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C1orf158 Gene

protein-coding   GIFtS: 39
GCID: GC01P012806

Chromosome 1 Open Reading Frame 158

  Search for C1orf158
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 1 Open Reading Frame 1581 2
Uncharacterized Protein C1orf1582

External Ids:    HGNC: 285671   Entrez Gene: 931902   Ensembl: ENSG000001573307   UniProtKB: Q8N1D53   
ORGUL members:         

Export aliases for C1orf158 gene to outside databases

Previous GC identifers: GC01P012741 GC01P011959


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1orf158 Gene:
C1orf158 (chromosome 1 open reading frame 158) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1orf158 gene promoter:
         RFX1   AML1a   POU3F1   IRF-7A   Msx-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C1orf158

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1orf158


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

C1orf158 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf158 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012806:  view genomic region     (about GC identifiers)

Start:
12,806,163 bp from pter      End:
12,823,847 bp from pter
Size:
17,685 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CA158_HUMAN, Q8N1D5 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf158  
Size: 194 amino acids; 23067 Da
Secondary accessions: Q5VUY4

Explore the universe of human proteins at neXtProt for C1orf158: NX_Q8N1D5

Explore proteomics data for C1orf158 at MOPED


See C1orf158 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689503.3  
ENSEMBL proteins: 
 ENSP00000288048   ENSP00000365383  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8N1D5


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1orf158
Interactions:

    Search GeneGlobe Interaction Network for C1orf158

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for C1orf158 (ENSP000002880484) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
--ENSP000004090974STRING: ENSP00000409097
--ENSP000003933354STRING: ENSP00000393335
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C1orf158 (CA158)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for C1orf158 gene: 
NM_152290.3  

Unigene Cluster for C1orf158:

Chromosome 1 open reading frame 158
Hs.98095  [show with all ESTs]
Unigene Representative Sequence: BX647383
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000288048(uc010obe.1 uc001auh.3) ENST00000474179 ENST00000376210

miRNA
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Additional mRNA sequence: 

AK026705.1 AK298760.1 BC029894.1 BX647383.1 

5 DOTS entries:

DT.97790251  DT.86852124  DT.100676441  DT.95071154  DT.99958800 

Selected AceView cDNA sequences (see all 36):

AA412565 BX094234 BU608072 AA609347 NM_152290 CN478763 BC029894 AI203603 
CF891309 BM554040 BI825720 BM980714 AA421166 AA889516 AK026705 BQ771713 
CB851749 AI656449 BV204610 AA421403 BE503667 BX647383 BI825136 CB241951 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C1orf158 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGGTCCCGGT
C1orf158 Expression
About this image

C1orf158 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C1orf158 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.98095
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for C1orf158 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 1700012P22Rik1 , 5 RIKEN cDNA 1700012P22 gene1, 5 78.87(n)1
75.26(a)1
  4 (77.98 cM)5
693641  NM_027056.11  NP_081332.11 
 1444181895 
chicken
(Gallus gallus)
Aves C21H1orf1581 AQ 56.28(n)
48.09(a)
  395744  NM_204914.2  NP_990245.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004904331 chromosome unknown open reading frame, human C1orf158 50(n)
45.63(a)
  100490433  XM_002937470.2  XP_002937516.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1000033071 uncharacterized LOC100003307 50.1(n)
43.11(a)
  100003307  XM_001341054.3  XP_001341090.2 


ENSEMBL Gene Tree for C1orf158 (if available)
TreeFam Gene Tree for C1orf158 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C1orf158 (see all 437)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs740576571,2
C,F--12804264(+) CTATCG/ACCATT 1 -- us2k12Minor allele frequency- A:0.14WA 120
rs772054181,2
C,F--12804285(+) TTTTTA/CCTATT 1 -- us2k11Minor allele frequency- C:0.13WA 118
rs1386783221,2
--12804312(+) CTTTCC/TAATGA 1 -- us2k10--------
rs1843668471,2
--12804366(+) AATGCA/GTGAAT 1 -- us2k10--------
rs30009221,2
C,F,A,H--12804402(-) gagtcT/Cgattt 1 -- us2k130Minor allele frequency- C:0.16NS EA NA WA CSA 2783
rs1893604071,2
C--12804525(+) ATTGCC/TATAGA 1 -- us2k10--------
rs75422501,2
C,F,A,H--12804582(+) gagggA/Gcatgt 1 -- us2k114Minor allele frequency- G:0.32EA NS NA WA CSA 624
rs740576591,2
C--12804596(+) GTACTT/CTGGGC 1 -- us2k12Minor allele frequency- C:0.14WA 120
rs802377921,2
C--12804747(+) TTGAA-/TTATACC 1 -- us2k10--------
rs75205231,2
C,F,A--12804789(+) cccagA/Cacttt 1 -- us2k18Minor allele frequency- C:0.47NA WA CSA 15

HapMap Linkage Disequilibrium report for C1orf158 (12806163 - 12823847 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for C1orf158 (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv2664000CNV Deletion23128226
nsv470695CNV Loss18288195
nsv528703CNV Loss19592680
nsv871119CNV Gain21882294
dgv146n71CNV Gain21882294
nsv466394CNV Gain19166990
nsv871047CNV Gain21882294
nsv832869CNV Gain+Loss17160897
nsv428410CNV Gain+Loss18775914
essv17144CNV CNV17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C1orf158 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C1orf158)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 93190 HGNC: 28567 AceView: MGC35194 Ensembl:ENSG00000157330 euGenes: HUgn93190
ECgene: C1orf158 H-InvDB: C1orf158

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C1orf158 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C1orf158 gene:
Search GeneIP for patents involving C1orf158

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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