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Aliases for C1QTNF9B Gene

Aliases for C1QTNF9B Gene

  • C1q And Tumor Necrosis Factor Related Protein 9B 2 3
  • C1q/TNF-Related Protein 9B 3 4
  • CTRP9B 3 4
  • Complement C1q And Tumor Necrosis Factor-Related Protein 9-Like 4
  • Collagen Triple Helix Repeat-Containing 3

External Ids for C1QTNF9B Gene

Previous GeneCards Identifiers for C1QTNF9B Gene

  • GC13M024462
  • GC13M005276

Summaries for C1QTNF9B Gene

GeneCards Summary for C1QTNF9B Gene

C1QTNF9B (C1q And Tumor Necrosis Factor Related Protein 9B) is a Protein Coding gene. An important paralog of this gene is COL8A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF9B Gene

Genomics for C1QTNF9B Gene

Genomic Location for C1QTNF9B Gene

Chromosome:
13
Start:
23,891,099 bp from pter
End:
23,902,655 bp from pter
Size:
11,557 bases
Orientation:
Minus strand

Genomic View for C1QTNF9B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1QTNF9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF9B Gene

No data available for Regulatory Elements for C1QTNF9B Gene

Proteins for C1QTNF9B Gene

  • Protein details for C1QTNF9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RNN3-C1T9B_HUMAN
    Recommended name:
    Complement C1q and tumor necrosis factor-related protein 9B
    Protein Accession:
    B2RNN3
    Secondary Accessions:
    • A2A3T6
    • B9EH31
    • Q0VGC5
    • Q5VX65
    • Q5VX66
    • Q8IUU4

    Protein attributes for C1QTNF9B Gene

    Size:
    333 amino acids
    Molecular mass:
    34713 Da
    Quaternary structure:
    • Interacts with CTRP9A and ADIPOQ. Forms heterotrimers and heterooligomeric complexes with CTRP9A.

    Alternative splice isoforms for C1QTNF9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QTNF9B Gene

Proteomics data for C1QTNF9B Gene at MOPED

Post-translational modifications for C1QTNF9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QTNF9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QTNF9B Gene

Domains & Families for C1QTNF9B Gene

Protein Domains for C1QTNF9B Gene

Suggested Antigen Peptide Sequences for C1QTNF9B Gene

Graphical View of Domain Structure for InterPro Entry

B2RNN3

UniProtKB/Swiss-Prot:

C1T9B_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
  • Contains 3 collagen-like domains.
genes like me logo Genes that share domains with C1QTNF9B: view

No data available for Gene Families for C1QTNF9B Gene

Function for C1QTNF9B Gene

Gene Ontology (GO) - Molecular Function for C1QTNF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19666007
genes like me logo Genes that share ontologies with C1QTNF9B: view

Phenotypes for C1QTNF9B Gene

GenomeRNAi human phenotypes for C1QTNF9B:
genes like me logo Genes that share phenotypes with C1QTNF9B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1QTNF9B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF9B Gene

Localization for C1QTNF9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF9B Gene

Secreted. Note=Heteromeric complex formation with CTRP9A or ADIPOQ is required for secretion, otherwise, it is retained in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1QTNF9B Gene COMPARTMENTS Subcellular localization image for C1QTNF9B gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for C1QTNF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C1QTNF9B: view

Pathways & Interactions for C1QTNF9B Gene

SuperPathways for C1QTNF9B Gene

No Data Available

Interacting Proteins for C1QTNF9B Gene

Selected Interacting proteins: B2RNN3-C1T9B_HUMAN for C1QTNF9B Gene via UniProtKB

Symbol External ID(s) Details
C1QTNF9

Gene Ontology (GO) - Biological Process for C1QTNF9B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF9B Gene

Drugs & Compounds for C1QTNF9B Gene

No Compound Related Data Available

Transcripts for C1QTNF9B Gene

mRNA/cDNA for C1QTNF9B Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QTNF9B Gene

C1q and tumor necrosis factor related protein 9B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1QTNF9B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF9B Gene

No ASD Table

Relevant External Links for C1QTNF9B Gene

GeneLoc Exon Structure for
C1QTNF9B
ECgene alternative splicing isoforms for
C1QTNF9B

Expression for C1QTNF9B Gene

mRNA expression in normal human tissues for C1QTNF9B Gene

mRNA differential expression in normal tissues according to GTEx for C1QTNF9B Gene

This gene is overexpressed in Testis (x9.8) and Prostate (x6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C1QTNF9B Gene



SOURCE GeneReport for Unigene cluster for C1QTNF9B Gene Hs.740810

mRNA Expression by UniProt/SwissProt for C1QTNF9B Gene

B2RNN3-C1T9B_HUMAN
Tissue specificity: Expressed at low levels. Not expressed in adipose tissues.
genes like me logo Genes that share expression patterns with C1QTNF9B: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for C1QTNF9B Gene

Orthologs for C1QTNF9B Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF9B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1QTNF9 35
  • 80.98 (n)
  • 84.08 (a)
C1QTNF9 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C1QTNF9 35
  • 86.59 (n)
  • 88.89 (a)
-- 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia C1qtnf9 35
  • 81.68 (n)
  • 83.48 (a)
C1qtnf9 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF9B 35
  • 98.29 (n)
  • 96.69 (a)
-- 36
  • 96 (a)
ManyToMany
-- 36
  • 97 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia C1qtnf9 35
  • 82.48 (n)
  • 83.38 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves C1QTNF9 35
  • 66.77 (n)
  • 65.17 (a)
-- 36
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii c1qtnf9 36
  • 54 (a)
OneToMany
Species with no ortholog for C1QTNF9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF9B Gene

ENSEMBL:
Gene Tree for C1QTNF9B (if available)
TreeFam:
Gene Tree for C1QTNF9B (if available)

Paralogs for C1QTNF9B Gene

genes like me logo Genes that share paralogs with C1QTNF9B: view

Variants for C1QTNF9B Gene

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF9B Gene

Variant ID Type Subtype PubMed ID
esv2422502 CNV Duplication 17116639
esv2747122 CNV Deletion 23290073
esv5325 CNV Complex 18987735
nsv455837 CNV Gain 19166990
nsv525965 CNV Gain 19592680
dgv1561n71 CNV Gain 21882294
esv2751136 CNV Loss 17911159
dgv1565n71 CNV Gain 21882294
esv2747134 CNV Deletion 23290073
nsv832566 CNV Gain 17160897

Variation tolerance for C1QTNF9B Gene

Residual Variation Intolerance Score: 94.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.72; 93.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF9B Gene

HapMap Linkage Disequilibrium report
C1QTNF9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C1QTNF9B Gene

Disorders for C1QTNF9B Gene

Relevant External Links for C1QTNF9B

Genetic Association Database (GAD)
C1QTNF9B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QTNF9B
genes like me logo Genes that share disorders with C1QTNF9B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF9B Gene

Publications for C1QTNF9B Gene

  1. C1q and its growing family. (PMID: 17544811) Ghai R. … Kishore U. (Immunobiology 2007) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  4. Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population. (PMID: 21640322) Shi Y. … Yang Z. (Am. J. Hum. Genet. 2011) 67
  5. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A. … Gyllensten U. (Obesity (Silver Spring) 2010) 67

Products for C1QTNF9B Gene

Sources for C1QTNF9B Gene

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