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Aliases for C1orf115 Gene

Aliases for C1orf115 Gene

  • Chromosome 1 Open Reading Frame 115 2 3 5

External Ids for C1orf115 Gene

Previous GeneCards Identifiers for C1orf115 Gene

  • GC01P217252
  • GC01P218929
  • GC01P220863
  • GC01P191538

Summaries for C1orf115 Gene

GeneCards Summary for C1orf115 Gene

C1orf115 (Chromosome 1 Open Reading Frame 115) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf115 Gene

Genomics for C1orf115 Gene

Regulatory Elements for C1orf115 Gene

Enhancers for C1orf115 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G220732 1.3 Ensembl ENCODE 32.2 +43.9 43908 3.0 FOXA2 ARID4B DMAP1 FEZF1 YY1 ZNF766 GLIS2 GATA2 ELK1 ZNF143 C1orf115 MARC1 MARC2
GH01G220689 1.3 FANTOM5 ENCODE 22.1 +1.3 1298 2.8 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZBTB7B YY1 GLIS2 ZNF143 C1orf115 MARC1 MARC2
GH01G220766 1.2 Ensembl ENCODE 22.4 +78.2 78216 3.5 ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA YY1 CREM MIXL1 CEBPB C1orf115 MARC1 MARC2
GH01G220746 1.3 Ensembl ENCODE 11.2 +59.5 59526 5.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 GLIS2 C1orf115 MARC1 MARC2
GH01G220299 1.3 Ensembl ENCODE 9.7 -389.1 -389144 1.6 ARNT FEZF1 ZNF2 ZNF766 ZNF302 ZNF548 ZNF263 SP3 REST SMARCA4 RPS15AP12 SNX2P1 C1orf115 GC01M220298 XRCC6P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf115 on UCSC Golden Path with GeneCards custom track

Promoters for C1orf115 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000020401 855 1401 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZBTB7B YY1 GLIS2 ZNF143

Genomic Location for C1orf115 Gene

Chromosome:
1
Start:
220,689,845 bp from pter
End:
220,699,157 bp from pter
Size:
9,313 bases
Orientation:
Plus strand

Genomic View for C1orf115 Gene

Genes around C1orf115 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf115 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf115 Gene

Proteins for C1orf115 Gene

  • Protein details for C1orf115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7X2-CA115_HUMAN
    Recommended name:
    Uncharacterized protein C1orf115
    Protein Accession:
    Q9H7X2
    Secondary Accessions:
    • B3KRN3
    • D3DTB2

    Protein attributes for C1orf115 Gene

    Size:
    142 amino acids
    Molecular mass:
    15517 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf115 Gene

Post-translational modifications for C1orf115 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf115 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf115 Gene

Domains & Families for C1orf115 Gene

Protein Domains for C1orf115 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf115: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf115 Gene

Function for C1orf115 Gene

Phenotypes for C1orf115 Gene

GenomeRNAi human phenotypes for C1orf115:
genes like me logo Genes that share phenotypes with C1orf115: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf115 Gene

Localization for C1orf115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1orf115 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf115 gene
Compartment Confidence
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for C1orf115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1orf115: view

Pathways & Interactions for C1orf115 Gene

SuperPathways for C1orf115 Gene

No Data Available

Interacting Proteins for C1orf115 Gene

Selected Interacting proteins: Q9H7X2-CA115_HUMAN for C1orf115 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for C1orf115 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf115 Gene

Drugs & Compounds for C1orf115 Gene

No Compound Related Data Available

Transcripts for C1orf115 Gene

mRNA/cDNA for C1orf115 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(144) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf115 Gene

Chromosome 1 open reading frame 115:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf115 Gene

No ASD Table

Relevant External Links for C1orf115 Gene

GeneLoc Exon Structure for
C1orf115
ECgene alternative splicing isoforms for
C1orf115

Expression for C1orf115 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf115 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf115 Gene

This gene is overexpressed in Brain - Cortex (x4.3), Brain - Frontal Cortex (BA9) (x4.2), and Liver (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of C1orf115 Gene:

C1orf115

SOURCE GeneReport for Unigene cluster for C1orf115 Gene:

Hs.519839

Evidence on tissue expression from TISSUES for C1orf115 Gene

  • Nervous system(4.7)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with C1orf115: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf115 Gene

Orthologs for C1orf115 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf115 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf115 34
  • 99.06 (n)
C1orf115 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf115 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C16H1orf115 34 35
  • 86.03 (n)
rat
(Rattus norvegicus)
Mammalia RGD1310587 34
  • 77.38 (n)
mouse
(Mus musculus)
Mammalia C130074G19Rik 34 16 35
  • 76.83 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf115 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf115 35
  • 51 (a)
OneToOne
Species where no ortholog for C1orf115 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf115 Gene

ENSEMBL:
Gene Tree for C1orf115 (if available)
TreeFam:
Gene Tree for C1orf115 (if available)

Paralogs for C1orf115 Gene

No data available for Paralogs for C1orf115 Gene

Variants for C1orf115 Gene

Sequence variations from dbSNP and Humsavar for C1orf115 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000404198 -- 220,690,879(+) CGAGT(A/C)GTGAT intron-variant
rs1000608540 -- 220,696,961(+) GAATT(C/T)GGCGG utr-variant-3-prime
rs1000812476 -- 220,690,070(+) CGTTG(C/T)TAATT upstream-variant-2KB
rs1001093713 -- 220,695,120(+) CCTCA(G/T)GGGTT intron-variant
rs1001451535 -- 220,694,844(+) GACTG(C/T)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf115 Gene

Variant ID Type Subtype PubMed ID
nsv468194 CNV loss 19166990
nsv549227 CNV loss 21841781
nsv826742 CNV loss 20364138
nsv945303 CNV duplication 23825009

Variation tolerance for C1orf115 Gene

Gene Damage Index Score: 1.02; 20.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf115 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf115

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf115 Gene

Disorders for C1orf115 Gene

Relevant External Links for C1orf115

Genetic Association Database (GAD)
C1orf115
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf115

No disorders were found for C1orf115 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf115 Gene

Publications for C1orf115 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for C1orf115 Gene

Sources for C1orf115 Gene

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