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C1orf168 Gene

protein-coding   GIFtS: 46
GCID: GC01M057184

Chromosome 1 Open Reading Frame 168

  Search for C1orf168
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 1 Open Reading Frame 1681 2
RP4-758N20.22
Uncharacterized Protein C1orf1682

External Ids:    HGNC: 272951   Entrez Gene: 1999202   Ensembl: ENSG000001878897   UniProtKB: Q5VWT53   

Export aliases for C1orf168 gene to outside databases

Previous GC identifers: GC01M056897 GC01M055296


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1orf168 Gene:
C1orf168 (chromosome 1 open reading frame 168) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1orf168 gene promoter:
         SRF   SRF (504 AA)   IRF-1   IRF-2   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C1orf168

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1orf168


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.2   Ensembl cytogenetic band:  1p32.2   HGNC cytogenetic band: 1p32.2

C1orf168 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf168 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M057184:  view genomic region     (about GC identifiers)

Start:
57,184,477 bp from pter      End:
57,285,369 bp from pter
Size:
100,893 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CA168_HUMAN, Q5VWT5 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf168  
Size: 728 amino acids; 82070 Da
Secondary accessions: Q63HM3 Q6ZUY6
Alternative splicing: 2 isoforms:  Q5VWT5-1   Q5VWT5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C1orf168: NX_Q5VWT5

Explore proteomics data for C1orf168 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C1orf168 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004303.3  
    ENSEMBL proteins: 
     ENSP00000345972  

    C1orf168 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for C1orf168 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q5VWT5

    ProtoNet protein and cluster: Q5VWT5


    Find genes that share domains with C1orf168           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with C1orf168           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf168
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    miRNA
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    miRTarBase miRNAs that target C1orf168:
    hsa-mir-148b-3p (MIRT019374), hsa-mir-335-5p (MIRT018257)

    Block miRNA regulation of human, mouse, rat C1orf168 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C1orf168 (see all 18):
    hsa-miR-3910 hsa-miR-30c hsa-miR-4263 hsa-miR-30d hsa-miR-105 hsa-miR-30a hsa-miR-3662 hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidC1orf168 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C1orf168

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf168


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1orf168
    Interactions:

        Search GeneGlobe Interaction Network for C1orf168

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C1orf168 (Q5VWT53 ENSP000003459724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FDFT1P372683, ENSP000002205844I2D: score=1 STRING: ENSP00000220584
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1orf168 (CA168)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C1orf168 gene: 
    NM_001004303.4  

    Unigene Cluster for C1orf168:

    Chromosome 1 open reading frame 168
    Hs.437655  [show with all ESTs]
    Unigene Representative Sequence: NM_001004303
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343433(uc001cym.4) ENST00000493000(uc001cyl.3) ENST00000497991
    ENST00000484327(uc009vzu.1 uc009vzv.1) ENST00000371240
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate C1orf168 (see all 18):
    hsa-miR-3910 hsa-miR-30c hsa-miR-4263 hsa-miR-30d hsa-miR-105 hsa-miR-30a hsa-miR-3662 hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidC1orf168 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat C1orf168
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat C1orf168
      QuantiFast Probe-based Assays in human, mouse, rat C1orf168

    Additional mRNA sequence: 

    AK093468.1 AK125198.1 AK310842.1 BX648439.1 

    6 DOTS entries:

    DT.101972848  DT.101966421  DT.104943  DT.100742147  DT.121434448  DT.426745 

    Selected AceView cDNA sequences (see all 48):

    AI733816 NM_001004303 BG190830 AI553712 AI078379 BX108433 AA678172 AK093468 
    AA676740 CA396100 AI792637 AI475949 AX748145 AI261464 AI076431 AI824534 
    AK125198 BU686304 AV719816 AI685034 BM978931 BX648439 AV653001 AI452457 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf168    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                -                                                               
    SP2:                                                        -           -           -               


    ECgene alternative splicing isoforms for C1orf168

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C1orf168 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAAATTTT
    C1orf168 Expression
    About this image


    C1orf168 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
    C1orf168 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1orf168 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437655
        Custom PCR Arrays for C1orf168
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf168

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C1orf168 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700024P16Rik1 , 5 RIKEN cDNA 1700024P16 gene1, 5 72.61(n)1
    59.2(a)1
      4 (48.86 cM)5
    2425941  NM_001285952.11  NP_001272881.11 
     1049135245 
    chicken
    (Gallus gallus)
    Aves C1orf1686
    chromosome 1 open reading frame 168
    28(a)
    1 ↔ 1
    8(24687128-24702955)
    lizard
    (Anolis carolinensis)
    Reptilia C1orf1686
    chromosome 1 open reading frame 168
    25(a)
    1 ↔ 1
    4(103239427-103285012)


    ENSEMBL Gene Tree for C1orf168 (if available)
    TreeFam Gene Tree for C1orf168 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C1orf168 (see all 2113)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357278781,2
    C--57183974(+) AGACA-/GACA  
            
    TTCTA
    1 -- int10--------
    rs1474791191,2
    --57184000(+) TTACTC/TTGAAT 1 -- int10--------
    rs2010367371,2
    --57184048(+) TCTTC-/CATCAATC 1 -- int10--------
    rs105912061,2
    C--57184049(+) CTTCC-/ATCA  
            
    ATCAT
    1 -- int10--------
    rs763491061,2
    C,F--57184118(+) TTACCT/GTCTCT 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1860718221,2
    --57184170(+) TGTTTA/GATTAC 1 -- int10--------
    rs1903387461,2
    --57184200(+) ACAGAG/TCTCCT 1 -- int10--------
    rs118047231,2
    C,F,H--57184436(+) TTTTCA/GGCGCT 1 -- int18Minor allele frequency- G:0.18NA WA CSA 429
    rs1820461601,2
    --57184438(+) TTCAGC/TGCTGA 1 -- int10--------
    rs8571421,2
    C,F,H--57184465(-) AGTTTC/AAAATT 1 -- int116Minor allele frequency- A:0.19NS EA NA WA CSA 792

    HapMap Linkage Disequilibrium report for C1orf168 (57184477 - 57285369 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for C1orf168 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748674CNV Deletion23290073
    esv2663893CNV Deletion23128226
    esv2296236CNV Deletion18987734
    esv2568213CNV Deletion19546169
    esv3554CNV Deletion18987735
    esv988788CNV Deletion20482838
    esv1167886CNV Deletion17803354
    esv270436CNV Insertion20981092
    nsv160326CNV Loss16902084
    nsv520726CNV Loss19592680

    Human Gene Mutation Database (HGMD): C1orf168
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C1orf168
    DNA2.0 Custom Variant and Variant Library Synthesis for C1orf168

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with C1orf168           About GenesLikeMe

    Genetic Association Database (GAD): C1orf168

    Export disorders for C1orf168 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C1orf168 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C1orf168)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PubMed id 22843503)1 Qi Q....Qi L. (Hum. Mol. Genet. 2012)
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 199920 HGNC: 27295 AceView: LOC199920 Ensembl:ENSG00000187889 euGenes: HUgn199920
    ECgene: C1orf168 H-InvDB: C1orf168

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C1orf168 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C1orf168 gene:
    Search GeneIP for patents involving C1orf168

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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