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Aliases for C1orf112 Gene

Aliases for C1orf112 Gene

  • Chromosome 1 Open Reading Frame 112 2 3 5

External Ids for C1orf112 Gene

Previous GeneCards Identifiers for C1orf112 Gene

  • GC01P166496
  • GC01P168030
  • GC01P169631
  • GC01P140986

Summaries for C1orf112 Gene

GeneCards Summary for C1orf112 Gene

C1orf112 (Chromosome 1 Open Reading Frame 112) is a Protein Coding gene.

Additional gene information for C1orf112 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf112 Gene

Genomics for C1orf112 Gene

Regulatory Elements for C1orf112 Gene

Enhancers for C1orf112 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H169889 1.8 FANTOM5 ENCODE dbSUPER 35.7 +230.2 230230 5.5 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 METTL18 C1orf112 SCYL3 KIFAP3 MRPS10P1 ENSG00000230704 HAUS4P1 RPL29P7 RN7SL333P
GH01H169362 1.6 Ensembl ENCODE dbSUPER 23.8 -296.0 -296019 7.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NME7 C1orf112 CCDC181 METTL18 BLZF1 ENSG00000235575
GH01H169793 1.1 ENCODE 33.8 +133.1 133057 2.3 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143 DEK METTL18 SCYL3 C1orf112 RN7SL333P KIFAP3
GH01H168708 1.2 Ensembl ENCODE 24.7 -952.4 -952424 2.7 PKNOX1 INSM2 RAD21 ZNF2 RFX5 ZNF366 RCOR1 FOS EGR2 SMARCA5 C1orf112 TIPRL LOC101928596 ATP1B1 CCDC181 DPT GC01M168701 LOC105371604
GH01H169941 1.2 VISTA 24.4 +280.6 280590 2.7 PKNOX1 FEZF1 ZNF2 ZNF121 KLF7 TSHZ1 ZNF488 ZNF610 ZSCAN16 GLIS1 METTL18 C1orf112 GORAB SCYL3 RN7SL333P GC01P169942 GC01M169872
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1orf112 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C1orf112 Gene

Genomic Locations for C1orf112 Gene
chr1:169,662,007-169,854,080
(GRCh38/hg38)
Size:
192,074 bases
Orientation:
Plus strand
chr1:169,631,245-169,823,221
(GRCh37/hg19)

Genomic View for C1orf112 Gene

Genes around C1orf112 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf112 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf112 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf112 Gene

Proteins for C1orf112 Gene

  • Protein details for C1orf112 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSG2-CA112_HUMAN
    Recommended name:
    Uncharacterized protein C1orf112
    Protein Accession:
    Q9NSG2
    Secondary Accessions:
    • A6NFP1
    • B3KU42
    • Q3KNQ1
    • Q9H8L5
    • Q9NVJ0

    Protein attributes for C1orf112 Gene

    Size:
    853 amino acids
    Molecular mass:
    96554 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1orf112 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf112 Gene

Post-translational modifications for C1orf112 Gene

  • Ubiquitination at posLast=2525 and Lys783
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C1orf112 Gene

Domains & Families for C1orf112 Gene

Gene Families for C1orf112 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf112 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1orf112 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf112: view

No data available for UniProtKB/Swiss-Prot for C1orf112 Gene

Function for C1orf112 Gene

Phenotypes From GWAS Catalog for C1orf112 Gene

Phenotypes for C1orf112 Gene

genes like me logo Genes that share phenotypes with C1orf112: view

Animal Models for C1orf112 Gene

MGI Knock Outs for C1orf112:

Animal Model Products

CRISPR Products

miRNA for C1orf112 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1orf112 Gene

Localization for C1orf112 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf112 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf112 Gene

Pathways & Interactions for C1orf112 Gene

SuperPathways for C1orf112 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1orf112 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf112 Gene

Drugs & Compounds for C1orf112 Gene

No Compound Related Data Available

Transcripts for C1orf112 Gene

Unigene Clusters for C1orf112 Gene

Chromosome 1 open reading frame 112:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf112 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1:
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6: - - - - -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for C1orf112 Gene

GeneLoc Exon Structure for
C1orf112
ECgene alternative splicing isoforms for
C1orf112

Expression for C1orf112 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf112 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1orf112 Gene

This gene is overexpressed in Bone (62.7) and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C1orf112 Gene



Protein tissue co-expression partners for C1orf112 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1orf112 Gene:

C1orf112

SOURCE GeneReport for Unigene cluster for C1orf112 Gene:

Hs.443551

Evidence on tissue expression from TISSUES for C1orf112 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with C1orf112: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf112 Gene

Orthologs for C1orf112 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf112 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf112 33
  • 99.3 (n)
C1orf112 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf112 33
  • 87.55 (n)
C1orf112 34
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C16H1orf112 33
  • 87.29 (n)
C1orf112 34
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC498265 33
  • 81.67 (n)
mouse
(Mus musculus)
Mammalia BC055324 33 16 34
  • 81.36 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf112 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves C8H1ORF112 33
  • 68.05 (n)
C1orf112 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf112 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf112 33
  • 59.97 (n)
Str.481 33
zebrafish
(Danio rerio)
Actinopterygii si:dkey-97o5.1 33
  • 54.41 (n)
C20H1orf112 34
  • 43 (a)
OneToOne
Species where no ortholog for C1orf112 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf112 Gene

ENSEMBL:
Gene Tree for C1orf112 (if available)
TreeFam:
Gene Tree for C1orf112 (if available)

Paralogs for C1orf112 Gene

No data available for Paralogs for C1orf112 Gene

Variants for C1orf112 Gene

Sequence variations from dbSNP and Humsavar for C1orf112 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000148262 -- 169,844,885(+) GGTTT(G/T)CAGAT intron-variant
rs1000155314 -- 169,820,689(+) ACCCA(A/G)TCCTC intron-variant
rs1000168905 -- 169,817,396(+) GCCAT(A/T)ATTGA intron-variant
rs1000192717 -- 169,831,316(+) CATAT(A/G)AGATG intron-variant
rs1000214862 -- 169,850,981(+) ATGGC(C/T)TTTTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C1orf112 Gene

Variant ID Type Subtype PubMed ID
nsv428268 CNV gain+loss 18775914
nsv1078878 OTHER inversion 25765185
esv3578257 CNV loss 25503493
esv2758976 CNV gain+loss 17122850
esv2719417 CNV deletion 23290073

Variation tolerance for C1orf112 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf112 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1orf112

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf112 Gene

Disorders for C1orf112 Gene

Relevant External Links for C1orf112

Human Genome Epidemiology (HuGE) Navigator
C1orf112
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf112

No disorders were found for C1orf112 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf112 Gene

Publications for C1orf112 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for C1orf112 Gene

Sources for C1orf112 Gene

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