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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C1orf141 Gene

protein-coding GIFtS: 37
GCID: GC01M067557

chromosome 1 open reading frame 141

Search for C1orf141
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 1 Open Reading Frame 141¹ ²
Uncharacterized Protein C1orf141²

External Ids:	HGNC: 32044¹	Entrez Gene: 400757²	Ensembl: ENSG00000203963⁷	UniProtKB: Q5JVX7³

Export aliases for C1orf141 gene to outside databases

Previous GC identifers: GC01M067271 GC01M065666

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C1orf141 gene promoter:
AREB6 POU2F1 POU2F1a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C1orf141

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf141

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31.2

C1orf141 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf141 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M067557: view genomic region (about GC identifiers)

Start:	67,557,859 bp from pter	End:	67,600,639 bp from pter
Size:	42,781 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CA141_HUMAN, Q5JVX7 (See protein sequence)

Recommended Name: Uncharacterized protein C1orf141

Size: 400 amino acids; 46135 Da

Secondary accessions: Q0P5P5 Q5JVX5

Alternative splicing: 2 isoforms: Q5JVX7-1 Q5JVX7-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C1orf141: NX_Q5JVX7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5JVX7

C1orf141 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001013696.1 NP_001263280.1 NP_001263281.1

ENSEMBL proteins:

ENSP00000360046 ENSP00000360043 ENSP00000415519 ENSP00000432856 ENSP00000360045

ENSP00000444018

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q5JVX7

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for C1orf141:

Decreased viability

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C1orf141

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for C1orf141 (ENSP00000360045⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALG6	ENSP00000360149⁴	STRING: ENSP00000360149
C10orf107	ENSP00000328698⁴	STRING: ENSP00000328698
SSU72	ENSP00000291386⁴	STRING: ENSP00000291386
--	ENSP00000389607⁴	STRING: ENSP00000389607
--	ENSP00000372695⁴	STRING: ENSP00000372695

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C1orf141
Search CenterWatch for drugs/clinical trials and news about C1orf141 / CA141

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C1orf141 gene (3 alternative transcripts):

NM_001013674.1 NM_001276351.1 NM_001276352.1

Unigene Cluster for C1orf141:

Chromosome 1 open reading frame 141

Hs.666621 [show with all ESTs]

Unigene Representative Sequence: BC047053

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371007(uc001ddl.1) ENST00000371004 ENST00000448166 ENST00000475209

ENST00000371006(uc001ddm.1 uc001ddn.1) ENST00000544837

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Additional cDNA sequence:

BC047053.1 BC062728.1 BC090886.1

5 DOTS entries:

DT.75190283 DT.99977539 DT.99998744 DT.75154085 DT.99984594

12 AceView cDNA sequences:

BX091773 AI699305 BG772061 AI015035 BU686961 CD244124 BU854246 BI830372

BC047053 BC062728 BU853504 CD557483

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C1orf141 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTTCTATT

About this image

C1orf141 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

See C1orf141 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.666621

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C1orf141 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	4921539E11Rik^{1 , 5}	RIKEN cDNA 4921539E11 gene^{1, 5}	62.47(n)¹ 39.95(a)¹		4 (47.50 cM)⁵ 70941¹ NM_027612.1¹ NP_081888.1¹ 103230445⁵

ENSEMBL Gene Tree for C1orf141 (if available)
TreeFam Gene Tree for C1orf141 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76923534^1,2		--	67557388(+)	`TATGCC/TCCTTC`	1	--	ds500¹		0	--	--	--	--
rs61336504^1,2		--	67557412(+)	`GACCCG/CAGCCC`	1	--	ds500¹		1		CSA	2
rs11799729^1,2	C,H,	--	67557474(+)	`CTCCAG/AGTACA`	1	--	ds500¹		4		WA NA EA	360
rs138050056^1,2	C,	--	67557525(+)	`TTTTT-/GAGAGTC`	1	--	ds500¹		0	--	--	--	--
rs11799739^1,2	C,F,A,H,	--	67557616(+)	`TAGAAG/ACAGAG`	1	--	ds500¹		5		NA WA EA	364
rs117744703^1,2	F,	--	67557672(+)	`ACCCCG/AAAAGC`	1	--	ds500¹		1		EA	120
rs182521273^1,2		--	67557723(+)	`TTCAAC/GTAGTA`	1	--	ds500¹		0	--	--	--	--
rs145735336^1,2		--	67557817(+)	`TCACAC/TAAGCT`	1	--	ds500¹		0	--	--	--	--
rs187179949^1,2		--	67557920(+)	`CCAAAC/TAAATG`	1	--	ut3¹		0	--	--	--	--
rs6672194^1,2	C,F,H,	--	67557966(+)	`TAAGTT/GGAATT`	1	--	ut3¹ ese³		12		NA WA CSA EA	377

HapMap Linkage Disequilibrium report for C1orf141 (67557859 - 67600639 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1orf141: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C1orf141 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1orf141)

Utopia: connect your pdf to the dynamic
world of online information

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)¹ Kenny E.E....Peter I. (2012)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 400757	HGNC: 32044	AceView: LOC400757	Ensembl:ENSG00000203963	euGenes: HUgn400757
ECgene: C1orf141	H-InvDB: C1orf141

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C1orf141	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C1orf141 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C1orf141 gene:
Search GeneIP for patents involving C1orf141

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C1orf141 gene at Home site.

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C1orf141 Gene

chromosome 1 open reading frame 141

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C1orf141 Gene

chromosome 1 open reading frame 141

Aliasesfor C1orf141 gene

Summariesfor C1orf141 gene

Genomic Viewsfor C1orf141 gene

Proteinsfor C1orf141 gene

Protein Domains /Familiesfor C1orf141 gene

Functionfor C1orf141 gene

Pathways & Interactionsfor C1orf141 gene

Drugs & Compoundsfor C1orf141 gene

Transcriptsfor C1orf141 gene

Expression for C1orf141 gene

Orthologsfor C1orf141 gene

Paralogsfor C1orf141 gene

Genomic Variantsfor C1orf141 gene

Disorders / Diseasesfor C1orf141 gene

Publicationsfor C1orf141 gene

External Searches for C1orf141 gene

Genome Databases showing C1orf141 gene

Other Databases showing C1orf141 gene

Specialized Databases showing C1orf141 gene

Intellectual Propertyfor C1orf141 gene

Productsfor C1orf141 gene

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Aliases
for C1orf141 gene

Summaries
for C1orf141 gene

Genomic Views
for C1orf141 gene

Proteins
for C1orf141 gene

Protein Domains /
Families
for C1orf141 gene

Function
for C1orf141 gene

Pathways & Interactions
for C1orf141 gene

Drugs & Compounds
for C1orf141 gene

Transcripts
for C1orf141 gene

Expression
for C1orf141 gene

Orthologs
for C1orf141 gene

Paralogs
for C1orf141 gene

Genomic Variants
for C1orf141 gene

Disorders / Diseases
for C1orf141 gene

Publications
for C1orf141 gene

Intellectual Property
for C1orf141 gene

Products
for C1orf141 gene