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Aliases for C1orf131 Gene

Aliases for C1orf131 Gene

  • Chromosome 1 Open Reading Frame 131 2 3 5
  • CPERP-A 4

External Ids for C1orf131 Gene

Previous GeneCards Identifiers for C1orf131 Gene

  • GC01M227667
  • GC01M229429
  • GC01M231359
  • GC01M201842

Summaries for C1orf131 Gene

GeneCards Summary for C1orf131 Gene

C1orf131 (Chromosome 1 Open Reading Frame 131) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf131 Gene

Genomics for C1orf131 Gene

Regulatory Elements for C1orf131 Gene

Enhancers for C1orf131 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F231037 1.1 ENCODE 34.7 +201.7 201686 4.0 HDGF PKNOX1 SIN3A FEZF1 ZNF2 KLF13 ZNF263 SP3 REST ZFP41 C1orf131 FAM89A COG2 LOC644006 MIR1182
GH01F230862 1.6 FANTOM5 Ensembl ENCODE 22.2 +374.5 374548 7.6 CREB3L1 ZNF133 ZFP64 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2 YY1 C1orf131 LOC101927604 C1orf198 FAM89A ENSG00000225656
GH01F230820 1.1 Ensembl ENCODE 27.2 +416.5 416493 8.2 TBP PKNOX1 ZNF23 ZNF548 FOS CEBPB JUNB ZNF623 NR2F2 MEF2D C1orf131 C1orf198 LOC101927604 CAPN9 COG2 ENSG00000244137 ENSG00000225656 RNA5SP79
GH01F231418 1.2 ENCODE 24 -180.0 -180018 5.5 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS C1orf131 COG2 SNRPD2P2 RN7SL837P RPS24P4 LINC01737 EGLN1 SPRTN PIR59803
GH01F231105 1.3 Ensembl ENCODE 22.1 +134.8 134848 1.1 PKNOX1 ATF1 DMAP1 FEZF1 GLI4 ZNF121 ZNF302 ZNF263 SP3 YY2 C1orf131 LOC100288703 GC01M231050
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf131 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf131 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083577 -213 3201 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for C1orf131 Gene

231,223,763 bp from pter
231,241,187 bp from pter
17,425 bases
Minus strand

Genomic View for C1orf131 Gene

Genes around C1orf131 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf131 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf131 Gene

Proteins for C1orf131 Gene

  • Protein details for C1orf131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C1orf131
    Protein Accession:
    Secondary Accessions:
    • Q5TBI0
    • Q5TBI1
    • Q6P6B4
    • Q7Z6H5
    • Q8N432
    • Q96NM6

    Protein attributes for C1orf131 Gene

    294 amino acids
    Molecular mass:
    32766 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf131 Gene


neXtProt entry for C1orf131 Gene

Post-translational modifications for C1orf131 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf131 Gene

No data available for DME Specific Peptides for C1orf131 Gene

Domains & Families for C1orf131 Gene

Protein Domains for C1orf131 Gene


Suggested Antigen Peptide Sequences for C1orf131 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf131: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf131 Gene

Function for C1orf131 Gene

Gene Ontology (GO) - Molecular Function for C1orf131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with C1orf131: view

Phenotypes for C1orf131 Gene

MGI mutant phenotypes for C1orf131:
inferred from 1 alleles
GenomeRNAi human phenotypes for C1orf131:
genes like me logo Genes that share phenotypes with C1orf131: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1orf131 Gene

Localization for C1orf131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf131 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf131 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C1orf131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome IDA 20813266
genes like me logo Genes that share ontologies with C1orf131: view

Pathways & Interactions for C1orf131 Gene

SuperPathways for C1orf131 Gene

No Data Available

Interacting Proteins for C1orf131 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000355609 Q8NDD1-CA131_HUMAN for C1orf131 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C1orf131 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf131 Gene

Transcripts for C1orf131 Gene

Unigene Clusters for C1orf131 Gene

Chromosome 1 open reading frame 131:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf131 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - - -

Relevant External Links for C1orf131 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf131 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1orf131 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1orf131 Gene

This gene is overexpressed in Platelet (54.6) and Blymphocyte (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf131 Gene

Protein tissue co-expression partners for C1orf131 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf131 Gene:


SOURCE GeneReport for Unigene cluster for C1orf131 Gene:

genes like me logo Genes that share expression patterns with C1orf131: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C1orf131 Gene

Orthologs for C1orf131 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf131 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf131 34
  • 98.98 (n)
C1orf131 35
  • 98 (a)
(Canis familiaris)
Mammalia C4H1orf131 34
  • 82.69 (n)
C1orf131 35
  • 75 (a)
(Bos Taurus)
Mammalia LOC514234 34
  • 80.26 (n)
C1orf131 35
  • 69 (a)
(Rattus norvegicus)
Mammalia RGD1562218 34
  • 76.21 (n)
(Mus musculus)
Mammalia 2810004N23Rik 34 16 35
  • 74.58 (n)
(Monodelphis domestica)
Mammalia C1orf131 35
  • 61 (a)
(Gallus gallus)
Aves C1ORF131 34
  • 57.54 (n)
C1orf131 35
  • 34 (a)
(Anolis carolinensis)
Reptilia C1orf131 35
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf131 34
  • 53.69 (n)
(Danio rerio)
Actinopterygii zgc:194224 34
  • 54.55 (n)
C20H1orf131 35
  • 35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1442 34
Species where no ortholog for C1orf131 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf131 Gene

Gene Tree for C1orf131 (if available)
Gene Tree for C1orf131 (if available)

Paralogs for C1orf131 Gene

No data available for Paralogs for C1orf131 Gene

Variants for C1orf131 Gene

Sequence variations from dbSNP and Humsavar for C1orf131 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs113480953 Benign 231,241,404(+) TAACT(C/T)TTATT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs10495305 -- 231,236,764(+) TGCTC(A/G)CCAAC intron-variant
rs11122254 -- 231,232,224(+) TATTC(A/T)CTGCA intron-variant
rs11122255 -- 231,232,225(+) ATTCT(C/T)TGCAG intron-variant
rs11122256 -- 231,242,758(+) TGTTT(A/G)TTTGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1orf131 Gene

Variant ID Type Subtype PubMed ID
nsv1011066 CNV gain 25217958
nsv1000488 CNV gain 25217958
esv3589106 CNV gain 21293372
esv3589093 CNV gain 21293372

Variation tolerance for C1orf131 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 62.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf131 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf131 Gene

Disorders for C1orf131 Gene

Relevant External Links for C1orf131

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C1orf131 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf131 Gene

Publications for C1orf131 Gene

  1. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S. … Rappsilber J. (Cell 2010) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for C1orf131 Gene

Sources for C1orf131 Gene

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