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Aliases for C1RL Gene

Aliases for C1RL Gene

  • Complement C1r Subcomponent Like 2 3 5
  • Complement Component 1, R Subcomponent-Like 2 3
  • C1r-Like Serine Protease Analog Protein 3 4
  • C1r-Like Protein 3 4
  • C1r-LP 3 4
  • C1RL1 3 4
  • C1RLP 3 4
  • CLSPa 3 4
  • Complement C1r Subcomponent-Like Protein 3
  • Complement C1r-Like Proteinase 3
  • EC 58
  • EC 3.4.21.- 4
  • EC 3.4.21 58

External Ids for C1RL Gene

Previous GeneCards Identifiers for C1RL Gene

  • GC12M007147
  • GC12M007138
  • GC12M007061
  • GC12M007247
  • GC12M007245

Summaries for C1RL Gene

GeneCards Summary for C1RL Gene

C1RL (Complement C1r Subcomponent Like) is a Protein Coding gene. Diseases associated with C1RL include Ovary Adenocarcinoma. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is C1R.

UniProtKB/Swiss-Prot for C1RL Gene

  • Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.

Additional gene information for C1RL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1RL Gene

Genomics for C1RL Gene

Regulatory Elements for C1RL Gene

Enhancers for C1RL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H007059 1.2 Ensembl ENCODE 11.9 +48.5 48511 2.5 ELF3 FOXA2 ARID4B SIN3A RAD21 YY1 ZNF143 THAP11 MXD4 CEBPB C1R C1RL C1RL-AS1 LPCAT3 PHB2 EMG1 SCARNA12 RNU6-485P GC12P007479 PIR50287
GH12H006880 0.8 ENCODE 10 +228.4 228407 1.6 DRAP1 SAP130 ARID4B MAX CEBPG DMAP1 ZSCAN9 TEAD3 POLR2A GATAD2A SPSB2 CDCA3 USP5 GNB3 ATN1 C12orf57 RNU7-1 P3H3 GPR162 CD4
GH12H007142 0.6 ENCODE 11.3 -33.0 -32972 0.2 CTCF ZNF512 SMC3 ZNF530 ZNF143 RAD21 RNU6-485P C1RL-AS1 C1RL ENSG00000256967 PEX5
GH12H007144 0.6 ENCODE 11.3 -35.6 -35575 1.1 CTCF ZNF654 TAL1 HLF RAD21 NFIL3 ZNF316 ZNF143 NFE2 RNU6-485P C1RL-AS1 C1RL ENSG00000256967 PEX5
GH12H006913 1.2 ENCODE dbSUPER 5.4 +194.3 194344 2.5 HDGF FOXA2 ARID4B DMAP1 ZNF2 GLIS2 GATA2 FOS SP3 YY2 LRRC23 ZNF384 ENSG00000247853 ENSG00000219410 CHD4 SPSB2 NCAPD2 P3H3 C1RL ENO2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1RL on UCSC Golden Path with GeneCards custom track

Promoters for C1RL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048392 778 1801 HDGF ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 DEK SP5

Genomic Locations for C1RL Gene

Genomic Locations for C1RL Gene
19,692 bases
Minus strand

Genomic View for C1RL Gene

Genes around C1RL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1RL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1RL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1RL Gene

Proteins for C1RL Gene

  • Protein details for C1RL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1r subcomponent-like protein
    Protein Accession:
    Secondary Accessions:
    • Q53GX9

    Protein attributes for C1RL Gene

    487 amino acids
    Molecular mass:
    53498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1RL Gene

Selected DME Specific Peptides for C1RL Gene


Post-translational modifications for C1RL Gene

  • Glycosylation at posLast=147147, Asn166, Asn242, Asn296, and Asn363
  • Modification sites at PhosphoSitePlus

Domains & Families for C1RL Gene

Gene Families for C1RL Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for C1RL Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with C1RL: view

Function for C1RL Gene

Molecular function for C1RL Gene

UniProtKB/Swiss-Prot Function:
Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.
UniProtKB/Swiss-Prot Induction:
Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation.

Enzyme Numbers (IUBMB) for C1RL Gene

Gene Ontology (GO) - Molecular Function for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with C1RL: view
genes like me logo Genes that share phenotypes with C1RL: view

Animal Models for C1RL Gene

MGI Knock Outs for C1RL:
  • C1rl tm1b(EUCOMM)Hmgu

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1RL Gene

Localization for C1RL Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1RL Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1RL gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IEA 16502470
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C1RL: view

Pathways & Interactions for C1RL Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006958 complement activation, classical pathway IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with C1RL: view

No data available for Pathways by source and SIGNOR curated interactions for C1RL Gene

Drugs & Compounds for C1RL Gene

(1) Drugs for C1RL Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with C1RL: view

Transcripts for C1RL Gene

Unigene Clusters for C1RL Gene

Complement component 1, r subcomponent-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1RL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -

Relevant External Links for C1RL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1RL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1RL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1RL Gene

This gene is overexpressed in Liver (x5.3) and Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for C1RL Gene

This gene is overexpressed in Serum (27.9), Plasma (13.6), and Urine (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C1RL Gene

Protein tissue co-expression partners for C1RL Gene

NURSA nuclear receptor signaling pathways regulating expression of C1RL Gene:


SOURCE GeneReport for Unigene cluster for C1RL Gene:


mRNA Expression by UniProt/SwissProt for C1RL Gene:

Tissue specificity: Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).

Evidence on tissue expression from TISSUES for C1RL Gene

  • Liver(4.4)
  • Bone marrow(4.2)
  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with C1RL: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C1RL Gene

Orthologs for C1RL Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1RL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1RL 33 34
  • 99.18 (n)
(Canis familiaris)
Mammalia C1RL 33 34
  • 81.04 (n)
(Rattus norvegicus)
Mammalia C1rl 33
  • 79.61 (n)
(Mus musculus)
Mammalia C1rl 33 16 34
  • 78.99 (n)
(Bos Taurus)
Mammalia C1RL 33 34
  • 78.32 (n)
(Monodelphis domestica)
Mammalia C1RL 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
(Gallus gallus)
Aves -- 34
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
(Danio rerio)
Actinopterygii wu:fd46c06 33
  • 43.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
-- 34
  • 16 (a)
CSA.10613 34
  • 16 (a)
-- 34
  • 15 (a)
-- 34
  • 2 (a)
Species where no ortholog for C1RL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1RL Gene

Gene Tree for C1RL (if available)
Gene Tree for C1RL (if available)

Paralogs for C1RL Gene

Paralogs for C1RL Gene

genes like me logo Genes that share paralogs with C1RL: view

Variants for C1RL Gene

Sequence variations from dbSNP and Humsavar for C1RL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000037896 -- 7,096,700(+) GTAGT(C/T)AGCCA intron-variant, reference, synonymous-codon, utr-variant-3-prime
rs1000093468 -- 7,102,958(+) TATAT(A/C)CTAGG intron-variant
rs1000884969 -- 7,107,338(+) TAATT(C/T)TTAAA intron-variant, upstream-variant-2KB
rs1000975041 -- 7,100,267(+) TAAAT(C/T)AGCAA intron-variant
rs1001290109 -- 7,094,852(+) GGGGG(G/T)ATAAG intron-variant, utr-variant-3-prime

Variation tolerance for C1RL Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.85; 93.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1RL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C1RL Gene

Disorders for C1RL Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1RL Gene - From: GeneCards

Disorder Aliases PubMed IDs
ovary adenocarcinoma
  • adenocarcinoma of the ovary
- elite association - COSMIC cancer census association via MalaCards
Search C1RL in MalaCards View complete list of genes associated with diseases

Relevant External Links for C1RL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C1RL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1RL Gene

Publications for C1RL Gene

  1. A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity. (PMID: 15358180) Lin N … Cao X (Biochemical and biophysical research communications 2004) 3 4 22 60
  2. Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein. (PMID: 15385675) Wicher KB … Fries E (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 45 60

Products for C1RL Gene

Sources for C1RL Gene

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