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Aliases for C1orf141 Gene

Aliases for C1orf141 Gene

  • Chromosome 1 Open Reading Frame 141 2 3 5

External Ids for C1orf141 Gene

Previous GeneCards Identifiers for C1orf141 Gene

  • GC01M067271
  • GC01M067557
  • GC01M065666

Summaries for C1orf141 Gene

GeneCards Summary for C1orf141 Gene

C1orf141 (Chromosome 1 Open Reading Frame 141) is a Protein Coding gene. Diseases associated with C1orf141 include leprosy.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf141 Gene

Genomics for C1orf141 Gene

Regulatory Elements for C1orf141 Gene

Transcription factor binding sites by QIAGEN in the C1orf141 gene promoter:

Genomic Location for C1orf141 Gene

Chromosome:
1
Start:
67,092,165 bp from pter
End:
67,231,853 bp from pter
Size:
139,689 bases
Orientation:
Minus strand

Genomic View for C1orf141 Gene

Genes around C1orf141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf141 Gene

Proteins for C1orf141 Gene

  • Protein details for C1orf141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JVX7-CA141_HUMAN
    Recommended name:
    Uncharacterized protein C1orf141
    Protein Accession:
    Q5JVX7
    Secondary Accessions:
    • Q0P5P5
    • Q5JVX5

    Protein attributes for C1orf141 Gene

    Size:
    400 amino acids
    Molecular mass:
    46135 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf141 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf141 Gene

Proteomics data for C1orf141 Gene at MOPED

Post-translational modifications for C1orf141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C1orf141 Gene

Domains & Families for C1orf141 Gene

Protein Domains for C1orf141 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf141: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf141 Gene

Function for C1orf141 Gene

Phenotypes for C1orf141 Gene

GenomeRNAi human phenotypes for C1orf141:
genes like me logo Genes that share phenotypes with C1orf141: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf141 Gene

Localization for C1orf141 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf141 Gene COMPARTMENTS Subcellular localization image for C1orf141 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf141 Gene

Pathways & Interactions for C1orf141 Gene

SuperPathways for C1orf141 Gene

No Data Available

Interacting Proteins for C1orf141 Gene

Gene Ontology (GO) - Biological Process for C1orf141 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf141 Gene

Drugs & Compounds for C1orf141 Gene

No Compound Related Data Available

Transcripts for C1orf141 Gene

mRNA/cDNA for C1orf141 Gene

Unigene Clusters for C1orf141 Gene

Chromosome 1 open reading frame 141:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf141 Gene

No ASD Table

Relevant External Links for C1orf141 Gene

GeneLoc Exon Structure for
C1orf141
ECgene alternative splicing isoforms for
C1orf141

Expression for C1orf141 Gene

mRNA expression in normal human tissues for C1orf141 Gene

mRNA differential expression in normal tissues according to GTEx for C1orf141 Gene

This gene is overexpressed in Testis (x27.1).

Protein differential expression in normal tissues from HIPED for C1orf141 Gene

This gene is overexpressed in Brain (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1orf141 Gene



SOURCE GeneReport for Unigene cluster for C1orf141 Gene Hs.666621

genes like me logo Genes that share expression patterns with C1orf141: view

Protein tissue co-expression partners for C1orf141 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C1orf141 Gene

Orthologs for C1orf141 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf141 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf141 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf141 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4921539E11Rik 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf141 36
  • 22 (a)
OneToOne
Species with no ortholog for C1orf141:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf141 Gene

ENSEMBL:
Gene Tree for C1orf141 (if available)
TreeFam:
Gene Tree for C1orf141 (if available)

Paralogs for C1orf141 Gene

No data available for Paralogs for C1orf141 Gene

Variants for C1orf141 Gene

Sequence variations from dbSNP and Humsavar for C1orf141 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2273682 - 67,115,444(+) CAGGC(C/T)CACAT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs11208997 - 67,095,273(+) GTTGA(C/T)TATCT intron-variant, downstream-variant-500B, reference, missense
rs1885276 -- 67,103,141(+) AAGAC(G/T)AATAT intron-variant
rs1885278 -- 67,098,495(+) AGCCT(A/G)GGCGA intron-variant
rs1885279 -- 67,098,598(+) CAGCA(A/C)TACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf141 Gene

Variant ID Type Subtype PubMed ID
nsv461751 CNV Loss 19166990
nsv461762 CNV Gain 19166990
nsv870950 CNV Gain 21882294

Variation tolerance for C1orf141 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf141 Gene

HapMap Linkage Disequilibrium report
C1orf141
Human Gene Mutation Database (HGMD)
C1orf141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf141 Gene

Disorders for C1orf141 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1orf141 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leprosy
  • leprosy, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C1orf141

Genetic Association Database (GAD)
C1orf141
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf141
genes like me logo Genes that share disorders with C1orf141: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1orf141 Gene

Publications for C1orf141 Gene

  1. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PMID: 22019778) Zhang F. … Zhang X. (Nat. Genet. 2011) 3 48 67
  2. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. (PMID: 25642632) Liu H. … Zhang F. (Nat. Genet. 2015) 3
  3. Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3. (PMID: 25108386) Hou S. … Yang P. (Nat. Genet. 2014) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3

Products for C1orf141 Gene

Sources for C1orf141 Gene

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