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Aliases for C1orf198 Gene

Aliases for C1orf198 Gene

  • Chromosome 1 Open Reading Frame 198 2 3 5

External Ids for C1orf198 Gene

Previous GeneCards Identifiers for C1orf198 Gene

  • GC01M229039
  • GC01M230972
  • GC01M201457

Summaries for C1orf198 Gene

GeneCards Summary for C1orf198 Gene

C1orf198 (Chromosome 1 Open Reading Frame 198) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf198 Gene

Genomics for C1orf198 Gene

Regulatory Elements for C1orf198 Gene

Enhancers for C1orf198 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G230862 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.3 +3.0 2950 7.6 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 LOC101927604 C1orf198 C1orf131 FAM89A ENSG00000225656
GH01G230820 1.4 Ensembl ENCODE dbSUPER 18 +44.9 44895 8.2 TBP PKNOX1 ZNF23 ZNF766 ZNF548 FOS RELB CEBPB JUNB ZNF623 C1orf131 C1orf198 LOC101927604 CAPN9 COG2 ENSG00000244137 RNA5SP79 ENSG00000225656
GH01G230806 1.1 FANTOM5 ENCODE dbSUPER 17.8 +61.6 61580 3.2 ZNF316 ZNF146 ZNF280D ZSCAN5C ZMYM3 ZNF580 ATF2 C1orf198 CAPN9 LOC101927604 COG2 GC01P230821 ENSG00000244137
GH01G230848 2 VISTA Ensembl ENCODE dbSUPER 9.1 +19.0 19024 3.9 HDGF ATF1 ARNT SIN3A FEZF1 TCF12 ZNF121 GATA2 FOS KLF13 LOC101927604 C1orf198 ENSG00000225656
GH01G230842 1.1 dbSUPER 16.5 +25.2 25216 3.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 ZNF766 LOC101927604 C1orf198 GNPAT ENSG00000244137 ENSG00000225656
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf198 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf198 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021652 1789 2401 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 KLF13 SP3 REST

Genomic Location for C1orf198 Gene

Chromosome:
1
Start:
230,837,119 bp from pter
End:
230,869,589 bp from pter
Size:
32,471 bases
Orientation:
Minus strand

Genomic View for C1orf198 Gene

Genes around C1orf198 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf198 Gene

Proteins for C1orf198 Gene

  • Protein details for C1orf198 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H425-CA198_HUMAN
    Recommended name:
    Uncharacterized protein C1orf198
    Protein Accession:
    Q9H425
    Secondary Accessions:
    • A8K8R8
    • B3KTW1
    • G5EA08

    Protein attributes for C1orf198 Gene

    Size:
    327 amino acids
    Molecular mass:
    36346 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf198 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf198 Gene

Post-translational modifications for C1orf198 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf198 Gene

No data available for DME Specific Peptides for C1orf198 Gene

Domains & Families for C1orf198 Gene

Protein Domains for C1orf198 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf198 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf198: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf198 Gene

Function for C1orf198 Gene

genes like me logo Genes that share phenotypes with C1orf198: view

Animal Models for C1orf198 Gene

MGI Knock Outs for C1orf198:

Animal Model Products

CRISPR Products

miRNA for C1orf198 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1orf198 Gene

Localization for C1orf198 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf198 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf198 gene
Compartment Confidence
cytosol 5
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C1orf198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C1orf198: view

Pathways & Interactions for C1orf198 Gene

SuperPathways for C1orf198 Gene

No Data Available

Interacting Proteins for C1orf198 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355623%0d%0a9606.ENSP00000308576%0d%0a
Selected Interacting proteins: Q9H425-CA198_HUMAN ENSP00000355623 for C1orf198 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C1orf198 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf198 Gene

Drugs & Compounds for C1orf198 Gene

No Compound Related Data Available

Transcripts for C1orf198 Gene

Unigene Clusters for C1orf198 Gene

Chromosome 1 open reading frame 198:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf198 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - -
SP5:
SP6:
SP7: -

Relevant External Links for C1orf198 Gene

GeneLoc Exon Structure for
C1orf198
ECgene alternative splicing isoforms for
C1orf198

Expression for C1orf198 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf198 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1orf198 Gene

This gene is overexpressed in Bone marrow stromal cell (25.3), Adrenal (7.9), Peripheral blood mononuclear cells (7.8), and Gallbladder (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf198 Gene



NURSA nuclear receptor signaling pathways regulating expression of C1orf198 Gene:

C1orf198

SOURCE GeneReport for Unigene cluster for C1orf198 Gene:

Hs.520494

Evidence on tissue expression from TISSUES for C1orf198 Gene

  • Nervous system(4.5)
  • Kidney(4.2)
  • Liver(4.1)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with C1orf198: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf198 Gene

Orthologs for C1orf198 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf198 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf198 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H1orf198 34
  • 86.97 (n)
C1orf198 35
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C28H1orf198 34
  • 85.15 (n)
C1orf198 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310022B05Rik 34 16 35
  • 80.35 (n)
rat
(Rattus norvegicus)
Mammalia RGD1559896 34
  • 79.63 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf198 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf198 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485462 34
  • 59.91 (n)
zebrafish
(Danio rerio)
Actinopterygii wu:fa18f11 34
  • 57.13 (n)
C20H1orf198 35
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToOne
Species where no ortholog for C1orf198 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf198 Gene

ENSEMBL:
Gene Tree for C1orf198 (if available)
TreeFam:
Gene Tree for C1orf198 (if available)

Paralogs for C1orf198 Gene

No data available for Paralogs for C1orf198 Gene

Variants for C1orf198 Gene

Sequence variations from dbSNP and Humsavar for C1orf198 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000014350 -- 230,843,510(+) CTCAC(A/G)TTGGG reference, synonymous-codon
rs1000142644 -- 230,857,965(+) ACTGA(A/T)TGGTA intron-variant, upstream-variant-2KB
rs1000237614 -- 230,863,610(+) AGGAG(A/C)CAGCA intron-variant
rs1000376690 -- 230,851,460(+) GCCTG(A/G)GGAAT intron-variant
rs1000400867 -- 230,847,632(+) TGTGT(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf198 Gene

Variant ID Type Subtype PubMed ID
esv3589093 CNV gain 21293372
nsv1000488 CNV gain 25217958
nsv1010882 CNV gain 25217958

Variation tolerance for C1orf198 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf198 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf198

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf198 Gene

Disorders for C1orf198 Gene

Relevant External Links for C1orf198

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf198

No disorders were found for C1orf198 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf198 Gene

Publications for C1orf198 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C1orf198 Gene

Sources for C1orf198 Gene

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