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Aliases for C1orf186 Gene

Aliases for C1orf186 Gene

  • Chromosome 1 Open Reading Frame 186 2 3 5
  • Regulator Of Human Erythroid Cell Expansion 3
  • RHEX 3

External Ids for C1orf186 Gene

Previous GeneCards Identifiers for C1orf186 Gene

  • GC01M202783
  • GC01M204405
  • GC01M206238
  • GC01M177171

Summaries for C1orf186 Gene

GeneCards Summary for C1orf186 Gene

C1orf186 (Chromosome 1 Open Reading Frame 186) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf186 Gene

Genomics for C1orf186 Gene

Regulatory Elements for C1orf186 Gene

Enhancers for C1orf186 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C1orf186 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf186 Gene

Chromosome:
1
Start:
206,037,231 bp from pter
End:
206,102,701 bp from pter
Size:
65,471 bases
Orientation:
Plus strand

Genomic View for C1orf186 Gene

Genes around C1orf186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf186 Gene

Proteins for C1orf186 Gene

  • Protein details for C1orf186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWK4-CA186_HUMAN
    Recommended name:
    Uncharacterized protein C1orf186
    Protein Accession:
    Q6ZWK4

    Protein attributes for C1orf186 Gene

    Size:
    172 amino acids
    Molecular mass:
    19405 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf186 Gene

Proteomics data for C1orf186 Gene at MOPED

Post-translational modifications for C1orf186 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf186 Gene

No data available for DME Specific Peptides for C1orf186 Gene

Domains & Families for C1orf186 Gene

Protein Domains for C1orf186 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf186: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf186 Gene

Function for C1orf186 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf186 Gene

Localization for C1orf186 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf186 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf186 Gene COMPARTMENTS Subcellular localization image for C1orf186 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for C1orf186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 25092874
genes like me logo Genes that share ontologies with C1orf186: view

Pathways & Interactions for C1orf186 Gene

SuperPathways for C1orf186 Gene

No Data Available

Interacting Proteins for C1orf186 Gene

Gene Ontology (GO) - Biological Process for C1orf186 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf186 Gene

Drugs & Compounds for C1orf186 Gene

No Compound Related Data Available

Transcripts for C1orf186 Gene

mRNA/cDNA for C1orf186 Gene

Unigene Clusters for C1orf186 Gene

Chromosome 1 open reading frame 186:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf186 Gene

No ASD Table

Relevant External Links for C1orf186 Gene

GeneLoc Exon Structure for
C1orf186
ECgene alternative splicing isoforms for
C1orf186

Expression for C1orf186 Gene

mRNA expression in normal human tissues for C1orf186 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf186 Gene

This gene is overexpressed in Cervix - Endocervix (x11.9) and Kidney - Cortex (x8.9).

SOURCE GeneReport for Unigene cluster for C1orf186 Gene Hs.662248

genes like me logo Genes that share expression patterns with C1orf186: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C1orf186 Gene

Orthologs for C1orf186 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf186 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C16H1orf186 35
  • 71.06 (n)
  • 60.48 (a)
dog
(Canis familiaris)
Mammalia C38H1orf186 35
  • 82.24 (n)
  • 68.86 (a)
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf186 35
  • 99.42 (n)
  • 99.42 (a)
Species with no ortholog for C1orf186:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf186 Gene

ENSEMBL:
Gene Tree for C1orf186 (if available)
TreeFam:
Gene Tree for C1orf186 (if available)

Paralogs for C1orf186 Gene

No data available for Paralogs for C1orf186 Gene

Variants for C1orf186 Gene

Sequence variations from dbSNP and Humsavar for C1orf186 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4053 -- 206,056,642(+) taatt(G/T)tattt intron-variant
rs1132536 -- 206,055,448(-) ccttt(C/T)accct intron-variant
rs1132537 -- 206,055,458(-) tggca(C/T)ttcat intron-variant
rs1132540 -- 206,055,500(-) acatc(A/G)taaag intron-variant
rs1132541 -- 206,055,523(-) cttat(A/G)ggtct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf186 Gene

Variant ID Type Subtype PubMed ID
nsv832414 CNV Gain 17160897
nsv873118 CNV Loss 21882294
nsv873123 CNV Gain 21882294
esv1695799 CNV Deletion 17803354
esv1010640 CNV Insertion 20482838
esv1000013 CNV Deletion 20482838
dgv10e180 CNV Loss 20482838
esv2667156 CNV Deletion 23128226
nsv4199 CNV Insertion 18451855
esv28442 CNV Gain 19812545
nsv499241 CNV Gain 21111241
esv991628 CNV Insertion 20482838
esv2663434 CNV Deletion 23128226

Variation tolerance for C1orf186 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf186 Gene

HapMap Linkage Disequilibrium report
C1orf186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf186 Gene

Disorders for C1orf186 Gene

Relevant External Links for C1orf186

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf186

No disorders were found for C1orf186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf186 Gene

Publications for C1orf186 Gene

  1. RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development. (PMID: 25092874) Verma R. … Wojchowski D.M. (J. Exp. Med. 2014) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for C1orf186 Gene

Sources for C1orf186 Gene

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