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Aliases for C1QTNF8 Gene

Aliases for C1QTNF8 Gene

  • C1q And TNF Related 8 2 3 5
  • C1q And Tumor Necrosis Factor Related Protein 8 2 3
  • C1q/TNF-Related Protein 8 3 4
  • CTRP8 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 8 3
  • UNQ5829 3

External Ids for C1QTNF8 Gene

Previous GeneCards Identifiers for C1QTNF8 Gene

  • GC16M001078
  • GC16M001069
  • GC16M001138

Summaries for C1QTNF8 Gene

GeneCards Summary for C1QTNF8 Gene

C1QTNF8 (C1q And TNF Related 8) is a Protein Coding gene. An important paralog of this gene is C1QTNF6.

Additional gene information for C1QTNF8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF8 Gene

Genomics for C1QTNF8 Gene

Regulatory Elements for C1QTNF8 Gene

Enhancers for C1QTNF8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001097 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -6.0 -5976 9.8 RB1 ARID4B ZNF76 KLF17 ZNF2 RAD21 GLIS2 SCRT2 ZNF143 KLF7 LUC7L IFT140 TSC2 WDR90 CRAMP1 WDR24 NME3 CCDC154 TELO2 ENSG00000262528
GH16H001081 1.6 FANTOM5 ENCODE dbSUPER 0.4 +13.2 13233 2.8 MLX ZFP64 ARID4B DMAP1 ZNF121 SLC30A9 GLIS2 FOS SP5 ZHX2 LUC7L IFT140 TSC2 ENSG00000269482 WDR90 CRAMP1 WDR24 NME3 CCDC154 TELO2
GH16H001095 0.9 ENCODE dbSUPER 0.7 +2.4 2391 0.2 RING1 TBP RNF2 NRF1 ARID4B DMAP1 SKIL ZFX LUC7L IFT140 TSC2 WDR90 CRAMP1 WDR24 NME3 CCDC154 TELO2 ENSG00000262528
GH16H001093 0.8 ENCODE 0.7 +2.7 2731 0.2 RING1 KLF1 ZSCAN4 ARID4B DMAP1 HIC1 ZFHX2 CTBP1 EGR1 ADNP LUC7L IFT140 TSC2 WDR90 CRAMP1 WDR24 NME3 CCDC154 TELO2 ENSG00000262528
GH16H001094 0.8 ENCODE dbSUPER 0.7 +2.1 2081 0.1 RNF2 SP2 REST ZNF600 ZFX C1QTNF8 SSTR5-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1QTNF8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C1QTNF8 Gene

Genomic Locations for C1QTNF8 Gene
chr16:1,088,226-1,096,306
(GRCh38/hg38)
Size:
8,081 bases
Orientation:
Minus strand
chr16:1,138,226-1,146,244
(GRCh37/hg19)

Genomic View for C1QTNF8 Gene

Genes around C1QTNF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF8 Gene

Proteins for C1QTNF8 Gene

  • Protein details for C1QTNF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60827-C1QT8_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 8
    Protein Accession:
    P60827
    Secondary Accessions:
    • B7U178

    Protein attributes for C1QTNF8 Gene

    Size:
    252 amino acids
    Molecular mass:
    27685 Da
    Quaternary structure:
    • Homotrimer. Forms heteromeric complexes with C1QL1.
    SequenceCaution:
    • Sequence=AAQ89191.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which does not match the genome.; Evidence={ECO:0000305}; Sequence=ACJ46463.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which does not match the genome.; Evidence={ECO:0000305};

neXtProt entry for C1QTNF8 Gene

Post-translational modifications for C1QTNF8 Gene

Other Protein References for C1QTNF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QTNF8 Gene

Domains & Families for C1QTNF8 Gene

Gene Families for C1QTNF8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for C1QTNF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QTNF8: view

No data available for UniProtKB/Swiss-Prot for C1QTNF8 Gene

Function for C1QTNF8 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19666007
genes like me logo Genes that share ontologies with C1QTNF8: view
genes like me logo Genes that share phenotypes with C1QTNF8: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF8 Gene

Localization for C1QTNF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF8 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C1QTNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QTNF8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QTNF8 Gene

Pathways & Interactions for C1QTNF8 Gene

SuperPathways for C1QTNF8 Gene

No Data Available

Interacting Proteins for C1QTNF8 Gene

Gene Ontology (GO) - Biological Process for C1QTNF8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF8 Gene

Drugs & Compounds for C1QTNF8 Gene

No Compound Related Data Available

Transcripts for C1QTNF8 Gene

mRNA/cDNA for C1QTNF8 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QTNF8 Gene

C1q and tumor necrosis factor related protein 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF8 Gene

No ASD Table

Relevant External Links for C1QTNF8 Gene

GeneLoc Exon Structure for
C1QTNF8
ECgene alternative splicing isoforms for
C1QTNF8

Expression for C1QTNF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QTNF8 Gene

mRNA differential expression in normal tissues according to GTEx for C1QTNF8 Gene

This gene is overexpressed in Artery - Aorta (x11.9), Pituitary (x11.1), and Fallopian Tube (x6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C1QTNF8 Gene



Protein tissue co-expression partners for C1QTNF8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF8 Gene:

C1QTNF8

SOURCE GeneReport for Unigene cluster for C1QTNF8 Gene:

Hs.527853

mRNA Expression by UniProt/SwissProt for C1QTNF8 Gene:

P60827-C1QT8_HUMAN
Tissue specificity: Expressed predominantly in lung and testis.

Evidence on tissue expression from TISSUES for C1QTNF8 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C1QTNF8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF8 Gene

Orthologs for C1QTNF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF8 33 34
  • 98.54 (n)
cow
(Bos Taurus)
Mammalia C1QTNF8 33 34
  • 85.78 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves C1QTNF8 33
  • 65.07 (n)
-- 34
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf1 33
  • 59.77 (n)
Str.8598 33
zebrafish
(Danio rerio)
Actinopterygii c1qtnf6a 34
  • 47 (a)
ManyToMany
CABZ01084570.1 34
  • 47 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
OneToMany
Species where no ortholog for C1QTNF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF8 Gene

ENSEMBL:
Gene Tree for C1QTNF8 (if available)
TreeFam:
Gene Tree for C1QTNF8 (if available)

Paralogs for C1QTNF8 Gene

Paralogs for C1QTNF8 Gene

(3) SIMAP similar genes for C1QTNF8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QTNF8: view

Variants for C1QTNF8 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000179039 -- 1,097,241(+) GGGAC(C/T)GCACC upstream-variant-2KB
rs1000276425 -- 1,092,373(+) CAGTC(A/G)GGGCA intron-variant
rs1000303863 -- 1,088,941(+) CTGGG(A/T)CCTTG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000610770 -- 1,091,571(+) CTGGA(A/G)GGACC intron-variant
rs1000643131 -- 1,096,272(+) AGGCC(A/G)GCTCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF8 Gene

Variant ID Type Subtype PubMed ID
nsv952898 CNV deletion 24416366
nsv833116 CNV loss 17160897
nsv571102 CNV loss 21841781
nsv571101 CNV gain 21841781
nsv571100 CNV loss 21841781
nsv571092 CNV gain 21841781
nsv571046 CNV gain 21841781
nsv471067 CNV gain 18288195
nsv471066 CNV loss 18288195
nsv457323 CNV loss 19166990
nsv457315 CNV gain 19166990
nsv428316 CNV gain+loss 18775914
nsv1160327 CNV deletion 26073780
nsv1046885 CNV gain 25217958
esv3637603 CNV gain 21293372
esv3364240 CNV duplication 20981092
esv2422427 CNV duplication 17116639
esv1360970 CNV insertion 17803354
dgv2692n100 CNV gain 25217958
dgv2691n100 CNV gain 25217958

Variation tolerance for C1QTNF8 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF8 Gene

Disorders for C1QTNF8 Gene

Relevant External Links for C1QTNF8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QTNF8

No disorders were found for C1QTNF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF8 Gene

Publications for C1QTNF8 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members. (PMID: 19666007) Peterson JM … Wong GW (Biochemical and biophysical research communications 2009) 3 4 60
  3. C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. (PMID: 24014093) Glogowska A … Klonisch T (The Journal of pathology 2013) 3 60
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 60

Products for C1QTNF8 Gene

Sources for C1QTNF8 Gene

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