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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C1orf170 Gene

protein-coding GIFtS: 34
GCID: GC01M000900

chromosome 1 open reading frame 170

Search for C1orf170
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 1 Open Reading Frame 170¹ ²
RP11-54O7.8¹ ²
MGC13275¹

External Ids:	HGNC: 28208¹	Entrez Gene: 84808²	Ensembl: ENSG00000187642⁷	UniProtKB: Q5SV97³

ORGUL members:
	NONCODE:n407979

Export aliases for C1orf170 gene to outside databases

Previous GC identifers: GC01M000951 GC01M000180

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004350.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C1orf170 gene promoter:
CREB deltaCREB E47
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf170

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33

C1orf170 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf170 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M000900: view genomic region (about GC identifiers)

Start:	910,579 bp from pter	End:	917,497 bp from pter
Size:	6,919 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CA170_HUMAN, Q5SV97 (See protein sequence)

Recommended Name: Uncharacterized protein C1orf170

Size: 696 amino acids; 71970 Da

Sequence caution: Sequence=BAC85711.1; Type=Erroneous initiation;

Secondary accessions: Q6ZVZ7 Q9BRF2

Alternative splicing: 2 isoforms: Q5SV97-1 Q5SV97-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C1orf170: NX_Q5SV97

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5SV97

C1orf170 Protein expression data from MOPED and PaxDb: About this image

ENSEMBL proteins:

ENSP00000343864 ENSP00000414022

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q5SV97

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C1orf170

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C1orf170 gene:

NM_032722.2

Unigene Cluster for C1orf170:

Chromosome 1 open reading frame 170

Hs.271462 [show with all ESTs]

Unigene Representative Sequence: NR_027693

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341290 ENST00000479361(uc001acg.2) ENST00000433179(uc001ach.2)

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Additional cDNA sequence:

AK123855.1 AK312221.1 BC006300.2 NR_027693.1

2 DOTS entries:

DT.436842 DT.121462121

10 AceView cDNA sequences:

F25037 BC006300 AK123855 AJ574533 F22110 BQ082009 AI623703 F16288

F32850 AI867502

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C1orf170 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGCAGCAC

About this image

C1orf170 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C1orf170 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf170

SOURCE GeneReport for Unigene cluster: Hs.271462

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C1orf170 gene from 3/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	2310042D19Rik⁵	RIKEN cDNA 2310042D19 gene	--		4 (88.62 cM) 156215927
chicken (Gallus gallus)	Aves	C1orf170⁶	Uncharacterized protein	69(a)	1 ↔ 1	21(2834544-2837360)
lizard (Anolis carolinensis)	Reptilia	C1orf170⁶	--	68(a)	1 ↔ 1	GL343334.1(907206-1084936)

ENSEMBL Gene Tree for C1orf170 (if available)
TreeFam Gene Tree for C1orf170 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for C1orf170 gene

C1orf170 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for C1orf170
PGOHUM00000263021

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3748588^1,2	C	--	911101(+)	`CCAGCC/TGGAGT`	1	--	nc-transcript-variantese³		4		EA CSA WA	1740
rs141461384^1,2		--	911129(+)	`CCTCCA/GAGGTC`	1	--	nc-transcript-variant		0	--	--	--	--
rs187245348^1,2		--	911160(+)	`AGCTCC/TCCCTG`	1	--	nc-transcript-variant		0	--	--	--	--
rs114918572^1,2		--	911181(+)	`GAAACG/ACAGGG`	1	--	nc-transcript-variant		1		NA	120
rs190126715^1,2		--	911236(+)	`ATGACC/TTCCCC`	1	--	nc-transcript-variant		0	--	--	--	--
rs145156989^1,2		--	911301(+)	`GCCACC/TCTCCT`	1	--	nc-transcript-variant		0	--	--	--	--
rs181589848^1,2		--	911336(+)	`CCCACC/TCAGAC`	1	--	nc-transcript-variant		0	--	--	--	--
rs113068688^1,2	C	--	911418(+)	`GCAGCA/CCCAGG`	1	--	nc-transcript-variant		2		CSA WA	120
rs7417106^1,2	C,F	--	911595(+)	`GCCCCG/ACCTGC`	1	--	nc-transcript-variant		8		NA CSA WA EA	370
rs185856602^1,2		--	911857(+)	`GCTCCC/TTCTGC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C1orf170 (910579 - 917497 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for C1orf170
4 CNVs: 2294 30362 3274 23374

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C1orf170 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1orf170)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization. (PubMed id 8681137)¹ Lanfranchi G....Valle G. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84808	HGNC: 28208	AceView: MGC13275	Ensembl:ENSG00000187642	euGenes: HUgn84808
ECgene: C1orf170	H-InvDB: C1orf170

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C1orf170	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C1orf170 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C1orf170 gene:
Search GeneIP for patents involving C1orf170

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C1orf170 gene at Home site.

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C1orf170 Gene

chromosome 1 open reading frame 170

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C1orf170 Gene

chromosome 1 open reading frame 170

Aliasesfor C1orf170 gene

Summariesfor C1orf170 gene

Genomic Viewsfor C1orf170 gene

Proteinsfor C1orf170 gene

Protein Domains /Familiesfor C1orf170 gene

Functionfor C1orf170 gene

Pathways & Interactionsfor C1orf170 gene

Drugs & Compoundsfor C1orf170 gene

Transcriptsfor C1orf170 gene

Expression for C1orf170 gene

Orthologsfor C1orf170 gene

Paralogsfor C1orf170 gene

Genomic Variantsfor C1orf170 gene

Disorders / Diseasesfor C1orf170 gene

Publicationsfor C1orf170 gene

External Searches for C1orf170 gene

Genome Databases showing C1orf170 gene

Other Databases showing C1orf170 gene

Specialized Databases showing C1orf170 gene

Intellectual Propertyfor C1orf170 gene

Productsfor C1orf170 gene

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Aliases
for C1orf170 gene

Summaries
for C1orf170 gene

Genomic Views
for C1orf170 gene

Proteins
for C1orf170 gene

Protein Domains /
Families
for C1orf170 gene

Function
for C1orf170 gene

Pathways & Interactions
for C1orf170 gene

Drugs & Compounds
for C1orf170 gene

Transcripts
for C1orf170 gene

Expression
for C1orf170 gene

Orthologs
for C1orf170 gene

Paralogs
for C1orf170 gene

Genomic Variants
for C1orf170 gene

Disorders / Diseases
for C1orf170 gene

Publications
for C1orf170 gene

Intellectual Property
for C1orf170 gene

Products
for C1orf170 gene