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Aliases for C1orf106 Gene

Aliases for C1orf106 Gene

  • Chromosome 1 Open Reading Frame 106 2 3 5

External Ids for C1orf106 Gene

Previous GeneCards Identifiers for C1orf106 Gene

  • GC01P197593
  • GC01P199127
  • GC01P200860
  • GC01P172028

Summaries for C1orf106 Gene

GeneCards Summary for C1orf106 Gene

C1orf106 (Chromosome 1 Open Reading Frame 106) is a Protein Coding gene. An important paralog of this gene is NF2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf106 Gene

Genomics for C1orf106 Gene

Regulatory Elements for C1orf106 Gene

Promoters for C1orf106 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1orf106 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf106 Gene

Chromosome:
1
Start:
200,891,048 bp from pter
End:
200,915,736 bp from pter
Size:
24,689 bases
Orientation:
Plus strand

Genomic View for C1orf106 Gene

Genes around C1orf106 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf106 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf106 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf106 Gene

Proteins for C1orf106 Gene

  • Protein details for C1orf106 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KP66-CA106_HUMAN
    Recommended name:
    Uncharacterized protein C1orf106
    Protein Accession:
    Q3KP66
    Secondary Accessions:
    • B4E1K9
    • E9PFY0
    • Q9NV65
    • Q9NVI0

    Protein attributes for C1orf106 Gene

    Size:
    663 amino acids
    Molecular mass:
    72914 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91771.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for C1orf106 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1orf106 Gene

Proteomics data for C1orf106 Gene at MOPED

Post-translational modifications for C1orf106 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf106 Gene

No data available for DME Specific Peptides for C1orf106 Gene

Domains & Families for C1orf106 Gene

Protein Domains for C1orf106 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf106: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C1orf106 Gene

Function for C1orf106 Gene

Phenotypes for C1orf106 Gene

genes like me logo Genes that share phenotypes with C1orf106: view

Animal Models for C1orf106 Gene

MGI Knock Outs for C1orf106:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1orf106 Gene

Localization for C1orf106 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1orf106 Gene COMPARTMENTS Subcellular localization image for C1orf106 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf106 Gene

Pathways & Interactions for C1orf106 Gene

SuperPathways for C1orf106 Gene

No Data Available

Interacting Proteins for C1orf106 Gene

Gene Ontology (GO) - Biological Process for C1orf106 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1orf106 Gene

Drugs & Compounds for C1orf106 Gene

No Compound Related Data Available

Transcripts for C1orf106 Gene

Unigene Clusters for C1orf106 Gene

Chromosome 1 open reading frame 106:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf106 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - -
SP2: - -
SP3:
SP4: - - -
SP5: -
SP6:
SP7: -
SP8:
SP9: - -

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for C1orf106 Gene

GeneLoc Exon Structure for
C1orf106
ECgene alternative splicing isoforms for
C1orf106

Expression for C1orf106 Gene

mRNA expression in normal human tissues for C1orf106 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf106 Gene

This gene is overexpressed in Colon - Transverse (x6.6), Esophagus - Mucosa (x6.5), Skin - Sun Exposed (Lower leg) (x6.2), Skin - Not Sun Exposed (Suprapubic) (x6.0), and Small Intestine - Terminal Ileum (x4.6).

Protein differential expression in normal tissues from HIPED for C1orf106 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C1orf106 Gene



SOURCE GeneReport for Unigene cluster for C1orf106 Gene Hs.518997

genes like me logo Genes that share expression patterns with C1orf106: view

Protein tissue co-expression partners for C1orf106 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for C1orf106 Gene

Orthologs for C1orf106 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1orf106 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf106 35
  • 96.8 (n)
  • 95.91 (a)
C1orf106 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf106 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 5730559C18Rik 16
5730559C18Rik 36
  • 75 (a)
OneToOne
5730559C18Rik 35
  • 84.54 (n)
  • 85.67 (a)
oppossum
(Monodelphis domestica)
Mammalia C1orf106 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf106 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1311892 35
  • 84.44 (n)
  • 85.82 (a)
chicken
(Gallus gallus)
Aves C1ORF106 35
  • 63.56 (n)
  • 57.63 (a)
C1orf106 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf106 36
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-163l21.4 35
  • 62.32 (n)
  • 58.39 (a)
C11H1orf106 (1 of 2) 36
  • 34 (a)
OneToMany
C8H1orf106 (2 of 2) 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F07C6.4 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 8 (a)
OneToMany
Species with no ortholog for C1orf106:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for C1orf106 Gene

ENSEMBL:
Gene Tree for C1orf106 (if available)
TreeFam:
Gene Tree for C1orf106 (if available)

Paralogs for C1orf106 Gene

Paralogs for C1orf106 Gene

Pseudogenes.org Pseudogenes for C1orf106 Gene

genes like me logo Genes that share paralogs with C1orf106: view

Variants for C1orf106 Gene

Sequence variations from dbSNP and Humsavar for C1orf106 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs296520 - 200,911,850(-) GCGGC(A/G)CAGCT reference, missense, utr-variant-3-prime
rs296528 -- 200,901,626(-) ACATA(C/G)CAATC intron-variant
rs296529 -- 200,902,748(-) TGAGG(C/T)TGGAC intron-variant
rs296530 -- 200,903,356(-) cagac(A/G)tgcac intron-variant
rs296533 -- 200,896,640(-) ACAAT(A/C)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf106 Gene

Variant ID Type Subtype PubMed ID
esv33174 CNV Loss 17666407
nsv873099 CNV Loss 21882294
esv2721362 CNV Deletion 23290073
esv2721373 CNV Deletion 23290073
esv2721384 CNV Deletion 23290073

Variation tolerance for C1orf106 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.61; 72.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf106 Gene

HapMap Linkage Disequilibrium report
C1orf106

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf106 Gene

Disorders for C1orf106 Gene

Relevant External Links for C1orf106

Genetic Association Database (GAD)
C1orf106
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1orf106

No disorders were found for C1orf106 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf106 Gene

Publications for C1orf106 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. (PMID: 25082827) JuliA A. … Marsal S. (Hum. Mol. Genet. 2014) 3
  3. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3
  5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3

Products for C1orf106 Gene

Sources for C1orf106 Gene

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