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C1orf141 Gene

protein-coding   GIFtS: 37
GCID: GC01M067557

Chromosome 1 Open Reading Frame 141

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 1 Open Reading Frame 1411 2
Uncharacterized Protein C1orf1412

External Ids:    HGNC: 320441   Entrez Gene: 4007572   Ensembl: ENSG000002039637   UniProtKB: Q5JVX73   

Export aliases for C1orf141 gene to outside databases

Previous GC identifers: GC01M067271 GC01M065666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1orf141 Gene:
C1orf141 (chromosome 1 open reading frame 141) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the C1orf141 gene promoter:
         AREB6   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C1orf141

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1orf141


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

C1orf141 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf141 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M067557:  view genomic region     (about GC identifiers)

Start:
67,557,848 bp from pter      End:
67,697,536 bp from pter
Size:
139,689 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CA141_HUMAN, Q5JVX7 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf141  
Size: 400 amino acids; 46135 Da
Secondary accessions: Q0P5P5 Q5JVX5
Alternative splicing: 2 isoforms:  Q5JVX7-1   Q5JVX7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C1orf141: NX_Q5JVX7

Explore proteomics data for C1orf141 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C1orf141 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001263280.1  NP_001263281.1  

    ENSEMBL proteins: 
     ENSP00000360046   ENSP00000415519   ENSP00000474902   ENSP00000432856   ENSP00000360045  
     ENSP00000444018  

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    Search eBioscience for ELISAs for C1orf141 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027847 DUF4545

    Graphical View of Domain Structure for InterPro Entry Q5JVX7

    ProtoNet protein and cluster: Q5JVX7


    Find genes that share domains with C1orf141           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for C1orf141:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf141
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    SwitchGear 3'UTR luciferase reporter plasmidC1orf141 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1orf141
    Interactions:

        Search GeneGlobe Interaction Network for C1orf141

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for C1orf141 (ENSP000003600454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALG6ENSP000003601494STRING: ENSP00000360149
    C10orf107ENSP000003286984STRING: ENSP00000328698
    ENSG00000206284ENSP000003726954STRING: ENSP00000372695
    ENSG00000224496ENSP000003896074STRING: ENSP00000389607
    SSU72ENSP000002913864STRING: ENSP00000291386
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1orf141 (CA141)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C1orf141 gene (3 alternative transcripts): 
    NM_001013674.1  NM_001276351.1  NM_001276352.1  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371007(uc001ddl.1) ENST00000371004 ENST00000448166 ENST00000603691
    ENST00000475209 ENST00000371006(uc001ddm.1 uc001ddn.1) ENST00000544837

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    hsa-miR-520d-5p hsa-miR-302f hsa-miR-4263 hsa-miR-524-5p hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidC1orf141 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat C1orf141

    12 AceView cDNA sequences:

    BX091773 BU854246 CD244124 AI699305 BU686961 AI015035 BC047053 BI830372 
    BG772061 BC062728 BU853504 CD557483 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C1orf141 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTCTATT
    C1orf141 Expression
    About this image


    C1orf141 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    C1orf141 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1orf141 Protein Expression
        Custom PCR Arrays for C1orf141
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf141

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for C1orf141 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4921539E11Rik5 RIKEN cDNA 4921539E11 gene   --   4 (47.50 cM) 103230445 


    ENSEMBL Gene Tree for C1orf141 (if available)
    TreeFam Gene Tree for C1orf141 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C1orf141 (see all 916)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769235341,2
    F--67557388(+) TATGCC/TCCTTC 3 -- ds50010--------
    rs613365041,2
    F--67557412(+) GACCCG/CAGCCC 3 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs117997291,2
    C,H--67557474(+) CTCCAG/AGTACA 3 -- ds50014Minor allele frequency- A:0.14WA NA EA 360
    rs1380500561,2
    C--67557525(+) TTTTT-/GAGAGTC 3 -- ds50010--------
    rs358008021,2
    C--67557526(+) TTGAG-/AGTCCAA 3 -- ds50010--------
    rs117997391,2
    C,F,A,H--67557616(+) TAGAAG/ACAGAG 3 -- ds50015Minor allele frequency- A:0.14NA WA EA 364
    rs1177447031,2
    C,F--67557672(+) ACCCCG/AAAAGC 3 -- ds50011Minor allele frequency- A:0.04EA 120
    rs1825212731,2
    --67557723(+) TTCAAC/GTAGTA 3 -- ds50010--------
    rs1457353361,2
    C--67557817(+) TCACAC/TAAGCT 3 -- ds50010--------
    rs1871799491,2
    --67557920(+) CCAAAC/TAAATG 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for C1orf141 (67557848 - 67697536 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C1orf141:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv461751CNV Loss19166990
    nsv870950CNV Gain21882294
    nsv461762CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with C1orf141           About GenesLikeMe

    Genetic Association Database (GAD): C1orf141

    Export disorders for C1orf141 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C1orf141 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C1orf141)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (PLoS Genet. 2012)
    2. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PubMed id 22019778)4 Zhang F....Zhang X. (Nat. Genet. 2011)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 400757 HGNC: 32044 AceView: LOC400757 Ensembl:ENSG00000203963 euGenes: HUgn400757
    ECgene: C1orf141 H-InvDB: C1orf141

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C1orf141 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C1orf141 gene:
    Search GeneIP for patents involving C1orf141

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     CLIAs for C1orf141



     Browse ESI BIO Cell Lines and PureStem Progenitors for C1orf141
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf141
     SwitchGear 3'UTR luciferase reporter plasmids for C1orf141
     Browse SwitchGear Promoter luciferase reporter plasmids for C1orf141
     Search ThermoFisher Antibodies for C1orf141
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf141
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf141
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C1orf141
     LSBio Antibodies in human, mouse, rat for C1orf141
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     Translational medicine
     Tissue-specific gene expresssion
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     Browse compounds at ApexBio
     Search Addgene for plasmids for C1orf141
      Search eBioscience for proteins for C1orf141
      Search eBioscience for elisas for C1orf141
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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