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Aliases for C1orf174 Gene

Aliases for C1orf174 Gene

  • Chromosome 1 Open Reading Frame 174 2 3 5
  • UPF0688 Protein C1orf174 3
  • RP13-531C17.2 3

External Ids for C1orf174 Gene

Previous GeneCards Identifiers for C1orf174 Gene

  • GC01M003829
  • GC01M003101
  • GC01M003805

Summaries for C1orf174 Gene

GeneCards Summary for C1orf174 Gene

C1orf174 (Chromosome 1 Open Reading Frame 174) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf174 Gene

Genomics for C1orf174 Gene

Regulatory Elements for C1orf174 Gene

Enhancers for C1orf174 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G003899 1.8 FANTOM5 ENCODE dbSUPER 44.3 -0.2 -182 2.7 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC TBX21 C1orf174 TP73-AS1 DFFB ENSG00000272153 LRRC47 PIR33659 LINC01134
GH01G003889 1.1 Ensembl ENCODE 53.7 +9.8 9774 2.8 NFIB TCF12 EGR1 CREM EGR2 CEBPB ZEB2 NFIC RAD51 KLF16 C1orf174 DFFB CEP104 PIR62209
GH01G003065 1.6 FANTOM5 ENCODE dbSUPER 32.5 +829.8 829791 9.4 PKNOX1 YBX1 ZNF48 GLIS2 ZNF143 ZNF416 ZNF548 ZNF263 REST CBX8 TP73-AS1 LOC100129534 MORN1 C1orf174 ENSG00000272153 ACTRT2 ENSG00000272420 SKI PRDM16 LOC100420339
GH01G003687 1.5 FANTOM5 Ensembl ENCODE 23.4 +210.5 210452 3.7 HDGF PKNOX1 ARNT TCF12 GLIS2 ZNF548 KDM4B KLF13 JUNB SMARCA4 TP73-AS1 TP73 C1orf174 ENSG00000272153 CEP104 AJAP1 WRAP73 LOC105378609 ENSG00000235131
GH01G003885 0.7 dbSUPER 32.3 +13.7 13672 1.3 PHF8 L3MBTL2 RNF2 ZBTB11 NR4A1 CEBPB RBBP5 CEBPG TFDP1 SMARCA4 C1orf174 CEP104 DFFB PIR62209
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf174 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf174 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000530 -207 2600 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC TBX21

Genomic Location for C1orf174 Gene

Chromosome:
1
Start:
3,889,125 bp from pter
End:
3,900,293 bp from pter
Size:
11,169 bases
Orientation:
Minus strand

Genomic View for C1orf174 Gene

Genes around C1orf174 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf174 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf174 Gene

Proteins for C1orf174 Gene

  • Protein details for C1orf174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYL3-CA174_HUMAN
    Recommended name:
    UPF0688 protein C1orf174
    Protein Accession:
    Q8IYL3
    Secondary Accessions:
    • A8K0C8
    • A8MUG9
    • Q5SR20
    • Q6NX36

    Protein attributes for C1orf174 Gene

    Size:
    243 amino acids
    Molecular mass:
    25977 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35643.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C1orf174 Gene

Post-translational modifications for C1orf174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf174 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf174 Gene

Domains & Families for C1orf174 Gene

Protein Domains for C1orf174 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf174 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYL3

UniProtKB/Swiss-Prot:

CA174_HUMAN :
  • Belongs to the UPF0688 family.
Family:
  • Belongs to the UPF0688 family.
genes like me logo Genes that share domains with C1orf174: view

No data available for Gene Families for C1orf174 Gene

Function for C1orf174 Gene

Gene Ontology (GO) - Molecular Function for C1orf174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with C1orf174: view

Phenotypes for C1orf174 Gene

MGI mutant phenotypes for C1orf174:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with C1orf174: view

Animal Models for C1orf174 Gene

MGI Knock Outs for C1orf174:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1orf174 Gene

Localization for C1orf174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf174 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf174 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C1orf174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with C1orf174: view

Pathways & Interactions for C1orf174 Gene

SuperPathways for C1orf174 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf174 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf174 Gene

Drugs & Compounds for C1orf174 Gene

No Compound Related Data Available

Transcripts for C1orf174 Gene

Unigene Clusters for C1orf174 Gene

Chromosome 1 open reading frame 174:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf174 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for C1orf174 Gene

GeneLoc Exon Structure for
C1orf174
ECgene alternative splicing isoforms for
C1orf174

Expression for C1orf174 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf174 Gene

Protein differential expression in normal tissues from HIPED for C1orf174 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.8), CD8 Tcells (9.5), Lung (9.3), NK cells (8.4), and Monocytes (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf174 Gene



Protein tissue co-expression partners for C1orf174 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf174 Gene:

C1orf174

SOURCE GeneReport for Unigene cluster for C1orf174 Gene:

Hs.103939

Evidence on tissue expression from TISSUES for C1orf174 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C1orf174: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf174 Gene

Orthologs for C1orf174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf174 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf174 34 35
  • 98.77 (n)
rat
(Rattus norvegicus)
Mammalia RGD1304567 34
  • 74.61 (n)
dog
(Canis familiaris)
Mammalia C5H1orf174 34
  • 73.93 (n)
C1orf174 35
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A430005L14Rik 34 16 35
  • 73.91 (n)
cow
(Bos Taurus)
Mammalia C16H1orf174 34 35
  • 67.12 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf174 35
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf174 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf174 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf174 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16480 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23827 34
zebrafish
(Danio rerio)
Actinopterygii C8H1orf174 35
  • 25 (a)
OneToOne
Species where no ortholog for C1orf174 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf174 Gene

ENSEMBL:
Gene Tree for C1orf174 (if available)
TreeFam:
Gene Tree for C1orf174 (if available)

Paralogs for C1orf174 Gene

No data available for Paralogs for C1orf174 Gene

Variants for C1orf174 Gene

Sequence variations from dbSNP and Humsavar for C1orf174 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000177534 -- 3,891,773(+) CTCCA(C/T)AGCAC intron-variant, reference, synonymous-codon
rs1000256530 -- 3,900,384(+) TCACA(C/G/T)GCCTT upstream-variant-2KB
rs1000329359 -- 3,897,389(+) ATAAC(A/G)AAATT intron-variant, utr-variant-5-prime
rs1000386651 -- 3,897,049(+) CCAGG(A/G)TTGGG intron-variant, utr-variant-5-prime
rs1000543148 -- 3,901,240(+) GGGTC(A/C/T)GGCGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf174 Gene

Variant ID Type Subtype PubMed ID
esv1352346 CNV deletion 17803354
esv26417 CNV gain 19812545
esv3585042 CNV gain 21293372
esv3585052 CNV gain 21293372
nsv1012423 CNV gain 25217958
nsv474199 CNV novel sequence insertion 20440878
nsv509590 CNV insertion 20534489
nsv545130 CNV gain 21841781

Variation tolerance for C1orf174 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf174 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf174

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf174 Gene

Disorders for C1orf174 Gene

Relevant External Links for C1orf174

Genetic Association Database (GAD)
C1orf174
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf174

No disorders were found for C1orf174 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf174 Gene

Publications for C1orf174 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for C1orf174 Gene

Sources for C1orf174 Gene

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