C1QTNF9 Gene
protein-coding GIFtS: 43
GCID: GC13P024881
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C1q and tumor necrosis factor related protein 9
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Aliases
for C1QTNF9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C1q And Tumor Necrosis Factor Related Protein 91 2 | | MGC489151 | | C1QTNF9A1 2 3 | | Complement C1q And Tumor Necrosis Factor-Related Protein 9A2 | | AQL11 2 | | Complement C1q Tumor Necrosis Factor-Related Protein 92 | | CTRP91 2 | | Complement C1q Tumor Necrosis Factor-Related Protein 9A2 | | Complement C1q And Tumor Necrosis Factor-Related Protein 92 3 | | |
Export aliases for C1QTNF9 gene to outside databasesPrevious GC identifers: GC13P023779 GC13P005695 |
Summaries
for C1QTNF9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862Function: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways (By similarity)
|
Genomic Views
for C1QTNF9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1QTNF9 gene promoter:
AhR Lmo2 E2F-2 STAT5A GATA-2 Arnt PPAR-alpha E2F-1 Ik-2 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1QTNF9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1QTNF9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.12 Ensembl cytogenetic band: 13q12.12 HGNC cytogenetic band: 13q12.12C1QTNF9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P024881: view genomic region
(about GC identifiers)
Start:
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24,881,304 bp from pter |
End:
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24,896,673 bp from pter |
Size:
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15,370 bases |
Orientation:
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plus strand |
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Proteins
for C1QTNF9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862 (See
protein sequence)Recommended Name: Complement C1q and tumor necrosis factor-related protein 9A precursor Size: 333 amino acids; 34681 Da
Subunit: Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex(By similarity). Interacts with CTRP9B. Forms heterotrimers and heterooligomeric complexes with CTRP9B
Subcellular location: Secreted (By similarity)
Secondary accessions: A2A3T6 Q0VGC5 Q5VX65 Q5VX66 Q8IUU4Explore the universe of human proteins at neXtProt for C1QTNF9: NX_P0C862
C1QTNF9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848635.2
ENSEMBL proteins: ENSP00000371503 ENSP00000333737 ENSP00000371498
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005581 | collagen |
IEA | -- |
C1QTNF9 for ontologies About GeneDecksing
C1QTNF9 Antibody Products:
Assay Products for C1QTNF9: |
Protein
Domains /
Families
for C1QTNF9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C1QTNF9 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0C862ProtoNet protein and cluster: P0C862 UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862Similarity: Contains 1 C1q domainSimilarity: Contains 3 collagen-like domains |
Function
for C1QTNF9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862Function: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1QTNF9 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1QTNF9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C1QTNF9 (NM_178540) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1QTNF9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QTNF9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QTNF9 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005179 | hormone activity |
IEA | -- |
C1QTNF9 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out C1qtnf9tm1Lex for C1QTNF9
1 MGI phenotypic allele  for C1qtnf9 (no phenotypes)
C1QTNF9 for phenotypes About GeneDecksing
|
Pathways & Interactions
for C1QTNF9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1QTNF9
|
Drugs & Compounds
for C1QTNF9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1QTNF9
Search CenterWatch for drugs/clinical trials and news about C1QTNF9 / C1T9A
|
Transcripts
for C1QTNF9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1QTNF9 gene: NM_178540.3 Unigene Cluster for C1QTNF9: C1q and tumor necrosis factor related protein 9 Hs.362854 [show with all ESTs]Unigene Representative Sequence: NM_1785403 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382071 ENST00000332018(uc001upj.3) ENST00000382066
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1QTNF9 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1QTNF9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C1QTNF9 (NM_178540) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1QTNF9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QTNF9 |
Additional cDNA sequence: AY358145.1 BC040438.1 1 DOTS entry: DT.95304754 24/228 AceView cDNA sequences (see all 228): AK123031 AA253426 AA250723 BX644087 BX107153 H03469 BE856262 AA360954 BM728412 AA732279 AW206404 AL707817 AK055770 BX646944 NM_153023 AL699742 AW075731 CD723650 BE502293 BM710110 R78453 AI306427 BU742194 BM853281
GeneLoc Exon Structure
|
Expression
for C1QTNF9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1QTNF9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTAGCTAT
About this image
See C1QTNF9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1QTNF9
SOURCE GeneReport for Unigene cluster: Hs.362854
UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862Tissue specificity: Expressed predominantly in adipose tissue
SABiosciences Custom PCR Arrays for C1QTNF9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1QTNF9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C1QTNF9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1QTNF9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1QTNF9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QTNF9 |
Orthologs
for C1QTNF9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C1QTNF9 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for C1QTNF9 (if available)
TreeFam Gene Tree for C1QTNF9 (if available) |
Paralogs
for C1QTNF9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C1QTNF9 gene
- C1QL32 COL8A22 C1QL22 C1QTNF52 OTOL12 C1QB2 COL10A12 C1QTNF32
- C1QTNF9B2 C1QA2 COL8A12 C1QL12 C1QTNF72 C1QTNF22 C1QC2 C1QL42
- ADIPOQ2
18/36 SIMAP similar genes for C1QTNF9 using alignment to 1 protein entry: C1T9A_HUMAN(see all similar genes):C1QTNF9B ADIPOQ C1QTNF2 OTOL1 C1QTNF7 COL11A1
COL11A2 COL9A1 COL1A2 COL8A2 COL3A1 COL2A1
COL4A2 COL5A1 COL6A3 COL9A2 C1QC C1QL1
C1QTNF9 for paralogs About GeneDecksing
|
Genomic Variants
for C1QTNF9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C1QTNF9 (24881304 - 24896673 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for C1QTNF9
4 CNVs: 8747 5317 5315 9216 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1QTNF9 |
|
Disorders
/ Diseases
for C1QTNF9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C1QTNF9 for disorders About MalaCards
C1QTNF9 for disorders About GeneDecksing
OMIM gene information: 614285
OMIM disorders: --
Export disorders for C1QTNF9 gene to outside databases
|
Publications
for C1QTNF9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1QTNF9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1QTNF9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. (PubMed id 18787108)1, 3 Wong G.W....Lodish H.F. (2009)
- CTRP8 and CTRP9B are novel proteins that hetero-oligo merize with C1q/TNF family members. (PubMed id 19666007)2 Peterson J.M....Wong G.W. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C1QTNF9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C1QTNF9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C1QTNF9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1QTNF9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C1QTNF9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C1QTNF9 gene:
Search GeneIP for patents involving C1QTNF9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1QTNF9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | C1QTNF9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QTNF9 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QTNF9 |
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