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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1orf168 Gene

protein-coding   GIFtS: 44
GCID: GC01M057184

Chromosome 1 Open Reading Frame 168

  Search for C1orf168
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 1 Open Reading Frame 1681 2
Uncharacterized Protein C1orf1682

External Ids:    HGNC: 272951   Entrez Gene: 1999202   Ensembl: ENSG000001878897   UniProtKB: Q5VWT53   

Export aliases for C1orf168 gene to outside databases

Previous GC identifers: GC01M056897 GC01M055296


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C1orf168 Gene: 
C1orf168 (chromosome 1 open reading frame 168) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1orf168 gene promoter:
         SRF   SRF (504 AA)   IRF-1   IRF-2   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C1orf168

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf168


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.2   Ensembl cytogenetic band:  1p32.2   HGNC cytogenetic band: 1p32.2

C1orf168 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf168 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M057184:  view genomic region     (about GC identifiers)

Start:
57,184,477 bp from pter      End:
57,285,369 bp from pter
Size:
100,893 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CA168_HUMAN, Q5VWT5 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf168  
Size: 728 amino acids; 82070 Da
Secondary accessions: Q63HM3 Q6ZUY6
Alternative splicing: 2 isoforms:  Q5VWT5-1   Q5VWT5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C1orf168: NX_Q5VWT5

Explore proteomics data for C1orf168 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VWT5

  • C1orf168 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C1orf168 Protein Expression
    REFSEQ proteins: NP_001004303.3  
    ENSEMBL proteins: 
     ENSP00000345972  

    Human Recombinant Protein Products for C1orf168: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q5VWT5

    ProtoNet protein and cluster: Q5VWT5


    C1orf168 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    C1orf168 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidC1orf168 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf168


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf168

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C1orf168 (Q5VWT53 ENSP000003459724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FDFT1P372683, ENSP000002205844I2D: score=1 STRING: ENSP00000220584
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1orf168 (CA168)

    Search CenterWatch for drugs/clinical trials and news about C1orf168 / CA168

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C1orf168 gene: 
    NM_001004303.4  

    Unigene Cluster for C1orf168:

    Chromosome 1 open reading frame 168
    Hs.437655  [show with all ESTs]
    Unigene Representative Sequence: NM_001004303
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343433(uc001cym.4) ENST00000493000(uc001cyl.3) ENST00000497991
    ENST00000484327(uc009vzu.1 uc009vzv.1) ENST00000371240
    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate C1orf168 (see all 18):
    hsa-miR-3910 hsa-miR-30c hsa-miR-4263 hsa-miR-30d hsa-miR-105 hsa-miR-30a hsa-miR-3662 hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidC1orf168 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C1orf168
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1orf168
    Clone
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    OriGene ORF clones in mouse, rat for C1orf168
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C1orf168 (NM_001004303)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1orf168
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C1orf168
    Sirion Biotech Customized lentivirus for stable overexpression of C1orf168 
                         Customized lentivirus expression plasmids for stable overexpression of C1orf168 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf168
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf168

    Additional mRNA sequence: 

    AK093468.1 AK125198.1 AK310842.1 BX648439.1 

    6 DOTS entries:

    DT.101972848  DT.101966421  DT.104943  DT.100742147  DT.121434448  DT.426745 

    24/48 AceView cDNA sequences (see all 48):

    AX748145 AI078379 AI553712 BG190830 AI076431 AA678172 AK125198 AA676740 
    BX108433 AI824534 AI261464 AI475949 CA396100 AI733816 NM_001004303 AK093468 
    AI792637 BM978931 BX101074 BE971223 AI367866 AV719816 AI452457 BG289509 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf168    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                -                                                               
    SP2:                                                        -           -           -               


    ECgene alternative splicing isoforms for C1orf168

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1orf168 expression in normal human tissues (normalized intensities)      C1orf168 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAAATTTT
    C1orf168 Expression
    About this image


    C1orf168 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Endothelium (Cardiovascular System)
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Epithelium (Respiratory System)
             airway epithelial cells   

    See C1orf168 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1orf168

    SOURCE GeneReport for Unigene cluster: Hs.437655
        SABiosciences Custom PCR Arrays for C1orf168
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for C1orf168
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf168

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C1orf168 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700024P16Rik1 , 5 RIKEN cDNA 1700024P16 gene1, 5 72.73(n)1
    59.31(a)1
      4 (48.86 cM)5
    2425941  NM_001162980.11  NP_001156452.11 
     1049135245 
    chicken
    (Gallus gallus)
    Aves C8H1orf1681 chromosome 8 open reading frame, human C1orf168 48.41(n)
    31.88(a)
      424668  XM_422501.3  XP_422501.2 
    lizard
    (Anolis carolinensis)
    Reptilia C1orf1686
    chromosome 1 open reading frame 168
    27(a)
    1 ↔ 1
    4(103239427-103285012)
    zebrafish
    (Danio rerio)
    Actinopterygii C11H1orf1686
    chromosome 1 open reading frame 168
    19(a)
    1 → many
    11(5620327-5635364)


    ENSEMBL Gene Tree for C1orf168 (if available)
    TreeFam Gene Tree for C1orf168 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2113 SNPs in C1orf168 are shown (see all 2113)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357278781,2
    C--57183974(+) AGACA-/GACA  
            
    TTCTA
    1 -- int10--------
    rs1474791191,2
    --57184000(+) TTACTC/TTGAAT 1 -- int10--------
    rs2010367371,2
    --57184048(+) TCTTC-/CATCAATC 1 -- int10--------
    rs105912061,2
    C--57184049(+) CTTCC-/ATCA  
            
    ATCAT
    1 -- int10--------
    rs763491061,2
    C,F--57184118(+) TTACCT/GTCTCT 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1860718221,2
    --57184170(+) TGTTTA/GATTAC 1 -- int10--------
    rs1903387461,2
    --57184200(+) ACAGAG/TCTCCT 1 -- int10--------
    rs118047231,2
    C,F,H--57184436(+) TTTTCA/GGCGCT 1 -- int18Minor allele frequency- G:0.18NA WA CSA 429
    rs1820461601,2
    --57184438(+) TTCAGC/TGCTGA 1 -- int10--------
    rs8571421,2
    C,F,H--57184465(-) AGTTTC/AAAATT 1 -- int116Minor allele frequency- A:0.19NS EA NA WA CSA 792

    HapMap Linkage Disequilibrium report for C1orf168 (57184477 - 57285369 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for C1orf168 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748674CNV Deletion23290073
    esv2663893CNV Deletion23128226
    esv2296236CNV Deletion18987734
    esv2568213CNV Deletion19546169
    esv3554CNV Deletion18987735
    esv988788CNV Deletion20482838
    esv1167886CNV Deletion17803354
    esv270436CNV Insertion20981092
    nsv160326CNV Loss16902084
    nsv520726CNV Loss19592680


    Human Gene Mutation Database (HGMD): C1orf168
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C1orf168
    DNA2.0 Custom Variant and Variant Library Synthesis for C1orf168

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C1orf168 for disorders           About MalaCards

    C1orf168 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C1orf168

    Export disorders for C1orf168 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1orf168 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C1orf168)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
    2. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PubMed id 22843503)1 Qi Q....Qi L. (2012)
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 199920 HGNC: 27295 AceView: LOC199920 Ensembl:ENSG00000187889 euGenes: HUgn199920
    ECgene: C1orf168 H-InvDB: C1orf168

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1orf168 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C1orf168 gene:
    Search GeneIP for patents involving C1orf168

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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