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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1orf115 Gene

protein-coding   GIFtS: 37
GCID: GC01P220863

chromosome 1 open reading frame 115
  Search for C1orf115
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C1orf115    

Aliases
for C1orf115 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 1 Open Reading Frame 1151 2
FLJ141461
RP11-322F10.42
Uncharacterized Protein C1orf1152

External Ids:    HGNC: 258731   Entrez Gene: 797622   Ensembl: ENSG000001628177   UniProtKB: Q9H7X23   

Export aliases for C1orf115 gene to outside databases

Previous GC identifers: GC01P217252 GC01P218929 GC01P191538


Summaries
for C1orf115 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C1orf115 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1orf115 gene promoter:
         AhR   SRF   GATA-3   Pax-5   SRF (504 AA)   CUTL1   Arnt   E47   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C1orf115 promoter sequence
   Search SABiosciences Chromatin IP Primers for C1orf115

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf115


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

C1orf115 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf115 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P220863:  view genomic region     (about GC identifiers)

Start:
 220,863,187 bp from pter      End:
 220,872,499 bp from pter
Size:
 9,313 bases      Orientation:
 plus strand

Proteins
for C1orf115 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CA115_HUMAN, Q9H7X2 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf115  
Size: 142 amino acids; 15517 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B3KRN3 D3DTB2

Explore the universe of human proteins at neXtProt for C1orf115: NX_Q9H7X2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H7X2

    • C1orf115 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_078985.3  
    ENSEMBL proteins: 
     ENSP00000294889  

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    Uscn Proteins for C1orf115

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    C1orf115 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for C1orf115 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9H7X2


    Function
    for C1orf115 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C1orf115 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1orf115

    Drugs & Compounds
    for C1orf115 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C1orf115
    Search CenterWatch for drugs/clinical trials and news about C1orf115 / CA115 

    Transcripts
    for C1orf115 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for C1orf115 gene: 
    NM_024709.4  

    Unigene Cluster for C1orf115:

    Chromosome 1 open reading frame 115
    Hs.519839  [show with all ESTs]
    Unigene Representative Sequence: AK125403
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000294889(uc001hmp.1)

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK024208.1 AK056749.1 AK091937.1 AK125403.1 BC036067.1 

    6 DOTS entries:

    DT.97805619  DT.442036  DT.100719553  DT.100790922  DT.91742576  DT.121354095 

    24/144 AceView cDNA sequences (see all 144):

    BQ644070 BU689376 CB164805 AW352090 CB241125 AK024208 AL703513 CB158782 
    CA438377 CB305682 AW663362 AW466969 AK091937 AW274505 BC036067 BM985420 
    BQ711722 BX091982 CB996449 BQ710303 BI757483 NM_024709 CR598857 CB156547 

    GeneLoc Exon Structure


    Expression
    for C1orf115 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1orf115 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCGAAGATTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C1orf115 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C1orf115 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1orf115

    SOURCE GeneReport for Unigene cluster: Hs.519839
        SABiosciences Custom PCR Arrays for C1orf115
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    In Situ
    Assay Products:     
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    Orthologs
    for C1orf115 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C1orf115 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia C130074G19Rik1 , 5 RIKEN cDNA C130074G19 gene1, 5 76.83(n)1
    70.21(a)1    		   1 (89.22 cM)5
    2267771  NM_178692.31  NP_848807.11 
     1848719265 
    chicken
    (Gallus gallus)    		 Aves C3H1orf1151 chromosome 3 open reading frame, human C1orf115 67.98(n)
    53.54(a)    		   421341  XM_429841.3  XP_429841.2 


    ENSEMBL Gene Tree for C1orf115 (if available)
    TreeFam Gene Tree for C1orf115 (if available) 

    Paralogs
    for C1orf115 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C1orf115 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/205 NCBI SNPs in C1orf115 are shown (see all 205)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs115904961,2
    		C,F,H,--220861668(+) CATACT/GGTTTT 1 -- us2k110Minor allele frequency- G:0.05NS EA NA 1194
    rs1874702061,2
    		--220861873(+) TTTCAC/TCTGAA 1 -- us2k10--------
    rs351483941,2
    		C,--220861947(+) AATAT-/AAGTCAT 1 -- us2k10--------
    rs1410227691,2
    		--220862071(+) GGCACA/GATCTC 1 -- us2k10--------
    rs1502720961,2
    		--220862096(+) TCTGCC/TTCTTG 1 -- us2k10--------
    rs1458901561,2
    		--220862138(+) AATAGC/TTGAGA 1 -- us2k10--------
    rs1114233071,2
    		--220862156(+) AGCACA/GCCACC 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1430421871,2
    		--220862200(+) CAGGGC/TTTCAC 1 -- us2k10--------
    rs118034951,2
    		C,H,--220862238(+) ctgacC/Ttcagg 1 -- us2k1 tfbs30--------
    rs1920372501,2
    		--220862253(+) CCACCA/GCCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C1orf115 (220863187 - 220872499 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C1orf115: --

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    Disorders / Diseases
    for C1orf115 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C1orf115 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1orf115 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C1orf115)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for C1orf115 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C1orf115 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79762 HGNC: 25873 AceView: FLJ14146 Ensembl:ENSG00000162817 euGenes: HUgn79762
    ECgene: C1orf115 H-InvDB: C1orf115

    Other Databases showing C1orf115 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C1orf115 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1orf115 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C1orf115 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C1orf115 gene:
    Search GeneIP for patents involving C1orf115

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C1orf115 gene

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    About This Section

     
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