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Aliases for C1RL Gene

Aliases for C1RL Gene

  • Complement C1r Subcomponent Like 2 3 5
  • Complement Component 1, R Subcomponent-Like 2 3
  • C1r-Like Serine Protease Analog Protein 3 4
  • C1r-Like Protein 3 4
  • C1r-LP 3 4
  • C1RL1 3 4
  • C1RLP 3 4
  • CLSPa 3 4
  • Complement C1r Subcomponent-Like Protein 3
  • Complement C1r-Like Proteinase 3
  • EC 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61

External Ids for C1RL Gene

Previous GeneCards Identifiers for C1RL Gene

  • GC12M007147
  • GC12M007138
  • GC12M007061
  • GC12M007247
  • GC12M007245

Summaries for C1RL Gene

GeneCards Summary for C1RL Gene

C1RL (Complement C1r Subcomponent Like) is a Protein Coding gene. Diseases associated with C1RL include Ovary Adenocarcinoma. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is C1R.

UniProtKB/Swiss-Prot for C1RL Gene

  • Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1RL Gene

Genomics for C1RL Gene

Regulatory Elements for C1RL Gene

Enhancers for C1RL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F007058 0.8 Ensembl 12 +50.9 50877 0.4 HDAC1 PTRF RARA ZBTB11 HDAC8 PPARG CREB3 TFDP1 MEF2D ZNF589 LPCAT3 C1R C1RL C1S CLSTN3 ENSG00000256967 RBP5 C1RL-AS1 RNU6-485P GC12P007380
GH12F007059 0.5 ENCODE 11.9 +48.5 48540 2.4 ARID4B SIN3A YY1 ZNF143 ZNF416 MXD4 REST ZNF518A KAT8 ZNF610 ENSG00000219410 ENSG00000247853 C1RL-AS1 SCARNA12 NCAPD2 SPSB2 C1R C1RL GDF3 LPCAT3
GH12F007036 0.6 Ensembl 11.9 +72.3 72278 0.4 CTCF HLF MAX TRIM22 REST THRB RAD21 NFIL3 ZNF143 SMC3 C1R C1RL C1S C1RL-AS1 PHB2 SCARNA12 EMG1 RNU6-485P CLSTN3 ENSG00000256967
GH12F007008 0.6 Ensembl 11.8 +100.9 100878 0.4 C1S C1R C1RL EMG1 PHB2 SCARNA12 C1RL-AS1 RNU6-485P CLSTN3 ENSG00000256967
GH12F007005 0.2 Ensembl 11.6 +103.7 103678 0.4 C1R C1RL EMG1 PHB2 SCARNA12 C1RL-AS1 GC12M007000 PIR35791 PIR59434 GC12M007017
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C1RL on UCSC Golden Path with GeneCards custom track

Promoters for C1RL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086747 878 2001 HDGF ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 DEK

Genomic Location for C1RL Gene

7,089,587 bp from pter
7,109,278 bp from pter
19,692 bases
Minus strand

Genomic View for C1RL Gene

Genes around C1RL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1RL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1RL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1RL Gene

Proteins for C1RL Gene

  • Protein details for C1RL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1r subcomponent-like protein
    Protein Accession:
    Secondary Accessions:
    • Q53GX9

    Protein attributes for C1RL Gene

    487 amino acids
    Molecular mass:
    53498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1RL Gene

Selected DME Specific Peptides for C1RL Gene


Post-translational modifications for C1RL Gene

  • Glycosylation at Asn 147, Asn 166, Asn 242, Asn 296, and Asn 363
  • Modification sites at PhosphoSitePlus

Domains & Families for C1RL Gene

Gene Families for C1RL Gene

Suggested Antigen Peptide Sequences for C1RL Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUB domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 CUB domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with C1RL: view

Function for C1RL Gene

Molecular function for C1RL Gene

UniProtKB/Swiss-Prot Function:
Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.
UniProtKB/Swiss-Prot Induction:
Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation.

Enzyme Numbers (IUBMB) for C1RL Gene

Gene Ontology (GO) - Molecular Function for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with C1RL: view
genes like me logo Genes that share phenotypes with C1RL: view

Animal Models for C1RL Gene

MGI Knock Outs for C1RL:
  • C1rl tm1b(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for C1RL

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1RL Gene

Localization for C1RL Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1RL Gene


Subcellular locations from

Jensen Localization Image for C1RL Gene COMPARTMENTS Subcellular localization image for C1RL gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C1RL: view

Pathways & Interactions for C1RL Gene

SuperPathways for C1RL Gene

No Data Available

Interacting Proteins for C1RL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NZP8-C1RL_HUMAN ENSP00000266542 for C1RL Gene via IID STRING

Gene Ontology (GO) - Biological Process for C1RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006958 complement activation, classical pathway IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with C1RL: view

No data available for Pathways by source and SIGNOR curated interactions for C1RL Gene

Drugs & Compounds for C1RL Gene

(1) Drugs for C1RL Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with C1RL: view

Transcripts for C1RL Gene

Unigene Clusters for C1RL Gene

Complement component 1, r subcomponent-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1RL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -

Relevant External Links for C1RL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1RL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1RL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1RL Gene

This gene is overexpressed in Liver (x5.3) and Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for C1RL Gene

This gene is overexpressed in Serum (27.9), Plasma (13.6), and Urine (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1RL Gene

Protein tissue co-expression partners for C1RL Gene

NURSA nuclear receptor signaling pathways regulating expression of C1RL Gene:


SOURCE GeneReport for Unigene cluster for C1RL Gene:


mRNA Expression by UniProt/SwissProt for C1RL Gene:

Tissue specificity: Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).
genes like me logo Genes that share expression patterns with C1RL: view

Primer Products

Orthologs for C1RL Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1RL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1RL 34 35
  • 99.18 (n)
(Canis familiaris)
Mammalia C1RL 34 35
  • 81.04 (n)
(Rattus norvegicus)
Mammalia C1rl 34
  • 79.61 (n)
(Mus musculus)
Mammalia C1rl 34 16 35
  • 78.99 (n)
(Bos Taurus)
Mammalia C1RL 34 35
  • 78.32 (n)
(Monodelphis domestica)
Mammalia C1RL 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
(Gallus gallus)
Aves -- 35
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
(Danio rerio)
Actinopterygii wu:fd46c06 34
  • 43.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
-- 35
  • 16 (a)
CSA.10613 35
  • 16 (a)
-- 35
  • 15 (a)
-- 35
  • 2 (a)
Species where no ortholog for C1RL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1RL Gene

Gene Tree for C1RL (if available)
Gene Tree for C1RL (if available)

Paralogs for C1RL Gene

Paralogs for C1RL Gene

genes like me logo Genes that share paralogs with C1RL: view

Variants for C1RL Gene

Sequence variations from dbSNP and Humsavar for C1RL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1075425 -- 7,102,191(+) CTAGA(C/T)GGGCC intron-variant
rs10840704 -- 7,098,869(+) CATTG(C/T)GAACA intron-variant, downstream-variant-500B
rs10841811 -- 7,102,774(+) TGGTG(C/T)TGCTT intron-variant
rs10842032 -- 7,103,867(+) AGGAA(C/G)GGGAC intron-variant
rs10842565 -- 7,106,785(+) AGGAA(A/G)CCCAA intron-variant, upstream-variant-2KB

Variation tolerance for C1RL Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.85; 93.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1RL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C1RL Gene

Disorders for C1RL Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1RL Gene - From: GeneCards

Disorder Aliases PubMed IDs
ovary adenocarcinoma
  • adenocarcinoma of the ovary
- elite association - COSMIC cancer census association via MalaCards
Search C1RL in MalaCards View complete list of genes associated with diseases

Relevant External Links for C1RL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C1RL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1RL Gene

Publications for C1RL Gene

  1. A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity. (PMID: 15358180) Lin N. … Cao X. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
  2. Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein. (PMID: 15385675) Wicher K.B. … Fries E. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64

Products for C1RL Gene

Sources for C1RL Gene

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