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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1orf158 Gene

protein-coding   GIFtS: 39
GCID: GC01P012806

Chromosome 1 Open Reading Frame 158

  Search for C1orf158
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 1 Open Reading Frame 1581 2
Uncharacterized Protein C1orf1582

External Ids:    HGNC: 285671   Entrez Gene: 931902   Ensembl: ENSG000001573307   UniProtKB: Q8N1D53   
ORGUL members:         
NONCODE14:n337720      

Export aliases for C1orf158 gene to outside databases

Previous GC identifers: GC01P012741 GC01P011959


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C1orf158 Gene: 
C1orf158 (chromosome 1 open reading frame 158) is a protein-coding gene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1orf158 gene promoter:
         RFX1   AML1a   POU3F1   IRF-7A   Msx-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C1orf158

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf158


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

C1orf158 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf158 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012806:  view genomic region     (about GC identifiers)

Start:
12,806,163 bp from pter      End:
12,823,847 bp from pter
Size:
17,685 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CA158_HUMAN, Q8N1D5 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf158  
Size: 194 amino acids; 23067 Da
Secondary accessions: Q5VUY4

Explore the universe of human proteins at neXtProt for C1orf158: NX_Q8N1D5

Explore proteomics data for C1orf158 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N1D5

  • C1orf158 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C1orf158 Protein Expression
    REFSEQ proteins: NP_689503.2  
    ENSEMBL proteins: 
     ENSP00000288048   ENSP00000365383  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N1D5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf158

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for C1orf158 (ENSP000002880484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000004090974STRING: ENSP00000409097
    --ENSP000003933354STRING: ENSP00000393335
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1orf158 (CA158)

    Search CenterWatch for drugs/clinical trials and news about C1orf158 / CA158

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C1orf158 gene: 
    NM_152290.2  

    Unigene Cluster for C1orf158:

    Chromosome 1 open reading frame 158
    Hs.98095  [show with all ESTs]
    Unigene Representative Sequence: BX647383
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288048(uc010obe.1 uc001auh.3) ENST00000474179 ENST00000376210

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    Inhib. RNA
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    Additional mRNA sequence: 

    AK026705.1 AK298760.1 BC029894.1 BX647383.1 

    5 DOTS entries:

    DT.97790251  DT.86852124  DT.100676441  DT.95071154  DT.99958800 

    24/36 AceView cDNA sequences (see all 36):

    BC029894 CN478763 BX094234 AA412565 NM_152290 AA609347 BU608072 AI656449 
    AK026705 AI203603 AA889516 BM980714 CB851749 AA421403 CF887467 BM554040 
    CB241951 AA421166 BI825720 BV204610 BI825136 BE503667 BQ771713 CF891309 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1orf158 expression in normal human tissues (normalized intensities)      C1orf158 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGTCCCGGT
    C1orf158 Expression
    About this image


    C1orf158 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)

    See C1orf158 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1orf158

    SOURCE GeneReport for Unigene cluster: Hs.98095
        SABiosciences Custom PCR Arrays for C1orf158
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf158

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C1orf158 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700012P22Rik1 , 5 RIKEN cDNA 1700012P22 gene1, 5 78.87(n)1
    75.26(a)1
      4 (77.98 cM)5
    693641  NM_027056.11  NP_081332.11 
     1444181895 
    chicken
    (Gallus gallus)
    Aves C21H1orf1581 AQ 56.28(n)
    48.09(a)
      395744  NM_204914.1  NP_990245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000033071 uncharacterized protein C1orf158 homolog 50.2(n)
    43.37(a)
      100003307  XM_001341054.2  XP_001341090.2 


    ENSEMBL Gene Tree for C1orf158 (if available)
    TreeFam Gene Tree for C1orf158 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/437 SNPs in C1orf158 are shown (see all 437)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740576571,2
    C,F--12804264(+) CTATCG/ACCATT 1 -- us2k12Minor allele frequency- A:0.14WA 120
    rs772054181,2
    C,F--12804285(+) TTTTTA/CCTATT 1 -- us2k11Minor allele frequency- C:0.13WA 118
    rs1386783221,2
    --12804312(+) CTTTCC/TAATGA 1 -- us2k10--------
    rs1843668471,2
    --12804366(+) AATGCA/GTGAAT 1 -- us2k10--------
    rs30009221,2
    C,F,A,H--12804402(-) gagtcT/Cgattt 1 -- us2k130Minor allele frequency- C:0.16NS EA NA WA CSA 2783
    rs1893604071,2
    C--12804525(+) ATTGCC/TATAGA 1 -- us2k10--------
    rs75422501,2
    C,F,A,H--12804582(+) gagggA/Gcatgt 1 -- us2k114Minor allele frequency- G:0.32EA NS NA WA CSA 624
    rs740576591,2
    C--12804596(+) GTACTT/CTGGGC 1 -- us2k12Minor allele frequency- C:0.14WA 120
    rs802377921,2
    C--12804747(+) TTGAA-/TTATACC 1 -- us2k10--------
    rs75205231,2
    C,F,A--12804789(+) cccagA/Cacttt 1 -- us2k18Minor allele frequency- C:0.47NA WA CSA 15

    HapMap Linkage Disequilibrium report for C1orf158 (12806163 - 12823847 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for C1orf158 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664000CNV Deletion23128226
    nsv470695CNV Loss18288195
    nsv528703CNV Loss19592680
    nsv871119CNV Gain21882294
    dgv146n71CNV Gain21882294
    nsv466394CNV Gain19166990
    nsv871047CNV Gain21882294
    nsv832869CNV Gain+Loss17160897
    nsv428410CNV Gain+Loss18775914
    essv17144CNV CNV17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1orf158 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C1orf158)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93190 HGNC: 28567 AceView: MGC35194 Ensembl:ENSG00000157330 euGenes: HUgn93190
    ECgene: C1orf158 H-InvDB: C1orf158

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1orf158 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C1orf158 gene:
    Search GeneIP for patents involving C1orf158

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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