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Aliases for C1orf141 Gene

Aliases for C1orf141 Gene

  • Chromosome 1 Open Reading Frame 141 2 3 5

External Ids for C1orf141 Gene

Previous GeneCards Identifiers for C1orf141 Gene

  • GC01M067271
  • GC01M067557
  • GC01M065666

Summaries for C1orf141 Gene

GeneCards Summary for C1orf141 Gene

C1orf141 (Chromosome 1 Open Reading Frame 141) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf141 Gene

Genomics for C1orf141 Gene

Regulatory Elements for C1orf141 Gene

Enhancers for C1orf141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G067191 0.9 ENCODE 20.4 +39.7 39726 2.1 HDAC1 HDGF PKNOX1 TBL1XR1 ARNT TCF12 GATA2 SMARCA5 ZBTB2 ELF1 C1orf141 MIER1 RNU6-586P GC01M067171
GH01G067018 1 Ensembl ENCODE 10.9 +212.0 212043 2.2 PKNOX1 JUN ZIC2 HIC1 ZNF316 ZFHX2 EGR2 MTA2 ZBTB8A NR2F2 WDR78 C1orf141 ENSG00000252433 MIER1 SLC35D1
GH01G067170 0.8 ENCODE 11.1 +60.5 60525 1.8 ZNF766 ZNF316 ARID3A CBX5 EED ETV6 IKZF2 CREM MTA2 CAVIN1 RNU6-586P C1orf141 ENSG00000252433 GC01M067171 GC01P067166
GH01G067112 0.6 ENCODE 12.3 +119.2 119241 0.2 MTA2 EED TARDBP IKZF1 NBN IKZF2 TBX21 C1orf141 ENSG00000252433 ENSG00000275678
GH01G067137 0.6 ENCODE 12 +93.4 93366 2.9 GATA3 HNF1A RAD51 L3MBTL2 HLF USF2 HNF4A EZH2 SPI1 C1orf141 ENSG00000252433 RNU6-586P SLC35D1 IL23R ENSG00000275678
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf141 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the C1orf141 gene promoter:

Genomic Location for C1orf141 Gene

Chromosome:
1
Start:
67,092,165 bp from pter
End:
67,231,853 bp from pter
Size:
139,689 bases
Orientation:
Minus strand

Genomic View for C1orf141 Gene

Genes around C1orf141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf141 Gene

Proteins for C1orf141 Gene

  • Protein details for C1orf141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JVX7-CA141_HUMAN
    Recommended name:
    Uncharacterized protein C1orf141
    Protein Accession:
    Q5JVX7
    Secondary Accessions:
    • Q0P5P5
    • Q5JVX5

    Protein attributes for C1orf141 Gene

    Size:
    400 amino acids
    Molecular mass:
    46135 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf141 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf141 Gene

Post-translational modifications for C1orf141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C1orf141 Gene

Domains & Families for C1orf141 Gene

Protein Domains for C1orf141 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf141: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf141 Gene

Function for C1orf141 Gene

Phenotypes for C1orf141 Gene

GenomeRNAi human phenotypes for C1orf141:
genes like me logo Genes that share phenotypes with C1orf141: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf141 Gene

Localization for C1orf141 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf141 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf141 Gene

Pathways & Interactions for C1orf141 Gene

SuperPathways for C1orf141 Gene

No Data Available

Interacting Proteins for C1orf141 Gene

Gene Ontology (GO) - Biological Process for C1orf141 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf141 Gene

Drugs & Compounds for C1orf141 Gene

No Compound Related Data Available

Transcripts for C1orf141 Gene

mRNA/cDNA for C1orf141 Gene

Unigene Clusters for C1orf141 Gene

Chromosome 1 open reading frame 141:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf141 Gene

No ASD Table

Relevant External Links for C1orf141 Gene

GeneLoc Exon Structure for
C1orf141
ECgene alternative splicing isoforms for
C1orf141

Expression for C1orf141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf141 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf141 Gene

This gene is overexpressed in Testis (x27.1).

Protein differential expression in normal tissues from HIPED for C1orf141 Gene

This gene is overexpressed in Brain (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf141 Gene



Protein tissue co-expression partners for C1orf141 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf141 Gene:

C1orf141

SOURCE GeneReport for Unigene cluster for C1orf141 Gene:

Hs.666621
genes like me logo Genes that share expression patterns with C1orf141: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf141 Gene

Orthologs for C1orf141 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf141 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf141 35
  • 54 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf141 35
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4921539E11Rik 35
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf141 35
  • 22 (a)
OneToOne
Species where no ortholog for C1orf141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf141 Gene

ENSEMBL:
Gene Tree for C1orf141 (if available)
TreeFam:
Gene Tree for C1orf141 (if available)

Paralogs for C1orf141 Gene

No data available for Paralogs for C1orf141 Gene

Variants for C1orf141 Gene

Sequence variations from dbSNP and Humsavar for C1orf141 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000096364 -- 67,113,470(+) AAGGG(A/G)TTCTC intron-variant
rs1000112841 -- 67,131,958(+) TTTTG(A/C/T)ATTTT intron-variant, upstream-variant-2KB
rs1000197812 -- 67,114,710(+) TCGCT(C/T)TTGTC intron-variant
rs1000252111 -- 67,108,162(+) TAAAA(G/T)CCCTT intron-variant
rs1000304300 -- 67,107,924(+) CTTTA(C/T)GGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf141 Gene

Variant ID Type Subtype PubMed ID
esv3586304 CNV loss 21293372
nsv461751 CNV loss 19166990
nsv461762 CNV gain 19166990
nsv546445 CNV loss 21841781
nsv546446 CNV gain 21841781

Variation tolerance for C1orf141 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf141 Gene

Human Gene Mutation Database (HGMD)
C1orf141
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf141 Gene

Disorders for C1orf141 Gene

Relevant External Links for C1orf141

Genetic Association Database (GAD)
C1orf141
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf141

No disorders were found for C1orf141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf141 Gene

Publications for C1orf141 Gene

  1. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PMID: 22019778) Zhang F. … Zhang X. (Nat. Genet. 2011) 3 46 64
  2. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. (PMID: 25642632) Liu H. … Zhang F. (Nat. Genet. 2015) 3 64
  3. Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3. (PMID: 25108386) Hou S. … Yang P. (Nat. Genet. 2014) 3 64
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3 64
  5. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3 64

Products for C1orf141 Gene

Sources for C1orf141 Gene

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