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Aliases for C1orf159 Gene

Aliases for C1orf159 Gene

  • Chromosome 1 Open Reading Frame 159 2 3 5

External Ids for C1orf159 Gene

Previous GeneCards Identifiers for C1orf159 Gene

  • GC01M001059
  • GC01M001008
  • GC01M000288
  • GC01M001018

Summaries for C1orf159 Gene

GeneCards Summary for C1orf159 Gene

C1orf159 (Chromosome 1 Open Reading Frame 159) is a Protein Coding gene.

Additional gene information for C1orf159 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf159 Gene

Genomics for C1orf159 Gene

Regulatory Elements for C1orf159 Gene

Enhancers for C1orf159 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H001373 1.2 ENCODE 24.2 -258.8 -258763 3 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ENSG00000230092 CDK11A ATAD3B LOC100288379 CCNL2 INTS11 ENSG00000237094 SDF4 ENSG00000240731 LOC100288069
GH01H001906 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -791.8 -791827 4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 LOC105378949 INTS11 ENSG00000240731 CALML6 CCNL2 CDK11A LOC100288379 C1orf159 TMEM52 NOC2L
GH01H001124 1.5 FANTOM5 ENCODE dbSUPER 14.4 -8.8 -8820 2 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF2 YY1 CBX5 SP5 PPARG CCNL2 ENSG00000240731 C1orf159 ATAD3B INTS11 SLC35E2 NOC2L LINC00115 RNF223 GC01M001125
GH01H001127 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -12.9 -12881 3 FOXA2 ARID4B DMAP1 RAD21 YY1 CREM EGR2 THAP11 KLF11 MCM3 SDF4 TTLL10 MXRA8 TTLL10-AS1 ENSG00000230092 B3GALT6 C1QTNF12 UBE2J2 LOC100288379 CDK11A
GH01H000957 1.1 ENCODE 13.8 +156.6 156617 4 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 SP3 SP5 ENSG00000230092 NOC2L ATAD3B UBE2J2 CDK11A WASH7P PUSL1 ENSG00000237094 LOC100288069 KLHL17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf159 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf159 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000136 361 2001 ARID4B SIN3A YY1 ZNF766 ZNF207 ZNF143 SP3 NFYC REST ZNF592

Genomic Location for C1orf159 Gene

Chromosome:
1
Start:
1,081,818 bp from pter
End:
1,116,361 bp from pter
Size:
34,544 bases
Orientation:
Minus strand

Genomic View for C1orf159 Gene

Genes around C1orf159 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf159 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf159 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf159 Gene

Proteins for C1orf159 Gene

  • Protein details for C1orf159 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HA4-CA159_HUMAN
    Recommended name:
    Uncharacterized protein C1orf159
    Protein Accession:
    Q96HA4
    Secondary Accessions:
    • B3KQ46
    • Q5T2W6
    • Q6UX67
    • Q6ZR77
    • Q9NWV0

    Protein attributes for C1orf159 Gene

    Size:
    380 amino acids
    Molecular mass:
    40283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf159 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf159 Gene

Post-translational modifications for C1orf159 Gene

  • Glycosylation at Asn104, posLast=111111, and posLast=128128
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C1orf159 Gene

Domains & Families for C1orf159 Gene

Gene Families for C1orf159 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for C1orf159 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf159 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf159: view

No data available for UniProtKB/Swiss-Prot for C1orf159 Gene

Function for C1orf159 Gene

Phenotypes From GWAS Catalog for C1orf159 Gene

genes like me logo Genes that share phenotypes with C1orf159: view

Animal Models for C1orf159 Gene

MGI Knock Outs for C1orf159:

Animal Model Products

CRISPR Products

miRNA for C1orf159 Gene

miRTarBase miRNAs that target C1orf159

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf159
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for C1orf159 (C1orf159/RIVIG)

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1orf159 Gene

Localization for C1orf159 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf159 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf159 gene
Compartment Confidence
extracellular 3
plasma membrane 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1orf159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1orf159: view

Pathways & Interactions for C1orf159 Gene

SuperPathways for C1orf159 Gene

No Data Available

Interacting Proteins for C1orf159 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368623%0d%0a9606.ENSP00000309576%0d%0a
Selected Interacting proteins: Q96HA4-CA159_HUMAN ENSP00000368623 for C1orf159 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C1orf159 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf159 Gene

Drugs & Compounds for C1orf159 Gene

No Compound Related Data Available

Transcripts for C1orf159 Gene

Unigene Clusters for C1orf159 Gene

Chromosome 1 open reading frame 159:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1orf159
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for C1orf159 (C1orf159/RIVIG)

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf159 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a ·
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - - - - -
SP10: - -
SP11: - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - - - - - - -
SP16:
SP17: - - - - - - - -
SP18:

ExUns: 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:

Relevant External Links for C1orf159 Gene

GeneLoc Exon Structure for
C1orf159
ECgene alternative splicing isoforms for
C1orf159

Expression for C1orf159 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf159 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf159 Gene



NURSA nuclear receptor signaling pathways regulating expression of C1orf159 Gene:

C1orf159

SOURCE GeneReport for Unigene cluster for C1orf159 Gene:

Hs.235095

Evidence on tissue expression from TISSUES for C1orf159 Gene

  • Nervous system(3)
genes like me logo Genes that share expression patterns with C1orf159: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf159 Gene

Orthologs for C1orf159 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf159 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf159 33
  • 96.85 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311517 33
  • 76.6 (n)
dog
(Canis familiaris)
Mammalia C5H1orf159 33
  • 76.46 (n)
C1orf159 34
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9430015G10Rik 33 16 34
  • 75.93 (n)
cow
(Bos Taurus)
Mammalia C16H1orf159 33
  • 75.04 (n)
FLJ20584 34
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf159 34
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf159 34
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves C21H1ORF159 33
  • 61.88 (n)
C1orf159 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf159 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf159 33
  • 55.16 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559239 33
  • 49.48 (n)
C6H1orf159 34
  • 41 (a)
OneToOne
Species where no ortholog for C1orf159 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf159 Gene

ENSEMBL:
Gene Tree for C1orf159 (if available)
TreeFam:
Gene Tree for C1orf159 (if available)

Paralogs for C1orf159 Gene

No data available for Paralogs for C1orf159 Gene

Variants for C1orf159 Gene

Sequence variations from dbSNP and Humsavar for C1orf159 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000036673 -- 1,106,029(+) AGTAC(A/G)TTTAA intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1000040358 -- 1,103,165(+) GACCT(A/G)AAATT intron-variant
rs1000050523 -- 1,083,131(+) AACCC(A/G)GATGC intron-variant, utr-variant-3-prime
rs1000194837 -- 1,085,711(+) AGTGA(C/T)GGGCC intron-variant
rs1000223283 -- 1,089,989(+) ACGGA(C/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf159 Gene

Variant ID Type Subtype PubMed ID
dgv15e59 CNV duplication 20981092
dgv2n67 CNV gain 20364138
dgv5n100 CNV gain 25217958
esv1010559 CNV gain 20482838
esv1281251 CNV insertion 17803354
esv23529 CNV gain 19812545
esv2762302 CNV gain 21179565
esv32594 CNV loss 17666407
nsv1003578 CNV gain 25217958
nsv1013524 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1119654 CNV deletion 24896259
nsv1126166 CNV deletion 24896259
nsv1137716 CNV deletion 24896259
nsv1146879 CNV insertion 26484159
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv1409 CNV insertion 18451855
nsv160439 CNV deletion 16902084
nsv428334 CNV gain 18775914
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509146 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544951 CNV gain 21841781
nsv945741 CNV duplication 23825009
nsv950451 CNV deletion 24416366
nsv950452 CNV deletion 24416366

Variation tolerance for C1orf159 Gene

Gene Damage Index Score: 1.52; 29.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf159 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf159

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf159 Gene

Disorders for C1orf159 Gene

Relevant External Links for C1orf159

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf159

No disorders were found for C1orf159 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf159 Gene

Publications for C1orf159 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for C1orf159 Gene

Sources for C1orf159 Gene

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