C1QTNF8 Gene
protein-coding GIFtS: 40
GCID: GC16M001138
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C1q and tumor necrosis factor related protein 8
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Aliases
for C1QTNF8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C1q And Tumor Necrosis Factor Related Protein 81 2 | | CTRP81 2 3 | | UNQ58291 2 | | C1q/TNF-Related Protein 82 3 | | Complement C1q Tumor Necrosis Factor-Related Protein 82 |
Export aliases for C1QTNF8 gene to outside databasesPrevious GC identifers: GC16M001078 GC16M001069 |
Summaries
for C1QTNF8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C1QTNF8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1QTNF8 gene promoter:
Bach2 Pax-2 CUTL1 Pax-2a c-Ets-1 HSF2 c-Myb ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1QTNF8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1QTNF8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3C1QTNF8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M001138: view genomic region
(about GC identifiers)
Start:
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1,138,226 bp from pter |
End:
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1,146,244 bp from pter |
Size:
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8,019 bases |
Orientation:
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minus strand |
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Proteins
for C1QTNF8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C1QT8_HUMAN, P60827 (See
protein sequence)Recommended Name: Complement C1q tumor necrosis factor-related protein 8 precursor Size: 252 amino acids; 27685 Da
Subunit: Homotrimer. Forms heteromeric complexes with C1QL1
Subcellular location: Secreted
Sequence caution: Sequence=AAQ89191.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which does notmatch the genome; Sequence=ACJ46463.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which does notmatch the genome;
Secondary accessions: B7U178Explore the universe of human proteins at neXtProt for C1QTNF8: NX_P60827
Post-translational modifications:
No N-glycosylation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P60827
C1QTNF8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997302.2
ENSEMBL proteins: ENSP00000330426
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005581 | collagen |
IEA | -- |
C1QTNF8 for ontologies About GeneDecksing
C1QTNF8 Antibody Products:
Assay Products for C1QTNF8: |
Protein
Domains /
Families
for C1QTNF8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C1QTNF8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P60827ProtoNet protein and cluster: P60827 2 Blocks protein families: IPB001073 Complement C1q protein IPB008160 Collagen triple helix repeat
UniProtKB/Swiss-Prot: C1QT8_HUMAN, P60827Similarity: Contains 1 C1q domainSimilarity: Contains 1 collagen-like domain |
Function
for C1QTNF8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1QTNF8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1QTNF8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QTNF8 |
|
Pathways & Interactions
for C1QTNF8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1QTNF8
|
Drugs & Compounds
for C1QTNF8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1QTNF8
Search CenterWatch for drugs/clinical trials and news about C1QTNF8 / C1QT8
|
Transcripts
for C1QTNF8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1QTNF8 gene: NM_207419.3 Unigene Cluster for C1QTNF8: C1q and tumor necrosis factor related protein 8 Hs.527853 [show with all ESTs]Unigene Representative Sequence: NM_2074191 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000328449(uc010uuw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1QTNF8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1QTNF8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C1QTNF8 (NM_207419) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1QTNF8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QTNF8 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1QTNF8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C1QTNF8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1QTNF8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1QTNF8 |
Additional cDNA sequence: AY358832.1 FJ422561.1 2 DOTS entries: DT.99952480 DT.120661174 3 AceView cDNA sequences: AY358832 NM_207419 BG926615
GeneLoc Exon Structure
|
Expression
for C1QTNF8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1QTNF8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACTTTATC
About this image
See C1QTNF8 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.527853
UniProtKB/Swiss-Prot: C1QT8_HUMAN, P60827Tissue specificity: Expressed predominantly in lung and testis
SABiosciences Custom PCR Arrays for C1QTNF8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1QTNF8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C1QTNF8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1QTNF8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1QTNF8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QTNF8 |
Orthologs
for C1QTNF8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C1QTNF8 gene from 4/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
C1QTNF81 |
C1q and tumor necrosis factor related protein 8 |
63.4(n)
60(a) |
|
427666 XM_425240.2 XP_425240.1 |
lizard
(Anolis carolinensis) |
Reptilia |
C1QTNF66 |
-- |
46(a) |
1 → many |
5(22814737-22817581) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.85982 |
Transcribed sequence with weak similarity to protein more |
75.66(n) |
|
CF377658.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01084570.16c1qtnf6a6 |
C1q and tumor necrosis factor related protein 6a |
47(a)47(a) |
possible orthologpossible ortholog |
6(164068-167270) 3(25322121-25323822) |
ENSEMBL Gene Tree for C1QTNF8 (if available)
TreeFam Gene Tree for C1QTNF8 (if available) |
Paralogs
for C1QTNF8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C1QTNF8 gene
- C1QTNF62 C1QTNF12 C1QTNF42
3 SIMAP similar genes for C1QTNF8 using alignment to 1 protein entry: C1QT8_HUMAN:C1QTNF6 dJ151B14.4 C1QTNF1
C1QTNF8 for paralogs About GeneDecksing
|
Genomic Variants
for C1QTNF8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C1QTNF8 (1138226 - 1146244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for C1QTNF8
6 CNVs: 29655 29991 29994 3987 29990 5329 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1QTNF8 |
|
Disorders
/ Diseases
for C1QTNF8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C1QTNF8 for disorders About MalaCards
C1QTNF8 for disorders About GeneDecksing
OMIM gene information: 614147
OMIM disorders: --
Export disorders for C1QTNF8 gene to outside databases
|
Publications
for C1QTNF8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1QTNF8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1QTNF8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- CTRP8 and CTRP9B are novel proteins that hetero-oligo merize with C1q/TNF family members. (PubMed id 19666007)1, 2 Peterson J.M....Wong G.W. (2009)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
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External Searches for C1QTNF8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C1QTNF8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C1QTNF8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1QTNF8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for C1QTNF8 gene:
Search GeneIP for patents involving C1QTNF8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1QTNF8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | C1QTNF8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QTNF8 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QTNF8 |
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