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Aliases for C1orf168 Gene

Aliases for C1orf168 Gene

  • Chromosome 1 Open Reading Frame 168 2 3 5
  • Uncharacterized Protein C1orf168 3
  • RP4-758N20.2 3

External Ids for C1orf168 Gene

Previous GeneCards Identifiers for C1orf168 Gene

  • GC01M056897
  • GC01M057184
  • GC01M055296

Summaries for C1orf168 Gene

GeneCards Summary for C1orf168 Gene

C1orf168 (Chromosome 1 Open Reading Frame 168) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf168 Gene

Genomics for C1orf168 Gene

Regulatory Elements for C1orf168 Gene

Enhancers for C1orf168 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F056907 1.2 FANTOM5 Ensembl ENCODE 18.1 -90.3 -90272 4.2 ATF1 ARID4B DMAP1 ZNF48 YY1 SP5 ZHX2 MXD4 MIER2 PPARG C8B C8A C1orf168 GC01P056889 LOC105378745
GH01F056575 1.3 FANTOM5 ENCODE 7.9 +240.6 240594 6.6 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 ZNF263 SP3 REST C8A C1orf168 C8B PRKAA2 PLPP3 RPL23AP85 GC01P056539
GH01F057006 0.5 FANTOM5 5.5 -187.1 -187122 0.1 C1orf168 C8A C8B GC01P057000 LOC105378748
GH01F057279 0.8 FANTOM5 ENCODE 2.4 -462.0 -461988 4.5 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 FOS SP5 NFYC C8A C8B C1orf168 GC01P057267 GC01P057293
GH01F056815 0.8 Ensembl ENCODE 0.8 +1.8 1760 4.1 ATF1 ZFP64 ARID4B DMAP1 ZNF48 YY1 ZNF263 SP5 JUNB PPARG C1orf168 GC01P056713
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C1orf168 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf168 Gene

Chromosome:
1
Start:
56,718,804 bp from pter
End:
56,819,696 bp from pter
Size:
100,893 bases
Orientation:
Minus strand

Genomic View for C1orf168 Gene

Genes around C1orf168 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf168 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf168 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf168 Gene

Proteins for C1orf168 Gene

  • Protein details for C1orf168 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWT5-CA168_HUMAN
    Recommended name:
    Uncharacterized protein C1orf168
    Protein Accession:
    Q5VWT5
    Secondary Accessions:
    • Q63HM3
    • Q6ZUY6

    Protein attributes for C1orf168 Gene

    Size:
    728 amino acids
    Molecular mass:
    82070 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf168 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf168 Gene

Post-translational modifications for C1orf168 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C1orf168 Gene

Domains & Families for C1orf168 Gene

Protein Domains for C1orf168 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf168: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf168 Gene

Function for C1orf168 Gene

Phenotypes for C1orf168 Gene

GenomeRNAi human phenotypes for C1orf168:
genes like me logo Genes that share phenotypes with C1orf168: view

Animal Model Products

miRNA for C1orf168 Gene

miRTarBase miRNAs that target C1orf168

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf168 Gene

Localization for C1orf168 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf168 Gene COMPARTMENTS Subcellular localization image for C1orf168 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf168 Gene

Pathways & Interactions for C1orf168 Gene

SuperPathways for C1orf168 Gene

No Data Available

Interacting Proteins for C1orf168 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345972%0d%0a9606.ENSP00000220584%0d%0a
Selected Interacting proteins: Q5VWT5-CA168_HUMAN ENSP00000345972 for C1orf168 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C1orf168 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
genes like me logo Genes that share ontologies with C1orf168: view

No data available for Pathways by source and SIGNOR curated interactions for C1orf168 Gene

Transcripts for C1orf168 Gene

Unigene Clusters for C1orf168 Gene

Chromosome 1 open reading frame 168:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf168 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: -
SP2: - - -

Relevant External Links for C1orf168 Gene

GeneLoc Exon Structure for
C1orf168
ECgene alternative splicing isoforms for
C1orf168

Expression for C1orf168 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf168 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf168 Gene

This gene is overexpressed in Liver (x14.0), Heart - Left Ventricle (x7.6), and Kidney - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for C1orf168 Gene

This gene is overexpressed in Liver (55.8) and Placenta (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf168 Gene



Protein tissue co-expression partners for C1orf168 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf168 Gene:

C1orf168

SOURCE GeneReport for Unigene cluster for C1orf168 Gene:

Hs.437655
genes like me logo Genes that share expression patterns with C1orf168: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for C1orf168 Gene

Orthologs for C1orf168 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf168 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf168 34
  • 98.86 (n)
C1orf168 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H1orf168 34
  • 80.49 (n)
C1orf168 35
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700024P16Rik 34 16 35
  • 72.61 (n)
cow
(Bos Taurus)
Mammalia C1orf168 35
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf168 35
  • 4 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf168 35
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf168 35
  • 25 (a)
OneToOne
Species where no ortholog for C1orf168 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf168 Gene

ENSEMBL:
Gene Tree for C1orf168 (if available)
TreeFam:
Gene Tree for C1orf168 (if available)

Paralogs for C1orf168 Gene

No data available for Paralogs for C1orf168 Gene

Variants for C1orf168 Gene

Sequence variations from dbSNP and Humsavar for C1orf168 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10082340 -- 56,799,650(+) CAGTA(A/G/T)TATAC intron-variant
rs10127804 -- 56,832,708(+) ataca(C/G)acaga upstream-variant-2KB
rs10127808 -- 56,832,762(+) TGTGT(A/G)TGTGT upstream-variant-2KB
rs10489617 -- 56,721,334(+) TGTAT(C/G)TATCT intron-variant
rs10489618 -- 56,727,175(+) GTATT(A/G)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf168 Gene

Variant ID Type Subtype PubMed ID
esv1167886 CNV deletion 17803354
esv2296236 CNV deletion 18987734
esv2568213 CNV deletion 19546169
esv2663893 CNV deletion 23128226
esv2748674 CNV deletion 23290073
esv2852457 CNV deletion 24192839
esv3306159 CNV mobile element insertion 20981092
esv3345680 CNV insertion 20981092
esv3411748 CNV insertion 20981092
esv3554 CNV loss 18987735
esv3562438 CNV deletion 23714750
esv3586130 CNV loss 21293372
esv7859 CNV loss 19470904
esv988788 CNV deletion 20482838
nsv1076468 CNV deletion 25765185
nsv1122348 CNV deletion 24896259
nsv1149723 CNV deletion 26484159
nsv160326 CNV deletion 16902084
nsv478675 CNV novel sequence insertion 20440878
nsv520726 CNV loss 19592680
nsv523032 CNV gain 19592680

Variation tolerance for C1orf168 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf168 Gene

Human Gene Mutation Database (HGMD)
C1orf168
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf168

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf168 Gene

Disorders for C1orf168 Gene

Relevant External Links for C1orf168

Genetic Association Database (GAD)
C1orf168
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf168

No disorders were found for C1orf168 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf168 Gene

Publications for C1orf168 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PMID: 22843503) Qi Q. … Qi L. (Hum. Mol. Genet. 2012) 3 64
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for C1orf168 Gene

Sources for C1orf168 Gene

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