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C1orf167 Gene

protein-coding   GIFtS: 34
GCID: GC01P011821          (predicted)

Chromosome 1 Open Reading Frame 167

  Search for C1orf167
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 1 Open Reading Frame 1671 2
Uncharacterized Protein C1orf1672

External Ids:    HGNC: 252621   Entrez Gene: 2844982   Ensembl: ENSG000002159107   UniProtKB: Q5SNV93   

Export aliases for C1orf167 gene to outside databases

Previous GC identifers: GC01P011757 GC01P011744 GC01P011755 GC01P010981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1orf167 Gene:
C1orf167 (chromosome 1 open reading frame 167) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1orf167 gene promoter:
         NRSF form 1   Bach2   Pax-2   Pax-2a   NRSF form 2   GATA-1   YY1   Arnt   MZF-1   HEN1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C1orf167

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1orf167


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

C1orf167 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf167 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P011821:  view genomic region     (about GC identifiers)

Start:
11,821,844 bp from pter      End:
11,849,642 bp from pter
Size:
27,799 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CA167_HUMAN, Q5SNV9 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf167  
Size: 1468 amino acids; 162423 Da
Sequence caution: Sequence=CAI15881.1; Type=Erroneous gene model prediction;
Secondary accessions: Q8NDA9 Q8NDF3
Alternative splicing: 2 isoforms:  Q5SNV9-1   Q5SNV9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C1orf167: NX_Q5SNV9

Explore proteomics data for C1orf167 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C1orf167 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000317749   ENSP00000398213   ENSP00000399272   ENSP00000414909   ENSP00000388259  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5SNV9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf167
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    mitochondrion1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1orf167
    Interactions:

        Search GeneGlobe Interaction Network for C1orf167

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1orf167 (CA167)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    Unigene Cluster for C1orf167:

    Chromosome 1 open reading frame 167
    Hs.585415  [show with all ESTs]
    Unigene Representative Sequence: AL834308
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484153 ENST00000312793(uc001ata.3) ENST00000444493 ENST00000449278
    ENST00000475041 ENST00000482358 ENST00000433342(uc001asy.1 uc001asz.3)
    ENST00000435090
    miRNA
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    Additional mRNA sequence: 

    AF398935.1 AL833920.1 AL833926.1 AL834308.1 BC031692.1 

    7 DOTS entries:

    DT.100745708  DT.40305574  DT.97824516  DT.87046276  DT.99948025  DT.40285938  DT.121440354 

    15 AceView cDNA sequences:

    BX118390 BM920101 AL833920 BI827615 BC031692 AF398935 CD557411 AL833926 
    AL834308 AI658585 AI291308 BI837287 AI808467 BE787903 AA582865 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C1orf167 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAGTGGGT
    C1orf167 Expression
    About this image

    C1orf167 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1orf167 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585415
        Custom PCR Arrays for C1orf167
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for C1orf167 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia C1orf1676
    chromosome 1 open reading frame 167
    28(a)
    1 ↔ 1
    2(84457906-84464019)


    ENSEMBL Gene Tree for C1orf167 (if available)
    TreeFam Gene Tree for C1orf167 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C1orf167 gene
    1 SIMAP similar gene for C1orf167 using alignment to 7 protein entries:     CA167_HUMAN (see all proteins):
    DKFZp434E1410

    Find genes that share paralogs with C1orf167           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C1orf167 (see all 216)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809087741,2
    C--10979794(+) AAAAAA/GAAAGC 1 -- int10--------
    rs586570381,2
    C--11820893(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- us2k12NA 4
    rs1390365021,2
    C--11825542(+) TTTCT-/T/TTTC
            
    TTTTT
    1 -- int10--------
    rs66686991,2,,4
    C,F,A,H--11826630(+) AACCCT/CCCGGT 2 /P /S mis113Minor allele frequency- C:0.31NS EA NA WA 726
    rs65409961,2
    C,F,H--11827304(+) GCCCCG/AGAGTC 2 /P syn126Minor allele frequency- A:0.06NA NS EA WA CSA EU 1858
    rs48458801,2,,4
    C,F,A,H--11828238(+) GTTGCA/GAAAGT 2 Q R mis116Minor allele frequency- G:0.35NS EA NA WA 1200
    rs48458811,2
    C,F,H--11828319(+) GGTCCA/GGAGCT 2 Q R mis121Minor allele frequency- G:0.40NS EA NA WA 2344
    rs65409981,2
    C,F,A,H--11828947(+) TGTTAC/GTCCTG 1 -- int110Minor allele frequency- G:0.07NS EA WA NA CSA 726
    rs1897378701,2
    --11828957(+) GTCCCC/TGCCCC 1 -- int10--------
    rs1388188261,2
    C--11828996(+) CAAGGC/TCAACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for C1orf167 (11821844 - 11849642 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for C1orf167: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing C1orf167
    DNA2.0 Custom Variant and Variant Library Synthesis for C1orf167

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with C1orf167           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: C1orf167 (6 documents)

    Export disorders for C1orf167 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C1orf167 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C1orf167)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms. (PubMed id 12370778)1, 3 Tran P.... Rozen R. (Mamm. Genome 2002)
    2. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1 Ban H.J....Park K.J. (BMC Genet. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    5. Candidate gene polymorphisms for ischemic stroke. (PubMed id 19729601)1 Matarin M....Meschia J.F. ( a journal of cerebral circulation 2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284498 HGNC: 25262 AceView: DKFZp434E1410 Ensembl:ENSG00000215910 euGenes: HUgn284498
    ECgene: C1orf167 H-InvDB: C1orf167

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C1orf167 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C1orf167 gene:
    Search GeneIP for patents involving C1orf167

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf167
     Browse SwitchGear 3'UTR luciferase reporter plasmids for C1orf167
     Browse SwitchGear Promoter luciferase reporter plasmids for C1orf167
     Search ThermoFisher Antibodies for C1orf167
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C1orf167
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf167
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C1orf167
     Search LSBio for Antibodies for C1orf167
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     Browse compounds at ApexBio
     Search Addgene for plasmids for C1orf167
      Search eBioscience for proteins for C1orf167
      Search eBioscience for elisas for C1orf167
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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