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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1orf146 Gene

protein-coding   GIFtS: 36
GCID: GC01P092683

Chromosome 1 Open Reading Frame 146

  Search for C1orf146
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 1 Open Reading Frame 1461 2
RP11-163M2.42
Uncharacterized Protein C1orf1462

External Ids:    HGNC: 240321   Entrez Gene: 3886492   Ensembl: ENSG000002039107   UniProtKB: Q5VVC03   

Export aliases for C1orf146 gene to outside databases

Previous GC identifers: GC01P092397 GC01P092456 GC01P090803


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C1orf146 Gene: 
C1orf146 (chromosome 1 open reading frame 146) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for C1orf146
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C1orf146

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf146


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

C1orf146 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf146 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P092683:  view genomic region     (about GC identifiers)

Start:
92,683,497 bp from pter      End:
92,711,370 bp from pter
Size:
27,874 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CA146_HUMAN, Q5VVC0 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf146  
Size: 180 amino acids; 20418 Da
Sequence caution: Sequence=CAH70760.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5VVC4

Explore the universe of human proteins at neXtProt for C1orf146: NX_Q5VVC0

Explore proteomics data for C1orf146 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VVC0

  • C1orf146 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C1orf146 Protein Expression
    REFSEQ proteins: NP_001012425.1  
    ENSEMBL proteins: 
     ENSP00000359401   ENSP00000359399  

    Human Recombinant Protein Products for C1orf146: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5VVC0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf146

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for C1orf146 (ENSP000003594014) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF10LENSP000003550604STRING: ENSP00000355060
    ASPMENSP000003563794STRING: ENSP00000356379
    ATPAF1ENSP000003610054STRING: ENSP00000361005
    DEPDC1ENSP000004122924STRING: ENSP00000412292
    ENSG00000184494ENSP000002297254STRING: ENSP00000229725
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1orf146 (CA146)

    Search CenterWatch for drugs/clinical trials and news about C1orf146 / CA146

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C1orf146 gene: 
    NM_001012425.1  

    Unigene Cluster for C1orf146:

    Chromosome 1 open reading frame 146
    Hs.558823  [show with all ESTs]
    Unigene Representative Sequence: BU160126
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370375(uc001doq.3 uc010ote.2) ENST00000370373
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    BC130499.1 BC171742.1 

    4 DOTS entries:

    DT.40118032  DT.65286526  DT.97834576  DT.40131249 

    10 AceView cDNA sequences:

    BU852979 BQ435801 BX108717 BQ428729 BU567193 AA897615 AA861282 AI217683 
    AI217387 AI217389 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1orf146 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTGAAGA
    C1orf146 Expression
    About this image


    See C1orf146 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.558823
        SABiosciences Custom PCR Arrays for C1orf146
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf146

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C1orf146 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700028K03Rik1 , 5 RIKEN cDNA 1700028K03 gene1, 5 86.4(n)1
    85.06(a)1
      5 (52.23 cM)5
    764211  NM_182745.21  NP_877422.11 
     1075089445 
    chicken
    (Gallus gallus)
    Aves C8H1orf1461 chromosome 8 open reading frame, human C1orf146 66.87(n)
    59.64(a)
      770460  XM_001233793.2  XP_001233794.2 
    lizard
    (Anolis carolinensis)
    Reptilia C1ORF1466
    Uncharacterized protein
    60(a)
    1 ↔ 1
    4(93873130-93881592)
    zebrafish
    (Danio rerio)
    Actinopterygii gb:ex1540421 expressed sequence EX154042 51.08(n)
    43.17(a)
      560357  XM_683763.4  XP_688855.1 


    ENSEMBL Gene Tree for C1orf146 (if available)
    TreeFam Gene Tree for C1orf146 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C1orf146 gene

    C1orf146 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for C1orf146
    PGOHUM00000235383


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/565 SNPs in C1orf146 are shown (see all 565)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888295021,2
    --92682148(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs1151045751,2
    C,F--92682178(+) AGCTAT/CATTCT 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs670115621,2
    C--92682285(+) TCTGG-/TCATAT 1 -- us2k10--------
    rs3696086851,2
    C--92682285(+) ATCTGG/TCATAT 1 -- us2k10--------
    rs355132391,2
    C,F,H--92682286(+) TCTGGC/G/TATATA 1 -- us2k114NS EA NA 1982
    rs1921546321,2
    --92682404(+) CATAAA/GTCTTT 1 -- us2k10--------
    rs1835124161,2
    --92682538(+) ACCAGG/TTAATT 1 -- us2k10--------
    rs1879436461,2
    --92682650(+) AAAATA/GGTTAT 1 -- us2k10--------
    rs8775121,2
    O,H--92682768(-) GTTAGG/CATACA 1 -- us2k16Minor allele frequency- C:0.00NA MN NS EA 684
    rs1924192201,2
    --92682803(+) TCTTTA/GTCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C1orf146 (92683497 - 92711370 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for C1orf146:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714684CNV Deletion23290073
    nsv870667CNV Loss21882294
    nsv871508CNV Gain21882294
    nsv830592CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1orf146 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C1orf146)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Finishing the euchromatic sequence of the human genome. (PubMed id 15496913)1, 3  . (2004)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388649 HGNC: 24032 AceView: LOC388649 Ensembl:ENSG00000203910 euGenes: HUgn388649
    ECgene: C1orf146 H-InvDB: C1orf146

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1orf146 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C1orf146 gene:
    Search GeneIP for patents involving C1orf146

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Proteins for C1orf146
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf146
     inGenious Targeting Laboratory - Custom generated mouse model solutions for C1orf146
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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