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Aliases for C1orf111 Gene

Aliases for C1orf111 Gene

  • Chromosome 1 Open Reading Frame 111 2 3 5
  • HSD20 3

External Ids for C1orf111 Gene

Previous GeneCards Identifiers for C1orf111 Gene

  • GC01M159076
  • GC01M160610
  • GC01M133588

Summaries for C1orf111 Gene

GeneCards Summary for C1orf111 Gene

C1orf111 (Chromosome 1 Open Reading Frame 111) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf111 Gene

Genomics for C1orf111 Gene

Regulatory Elements for C1orf111 Gene

Genomic Location for C1orf111 Gene

Chromosome:
1
Start:
162,373,203 bp from pter
End:
162,376,925 bp from pter
Size:
3,723 bases
Orientation:
Minus strand

Genomic View for C1orf111 Gene

Genes around C1orf111 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf111 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf111 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf111 Gene

Proteins for C1orf111 Gene

  • Protein details for C1orf111 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0L3-CA111_HUMAN
    Recommended name:
    Uncharacterized protein C1orf111
    Protein Accession:
    Q5T0L3
    Secondary Accessions:
    • Q6X961
    • Q8NEC3

    Protein attributes for C1orf111 Gene

    Size:
    261 amino acids
    Molecular mass:
    29150 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP20051.1; Type=Frameshift; Positions=224; Evidence={ECO:0000305};

neXtProt entry for C1orf111 Gene

Proteomics data for C1orf111 Gene at MOPED

Post-translational modifications for C1orf111 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf111 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C1orf111 Gene

Domains & Families for C1orf111 Gene

Protein Domains for C1orf111 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf111: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf111 Gene

Function for C1orf111 Gene

Phenotypes for C1orf111 Gene

GenomeRNAi human phenotypes for C1orf111:
genes like me logo Genes that share phenotypes with C1orf111: view

Animal Model Products

CRISPR Products

miRNA for C1orf111 Gene

miRTarBase miRNAs that target C1orf111

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf111 Gene

Localization for C1orf111 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf111 Gene COMPARTMENTS Subcellular localization image for C1orf111 gene
Compartment Confidence
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf111 Gene

Pathways & Interactions for C1orf111 Gene

SuperPathways for C1orf111 Gene

No Data Available

Interacting Proteins for C1orf111 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356912%0d%0a9606.ENSP00000340176%0d%0a9606.ENSP00000311695%0d%0a
Selected Interacting proteins: Q5T0L3-CA111_HUMAN ENSP00000356912 for C1orf111 Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for C1orf111 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf111 Gene

Drugs & Compounds for C1orf111 Gene

No Compound Related Data Available

Transcripts for C1orf111 Gene

Unigene Clusters for C1orf111 Gene

Chromosome 1 open reading frame 111:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf111 Gene

No ASD Table

Relevant External Links for C1orf111 Gene

GeneLoc Exon Structure for
C1orf111
ECgene alternative splicing isoforms for
C1orf111

Expression for C1orf111 Gene

mRNA expression in normal human tissues for C1orf111 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf111 Gene

This gene is overexpressed in Testis (x43.6).

SOURCE GeneReport for Unigene cluster for C1orf111 Gene Hs.97784

genes like me logo Genes that share expression patterns with C1orf111: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C1orf111 Gene

Orthologs for C1orf111 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C1orf111 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C3H1orf111 35
  • 83.13 (n)
  • 74.9 (a)
C3H1orf111 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C38H1orf111 35
  • 85.52 (n)
  • 78.69 (a)
C1orf111 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700015E13Rik 35
  • 85.22 (n)
  • 80.79 (a)
1700015E13Rik 16
1700015E13Rik 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf111 35
  • 99.49 (n)
  • 99.23 (a)
C1orf111 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565283 35
  • 86.21 (n)
  • 83.25 (a)
oppossum
(Monodelphis domestica)
Mammalia C1orf111 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf111 36
  • 39 (a)
OneToOne
Species with no ortholog for C1orf111:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1orf111 Gene

ENSEMBL:
Gene Tree for C1orf111 (if available)
TreeFam:
Gene Tree for C1orf111 (if available)

Paralogs for C1orf111 Gene

No data available for Paralogs for C1orf111 Gene

Variants for C1orf111 Gene

Sequence variations from dbSNP and Humsavar for C1orf111 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs164181 - 162,375,301(-) CACAG(C/T)GCTCT intron-variant, reference, missense, utr-variant-5-prime
rs17853130 - 162,374,184(+) GCTTG(C/T)GGTAG downstream-variant-500B, reference, missense
rs164156 -- 162,373,521(+) TACTC(A/C)GAGGC downstream-variant-500B
rs164157 -- 162,373,527(+) GAGGC(A/G)TATTT downstream-variant-500B
rs164158 -- 162,373,598(+) TCTTC(C/T)CCATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C1orf111 Gene

Variant ID Type Subtype PubMed ID
essv5883 CNV CNV 17122850
dgv141e1 CNV Complex 17122850
dgv399n71 CNV Gain 21882294
nsv818511 CNV Gain 17921354
esv34209 CNV Gain 17911159
nsv516482 CNV Gain+Loss 19592680

Variation tolerance for C1orf111 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf111 Gene

HapMap Linkage Disequilibrium report
C1orf111

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf111 Gene

Disorders for C1orf111 Gene

Relevant External Links for C1orf111

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf111

No disorders were found for C1orf111 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf111 Gene

Publications for C1orf111 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for C1orf111 Gene

Sources for C1orf111 Gene

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