Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C1RL Gene

Aliases for C1RL Gene

  • Complement Component 1, R Subcomponent-Like 2 3
  • C1r-Like Serine Protease Analog Protein 3 4
  • C1r-Like Protein 3 4
  • C1r-LP 3 4
  • C1RL1 3 4
  • C1RLP 3 4
  • CLSPa 3 4
  • Complement C1r-Like Proteinase 3
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for C1RL Gene

Previous GeneCards Identifiers for C1RL Gene

  • GC12M007147
  • GC12M007138
  • GC12M007061
  • GC12M007247
  • GC12M007245

Summaries for C1RL Gene

GeneCards Summary for C1RL Gene

C1RL (Complement Component 1, R Subcomponent-Like) is a Protein Coding gene. Diseases associated with C1RL include ovary adenocarcinoma. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot for C1RL Gene

  • Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1RL Gene

Genomics for C1RL Gene

Genomic Location for C1RL Gene

7,089,587 bp from pter
7,109,278 bp from pter
19,692 bases
Minus strand

Genomic View for C1RL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1RL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1RL Gene

Proteins for C1RL Gene

  • Protein details for C1RL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1r subcomponent-like protein
    Protein Accession:
    Secondary Accessions:
    • Q53GX9

    Protein attributes for C1RL Gene

    487 amino acids
    Molecular mass:
    53498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1RL Gene

Proteomics data for C1RL Gene at MOPED

Selected DME Specific Peptides for C1RL Gene

Post-translational modifications for C1RL Gene

  • Glycosylation at Asn 147, Asn 166, Asn 242, Asn 296, and Asn 363
  • Modification sites at PhosphoSitePlus

Domains & Families for C1RL Gene

Gene Families for C1RL Gene

Suggested Antigen Peptide Sequences for C1RL Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUB domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 CUB domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with C1RL: view

Function for C1RL Gene

Molecular function for C1RL Gene

UniProtKB/Swiss-Prot Function:
Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.
UniProtKB/Swiss-Prot Induction:
Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation.

Enzyme Numbers (IUBMB) for C1RL Gene

Gene Ontology (GO) - Molecular Function for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with C1RL: view
genes like me logo Genes that share phenotypes with C1RL: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for C1RL Gene

Localization for C1RL Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1RL Gene


Subcellular locations from

Jensen Localization Image for C1RL Gene COMPARTMENTS Subcellular localization image for C1RL gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C1RL: view

Pathways & Interactions for C1RL Gene

SuperPathways for C1RL Gene

No Data Available

Interacting Proteins for C1RL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NZP8-C1RL_HUMAN ENSP00000266542 for C1RL Gene via I2D STRING

Gene Ontology (GO) - Biological Process for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006958 complement activation, classical pathway IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with C1RL: view

No data available for Pathways by source and SIGNOR curated interactions for C1RL Gene

Drugs & Compounds for C1RL Gene

(1) Drugs for C1RL Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
serine Nutra 420
genes like me logo Genes that share compounds with C1RL: view

Transcripts for C1RL Gene

Unigene Clusters for C1RL Gene

Complement component 1, r subcomponent-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1RL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -

Relevant External Links for C1RL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1RL Gene

mRNA expression in normal human tissues for C1RL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1RL Gene

This gene is overexpressed in Liver (x5.3) and Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for C1RL Gene

This gene is overexpressed in Serum (27.9), Plasma (13.6), and Urine (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C1RL Gene

SOURCE GeneReport for Unigene cluster for C1RL Gene Hs.631730

mRNA Expression by UniProt/SwissProt for C1RL Gene

Tissue specificity: Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).
genes like me logo Genes that share expression patterns with C1RL: view

Protein tissue co-expression partners for C1RL Gene

Primer Products

In Situ Assay Products

Orthologs for C1RL Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1RL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C1RL 35
  • 78.32 (n)
  • 71.82 (a)
C1RL 36
  • 69 (a)
(Canis familiaris)
Mammalia C1RL 35
  • 81.04 (n)
  • 75.42 (a)
C1RL 36
  • 75 (a)
(Mus musculus)
Mammalia C1rl 35
  • 78.99 (n)
  • 75.85 (a)
C1rl 16
C1rl 36
  • 74 (a)
(Pan troglodytes)
Mammalia C1RL 35
  • 99.18 (n)
  • 98.97 (a)
C1RL 36
  • 99 (a)
(Rattus norvegicus)
Mammalia C1rl 35
  • 79.61 (n)
  • 75.66 (a)
(Monodelphis domestica)
Mammalia C1RL 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Gallus gallus)
Aves -- 36
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
(Danio rerio)
Actinopterygii wu:fd46c06 35
  • 43.73 (n)
  • 32.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
-- 36
  • 18 (a)
-- 36
  • 2 (a)
-- 36
  • 16 (a)
CSA.10613 36
  • 16 (a)
Species with no ortholog for C1RL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1RL Gene

Gene Tree for C1RL (if available)
Gene Tree for C1RL (if available)

Paralogs for C1RL Gene

Paralogs for C1RL Gene

genes like me logo Genes that share paralogs with C1RL: view

Variants for C1RL Gene

Sequence variations from dbSNP and Humsavar for C1RL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7709 -- 7,094,764(+) TTTGG(A/C)GATGG utr-variant-3-prime, intron-variant
rs744141 -- 7,102,574(-) ACTCA(C/G)AGAAG intron-variant
rs1075425 -- 7,102,191(+) CTAGA(C/T)GGGCC intron-variant
rs1132216 -- 7,094,799(-) GAGTT(C/G)AAGTC utr-variant-3-prime, intron-variant
rs3168379 -- 7,094,560(-) TATAT(A/G)CCTAT utr-variant-3-prime, intron-variant

Variation tolerance for C1RL Gene

Residual Variation Intolerance Score: 69.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.85; 93.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1RL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C1RL Gene

Disorders for C1RL Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1RL Gene - From: GeneCards

Disorder Aliases PubMed IDs
ovary adenocarcinoma
  • ovarian adenocarcinoma
- elite association
Search C1RL in MalaCards View complete list of genes associated with diseases

Relevant External Links for C1RL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C1RL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1RL Gene

Publications for C1RL Gene

  1. A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s. (PMID: 15527420) Ligoudistianou C. … Volanakis J.E. (Biochem. J. 2005) 23 67
  2. A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity. (PMID: 15358180) Lin N. … Cao X. (Biochem. Biophys. Res. Commun. 2004) 23 67
  3. Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein. (PMID: 15385675) Wicher K.B. … Fries E. (Proc. Natl. Acad. Sci. U.S.A. 2004) 23 67
  4. A novel murine complement-related gene encoding a C1r-like serum protein. (PMID: 12686506) Circolo A. … Volanakis J.E. (Mol. Immunol. 2003) 23 67
  5. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 67

Products for C1RL Gene

Sources for C1RL Gene

Back to Top