C1orf123 Gene
protein-coding GIFtS: 47
GCID: GC01M053679 (predicted)
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|
chromosome 1 open reading frame 123
| |
Aliases
for C1orf123 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 1 Open Reading Frame 1231 2 | | FLJ205801 | | UPF0587 Protein C1orf1232 |
Export aliases for C1orf123 gene to outside databasesPrevious GC identifers: GC01M053392 GC01M053452 GC01M051795 |
Summaries
for C1orf123 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C1orf123 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1orf123 gene promoter:
AML1a FOXO3 CUTL1 HNF-3beta FOXO3b FOXO3a AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1orf123
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf123 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3C1orf123 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M053679: view genomic region
(about GC identifiers)
Start:
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53,679,771 bp from pter |
End:
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53,686,289 bp from pter |
Size:
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6,519 bases |
Orientation:
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minus strand |
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Proteins
for C1orf123 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CA123_HUMAN, Q9NWV4 (See
protein sequence)Recommended Name: UPF0587 protein C1orf123 Size: 160 amino acids; 18048 DaExplore the universe of human proteins at neXtProt for C1orf123: NX_Q9NWV4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWV4
C1orf123 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060357.1
ENSEMBL proteins: ENSP00000294360 ENSP00000360535
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
C1orf123 for ontologies About GeneDecksing
C1orf123 Antibody Products:
Assay Products for C1orf123: |
Protein
Domains /
Families
for C1orf123 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C1orf123 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NWV4ProtoNet protein and cluster: Q9NWV4 UniProtKB/Swiss-Prot: CA123_HUMAN, Q9NWV4Similarity: Belongs to the UPF0587 family |
Function
for C1orf123 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf123 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf123
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: C1orf123 (NM_017887) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf123 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf123 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf123 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C1orf123 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C1orf123:
|
Pathways & Interactions
for C1orf123 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf123
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/13 Interacting proteins for C1orf123 (Q9NWV42, 3 ENSP000002943604) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
C1orf123 for ontologies About GeneDecksing
|
Drugs & Compounds
for C1orf123 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1orf123
Search CenterWatch for drugs/clinical trials and news about C1orf123 / CA123
|
Transcripts
for C1orf123 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1orf123 gene: NM_017887.1 Unigene Cluster for C1orf123: Chromosome 1 open reading frame 123 Hs.525391 [show with all ESTs]Unigene Representative Sequence: AK0927347 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000294360(uc001cvd.3) ENST00000483739 ENST00000470385 ENST00000478839
ENST00000371480 ENST00000489755 ENST00000474227
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf123 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf123
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C1orf123 (NM_017887) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1orf123 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf123 |
Additional cDNA sequence: AK000587.1 AK092734.1 AK094371.1 BC010908.1 CR457246.1 9 DOTS entries: DT.317688 DT.100784735 DT.101969476 DT.91759963 DT.436564 DT.100029761 DT.91759959 DT.97824259 DT.100706716 24/219 AceView cDNA sequences (see all 219): BI917099 AI284236 CR623839 BI771520 BM785162 AA975540 CD515353 CR603422 AI221366 AI200052 BM968653 F02899 AI244914 AI742539 BG779235 BF058914 AA917586 AI929048 AA449956 AK094371 CB155598 AL602818 CD108893 AI201921
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf123 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f |
|---|
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| SP1: | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C1orf123
|
Expression
for C1orf123 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1orf123 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGACTTTA
About this image
See C1orf123 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf123
SOURCE GeneReport for Unigene cluster: Hs.525391
SABiosciences Custom PCR Arrays for C1orf123
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf123
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C1orf123 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf123 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf123 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf123 |
Orthologs
for C1orf123 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C1orf123 gene from 9/33 species (see all 33) About this table
ENSEMBL Gene Tree for C1orf123 (if available)
TreeFam Gene Tree for C1orf123 (if available) |
Paralogs
for C1orf123 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C1orf123 gene
C1orf123 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for C1orf123
PGOHUM00000244811
|
Genomic Variants
for C1orf123 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C1orf123 (53679771 - 53686289 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C1orf123
1 CNV: 5196 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf123 |
|
Disorders
/ Diseases
for C1orf123 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C1orf123 for disorders About GeneDecksing
1  disease for C1orf123: About MalaCardsmalaria
Export disorders for C1orf123 gene to outside databases
|
Publications
for C1orf123 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1orf123 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C1orf123) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
|
External Searches for C1orf123 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C1orf123 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C1orf123 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1orf123 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C1orf123 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C1orf123 gene:
Search GeneIP for patents involving C1orf123
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1orf123 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C1orf123 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1orf123 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf123 | | | OriGene Protein Over-expression Lysate for C1orf123 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C1orf123 | | OriGene 3'-UTR Clone for C1orf123 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf123 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1orf123 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C1orf123 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C1orf123 | | OriGene Custom Protein Services for C1orf123 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf123 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf123 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf123 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1orf123 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf123 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1orf123 |
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 | | | C1orf123 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf123 |
|  |  |  | | | | Search ThermoFisher Antibodies for C1orf123 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf123 |
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