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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C1orf106 Gene

protein-coding GIFtS: 44
GCID: GC01P200860

chromosome 1 open reading frame 106

Explore 2 diseases affiliated with
C1orf106 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 1 Open Reading Frame 106¹ ²
FLJ10901¹
Uncharacterized Protein C1orf106²

External Ids:	HGNC: 25599¹	Entrez Gene: 55765²	Ensembl: ENSG00000163362⁷	UniProtKB: Q3KP66³

Export aliases for C1orf106 gene to outside databases

Previous GC identifers: GC01P197593 GC01P199127 GC01P172028

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C1orf106 gene promoter:
Egr-3 HEN1 PPAR-gamma1 Chx10 ZIC2/Zic2 PPAR-gamma2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C1orf106

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1orf106

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

C1orf106 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf106 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P200860: view genomic region (about GC identifiers)

Start:	200,860,176 bp from pter	End:	200,884,864 bp from pter
Size:	24,689 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CA106_HUMAN, Q3KP66 (See protein sequence)

Recommended Name: Uncharacterized protein C1orf106

Size: 663 amino acids; 72914 Da

Sequence caution: Sequence=BAA91771.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;

Secondary accessions: B4E1K9 E9PFY0 Q9NV65 Q9NVI0

Alternative splicing: 2 isoforms: Q3KP66-1 Q3KP66-3

Explore the universe of human proteins at neXtProt for C1orf106: NX_Q3KP66

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q3KP66

C1orf106 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001136041.1 NP_060735.3

ENSEMBL proteins:

ENSP00000431682 ENSP00000397255 ENSP00000356311 ENSP00000392105

Human Recombinant Protein Products for C1orf106:

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	Uscn ELISAs and CLIAs for C1orf106

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C1orf106 for domains About GeneDecksing

1 InterPro domain/family:

IPR021774 DUF3338

Graphical View of Domain Structure for InterPro Entry Q3KP66

ProtoNet protein and cluster: Q3KP66

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for C1orf106:

Decreased POU5F1-GFP protein e

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for C1orf106

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf106

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C1orf106

1 Interacting protein for C1orf106 (Q3KP66^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³	MINT-3976368 I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C1orf106
Search CenterWatch for drugs/clinical trials and news about C1orf106 / CA106

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C1orf106 gene (2 alternative transcripts):

NM_001142569.2 NM_018265.3

Unigene Cluster for C1orf106:

Chromosome 1 open reading frame 106

Hs.518997 [show with all ESTs]

Unigene Representative Sequence: NM_001142569

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000532631 ENST00000451872 ENST00000367342(uc001gvo.3 uc010ppm.2)

ENST00000413687 ENST00000531649 ENST00000526172 ENST00000465162

miRNA Products:		OriGene 3'-UTR Clone (see all 2): C1orf106 Browse OriGene MicroRNA Expression Plasmids
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		8 QIAGEN miScript miRNA Assays for microRNAs that regulate C1orf106:
		hsa-miR-330-5p hsa-miR-637 hsa-miR-326 hsa-miR-24 hsa-miR-766 hsa-miR-1224-5p hsa-miR-1912 hsa-miR-3160-3p

		SwitchGear 3'UTR luciferase reporter plasmid: C1orf106 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1orf106

Additional cDNA sequence:

AK001583.1 AK001763.1 AK025066.1 AK303885.1 AK316510.1 BC106877.2

10 DOTS entries:

DT.110464 DT.120866141 DT.95265750 DT.103765 DT.95265749 DT.100783493 DT.121427544 DT.86846088

DT.95265751 DT.95087471

24/92 AceView cDNA sequences (see all 92):

AK001583 CA433327 BP354265 BU845916 BF593673 BQ053223 AU130609 BE042659

AA468860 BM772705 CB321629 AW188430 AU133482 CB128961 AI828370 AI286309

CB143330 BU179597 BU684989 AI739207 AL045919 BE278506 BE042669 BM558086

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for C1orf106 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^
SP1:																													-				-
SP2:																													-				-
SP3:
SP4:					-		-		-
SP5:							-

ExUns:	17
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for C1orf106

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C1orf106 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTTTCCC

About this image

C1orf106 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Gut Tube

Midgut

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

See C1orf106 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1orf106

SOURCE GeneReport for Unigene cluster: Hs.518997

SABiosciences Custom PCR Arrays for C1orf106

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1orf106 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C1orf106 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC430729¹	chromosome unknown open reading frame, human C1orf1 more	64.9(n) 59.45(a)		430729 XM_428281.3 XP_428281.3
lizard (Anolis carolinensis)	Reptilia	C1orf106⁶	--	53(a)	1 ↔ 1	4(124649602-124669877)
zebrafish (Danio rerio)	Actinopterygii	zgc:153953¹	zgc:153953	51.16(n) 43.57(a)		563192 NM_001080005.1 NP_001073474.1

ENSEMBL Gene Tree for C1orf106 (if available)
TreeFam Gene Tree for C1orf106 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for C1orf106 gene

MSN² FRMD4A² NF2² FRMD4B² RDX² EZR²

C1orf106 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for C1orf106
PGOHUM00000237721

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190626887^1,2		--	200858946(+)	`GGCGAC/GGTGGG`	1	--	us2k¹		0	--	--	--	--
rs2134756^1,2	C,F,A,H	--	200858956(-)	`CCATTT/CTCCAC`	1	--	us2k¹		9		NA WA EA	370
rs59457695^1,2	C	--	200858970(+)	`ACCTTC/TCCTCT`	1	--	us2k¹		4		WA NA EA	360
rs181044805^1,2		--	200858988(+)	`GTGCAC/TAACCT`	1	--	us2k¹		0	--	--	--	--
rs201348783^1,2		--	200859037(+)	`TTTGT-/TGTGTGT`	1	--	us2k¹		0	--	--	--	--
rs144245789^1,2		--	200859201(+)	`TGCTCA/GCTAAT`	1	--	us2k¹		0	--	--	--	--
rs183495675^1,2		--	200859252(+)	`GCCCAG/TGCCAT`	1	--	us2k¹		0	--	--	--	--
rs79222189^1,2	F	--	200859279(+)	`TCAGGC/TGATCC`	1	--	us2k¹		1		NA	120
rs146610105^1,2		--	200859295(+)	`TATTGA/GCCTCC`	1	--	us2k¹		0	--	--	--	--
rs141346246^1,2		--	200859406(+)	`CAGGCC/TGGAGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C1orf106 (200860176 - 200884864 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C1orf106
1 CNV: 6805

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1orf106

DNA2.0 Custom Variant and Variant Library Synthesis for C1orf106

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C1orf106 for disorders About GeneDecksing

2 diseases for C1orf106: About MalaCards

ulcerative colitis crohn's disease

Export disorders for C1orf106 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C1orf106 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1orf106)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2, 3} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)¹ ....Compston A. (2011)
Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)¹ Anderson C.A....Rioux J.D. (2011)
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)¹ Franke A....Parkes M. (2010)
Genome-wide association study of ulcerative colitis i dentifies three new susceptibility loci, including the HNF4A region. (PubMed id 19915572)¹ .... D.P. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55765	HGNC: 25599	AceView: FLJ10901	Ensembl:ENSG00000163362	euGenes: HUgn55765
ECgene: C1orf106	H-InvDB: C1orf106

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C1orf106	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C1orf106 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C1orf106 gene:
Search GeneIP for patents involving C1orf106

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1orf106
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C1orf106 gene at Home site.

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C1orf106 Gene

chromosome 1 open reading frame 106

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C1orf106 Gene

chromosome 1 open reading frame 106

Aliasesfor C1orf106 gene

Summariesfor C1orf106 gene

Genomic Viewsfor C1orf106 gene

Proteinsfor C1orf106 gene

Protein Domains /Familiesfor C1orf106 gene

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for C1orf106 gene

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for C1orf106 gene

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for C1orf106 gene

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for C1orf106 gene

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for C1orf106 gene

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