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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1orf158 Gene

protein-coding   GIFtS: 39
GCID: GC01P012806

chromosome 1 open reading frame 158
  Search for C1orf158
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C1orf158    

Aliases
for C1orf158 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 1 Open Reading Frame 1581 2
MGC351941
Uncharacterized Protein C1orf1582

External Ids:    HGNC: 285671   Entrez Gene: 931902   Ensembl: ENSG000001573307   UniProtKB: Q8N1D53   
ORGUL members:         
NONCODE:n337720    

Export aliases for C1orf158 gene to outside databases

Previous GC identifers: GC01P012741 GC01P011959


Summaries
for C1orf158 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C1orf158 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1orf158 gene promoter:
         RFX1   AML1a   POU3F1   IRF-7A   Msx-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C1orf158

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf158


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

C1orf158 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf158 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012806:  view genomic region     (about GC identifiers)

Start:
 12,806,163 bp from pter      End:
 12,823,847 bp from pter
Size:
 17,685 bases      Orientation:
 plus strand

Proteins
for C1orf158 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CA158_HUMAN, Q8N1D5 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf158  
Size: 194 amino acids; 23067 Da
Secondary accessions: Q5VUY4

Explore the universe of human proteins at neXtProt for C1orf158: NX_Q8N1D5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N1D5

    • C1orf158 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689503.2  
    ENSEMBL proteins: 
     ENSP00000288048   ENSP00000365383  

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    Uscn Proteins for C1orf158


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    Protein Domains /
    Families
    for C1orf158 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N1D5


    Function
    for C1orf158 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C1orf158 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf158

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for C1orf158 (ENSP000002880484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000004090974STRING: ENSP00000409097
    --ENSP000003933354STRING: ENSP00000393335
    About this table

    Drugs & Compounds
    for C1orf158 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C1orf158
    Search CenterWatch for drugs/clinical trials and news about C1orf158 / CA158 

    Transcripts
    for C1orf158 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for C1orf158 gene: 
    NM_152290.2  

    Unigene Cluster for C1orf158:

    Chromosome 1 open reading frame 158
    Hs.98095  [show with all ESTs]
    Unigene Representative Sequence: BX647383
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288048(uc010obe.1 uc001auh.3) ENST00000474179 ENST00000376210


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    Inhib. RNA
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    Additional cDNA sequence: 

    AK026705.1 AK298760.1 BC029894.1 BX647383.1 

    5 DOTS entries:

    DT.97790251  DT.86852124  DT.100676441  DT.95071154  DT.99958800 

    24/36 AceView cDNA sequences (see all 36):

    BX094234 CN478763 BU608072 AA412565 BC029894 NM_152290 AA609347 AA421403 
    BI825136 BM980714 BM554040 BQ771713 AA889516 CF887467 AI203603 BV204610 
    AI656449 AI027239 BE503667 CF891309 BX647383 AK026705 CB241951 AA421166 

    GeneLoc Exon Structure


    Expression
    for C1orf158 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1orf158 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGTCCCGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C1orf158 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C1orf158 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1orf158

    SOURCE GeneReport for Unigene cluster: Hs.98095
        SABiosciences Custom PCR Arrays for C1orf158
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    In Situ
    Assay Products:     
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    Orthologs
    for C1orf158 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C1orf158 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 1700012P22Rik1 , 5 RIKEN cDNA 1700012P22 gene1, 5 78.87(n)1
    75.26(a)1    		   4 (77.98 cM)5
    693641  NM_027056.11  NP_081332.11 
     1444181895 
    chicken
    (Gallus gallus)    		 Aves C21H1orf1581 AQ 56.28(n)
    48.09(a)    		   395744  NM_204914.1  NP_990245.1 
    lizard
    (Anolis carolinensis)    		 Reptilia C1orf1586
    		 --
    		 44(a)
    		 1 ↔ 1
    		 AAWZ02036833(9869-13928)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000033071 uncharacterized protein C1orf158 homolog 50.2(n)
    43.37(a)    		   100003307  XM_001341054.2  XP_001341090.2 


    ENSEMBL Gene Tree for C1orf158 (if available)
    TreeFam Gene Tree for C1orf158 (if available) 

    Paralogs
    for C1orf158 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C1orf158 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/372 NCBI SNPs in C1orf158 are shown (see all 372)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs740576571,2
    		C,--12804264(+) CTATCG/ACCATT 1 -- us2k12Minor allele frequency- A:0.14WA 120
    rs772054181,2
    		C,F,--12804285(+) TTTTTA/CCTATT 1 -- us2k11Minor allele frequency- C:0.13WA 118
    rs1386783221,2
    		--12804312(+) CTTTCC/TAATGA 1 -- us2k10--------
    rs1843668471,2
    		--12804366(+) AATGCA/GTGAAT 1 -- us2k10--------
    rs30009221,2
    		C,F,A,H,--12804402(-) GAGTCT/CGATTT 1 -- us2k130Minor allele frequency- C:0.16NS EA NA WA CSA 2783
    rs1893604071,2
    		--12804525(+) ATTGCC/TATAGA 1 -- us2k10--------
    rs75422501,2
    		C,F,A,H,--12804582(+) GAGGGA/GCATGT 1 -- us2k114Minor allele frequency- G:0.32EA NS NA WA CSA 624
    rs740576591,2
    		C,--12804596(+) GTACTT/CTGGGC 1 -- us2k12Minor allele frequency- C:0.14WA 120
    rs802377921,2
    		C,--12804747(+) TTGAA-/TTATACC 1 -- us2k10--------
    rs75205231,2
    		C,F,A,--12804789(+) CCCAGA/CACTTT 1 -- us2k18Minor allele frequency- C:0.47NA WA CSA 15

    HapMap Linkage Disequilibrium report for C1orf158 (12806163 - 12823847 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for C1orf158
         4 CNVs: 2298 4403 29829 3283

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    Disorders / Diseases
    for C1orf158 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C1orf158 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1orf158 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C1orf158)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    External Searches for C1orf158 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C1orf158 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93190 HGNC: 28567 AceView: MGC35194 Ensembl:ENSG00000157330 euGenes: HUgn93190
    ECgene: C1orf158 H-InvDB: C1orf158

    Other Databases showing C1orf158 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C1orf158 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1orf158 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C1orf158 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C1orf158 gene:
    Search GeneIP for patents involving C1orf158

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C1orf158 gene

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    About This Section

     
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