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C1orf110 Gene

protein-coding   GIFtS: 41
GCID: GC01M162821

Chromosome 1 Open Reading Frame 110

  Search for C1orf110
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 1 Open Reading Frame 1101 2
Coiled-Coil Domain-Containing Protein C1orf1102

External Ids:    HGNC: 287361   Entrez Gene: 3395122   Ensembl: ENSG000001858607   UniProtKB: Q86UF43   
ORGUL members:         

Export aliases for C1orf110 gene to outside databases

Previous GC identifers: GC01M159556 GC01M161087 GC01M134069


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1orf110 Gene:
C1orf110 (chromosome 1 open reading frame 110) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1orf110 gene promoter:
         ER-alpha   Max1   RP58   RFX1   FOXD3   POU3F2   C/EBPalpha   GATA-2   Zic3   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C1orf110

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1orf110


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

C1orf110 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf110 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M162821:  view genomic region     (about GC identifiers)

Start:
162,794,248 bp from pter      End:
162,838,605 bp from pter
Size:
44,358 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CA110_HUMAN, Q86UF4 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein C1orf110  
Size: 302 amino acids; 34103 Da
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Sequence caution: Sequence=BC040018; Type=Frameshift; Positions=200; Sequence=CAI13459.1; Type=Erroneous
initiation;
Secondary accessions: Q5JSG1 Q6ZW57
Alternative splicing: 2 isoforms:  Q86UF4-1   Q86UF4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C1orf110: NX_Q86UF4

Explore proteomics data for C1orf110 at MOPED


See C1orf110 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_848645.3  
ENSEMBL proteins: 
 ENSP00000356888   ENSP00000356886   ENSP00000356887  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q86UF4


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for C1orf110:
 Decreased influenza A/WSN/33 r 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1orf110
Interactions:

    Search GeneGlobe Interaction Network for C1orf110

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C1orf110 (CA110)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C1orf110 gene: 
NM_178550.4  

Unigene Cluster for C1orf110:

Chromosome 1 open reading frame 110
Hs.407631  [show with all ESTs]
Unigene Representative Sequence: AK123573
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000524691(uc009wuw.1) ENST00000367912 ENST00000367910(uc001gck.2 uc009wux.1)
ENST00000524710 ENST00000367911
miRNA
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hsa-miR-214 hsa-miR-761
SwitchGear 3'UTR luciferase reporter plasmidC1orf110 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AK123573.1 AK309620.1 BC040018.1 

2 DOTS entries:

DT.95284302  DT.121389582 

10 AceView cDNA sequences:

AK123573 BI490420 BM921956 BF509861 CD701195 BM921939 BI489926 BC040018 
NM_178550 CD700064 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf110    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
SP1:        -                           
SP2:        -                           
SP3:                                    


ECgene alternative splicing isoforms for C1orf110

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C1orf110 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGCCACCTG
C1orf110 Expression
About this image

C1orf110 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C1orf110 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.407631
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for C1orf110 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 1700084C01Rik1 , 5 RIKEN cDNA 1700084C01 gene1, 5 71.91(n)1
56.64(a)1
  1 (76.84 cM)5
784651  NM_001033185.21  NP_001028357.11 
 1699286485 


ENSEMBL Gene Tree for C1orf110 (if available)
TreeFam Gene Tree for C1orf110 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C1orf110 (see all 403)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1502464911,2
--162823615(+) ATAGAC/TAAAAA 1 -- ds50010--------
rs1874906471,2
--162823618(+) GATAAA/GAAGTG 1 -- ds50010--------
rs741201171,2
C,F--162823748(+) TTGGAT/AGGGAA 1 -- ds50017Minor allele frequency- A:0.24WA NA CSA EA 366
rs768620591,2
--162823885(+) ATTTGA/TCAGCA 1 -- ds50010--------
rs1492815361,2
C--162823940(+) AGATAC/TGAGAG 1 -- ds50010--------
rs616022891,2
C,F--162824051(+) AAAGGC/AAGGAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
rs1837161541,2
--162824098(+) AAAGAA/GCAGAT 1 -- ut310--------
rs1378962621,2
--162824233(+) TCTCCC/TAGAGG 1 -- ut310--------
rs789063661,2
F--162824379(+) CATATA/GTTAGC 1 -- ut310--------
rs1459296011,2
--162824413(+) ATTCCC/TGGAAA 1 -- ut310--------

HapMap Linkage Disequilibrium report for C1orf110 (162794248 - 162838605 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for C1orf110:    About this table    
Variant IDTypeSubtypePubMed ID
esv2666263CNV Deletion23128226
nsv516482CNV Gain+Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with C1orf110           About GenesLikeMe

Genetic Association Database (GAD): C1orf110
Human Genome Epidemiology (HuGE) Navigator: C1orf110 (2 documents)

Export disorders for C1orf110 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C1orf110 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C1orf110)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. (PubMed id 23266556)1 Peters U....Hsu L. (Gastroenterology 2013)
  6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  7. Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of type 2 diabetes with cataract. (PubMed id 20664687)1 Lin H.J....Tsai F.J. (Mol. Vis. 2010)
  8. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
  9. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PubMed id 17068223)4 Duerr R.H.... Cho J.H. (Science 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 339512 HGNC: 28736 AceView: MGC48998 Ensembl:ENSG00000185860 euGenes: HUgn339512
ECgene: C1orf110 H-InvDB: C1orf110

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C1orf110 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C1orf110 gene:
Search GeneIP for patents involving C1orf110

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C1orf110
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf110
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C1orf110
 LSBio Antibodies in human, mouse, rat for C1orf110
Customized transgenic rodents for:
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 Browse compounds at ApexBio
 Search Addgene for plasmids for C1orf110
  Search eBioscience for proteins for C1orf110
  Search eBioscience for elisas for C1orf110
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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