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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C1orf162 Gene

protein-coding GIFtS: 37
GCID: GC01P112016

chromosome 1 open reading frame 162

Search for C1orf162
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 1 Open Reading Frame 162¹ ²
MGC24133¹
Transmembrane Protein C1orf162²

External Ids:	HGNC: 28344¹	Entrez Gene: 128346²	Ensembl: ENSG00000143110⁷	UniProtKB: Q8NEQ5³

Export aliases for C1orf162 gene to outside databases

Previous GC identifers: GC01P111729 GC01P111818 GC01P109888

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C1orf162 gene promoter:
HFH-3 Max1 TBP ISGF-3 AML1a Ik-3 Evi-1 FOXI1 Zic3 c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf162

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.2

C1orf162 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf162 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P112016: view genomic region (about GC identifiers)

Start:	112,016,414 bp from pter	End:	112,021,134 bp from pter
Size:	4,721 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CA162_HUMAN, Q8NEQ5 (See protein sequence)

Recommended Name: Transmembrane protein C1orf162

Size: 155 amino acids; 16886 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Secondary accessions: Q5QNZ1

Alternative splicing: 2 isoforms: Q8NEQ5-1 Q8NEQ5-2

Explore the universe of human proteins at neXtProt for C1orf162: NX_Q8NEQ5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NEQ5

C1orf162 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_777556.1

ENSEMBL proteins:

ENSP00000344218 ENSP00000358732

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

C1orf162 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8NEQ5

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C1orf162

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about C1orf162 / CA162

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C1orf162 gene:

NM_174896.2

Unigene Cluster for C1orf162:

Chromosome 1 open reading frame 162

Hs.288010 [show with all ESTs]

Unigene Representative Sequence: AK123160

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000343534(uc001ebe.3) ENST00000369718 ENST00000464591

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Additional cDNA sequence:

AK123160.1 BC017973.1

5 DOTS entries:

DT.101974935 DT.92421357 DT.308466 DT.95263365 DT.40265218

24/43 AceView cDNA sequences (see all 43):

AW662189 AV712255 CA439311 AA789100 AV717365 AV712950 AI431660 BC017973

BU198552 CA449728 BG540305 AW016896 AV716955 AI985175 BU198518 AA761112

NM_174896 AI421613 AV716324 AK123160 AA911556 N59284 AA989407 N77056

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf162 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:					-						-				-
SP2:					-						-
SP3:													-		-		-

ECgene alternative splicing isoforms for C1orf162

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C1orf162 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCAACTTG

About this image

C1orf162 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C1orf162 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf162

SOURCE GeneReport for Unigene cluster: Hs.288010

SABiosciences Custom PCR Arrays for C1orf162

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C1orf162 gene from 1/3 species (see all 3) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	I830077J02Rik^{1 , 5}	RIKEN cDNA I830077J02 gene^{1, 5}	71.73(n)¹ 57.6(a)¹		3 (46.45 cM)⁵ 433638¹ NM_001033780.3¹ NP_001028952.1¹ 105925891⁵

ENSEMBL Gene Tree for C1orf162 (if available)
TreeFam Gene Tree for C1orf162 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187411932^1,2		--	112014604(+)	`ATGTTA/GTATCT`	1	--	us2k¹		0	--	--	--	--
rs142010516^1,2		--	112014608(+)	`TATATC/TTCAAT`	1	--	us2k¹		0	--	--	--	--
rs114119426^1,2	F,	--	112014614(+)	`TCAATC/AAAAAA`	1	--	us2k¹		1		WA	118
rs74736450^1,2	F,	--	112014654(+)	`AATATG/ATCTTG`	1	--	us2k¹		1		WA	118
rs146335966^1,2		--	112014807(+)	`TGATCA/GTGACT`	1	--	us2k¹		0	--	--	--	--
rs78403721^1,2	F,	--	112014866(+)	`CCCCAA/GAGTGC`	1	--	us2k¹		2		NA EA	240
rs139653960^1,2		--	112014884(+)	`CAGGCA/GTCAAC`	1	--	us2k¹		0	--	--	--	--
rs74109574^1,2	C,	--	112015030(+)	`TATCCA/CCGCTC`	1	--	us2k¹		2		WA	120
rs144450798^1,2		--	112015067(+)	`TGATTG/TCTCCA`	1	--	us2k¹		0	--	--	--	--
rs12740822^1,2	C,F,H,	--	112015292(+)	`TGTCAT/CTGACT`	1	--	us2k¹		20		NS EA NA WA	2346

HapMap Linkage Disequilibrium report for C1orf162 (112016414 - 112021134 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1orf162: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C1orf162 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1orf162)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 128346	HGNC: 28344	AceView: MGC24133	Ensembl:ENSG00000143110	euGenes: HUgn128346
ECgene: C1orf162	H-InvDB: C1orf162

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C1orf162	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C1orf162 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C1orf162 gene:
Search GeneIP for patents involving C1orf162

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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C1orf162 Gene

chromosome 1 open reading frame 162

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C1orf162 Gene

chromosome 1 open reading frame 162

Aliasesfor C1orf162 gene

Summariesfor C1orf162 gene

Genomic Viewsfor C1orf162 gene

Proteinsfor C1orf162 gene

Protein Domains /Familiesfor C1orf162 gene

Functionfor C1orf162 gene

Pathways & Interactionsfor C1orf162 gene

Drugs & Compoundsfor C1orf162 gene

Transcriptsfor C1orf162 gene

Expression for C1orf162 gene

Orthologsfor C1orf162 gene

Paralogsfor C1orf162 gene

Genomic Variantsfor C1orf162 gene

Disorders / Diseasesfor C1orf162 gene

Publicationsfor C1orf162 gene

External Searches for C1orf162 gene

Genome Databases showing C1orf162 gene

Other Databases showing C1orf162 gene

Specialized Databases showing C1orf162 gene

Intellectual Propertyfor C1orf162 gene

Productsfor C1orf162 gene

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Aliases
for C1orf162 gene

Summaries
for C1orf162 gene

Genomic Views
for C1orf162 gene

Proteins
for C1orf162 gene

Protein Domains /
Families
for C1orf162 gene

Function
for C1orf162 gene

Pathways & Interactions
for C1orf162 gene

Drugs & Compounds
for C1orf162 gene

Transcripts
for C1orf162 gene

Expression
for C1orf162 gene

Orthologs
for C1orf162 gene

Paralogs
for C1orf162 gene

Genomic Variants
for C1orf162 gene

Disorders / Diseases
for C1orf162 gene

Publications
for C1orf162 gene

Intellectual Property
for C1orf162 gene

Products
for C1orf162 gene