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Aliases for C1orf185 Gene

Aliases for C1orf185 Gene

  • Chromosome 1 Open Reading Frame 185 2 3 5

External Ids for C1orf185 Gene

Previous GeneCards Identifiers for C1orf185 Gene

  • GC01P051281
  • GC01P051340
  • GC01P051567
  • GC01P049685
  • GC01P050976

Summaries for C1orf185 Gene

GeneCards Summary for C1orf185 Gene

C1orf185 (Chromosome 1 Open Reading Frame 185) is a Protein Coding gene.

Additional gene information for C1orf185 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf185 Gene

Genomics for C1orf185 Gene

Regulatory Elements for C1orf185 Gene

Enhancers for C1orf185 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H051874 1.7 FANTOM5 ENCODE dbSUPER 9.8 +775.2 775233 5 MLX DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC ZNF610 GLIS1 NBN ENSG00000266993 ZCCHC11 PRPF38A GAPDHP51 SLC25A6P3 TXNDC12-AS1 CC2D1B TXNDC12 NRDC CFL1P2
GH01H051062 0.6 ENCODE 0.3 -39.1 -39129 1 JUND JUN CEBPB FOS EP300 ATF2 MIR6500 C1orf185
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf185 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the C1orf185 gene promoter:

Genomic Location for C1orf185 Gene

51,102,234 bp from pter
51,148,086 bp from pter
45,853 bases
Plus strand

Genomic View for C1orf185 Gene

Genes around C1orf185 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf185 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf185 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf185 Gene

Proteins for C1orf185 Gene

  • Protein details for C1orf185 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C1orf185
    Protein Accession:
    Secondary Accessions:
    • A6NHS3

    Protein attributes for C1orf185 Gene

    199 amino acids
    Molecular mass:
    22411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf185 Gene

Post-translational modifications for C1orf185 Gene

No Post-translational modifications

Other Protein References for C1orf185 Gene

No data available for DME Specific Peptides for C1orf185 Gene

Domains & Families for C1orf185 Gene

Gene Families for C1orf185 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C1orf185 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf185: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf185 Gene

Function for C1orf185 Gene

Phenotypes From GWAS Catalog for C1orf185 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf185
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf185 Gene

Localization for C1orf185 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf185 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf185 gene
Compartment Confidence
plasma membrane 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C1orf185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1orf185: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1orf185 Gene

Pathways & Interactions for C1orf185 Gene

SuperPathways for C1orf185 Gene

No Data Available

Interacting Proteins for C1orf185 Gene

Gene Ontology (GO) - Biological Process for C1orf185 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf185 Gene

Drugs & Compounds for C1orf185 Gene

No Compound Related Data Available

Transcripts for C1orf185 Gene

mRNA/cDNA for C1orf185 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf185 Gene

Chromosome 1 open reading frame 185:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf185
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf185 Gene

No ASD Table

Relevant External Links for C1orf185 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf185 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf185 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf185 Gene

This gene is overexpressed in Testis (x52.3).

NURSA nuclear receptor signaling pathways regulating expression of C1orf185 Gene:


SOURCE GeneReport for Unigene cluster for C1orf185 Gene:

genes like me logo Genes that share expression patterns with C1orf185: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf185 Gene

Orthologs for C1orf185 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf185 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf185 33
  • 99.16 (n)
C1orf185 34
  • 98 (a)
(Canis familiaris)
Mammalia C15H1orf185 33
  • 89.78 (n)
C1orf185 34
  • 73 (a)
(Bos Taurus)
Mammalia C3H1orf185 33 34
  • 88.44 (n)
(Rattus norvegicus)
Mammalia LOC689589 33
  • 75.09 (n)
(Mus musculus)
Mammalia 4930522H14Rik 33 16 34
  • 72.59 (n)
Species where no ortholog for C1orf185 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf185 Gene

Gene Tree for C1orf185 (if available)
Gene Tree for C1orf185 (if available)

Paralogs for C1orf185 Gene

No data available for Paralogs for C1orf185 Gene

Variants for C1orf185 Gene

Sequence variations from dbSNP and Humsavar for C1orf185 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000010766 -- 51,139,774(+) ACTTC(A/C)GTAAC intron-variant
rs1000047459 -- 51,147,196(+) AAGGC(A/C)ATCAG intron-variant
rs1000103641 -- 51,127,787(+) TGACG(A/G)ATATT intron-variant
rs1000144143 -- 51,140,229(+) CTGTT(C/T)GTGCA intron-variant
rs1000147705 -- 51,140,124(+) CATAC(A/T)GGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf185 Gene

Variant ID Type Subtype PubMed ID
esv2671256 CNV deletion 23128226
esv3586027 CNV gain 21293372
esv3586028 CNV loss 21293372
esv3586029 CNV loss 21293372

Variation tolerance for C1orf185 Gene

Gene Damage Index Score: 1.46; 28.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf185 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf185 Gene

Disorders for C1orf185 Gene

Relevant External Links for C1orf185

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C1orf185 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf185 Gene

Publications for C1orf185 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PMID: 21076409) Sotoodehnia N … Arking DE (Nature genetics 2010) 3 60

Products for C1orf185 Gene

Sources for C1orf185 Gene

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