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Aliases for C1orf21 Gene

Aliases for C1orf21 Gene

  • Chromosome 1 Open Reading Frame 21 2 3 5
  • Cell Proliferation-Inducing Gene 13 Protein 3 4
  • Proliferation-Inducing Protein 13 2 3
  • Uncharacterized Protein C1orf21 3
  • PIG13 3

External Ids for C1orf21 Gene

Previous GeneCards Identifiers for C1orf21 Gene

  • GC01P181882
  • GC01P179784
  • GC01P180876
  • GC01P181595
  • GC01P181087
  • GC01P182622
  • GC01P155591

Summaries for C1orf21 Gene

GeneCards Summary for C1orf21 Gene

C1orf21 (Chromosome 1 Open Reading Frame 21) is a Protein Coding gene.

Gene Wiki entry for C1orf21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf21 Gene

Genomics for C1orf21 Gene

Regulatory Elements for C1orf21 Gene

Enhancers for C1orf21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G184415 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17 +31.2 31203 5.0 PKNOX1 SIN3A ZNF2 ZNF416 FOS ZNF263 SP3 ZNF662 REST ZNF579 C1orf21 ENSG00000271387 COLGALT2 ENSG00000230470 GC01P184462
GH01G184490 1.5 Ensembl ENCODE dbSUPER 16.5 +105.4 105436 4.5 PKNOX1 FOXA2 ATF1 DMAP1 YY1 ZNF766 FOS JUNB MEF2D CREB3 C1orf21 GC01P184462 LOC102724857
GH01G184478 1.2 Ensembl ENCODE dbSUPER 18.1 +96.2 96204 8.9 CTCF ESRRA ZSCAN4 ZNF384 CHD7 RAD21 CTBP1 GATA3 FOS ZNF202 C1orf21 GC01P184462 LOC102724857
GH01G184534 1 Ensembl ENCODE dbSUPER 18 +148.5 148487 2.7 PKNOX1 GATA3 MNT NR2F2 SP7 C1orf21 LOC102724857 GC01P184462
GH01G184407 1.3 Ensembl ENCODE dbSUPER 11.6 +21.5 21532 1.3 INSM2 KLF17 RAD21 YY1 SCRT2 FOS ZNF843 ZNF217 ZFP69B MBD2 C1orf21 COLGALT2 ENSG00000230470 GC01P184462
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf21 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000016989 484 2601 PKNOX1 ZNF133 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF416 KLF7 FOS

Genomic Location for C1orf21 Gene

Chromosome:
1
Start:
184,387,016 bp from pter
End:
184,629,021 bp from pter
Size:
242,006 bases
Orientation:
Plus strand

Genomic View for C1orf21 Gene

Genes around C1orf21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf21 Gene

Proteins for C1orf21 Gene

  • Protein details for C1orf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H246-CA021_HUMAN
    Recommended name:
    Uncharacterized protein C1orf21
    Protein Accession:
    Q9H246
    Secondary Accessions:
    • B2R551

    Protein attributes for C1orf21 Gene

    Size:
    121 amino acids
    Molecular mass:
    13865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf21 Gene

Post-translational modifications for C1orf21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf21 Gene

Domains & Families for C1orf21 Gene

Protein Domains for C1orf21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf21: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf21 Gene

Function for C1orf21 Gene

Gene Ontology (GO) - Molecular Function for C1orf21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C1orf21: view
genes like me logo Genes that share phenotypes with C1orf21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf21 Gene

Localization for C1orf21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf21 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf21 Gene

Pathways & Interactions for C1orf21 Gene

SuperPathways for C1orf21 Gene

No Data Available

Interacting Proteins for C1orf21 Gene

Gene Ontology (GO) - Biological Process for C1orf21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf21 Gene

Transcripts for C1orf21 Gene

mRNA/cDNA for C1orf21 Gene

Unigene Clusters for C1orf21 Gene

Chromosome 1 open reading frame 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf21 Gene

No ASD Table

Relevant External Links for C1orf21 Gene

GeneLoc Exon Structure for
C1orf21
ECgene alternative splicing isoforms for
C1orf21

Expression for C1orf21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf21 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for C1orf21 Gene

This gene is overexpressed in Frontal cortex (35.0), Oral epithelium (11.7), Urinary Bladder (6.7), and Prostate (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf21 Gene



NURSA nuclear receptor signaling pathways regulating expression of C1orf21 Gene:

C1orf21

SOURCE GeneReport for Unigene cluster for C1orf21 Gene:

Hs.497159

mRNA Expression by UniProt/SwissProt for C1orf21 Gene:

Q9H246-CA021_HUMAN
Tissue specificity: Expressed in spleen, prostate, testis and uterus.

Evidence on tissue expression from TISSUES for C1orf21 Gene

  • Nervous system(3.9)
  • Skin(2)
genes like me logo Genes that share expression patterns with C1orf21: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf21 Gene

Orthologs for C1orf21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1ORF21 35
  • 100 (a)
OneToOne
C1H1orf21 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia C16H1ORF21 35
  • 99 (a)
OneToMany
C16H1orf21 34
  • 96.69 (n)
-- 35
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C1orf21 35
  • 99 (a)
OneToOne
C7H1orf21 34
  • 96.97 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf21 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700025G04Rik 34 16 35
  • 93.94 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309104 34
  • 93.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf21 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf21 35
  • 93 (a)
OneToOne
C8H1ORF21 34
  • 92.84 (n)
lizard
(Anolis carolinensis)
Reptilia C1orf21 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf21 34
  • 75.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69115 34
zebrafish
(Danio rerio)
Actinopterygii zgc:92140 34
  • 64.64 (n)
C2H1orf21 35
  • 59 (a)
OneToOne
Dr.20974 34
Species where no ortholog for C1orf21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf21 Gene

ENSEMBL:
Gene Tree for C1orf21 (if available)
TreeFam:
Gene Tree for C1orf21 (if available)

Paralogs for C1orf21 Gene

No data available for Paralogs for C1orf21 Gene

Variants for C1orf21 Gene

Sequence variations from dbSNP and Humsavar for C1orf21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000005984 -- 184,551,706(+) TTGGA(C/T)AGAAA intron-variant
rs1000014650 -- 184,491,466(+) CACCT(C/T)AGCCT intron-variant
rs1000034846 -- 184,607,031(+) ATTCC(C/T)CTCTT intron-variant
rs1000037812 -- 184,563,608(+) ATTCC(G/T)GAATT intron-variant
rs1000039758 -- 184,388,196(+) TCCTG(A/G)GCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf21 Gene

Variant ID Type Subtype PubMed ID
dgv20n21 CNV loss 19592680
esv2668015 CNV deletion 23128226
esv2674731 CNV deletion 23128226
esv2720162 CNV deletion 23290073
esv3543567 CNV deletion 23714750
esv3588125 CNV loss 21293372
esv3588126 CNV loss 21293372
esv3588127 CNV loss 21293372
nsv1008237 CNV gain 25217958
nsv3821 CNV deletion 18451855
nsv478651 CNV novel sequence insertion 20440878
nsv832037 CNV gain 17160897

Variation tolerance for C1orf21 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf21 Gene

Disorders for C1orf21 Gene

Relevant External Links for C1orf21

Genetic Association Database (GAD)
C1orf21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf21

No disorders were found for C1orf21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf21 Gene

Publications for C1orf21 Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C1orf21 Gene

Sources for C1orf21 Gene

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