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Aliases for C1orf123 Gene

Aliases for C1orf123 Gene

  • Chromosome 1 Open Reading Frame 123 2 3 5

External Ids for C1orf123 Gene

Previous GeneCards Identifiers for C1orf123 Gene

  • GC01M053392
  • GC01M053452
  • GC01M053679
  • GC01M051795

Summaries for C1orf123 Gene

GeneCards Summary for C1orf123 Gene

C1orf123 (Chromosome 1 Open Reading Frame 123) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf123 Gene

Genomics for C1orf123 Gene

Regulatory Elements for C1orf123 Gene

Enhancers for C1orf123 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F053245 0.2 ENCODE 35.3 -26.1 -26054 1.4 PAF1 TBL1XR1 ZMYM3 TBX21 EP300 SP1 MAFK CREM SPI1 C1orf123 CPT2 ENSG00000232762 GC01M053244 LOC105378728
GH01F053218 0.6 ENCODE 32.3 +0.4 393 2.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 C1orf123 MAGOH ENSG00000230953 ZCCHC11 GPX7 GC01M053219 ENSG00000236723
GH01F053213 0.7 ENCODE 32 +5.9 5851 1.7 CTCF ZMYM3 ZNF24 RAD21 ZBTB20 C1orf123 ENSG00000236723 GC01M053219
GH01F053195 0.4 ENCODE 31.9 +23.4 23392 3.6 HDGF PKNOX1 SIN3A FEZF1 YY1 ZNF207 KLF13 SP3 SP5 REST C1orf123 HSPB11 CPT2 PIR34935
GH01F053237 1.3 FANTOM5 ENCODE 28.6 -18.0 -17960 2.0 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 C1orf123 PODN ENSG00000230953 ENSG00000236723 MAGOH CYB5RL LINC01771 LRP8 ZCCHC11 GPX7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C1orf123 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf123 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000077204 139 1401 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9
ENSR00001744960 1338 200 ZNF263 ZIC2

Genomic Location for C1orf123 Gene

Chromosome:
1
Start:
53,214,099 bp from pter
End:
53,220,639 bp from pter
Size:
6,541 bases
Orientation:
Minus strand

Genomic View for C1orf123 Gene

Genes around C1orf123 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf123 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf123 Gene

Proteins for C1orf123 Gene

  • Protein details for C1orf123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWV4-CA123_HUMAN
    Recommended name:
    UPF0587 protein C1orf123
    Protein Accession:
    Q9NWV4

    Protein attributes for C1orf123 Gene

    Size:
    160 amino acids
    Molecular mass:
    18048 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf123 Gene

Post-translational modifications for C1orf123 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf123 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf123 Gene

Domains & Families for C1orf123 Gene

Protein Domains for C1orf123 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf123 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWV4

UniProtKB/Swiss-Prot:

CA123_HUMAN :
  • Belongs to the UPF0587 family.
Family:
  • Belongs to the UPF0587 family.
genes like me logo Genes that share domains with C1orf123: view

No data available for Gene Families for C1orf123 Gene

Function for C1orf123 Gene

Gene Ontology (GO) - Molecular Function for C1orf123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C1orf123: view
genes like me logo Genes that share phenotypes with C1orf123: view

Animal Model Products

miRNA for C1orf123 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf123 Gene

Localization for C1orf123 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf123 Gene COMPARTMENTS Subcellular localization image for C1orf123 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C1orf123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C1orf123: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C1orf123 Gene

Pathways & Interactions for C1orf123 Gene

SuperPathways for C1orf123 Gene

No Data Available

Interacting Proteins for C1orf123 Gene

Gene Ontology (GO) - Biological Process for C1orf123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C1orf123: view

No data available for Pathways by source and SIGNOR curated interactions for C1orf123 Gene

Transcripts for C1orf123 Gene

Unigene Clusters for C1orf123 Gene

Chromosome 1 open reading frame 123:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf123 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6:
SP7: -

Relevant External Links for C1orf123 Gene

GeneLoc Exon Structure for
C1orf123
ECgene alternative splicing isoforms for
C1orf123

Expression for C1orf123 Gene

mRNA expression in normal human tissues for C1orf123 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C1orf123 Gene



Protein tissue co-expression partners for C1orf123 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf123 Gene:

C1orf123

SOURCE GeneReport for Unigene cluster for C1orf123 Gene:

Hs.525391
genes like me logo Genes that share expression patterns with C1orf123: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C1orf123 Gene

Orthologs for C1orf123 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C1orf123 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf123 34
  • 100 (n)
-- 35
  • 100 (a)
OneToMany
-- 35
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C3H1orf123 34 35
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia 0610037L13Rik 34 16 35
  • 91.56 (n)
dog
(Canis familiaris)
Mammalia C5H1orf123 34
  • 91.25 (n)
C1orf123 35
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1559786 34
  • 90.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf123 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf123 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf123 35
  • 84 (a)
OneToOne
C8H1ORF123 34
  • 79.58 (n)
lizard
(Anolis carolinensis)
Reptilia C1orf123 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497300 34
  • 75 (n)
zebrafish
(Danio rerio)
Actinopterygii C2H1orf123 35
  • 82 (a)
OneToOne
si:ch211-284b7.3 34
  • 74.79 (n)
Dr.23495 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10583 34
fruit fly
(Drosophila melanogaster)
Insecta CG4646 34 35
  • 55.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003919 34
  • 54.09 (n)
worm
(Caenorhabditis elegans)
Secernentea F46B6.12 34 35
  • 55.27 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10153g 34
  • 46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL238W 34
  • 43.61 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCR090C 34
  • 43.01 (n)
-- 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32930 34
  • 50.85 (n)
rice
(Oryza sativa)
Liliopsida Os01g0565600 34
  • 52.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08505 34
  • 51.9 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2D10.03c 34
  • 49.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for C1orf123 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C1orf123 Gene

ENSEMBL:
Gene Tree for C1orf123 (if available)
TreeFam:
Gene Tree for C1orf123 (if available)

Paralogs for C1orf123 Gene

Pseudogenes.org Pseudogenes for C1orf123 Gene

genes like me logo Genes that share paralogs with C1orf123: view

No data available for Paralogs for C1orf123 Gene

Variants for C1orf123 Gene

Sequence variations from dbSNP and Humsavar for C1orf123 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1056396 -- 53,214,678(-) CACCC(A/C)CCAGT downstream-variant-500B, reference, missense
rs1056397 -- 53,214,608(-) GTACT(C/T)TAAGC downstream-variant-500B, utr-variant-3-prime
rs1056425 -- 53,214,418(-) GAATT(C/T)GTGCA downstream-variant-500B, utr-variant-3-prime
rs1056438 -- 53,214,206(-) AATTA(A/G)GAACC downstream-variant-500B, utr-variant-3-prime
rs1056446 -- 53,213,929(-) TTTGT(C/T)TTTTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C1orf123 Gene

Variant ID Type Subtype PubMed ID
esv2422213 CNV duplication 17116639
nsv1001535 CNV gain 25217958
nsv829871 CNV loss 17160897

Variation tolerance for C1orf123 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf123 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf123

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf123 Gene

Disorders for C1orf123 Gene

Relevant External Links for C1orf123

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf123

No disorders were found for C1orf123 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf123 Gene

Publications for C1orf123 Gene

  1. Cloning, expression, purification, crystallization and X-ray crystallographic analysis of recombinant human C1ORF123 protein. (PMID: 26919524) Rahaman S.N. … Ng C.L. (Acta Crystallogr F Struct Biol Commun 2016) 2 3 64
  2. Integrated genomics and proteomics of the Torpedo californica electric organ: concordance with the mammalian neuromuscular junction. (PMID: 21798097) Mate S.E. … Hoffman E.P. (Skelet Muscle 2011) 2 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for C1orf123 Gene

Sources for C1orf123 Gene

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