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Aliases for C1RL Gene

Aliases for C1RL Gene

  • Complement Component 1, R Subcomponent-Like 2 3
  • C1RLP 3 4 6
  • CLSPa 3 4 6
  • C1r-Like Serine Protease Analog Protein 3 4
  • C1r-Like Protein 3 4
  • C1r-LP 3 4
  • C1RL1 3 4
  • Complement C1r Subcomponent-Like Protein 3
  • Complement C1r-Like Proteinase 3
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for C1RL Gene

Previous GeneCards Identifiers for C1RL Gene

  • GC12M007147
  • GC12M007138
  • GC12M007247
  • GC12M007245

Summaries for C1RL Gene

GeneCards Summary for C1RL Gene

C1RL (Complement Component 1, R Subcomponent-Like) is a Protein Coding gene. Diseases associated with C1RL include cll/sll and ovary adenocarcinoma. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot for C1RL Gene

  • Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1RL Gene

Genomics for C1RL Gene

Genomic Location for C1RL Gene

7,089,587 bp from pter
7,109,273 bp from pter
19,687 bases
Minus strand

Genomic View for C1RL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1RL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1RL Gene

Proteins for C1RL Gene

  • Protein details for C1RL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1r subcomponent-like protein
    Protein Accession:
    Secondary Accessions:
    • Q53GX9

    Protein attributes for C1RL Gene

    487 amino acids
    Molecular mass:
    53498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1RL Gene

Proteomics data for C1RL Gene at MOPED

Selected DME Specific Peptides for C1RL Gene

Post-translational modifications for C1RL Gene

  • Glycosylation at Asn147, Asn166, Asn242, Asn296, and Asn363
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for C1RL (Complement Component C1rLP)

Domains for C1RL Gene

Suggested Antigen Peptide Sequences for C1RL Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NZP8
  • Contains 1 CUB domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with C1RL: view

No data available for Gene Families for C1RL Gene

Function for C1RL Gene

Molecular function for C1RL Gene

UniProtKB/Swiss-Prot Function:
Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.
UniProtKB/Swiss-Prot Induction:
Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation.

Enzyme Numbers (IUBMB) for C1RL Gene

Gene Ontology (GO) - Molecular Function for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with C1RL: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C1RL Gene

Localization for C1RL Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1RL Gene


Subcellular locations from

Jensen Localization Image for C1RL Gene COMPARTMENTS Subcellular localization image for C1RL gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C1RL: view

Pathways for C1RL Gene

SuperPathways for C1RL Gene

No Data Available

Interacting Proteins for C1RL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000266542 Q9NZP8-C1RL_HUMAN for C1RL Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006958 complement activation, classical pathway IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with C1RL: view

No data available for Pathways by source for C1RL Gene

Compounds for C1RL Gene

(1) Novoseek inferred chemical compound relationships for C1RL Gene

Compound -log(P) Hits PubMed IDs
serine 45.5 4
genes like me logo Genes that share compounds with C1RL: view

Transcripts for C1RL Gene

Unigene Clusters for C1RL Gene

Complement component 1, r subcomponent-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1RL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1RL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -

Relevant External Links for C1RL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1RL Gene

mRNA expression in normal human tissues for C1RL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1RL Gene

This gene is overexpressed in Liver (5.3) and Whole Blood (4.2).

Protein differential expression in normal tissues for C1RL Gene

This gene is overexpressed in Serum (27.9), Plasma (13.6), and Urine (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C1RL Gene

SOURCE GeneReport for Unigene cluster for C1RL Gene Hs.631730

mRNA Expression by UniProt/SwissProt for C1RL Gene

Tissue specificity: Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).
genes like me logo Genes that share expressions with C1RL: view

Expression partners for C1RL Gene

In Situ Assay Products

Orthologs for C1RL Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1RL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C1RL 35
  • 78.32 (n)
  • 71.82 (a)
C1RL 36
  • 69 (a)
(Canis familiaris)
Mammalia C1RL 35
  • 81.04 (n)
  • 75.42 (a)
C1RL 36
  • 75 (a)
(Mus musculus)
Mammalia C1rl 35
  • 78.99 (n)
  • 75.85 (a)
C1rl 16
C1rl 36
  • 74 (a)
(Pan troglodytes)
Mammalia C1RL 35
  • 99.18 (n)
  • 98.97 (a)
C1RL 36
  • 99 (a)
(Rattus norvegicus)
Mammalia C1rl 35
  • 79.61 (n)
  • 75.66 (a)
(Monodelphis domestica)
Mammalia C1RL 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Gallus gallus)
Aves -- 36
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
(Danio rerio)
Actinopterygii wu:fd46c06 35
  • 43.73 (n)
  • 32.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
-- 36
  • 18 (a)
-- 36
  • 2 (a)
-- 36
  • 16 (a)
CSA.10613 36
  • 16 (a)
Species with no ortholog for C1RL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1RL Gene

Gene Tree for C1RL (if available)
Gene Tree for C1RL (if available)

Paralogs for C1RL Gene

Paralogs for C1RL Gene

genes like me logo Genes that share paralogs with C1RL: view

Variants for C1RL Gene

Sequence variations from dbSNP and Humsavar for C1RL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7709 -- 7,094,764(+) TTTGG(A/C)GATGG utr-variant-3-prime, intron-variant
rs744141 -- 7,102,574(-) ACTCA(C/G)AGAAG intron-variant
rs1075425 -- 7,102,191(+) CTAGA(C/T)GGGCC intron-variant
rs1132216 -- 7,094,799(-) GAGTT(C/G)AAGTC utr-variant-3-prime, intron-variant
rs3168379 -- 7,094,560(-) TATAT(A/G)CCTAT utr-variant-3-prime, intron-variant

Relevant External Links for C1RL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C1RL Gene

Disorders for C1RL Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for C1RL Gene in MalaCards »

(3) Diseases for C1RL Gene including...

(1) University of Copenhagen DISEASES for C1RL Gene

Relevant External Links for C1RL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with C1RL: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for C1RL Gene

Publications for C1RL Gene

  1. A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity. (PMID: 15358180) Lin N. … Cao X. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  2. Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein. (PMID: 15385675) Wicher K.B. … Fries E. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  3. A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s. (PMID: 15527420) Ligoudistianou C. … Volanakis J.E. (Biochem. J. 2005) 4 23
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for C1RL Gene

Sources for C1RL Gene

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