Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C1orf186 Gene

Aliases for C1orf186 Gene

  • Chromosome 1 Open Reading Frame 186 2 3 5
  • Regulator Of Human Erythroid Cell Expansion 3
  • Uncharacterized Protein C1orf186 3
  • RHEX 3

External Ids for C1orf186 Gene

Previous GeneCards Identifiers for C1orf186 Gene

  • GC01M202783
  • GC01M204405
  • GC01M206238
  • GC01M177171

Summaries for C1orf186 Gene

GeneCards Summary for C1orf186 Gene

C1orf186 (Chromosome 1 Open Reading Frame 186) is a Protein Coding gene.

Additional gene information for C1orf186 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf186 Gene

Genomics for C1orf186 Gene

Regulatory Elements for C1orf186 Gene

Enhancers for C1orf186 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H206106 1.3 Ensembl ENCODE dbSUPER 11.2 +69.4 69385 0 CTCF RB1 ARNT ARID4B KLF17 RAD21 RELA CC2D1A CTBP1 SMC3 ENSG00000252692 CTSE C1orf186 NUCKS1 IKBKE RAB29 AVPR1B
GH01H206065 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +30.0 30011 2 HDAC1 PKNOX1 TBL1XR1 TCF12 ZNF766 GATA2 ELK1 SCRT2 SIRT6 RUNX3 C1orf186 LOC105372857 PIR51502
GH01H206076 0.9 ENCODE dbSUPER 12.9 +38.3 38296 0 ZNF639 ZNF197 ZBTB11 E2F5 ZNF175 ZNF644 ZNF83 ZNF589 GATA2 IKZF1 C1orf186 CTSE LOC105372857 GC01P206081
GH01H206102 0.9 Ensembl dbSUPER 11.7 +65.1 65111 0 PKNOX1 CEBPB MAFG CEBPG IKZF1 NFE2 MAFK SPI1 ENSG00000252692 C1orf186 CTSE AVPR1B
GH01H206113 0.9 ENCODE dbSUPER 11.1 +76.2 76159 0 ELF3 SOX13 GATAD2A PKNOX1 ZNF687 SAP130 HLF ARID4B CEBPG GATA3 CTSE C1orf186 AVPR1B ENSG00000252692
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf186 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf186 Gene

Chromosome:
1
Start:
206,037,231 bp from pter
End:
206,102,701 bp from pter
Size:
65,471 bases
Orientation:
Plus strand

Genomic View for C1orf186 Gene

Genes around C1orf186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf186 Gene

Proteins for C1orf186 Gene

  • Protein details for C1orf186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWK4-CA186_HUMAN
    Recommended name:
    Uncharacterized protein C1orf186
    Protein Accession:
    Q6ZWK4

    Protein attributes for C1orf186 Gene

    Size:
    172 amino acids
    Molecular mass:
    19405 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf186 Gene

Post-translational modifications for C1orf186 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf186 Gene

No data available for DME Specific Peptides for C1orf186 Gene

Domains & Families for C1orf186 Gene

Gene Families for C1orf186 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C1orf186 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf186: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf186 Gene

Function for C1orf186 Gene

Phenotypes for C1orf186 Gene

GenomeRNAi human phenotypes for C1orf186:
genes like me logo Genes that share phenotypes with C1orf186: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf186
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf186 Gene

Localization for C1orf186 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf186 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf186 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for C1orf186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 25092874
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1orf186: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1orf186 Gene

Pathways & Interactions for C1orf186 Gene

SuperPathways for C1orf186 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf186 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf186 Gene

Drugs & Compounds for C1orf186 Gene

No Compound Related Data Available

Transcripts for C1orf186 Gene

mRNA/cDNA for C1orf186 Gene

Unigene Clusters for C1orf186 Gene

Chromosome 1 open reading frame 186:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf186
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf186 Gene

No ASD Table

Relevant External Links for C1orf186 Gene

GeneLoc Exon Structure for
C1orf186
ECgene alternative splicing isoforms for
C1orf186

Expression for C1orf186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf186 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf186 Gene

This gene is overexpressed in Cervix - Endocervix (x11.9) and Kidney - Cortex (x8.9).

NURSA nuclear receptor signaling pathways regulating expression of C1orf186 Gene:

C1orf186

SOURCE GeneReport for Unigene cluster for C1orf186 Gene:

Hs.662248

Evidence on tissue expression from TISSUES for C1orf186 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with C1orf186: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf186 Gene

Orthologs for C1orf186 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf186 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf186 33
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia C38H1orf186 33
  • 82.24 (n)
cow
(Bos Taurus)
Mammalia C16H1orf186 33
  • 71.06 (n)
Species where no ortholog for C1orf186 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf186 Gene

ENSEMBL:
Gene Tree for C1orf186 (if available)
TreeFam:
Gene Tree for C1orf186 (if available)

Paralogs for C1orf186 Gene

No data available for Paralogs for C1orf186 Gene

Variants for C1orf186 Gene

Sequence variations from dbSNP and Humsavar for C1orf186 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000508854 -- 206,070,790(+) TACCC(C/T)CCCCA intron-variant
rs1000532438 -- 206,102,972(+) CGCCT(A/G)TAGTC downstream-variant-500B
rs1000669265 -- 206,096,525(+) AGGGG(A/T)CTTGA intron-variant
rs1000756074 -- 206,054,191(+) TTCTT(C/G)TCCTG intron-variant, upstream-variant-2KB
rs1000796093 -- 206,090,339(+) TTGTT(A/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf186 Gene

Variant ID Type Subtype PubMed ID
dgv10e180 CNV loss 20482838
dgv784n54 CNV gain 21841781
dgv785n54 CNV loss 21841781
esv1000013 CNV deletion 20482838
esv1010640 CNV insertion 20482838
esv1695799 CNV deletion 17803354
esv2663434 CNV deletion 23128226
esv2667156 CNV deletion 23128226
esv28442 CNV gain 19812545
esv2848124 CNV deletion 24192839
esv3337264 CNV duplication 20981092
esv3386019 CNV duplication 20981092
esv3588649 CNV loss 21293372
esv3588651 CNV loss 21293372
esv3588652 CNV loss 21293372
esv991628 CNV insertion 20482838
nsv1132316 CNV duplication 24896259
nsv4199 CNV insertion 18451855
nsv499241 CNV gain 21111241
nsv832414 CNV gain 17160897

Variation tolerance for C1orf186 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf186 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf186 Gene

Disorders for C1orf186 Gene

Relevant External Links for C1orf186

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf186

No disorders were found for C1orf186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf186 Gene

Publications for C1orf186 Gene

  1. RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development. (PMID: 25092874) Verma R … Wojchowski DM (The Journal of experimental medicine 2014) 2 3 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for C1orf186 Gene

Sources for C1orf186 Gene

Content
Loading form....