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C1orf105 Gene

protein-coding   GIFtS: 40
GCID: GC01P172389

Chromosome 1 Open Reading Frame 105

  Search for C1orf105
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 1 Open Reading Frame 1051 2
Uncharacterized Protein C1orf1052

External Ids:    HGNC: 295911   Entrez Gene: 923462   Ensembl: ENSG000001809997   UniProtKB: O955613   

Export aliases for C1orf105 gene to outside databases

Previous GC identifers: GC01P169122 GC01P170656 GC01P143613


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1orf105 Gene:
C1orf105 (chromosome 1 open reading frame 105) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1orf105 gene promoter:
         COUP-TF1   USF1   COUP   HNF-4alpha2   HNF-4alpha1   Evi-1   Pax-3   COUP-TF   USF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C1orf105

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1orf105


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q24.3

C1orf105 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1orf105 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P172389:  view genomic region     (about GC identifiers)

Start:
172,389,828 bp from pter      End:
172,437,971 bp from pter
Size:
48,144 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CA105_HUMAN, O95561 (See protein sequence)
Recommended Name: Uncharacterized protein C1orf105  
Size: 183 amino acids; 21209 Da
Secondary accessions: Q8IY02

Explore the universe of human proteins at neXtProt for C1orf105: NX_O95561

Explore proteomics data for C1orf105 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C1orf105 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_640333.3  
    ENSEMBL proteins: 
     ENSP00000356700   ENSP00000435216   ENSP00000431442   ENSP00000356698  

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    Cloud-Clone Corp. CLIAs for C1orf105


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027845 DUF4548

    Graphical View of Domain Structure for InterPro Entry O95561

    ProtoNet protein and cluster: O95561


    C1orf105 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf105
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    hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidC1orf105 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    extracellular1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1orf105
    Interactions:

        Search GeneGlobe Interaction Network for C1orf105

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for C1orf105 (ENSP000003567004) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CELA3AENSP000002901224STRING: ENSP00000290122
    CRYZENSP000003393994STRING: ENSP00000339399
    ENSG00000173503ENSP000003729914STRING: ENSP00000372991
    ENSG00000228284ENSP000004143604STRING: ENSP00000414360
    FNDC5ENSP000003625704STRING: ENSP00000362570
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1orf105 (CA105)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C1orf105 gene: 
    NM_139240.3  

    Unigene Cluster for C1orf105:

    Chromosome 1 open reading frame 105
    Hs.517991  [show with all ESTs]
    Unigene Representative Sequence: BC038410
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367727(uc001gik.3) ENST00000460397 ENST00000488100 ENST00000367726
    ENST00000367725
    miRNA
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    hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidC1orf105 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat C1orf105
      QuantiFast Probe-based Assays in human, mouse, rat C1orf105

    Additional mRNA sequence: 

    AL035295.1 BC038410.1 

    5 DOTS entries:

    DT.100018732  DT.91899623  DT.121390294  DT.121390224  DT.444042 

    Selected AceView cDNA sequences (see all 31):

    AW510869 W56365 BI827163 AI828633 AL035295 AA954090 BC038410 CD386750 
    BM873777 AW444454 AA693603 AI659525 CB159852 NM_139240 BV203381 AI052662 
    AI191972 AA923390 AI033856 BQ188191 BX104688 W56576 BQ185352 W81520 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C1orf105 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATAAAGA
    C1orf105 Expression
    About this image

    C1orf105 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1orf105 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517991
        Custom PCR Arrays for C1orf105
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf105

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for C1orf105 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4930558K02Rik1 , 5 RIKEN cDNA 4930558K02 gene1, 5 72.1(n)1
    60.11(a)1
      1 (69.95 cM)5
    753681  NM_001204904.11  NP_001191833.11 
     1619420865 


    ENSEMBL Gene Tree for C1orf105 (if available)
    TreeFam Gene Tree for C1orf105 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C1orf105 (see all 881)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs676125301,2
    C--143659690(-) gtgat-/TGTGTGT
    GTGTGTGTG
    tgtgt
    1 -- int11Minor allele frequency- TGTGTGTGTGTGTGTG:0.00NA 2
    rs618061031,2
    --172388386(+) AGTAGA/TCCTTC 1 -- us2k10--------
    rs1842566101,2
    --172388391(+) TCCTTC/TTCAAA 1 -- us2k10--------
    rs49161851,2
    C,F,H--172388441(+) GATGAT/CAGAAA 1 -- us2k131Minor allele frequency- C:0.05NA NS EA WA CSA 2748
    rs1424520891,2
    --172388553(+) AGGAAA/CCCCCA 1 -- us2k10--------
    rs1875849841,2
    --172388649(+) AAAAAA/TCAGTT 1 -- us2k10--------
    rs761357101,2
    C--172388731(+) AAAATC/TAGTGA 1 -- us2k10--------
    rs94253111,2
    C,F,A,H--172388778(+) CAACTG/TAAGCT 1 -- us2k123Minor allele frequency- T:0.39NA NS EA 2372
    rs1927900481,2
    --172388787(+) CTCATA/GTATAG 1 -- us2k10--------
    rs1854839661,2
    --172388921(+) AATAGA/GCAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C1orf105 (172389828 - 172437971 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C1orf105:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669467CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C1orf105
    DNA2.0 Custom Variant and Variant Library Synthesis for C1orf105

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    C1orf105 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: C1orf105 (1 document)

    Export disorders for C1orf105 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C1orf105 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C1orf105)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92346 HGNC: 29591 AceView: LOC92346 Ensembl:ENSG00000180999 euGenes: HUgn92346
    ECgene: C1orf105 H-InvDB: C1orf105

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C1orf105 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C1orf105 gene:
    Search GeneIP for patents involving C1orf105

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for C1orf105
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1orf105
     SwitchGear 3'UTR luciferase reporter plasmids for C1orf105
     Browse SwitchGear Promoter luciferase reporter plasmids for C1orf105
     Search ThermoFisher Antibodies for C1orf105
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1orf105
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1orf105
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C1orf105
     LSBio Antibodies in human, mouse, rat for C1orf105
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