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Aliases for C1orf174 Gene

Aliases for C1orf174 Gene

  • Chromosome 1 Open Reading Frame 174 2 3 5
  • RP13-531C17.2 3

External Ids for C1orf174 Gene

Previous GeneCards Identifiers for C1orf174 Gene

  • GC01M003829
  • GC01M003101
  • GC01M003805

Summaries for C1orf174 Gene

GeneCards Summary for C1orf174 Gene

C1orf174 (Chromosome 1 Open Reading Frame 174) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf174 Gene

Genomics for C1orf174 Gene

Regulatory Elements for C1orf174 Gene

Promoters for C1orf174 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1orf174 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf174 Gene

Chromosome:
1
Start:
3,889,125 bp from pter
End:
3,900,293 bp from pter
Size:
11,169 bases
Orientation:
Minus strand

Genomic View for C1orf174 Gene

Genes around C1orf174 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf174 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf174 Gene

Proteins for C1orf174 Gene

  • Protein details for C1orf174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYL3-CA174_HUMAN
    Recommended name:
    UPF0688 protein C1orf174
    Protein Accession:
    Q8IYL3
    Secondary Accessions:
    • A8K0C8
    • A8MUG9
    • Q5SR20
    • Q6NX36

    Protein attributes for C1orf174 Gene

    Size:
    243 amino acids
    Molecular mass:
    25977 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35643.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C1orf174 Gene

Proteomics data for C1orf174 Gene at MOPED

Post-translational modifications for C1orf174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf174 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C1orf174 Gene

Domains & Families for C1orf174 Gene

Protein Domains for C1orf174 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf174 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYL3

UniProtKB/Swiss-Prot:

CA174_HUMAN :
  • Belongs to the UPF0688 family.
Family:
  • Belongs to the UPF0688 family.
genes like me logo Genes that share domains with C1orf174: view

No data available for Gene Families for C1orf174 Gene

Function for C1orf174 Gene

Phenotypes for C1orf174 Gene

MGI mutant phenotypes for C1orf174:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with C1orf174: view

Animal Models for C1orf174 Gene

MGI Knock Outs for C1orf174:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1orf174 Gene

Localization for C1orf174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf174 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf174 Gene COMPARTMENTS Subcellular localization image for C1orf174 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for C1orf174 Gene

Pathways & Interactions for C1orf174 Gene

SuperPathways for C1orf174 Gene

No Data Available

Interacting Proteins for C1orf174 Gene

Gene Ontology (GO) - Biological Process for C1orf174 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf174 Gene

Drugs & Compounds for C1orf174 Gene

No Compound Related Data Available

Transcripts for C1orf174 Gene

Unigene Clusters for C1orf174 Gene

Chromosome 1 open reading frame 174:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf174 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for C1orf174 Gene

GeneLoc Exon Structure for
C1orf174
ECgene alternative splicing isoforms for
C1orf174

Expression for C1orf174 Gene

mRNA expression in normal human tissues for C1orf174 Gene

Protein differential expression in normal tissues from HIPED for C1orf174 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.8), CD8 Tcells (9.5), Lung (9.3), NK cells (8.4), and Monocytes (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C1orf174 Gene



SOURCE GeneReport for Unigene cluster for C1orf174 Gene Hs.103939

genes like me logo Genes that share expression patterns with C1orf174: view

Protein tissue co-expression partners for C1orf174 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C1orf174 Gene

Orthologs for C1orf174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf174 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C16H1orf174 35
  • 67.12 (n)
  • 60.99 (a)
C16H1orf174 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H1orf174 35
  • 73.93 (n)
  • 65.78 (a)
C1orf174 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A430005L14Rik 35
  • 73.91 (n)
  • 69.68 (a)
A430005L14Rik 16
A430005L14Rik 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf174 35
  • 98.77 (n)
  • 97.94 (a)
C1H1orf174 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1304567 35
  • 74.61 (n)
  • 69.63 (a)
oppossum
(Monodelphis domestica)
Mammalia C1orf174 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf174 36
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf174 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf174 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16480 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23827 35
zebrafish
(Danio rerio)
Actinopterygii C8H1orf174 36
  • 25 (a)
OneToOne
Species with no ortholog for C1orf174:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf174 Gene

ENSEMBL:
Gene Tree for C1orf174 (if available)
TreeFam:
Gene Tree for C1orf174 (if available)

Paralogs for C1orf174 Gene

No data available for Paralogs for C1orf174 Gene

Variants for C1orf174 Gene

Sequence variations from dbSNP and Humsavar for C1orf174 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4274008 - 3,891,029(+) TTCGC(C/G)TGTCT reference, missense
rs10909820 - 3,890,886(+) CAAGG(A/C)ACTGC downstream-variant-500B, reference, missense
rs12036962 - 3,890,694(+) CCCTG(C/G)CTCAT downstream-variant-500B, reference, missense
rs1129064 -- 3,889,403(-) CCTTT(C/T)TTATA utr-variant-3-prime
rs4075974 -- 3,889,510(+) CCAAC(A/G)TGGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C1orf174 Gene

Variant ID Type Subtype PubMed ID
nsv509590 CNV Insertion 20534489
esv26417 CNV Gain 19812545
esv2730584 CNV Deletion 23290073
esv1352346 CNV Deletion 17803354
esv2730695 CNV Deletion 23290073
esv2730806 CNV Deletion 23290073

Variation tolerance for C1orf174 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf174 Gene

HapMap Linkage Disequilibrium report
C1orf174

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf174 Gene

Disorders for C1orf174 Gene

Relevant External Links for C1orf174

Genetic Association Database (GAD)
C1orf174
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf174

No disorders were found for C1orf174 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf174 Gene

Publications for C1orf174 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for C1orf174 Gene

Sources for C1orf174 Gene

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