsa-miR-520f hsa-miR-199a-3p hsa-miR-128 hsa-miR-134 hsa-miR-3653 hsa-miR-138-2* hsa-miR-298
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: BX648959.1 

    8 DOTS entries:

    DT.447095  DT.100732803  DT.97845465  DT.95068957  DT.97845461  DT.97845464  DT.92426770  DT.95068960 

    24/243 AceView cDNA sequences (see all 243):

    T95065 CA435737 BU189106 AA360610 AA779743 AK056487 AA411752 AW297075 
    AI948841 BE382574 BM990978 AI359813 BQ021628 AA676234 Z43044 AA775393 
    BC028567 BM831420 AA477739 BQ721971 BU619279 F09276 BI819015 W70338 

    GeneLoc Exon Structure


    Expression
    for C1orf21 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1orf21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTGATGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C1orf21 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungTracheaBasal CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)

    See C1orf21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1orf21

    SOURCE GeneReport for Unigene clusters: Hs.497159 Hs.743658

    UniProtKB/Swiss-Prot: CA021_HUMAN, Q9H246
    Tissue specificity: Expressed in spleen, prostate, testis and uterus

        SABiosciences Custom PCR Arrays for C1orf21
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf21

    Orthologs
    for C1orf21 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C1orf21 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 1700025G04Rik1 , 5 RIKEN cDNA 1700025G04 gene1, 5 93.94(n)1
    96.69(a)1    		   1 (64.43 cM)5
    693991  NM_197990.31  NP_932107.11 
     1518908485 
    chicken
    (Gallus gallus)    		 Aves C8H1orf211 chromosome 8 open reading frame, human C1orf21 92.84(n)
    93.39(a)    		   424449  XM_001233451.2  XP_001233452.1 
    lizard
    (Anolis carolinensis)    		 Reptilia C1orf216
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL343203.1(3440851-3535258)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC691152 hypothetical protein MGC69115 80.09(n)    BC056102.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.209742 Danio rerio cDNA clone MGC55943 IMAGE3819290, complete more 79.47(n)    BC044550.1 


    ENSEMBL Gene Tree for C1orf21 (if available)
    TreeFam Gene Tree for C1orf21 (if available) 

    Paralogs
    for C1orf21 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C1orf21 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3848 NCBI SNPs in C1orf21 are shown (see all 3848)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs127464991,2
    		C,F,H,--184354199(+) ATTTAT/CTTCAT 1 -- us2k118Minor allele frequency- C:0.04NS EA WA NA 2478
    rs168230651,2
    		C,F,H,--184354234(+) CAGGGC/AGTAAA 1 -- us2k129Minor allele frequency- A:0.13NA NS EA WA 3100
    rs127262041,2
    		C,F,H,--184354245(+) AACCCA/GAGGGA 1 -- us2k1 tfbs3 trp321Minor allele frequency- G:0.04NS EA NA WA 2750
    rs1883456211,2
    		--184354440(+) CATTGA/CCACCT 1 -- us2k10--------
    rs755936681,2
    		--184354447(+) ACCTCG/ATTTTA 1 -- us2k12Minor allele frequency- A:0.08CSA WA 120
    rs1923711831,2
    		--184354557(+) TGAAAC/GGGATG 1 -- us2k10--------
    rs1849171391,2
    		--184354670(+) TGAACA/CAGAAT 1 -- us2k10--------
    rs1469570671,2
    		--184354702(+) AATGTA/GAGTTG 1 -- us2k10--------
    rs569999001,2
    		C,--184354908(+) TAATTC/TGAAAA 1 -- us2k11Minor allele frequency- T:0.00WA 2
    rs355079781,2
    		C,--184354909(+) ATTTG-/AAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C1orf21 (184356150 - 184598155 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C1orf21: --

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    Disorders / Diseases
    for C1orf21 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    C1orf21 for disorders           About GeneDecksing

    3 diseases for C1orf21:    About MalaCards
    prostatic hypertrophy    prostatitis    prostate cancer


    Export disorders for C1orf21 gene to outside databases

    Publications
    for C1orf21 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1orf21 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with C1orf21)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PubMed id 11318611)1, 2, 3 Sood R....Carpten J.D. (2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)

    External Searches for C1orf21 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C1orf21 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81563 HGNC: 15494 AceView: C1orf21 Ensembl:ENSG00000116667 euGenes: HUgn81563
    ECgene: C1orf21 H-InvDB: C1orf21

    Other Databases showing C1orf21 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C1orf21 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1orf21 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C1orf21 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C1orf21 gene:
    Search GeneIP for patents involving C1orf21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C1orf21 gene

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    About This Section

     
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    von Willebrand factor
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