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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C1orf185 Gene

protein-coding GIFtS: 32
GCID: GC01P051567 (predicted)

chromosome 1 open reading frame 185

Search for C1orf185
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 1 Open Reading Frame 185¹ ²
FLJ27485¹
Uncharacterized Protein C1orf185²

External Ids:	HGNC: 28096¹	Entrez Gene: 284546²	Ensembl: ENSG00000204006⁷	UniProtKB: Q5T7R7³

Export aliases for C1orf185 gene to outside databases

Previous GC identifers: GC01P051281 GC01P051340 GC01P049685

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C1orf185 gene promoter:
HFH-3 FOXI1 GATA-1
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf185

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3

C1orf185 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf185 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P051567: view genomic region (about GC identifiers)

Start:	51,567,906 bp from pter	End:	51,613,754 bp from pter
Size:	45,849 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CA185_HUMAN, Q5T7R7 (See protein sequence)

Recommended Name: Uncharacterized protein C1orf185

Size: 199 amino acids; 22411 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Secondary accessions: A6NHS3

Explore the universe of human proteins at neXtProt for C1orf185: NX_Q5T7R7

C1orf185 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001129980.1

ENSEMBL proteins:

ENSP00000360824

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	Uscn Proteins for C1orf185

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

C1orf185 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q5T7R7

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C1orf185

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about C1orf185 / CA185

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for C1orf185 gene:

NM_001136508.1

Unigene Cluster for C1orf185:

Chromosome 1 open reading frame 185

Hs.176177 [show with all ESTs]

Unigene Representative Sequence: BQ435507

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371759(uc001csh.3) ENST00000467127 ENST00000474016

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Additional cDNA sequence: AK130995.1

3 DOTS entries:

DT.40299019 DT.121399248 DT.426509

8 AceView cDNA sequences:

AA400579 AK130995 AI024727 AI150029 AA400472 BU570783 AI911010 AI808993

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C1orf185 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAATATTGC

About this image

C1orf185 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatid

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C1orf185 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.176177

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C1orf185 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	4930522H14Rik^{1 , 5}	RIKEN cDNA 4930522H14 gene^{1, 5}	72.62(n)¹ 57.65(a)¹		4 (51.29 cM)⁵ 67646¹ NM_026291.3¹ NP_080567.1¹ 109505337⁵

ENSEMBL Gene Tree for C1orf185 (if available)
TreeFam Gene Tree for C1orf185 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78620259^1,2	C,F,	--	51566227(+)	`GAAAAC/TAAAAC`	1	--	us2k¹		1		EA	120
rs184853549^1,2		--	51566279(+)	`GTGCAC/GAATGA`	1	--	us2k¹		0	--	--	--	--
rs189694452^1,2		--	51566367(+)	`AGAAAC/GCATGA`	1	--	us2k¹		0	--	--	--	--
rs141345012^1,2		--	51566393(+)	`TGCCTC/GAGGAC`	1	--	us2k¹		0	--	--	--	--
rs192607256^1,2		--	51566450(+)	`ATGCAA/CCCCCT`	1	--	us2k¹		0	--	--	--	--
rs150402120^1,2		--	51566546(+)	`GCAAT-/AAAAAG`	1	--	us2k¹		0	--	--	--	--
rs12091587^1,2	H	--	51566604(+)	`ggagtC/Ttgagg`	1	--	us2k¹		4		NS EA	416
rs6685699^1,2	H	--	51566673(+)	`catctC/Ttacga`	1	--	us2k¹		3		EA NS	296
rs184400998^1,2		--	51566676(+)	`CTCTAC/TGAAAA`	1	--	us2k¹		0	--	--	--	--
rs75371861^1,2	C,	--	51566686(+)	`AAAAAA/TTTTAA`	1	--	us2k¹		5		WA CSA NA EA	362

HapMap Linkage Disequilibrium report for C1orf185 (51567906 - 51613754 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1orf185: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C1orf185 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1orf185)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Common variants in 22 loci are associated with QRS du ration and cardiac ventricular conduction. (PubMed id 21076409)¹ Sotoodehnia N....Arking D.E. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284546	HGNC: 28096	AceView: LOC284546	Ensembl:ENSG00000204006	euGenes: HUgn284546
ECgene: C1orf185	H-InvDB: C1orf185

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C1orf185	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C1orf185 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C1orf185 gene:
Search GeneIP for patents involving C1orf185

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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C1orf185 Gene

chromosome 1 open reading frame 185

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C1orf185 Gene

chromosome 1 open reading frame 185

Aliasesfor C1orf185 gene

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Aliases
for C1orf185 gene

Summaries
for C1orf185 gene

Genomic Views
for C1orf185 gene

Proteins
for C1orf185 gene

Protein Domains /
Families
for C1orf185 gene

Function
for C1orf185 gene

Pathways & Interactions
for C1orf185 gene

Drugs & Compounds
for C1orf185 gene

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for C1orf185 gene

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for C1orf185 gene

Orthologs
for C1orf185 gene

Paralogs
for C1orf185 gene

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for C1orf185 gene

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for C1orf185 gene

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for C1orf185 gene

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for C1orf185 gene

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for C1orf185 gene