C1orf174 Gene
protein-coding GIFtS: 41
GCID: GC01M003805
|
|
chromosome 1 open reading frame 174
| |
Aliases
for C1orf174 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 1 Open Reading Frame 1741 2 | | RP13-531C17.21 2 | | UPF0688 Protein C1orf1742 |
Export aliases for C1orf174 gene to outside databasesPrevious GC identifers: GC01M003829 GC01M003101 |
Summaries
for C1orf174 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C1orf174 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1orf174 gene promoter:
Lmo2 STAT5A Meis-1b HNF-4alpha1 MEF-2A Msx-1 Meis-1a aMEF-2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1orf174
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf174 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.32 Ensembl cytogenetic band: 1p36.32 HGNC cytogenetic band: 1p36.32C1orf174 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M003805: view genomic region
(about GC identifiers)
Start:
|
3,805,689 bp from pter |
End:
|
3,816,857 bp from pter |
Size:
|
11,169 bases |
Orientation:
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minus strand |
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Proteins
for C1orf174 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CA174_HUMAN, Q8IYL3 (See
protein sequence)Recommended Name: UPF0688 protein C1orf174 Size: 243 amino acids; 25977 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAH35643.1; Type=Erroneous initiation;
Secondary accessions: A8K0C8 A8MUG9 Q5SR20 Q6NX36Explore the universe of human proteins at neXtProt for C1orf174: NX_Q8IYL3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYL3
C1orf174 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997239.2
ENSEMBL proteins: ENSP00000355306
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
C1orf174 for ontologies About GeneDecksing
C1orf174 Antibody Products:
Assay Products for C1orf174: |
Protein
Domains /
Families
for C1orf174 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IYL3 UniProtKB/Swiss-Prot: CA174_HUMAN, Q8IYL3Similarity: Belongs to the UPF0688 family |
Function
for C1orf174 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf174 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf174
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C1orf174 (NM_207356) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf174 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf174 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf174 |
|
Pathways & Interactions
for C1orf174 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf174
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/6 Interacting proteins for C1orf174 (Q8IYL32, 3 ENSP000003553064) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for C1orf174 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1orf174
Search CenterWatch for drugs/clinical trials and news about C1orf174 / CA174
|
Transcripts
for C1orf174 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1orf174 gene: NM_207356.2 Unigene Cluster for C1orf174: Chromosome 1 open reading frame 174 Hs.103939 [show with all ESTs]Unigene Representative Sequence: AK1250923 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486765(uc009vls.3) ENST00000361605 ENST00000474140(uc001alf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf174 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf174
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C1orf174 (NM_207356) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf174 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf174 |
Additional cDNA sequence: AK125092.1 AK289493.1 BC035643.1 BC047611.1 BC067302.1 8 DOTS entries: DT.406670 DT.100021407 DT.101981113 DT.40281556 DT.97814148 DT.121406085 DT.97793364 DT.406669 24/75 AceView cDNA sequences (see all 75): AL705905 CR612189 CA425637 AA431985 NM_207356 BM795678 BC067302 AL353972 BI753170 BX362947 BX452417 BM468314 BC035643 BG284262 BC047611 BU620273 F04992 AI453753 BI822841 BM834104 BM923230 BM994753 BM837562 BX417418
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf174 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C1orf174
|
Expression
for C1orf174 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1orf174 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGAAAGAA
About this image
See C1orf174 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf174
SOURCE GeneReport for Unigene cluster: Hs.103939
SABiosciences Custom PCR Arrays for C1orf174
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf174
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C1orf174 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf174 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf174 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf174 |
Orthologs
for C1orf174 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C1orf174 gene from 5/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
A430005L14Rik1 , 5 |
RIKEN cDNA A430005L14 gene1, 5 |
74.3(n)1
69.16(a)1 |
|
4 (83.78 cM)5
971591 NM_175287.41 NP_780496.21
1539572375 |
chicken
(Gallus gallus) |
Aves |
C21H1orf1741 |
chromosome 21 open reading frame, human C1orf174 |
52.69(n)
37.88(a) |
|
419378 XM_417541.3 XP_417541.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C1orf1746 |
-- |
56(a) |
1 ↔ 1 |
GL343537.1(60060-61720) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.238272 |
Xenopus laevis transcribed sequence with strong similarity to protein pirT00334 (H.sapiens) T00334 hypothetical protein KIAA0562 - human less |
77.59(n) |
|
48052500 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-147a11.36 |
si:ch211-147a11.3 |
25(a) |
1 ↔ 1 |
8(22891149-22895846) |
ENSEMBL Gene Tree for C1orf174 (if available)
TreeFam Gene Tree for C1orf174 (if available) |
Paralogs
for C1orf174 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C1orf174 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C1orf174 (3805689 - 3816857 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C1orf174
1 Indel: 69701 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf174 |
|
Disorders
/ Diseases
for C1orf174 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C1orf174 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1orf174 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with C1orf174) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. (PubMed id 22361696)2 Stadler C.... Lundberg E. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for C1orf174 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C1orf174 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C1orf174 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1orf174 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C1orf174 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C1orf174 gene:
Search GeneIP for patents involving C1orf174
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1orf174 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C1orf174 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1orf174 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf174 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C1orf174 | | OriGene 3'-UTR Clone for C1orf174 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf174 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf174 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C1orf174 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C1orf174 | | OriGene Custom Protein Services for C1orf174 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf174 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf174 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf174 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1orf174 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf174 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf174 |
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 | | | C1orf174 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf174 |
|  |  |  | | | | Search ThermoFisher Antibodies for C1orf174 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf174 |
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