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C1RL Gene

protein-coding   GIFtS: 52
GCID: GC12M007245

Complement Component 1, R Subcomponent-Like

  See C1RL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complement Component 1, R Subcomponent-Like1 2     CLSPA3 5
C1RLP2 3 5     Complement C1r Subcomponent-Like Protein2
C1RL12 3     Complement C1r-Like Proteinase2
C1r-LP2 3     EC 3.4.21.-3
CLSPa2 3     EC 3.4.218
C1r-Like Protein2 3     EC 3.4.21.418
C1r-Like Serine Protease Analog Protein2 3     

External Ids:    HGNC: 212651   Entrez Gene: 512792   Ensembl: ENSG000001391787   OMIM: 6089745   UniProtKB: Q9NZP83   

Export aliases for C1RL gene to outside databases

Previous GC identifers: GC12M007147 GC12M007138 GC12M007061 GC12M007247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1RL Gene:
C1RL (complement component 1, r subcomponent-like) is a protein-coding gene. Diseases associated with C1RL include ovary adenocarcinoma, and cll/sll. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PROZ.

UniProtKB/Swiss-Prot: C1RL_HUMAN, Q9NZP8
Function: Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1RL gene promoter:
         RP58   NF-1   NF-1/L   HNF-4alpha2   IRF-1   Tal-1beta   NF-kappaB   HNF-4alpha1   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): C1RL promoter sequence
   Search Chromatin IP Primers for C1RL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1RL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

C1RL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1RL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007245:  view genomic region     (about GC identifiers)

Start:
7,242,183 bp from pter      End:
7,261,869 bp from pter
Size:
19,687 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: C1RL_HUMAN, Q9NZP8 (See protein sequence)
Recommended Name: Complement C1r subcomponent-like protein precursor  
Size: 487 amino acids; 53498 Da
Caution: Does not associate with the C1 complex. According to PubMed:15385675, doesn't cleave the proform of
complement C1s
Secondary accessions: Q53GX9

Explore the universe of human proteins at neXtProt for C1RL: NX_Q9NZP8

Explore proteomics data for C1RL at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn147, Asn166, Asn242, Asn296, Asn363
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for C1RL (Q9NZP8) (see all 5)
     TGIVSWG  VSWGIGC  CLPDNET  DIALLEL 


    See C1RL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057630.2  
    ENSEMBL proteins: 
     ENSP00000444157   ENSP00000438286   ENSP00000266542   ENSP00000441885   ENSP00000439180  
     ENSP00000437398   ENSP00000438951   ENSP00000437569   ENSP00000442611  

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    Novus Biologicals C1RL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for C1RL 

    C1RL Antibody Products:

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    Search eBioscience for ELISAs for C1RL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001314 Peptidase_S1A
     IPR000436 Sushi_SCR_CCP
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR000859 CUB_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZP8

    ProtoNet protein and cluster: Q9NZP8

    3 Blocks protein domains:
    IPB000859 CUB domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: C1RL_HUMAN, Q9NZP8
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 CUB domain
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with C1RL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C1RL_HUMAN, Q9NZP8
    Function: Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum
    Induction: Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.412 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    Find genes that share ontologies with C1RL           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for C1rl (no phenotypes)

    Find genes that share phenotypes with C1RL           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1RL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C1RL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C1RL
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    7 qRT-PCR Assays for microRNAs that regulate C1RL:
    hsa-miR-1265 hsa-miR-206 hsa-miR-518a-5p hsa-miR-613 hsa-miR-1 hsa-miR-138-2* hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidC1RL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C1RL

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    GenScript: all cDNA clones in your preferred vector: C1RL (NM_016546)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1RL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1RL

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for C1RL 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1RL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C1RL_HUMAN, Q9NZP8: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with C1RL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1RL
    Interactions:

        Search GeneGlobe Interaction Network for C1RL

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C1RL (Q9NZP83 ENSP000002665424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HPP007383, ENSP000003481704I2D: score=1 STRING: ENSP00000348170
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006958complement activation, classical pathway IEA--
    GO:0045087innate immune response IEA--

    Find genes that share ontologies with C1RL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1RL

    1 Novoseek inferred chemical compound relationship for C1RL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 45.5 7 15358180 (2), 15527420 (1), 12686506 (1)



    Find genes that share compounds with C1RL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C1RL gene: 
    NM_016546.2  

    Unigene Cluster for C1RL:

    Complement component 1, r subcomponent-like
    Hs.631730  [show with all ESTs]
    Unigene Representative Sequence: NM_016546
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539803 ENST00000545280 ENST00000266542(uc001qsn.3 uc009zft.3)
    ENST00000504702 ENST00000544702 ENST00000534950 ENST00000543933 ENST00000537833
    ENST00000534969 ENST00000545337(uc001qso.2) ENST00000543941 ENST00000539927

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C1RL using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate C1RL:
    hsa-miR-1265 hsa-miR-206 hsa-miR-518a-5p hsa-miR-613 hsa-miR-1 hsa-miR-138-2* hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidC1RL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C1RL
    Predesigned siRNA for gene silencing in human, mouse, rat C1RL
    Clone
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    OriGene clones in human, mouse for C1RL (see all 8)
    OriGene ORF clones in mouse, rat for C1RL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C1RL (NM_016546)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1RL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1RL
    Primer
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    OriGene qPCR primer pairs and template standards for C1RL
    OriGene qSTAR qPCR primer pairs in human, mouse for C1RL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C1RL
      QuantiTect SYBR Green Assays in human, mouse, rat C1RL
      QuantiFast Probe-based Assays in human, mouse, rat C1RL

    Additional mRNA sequence: 

    AF178985.1 AK024084.1 AK222802.1 AK314299.1 BC062428.1 

    17 DOTS entries:

    DT.452764  DT.423871  DT.100021680  DT.100788295  DT.101976484  DT.121109930  DT.99951751  DT.100887485 
    DT.91690328  DT.95267568  DT.100044782  DT.100788292  DT.121109710  DT.95228363  DT.100044777  DT.102841600 
    DT.97780531 

    Selected AceView cDNA sequences (see all 500):

    BP346013 BP342393 AU279668 AU122608 CA407433 CA952612 CB989164 BP342929 
    AW579244 AU142140 BP345756 AW450562 AA345638 CB151034 AA344353 AA953809 
    AL518685 BX358508 AW082744 CA311908 BX337339 BX427483 BX336967 BU528204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C1RL (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
    SP1:                    -                       -                                       
    SP2:                    -     -           -     -     -           -     -     -         
    SP3:                    -                       -     -     -                           
    SP4:                    -                                                               
    SP5:                                            -     -     -     -                     


    ECgene alternative splicing isoforms for C1RL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C1RL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGTTTTT
    C1RL Expression
    About this image


    C1RL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Liver (Hepatobiliary System)
    C1RL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1RL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631730

    UniProtKB/Swiss-Prot: C1RL_HUMAN, Q9NZP8
    Tissue specificity: Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate,
    ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in
    PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon
    adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid
    carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in
    myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia),
    HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the
    liver and in serum (at protein level)

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    QuantiFast Probe-based Assays in human, mouse, rat C1RL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1RL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C1RL gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C1rl1 , 5 complement component 1, r subcomponent-like1, 5 78.99(n)1
    75.85(a)1
      6 (59.16 cM)5
    2323711  NM_181344.51  NP_851989.31 
     1244931135 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    31(a)
    1 → many
    1(76872313-76879240)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    29(a)
    1 → many
    GL343218.1(93834-117480)
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fd46c061 wu:fd46c06 43.73(n)
    32.33(a)
      793504  NM_001114449.1  NP_001107921.1 


    ENSEMBL Gene Tree for C1RL (if available)
    TreeFam Gene Tree for C1RL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C1RL gene
    PROZ2  C1S2  C1R2  F92  F102  MASP12  F22  HPR2  
    HP2  PROC2  F72  MASP22  
    9 SIMAP similar genes for C1RL using alignment to 10 protein entries:     C1RL_HUMAN (see all proteins):
    DKFZp586F0824    C1R    F9    PROC    PROC1    C1S
    DKFZp686M0562    HP    MASP1

    Find genes that share paralogs with C1RL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C1RL (see all 268)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824041991,2
    --7076701(+) GAAGAC/TGAAAT 1 -- us2k10--------
    rs64885731,2
    C,H--7247045(+) CATCAT/AGTCTA 1 -- ds50016Minor allele frequency- A:0.09WA NA EA 364
    rs64885741,2
    C,F,H--7247046(+) ATCAAC/GTCTAT 1 -- ds50017Minor allele frequency- G:0.10WA NA EA 366
    rs1910981381,2
    --7247126(+) AGATAC/TAGATC 1 -- ds50010--------
    rs31683791,2
    C,A--7247156(-) TATATG/ACCTAT 1 -- ut31 ese31Minor allele frequency- A:0.00CSA 1
    rs755924681,2
    C--7247165(+) ATATA-/AWTTTT 1 -- ut310--------
    rs113439111,2
    C--7247166(+) TATAT-/ATTTTT 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs1497184371,2
    C--7247229(+) AAATAA/GAATAA 1 -- ut310--------
    rs1828899731,2
    C--7247288(+) AAAACA/CAAACA 1 -- ut310--------
    rs777608831,2
    C--7247342(+) GAGAAT/CTATTA 1 -- ut312Minor allele frequency- C:0.13WA 120

    HapMap Linkage Disequilibrium report for C1RL (7242183 - 7261869 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for C1RL: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C1RL
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608974    OMIM disorders: --

    2 diseases for C1RL:    
    About MalaCards
    ovary adenocarcinoma    cll/sll

    1 disease from the University of Copenhagen DISEASES database for C1RL:
    CLL/SLL

    Find genes that share disorders with C1RL           About GenesLikeMe

    Genetic Association Database (GAD): C1RL
    Human Genome Epidemiology (HuGE) Navigator: C1RL (6 documents)

    Export disorders for C1RL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C1RL gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with C1RL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity. (PubMed id 15358180)1, 2, 9 Lin N.... Cao X. (Biochem. Biophys. Res. Commun. 2004)
    2. Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein. (PubMed id 15385675)1, 2, 9 Wicher K.B. and Fries E. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (Br. J. Haematol. 2009)
    7. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    8. A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s. (PubMed id 15527420)2, 9 Ligoudistianou C.... Volanakis J.E. (Biochem. J. 2005)
    9. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
    10. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51279 HGNC: 21265 AceView: C1RL Ensembl:ENSG00000139178 euGenes: HUgn51279
    ECgene: C1RL H-InvDB: C1RL

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C1RL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for C1RL gene:
    Search GeneIP for patents involving C1RL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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