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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1QTNF8 Gene

protein-coding   GIFtS: 39
GCID: GC16M001138

C1q And Tumor Necrosis Factor Related Protein 8

  Search for C1QTNF8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C1q And Tumor Necrosis Factor Related Protein 81 2
CTRP82 3
C1q/TNF-Related Protein 82 3
UNQ58292
Complement C1q Tumor Necrosis Factor-Related Protein 82

External Ids:    HGNC: 313741   Entrez Gene: 3906642   Ensembl: ENSG000001844717   OMIM: 6141475   UniProtKB: P608273   

Export aliases for C1QTNF8 gene to outside databases

Previous GC identifers: GC16M001078 GC16M001069


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C1QTNF8 Gene: 
C1QTNF8 (C1q and tumor necrosis factor related protein 8) is a protein-coding gene. An important paralog of this gene is C1QTNF6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1QTNF8 gene promoter:
         Bach2   Pax-2   CUTL1   Pax-2a   c-Ets-1   HSF2   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): C1QTNF8 promoter sequence
   Search SABiosciences Chromatin IP Primers for C1QTNF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1QTNF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

C1QTNF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1QTNF8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001138:  view genomic region     (about GC identifiers)

Start:
1,138,226 bp from pter      End:
1,146,244 bp from pter
Size:
8,019 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C1QT8_HUMAN, P60827 (See protein sequence)
Recommended Name: Complement C1q tumor necrosis factor-related protein 8 precursor  
Size: 252 amino acids; 27685 Da
Subunit: Homotrimer. Forms heteromeric complexes with C1QL1
Subcellular location: Secreted
Sequence caution: Sequence=AAQ89191.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which does
not match the genome; Sequence=ACJ46463.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which
does not match the genome;
Secondary accessions: B7U178

Explore the universe of human proteins at neXtProt for C1QTNF8: NX_P60827

Explore proteomics data for C1QTNF8 at MOPED 

Post-translational modifications:

  • UniProtKB: No N-glycosylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P60827

  • C1QTNF8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C1QTNF8 Protein Expression
    REFSEQ proteins: NP_997302.2  
    ENSEMBL proteins: 
     ENSP00000330426  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005581collagen IEA--

    C1QTNF8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR008160 Collagen
     IPR001073 C1q

    Graphical View of Domain Structure for InterPro Entry P60827

    ProtoNet protein and cluster: P60827

    2 Blocks protein domains:
    IPB001073 Complement C1q protein
    IPB008160 Collagen triple helix repeat


    UniProtKB/Swiss-Prot: C1QT8_HUMAN, P60827
    Similarity: Contains 1 C1q domain
    Similarity: Contains 1 collagen-like domain


    C1QTNF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    C1QTNF8 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1QTNF8

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1QTNF8 (C1QT8)

    Search CenterWatch for drugs/clinical trials and news about C1QTNF8 / C1QT8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C1QTNF8 gene: 
    NM_207419.3  

    Unigene Cluster for C1QTNF8:

    C1q and tumor necrosis factor related protein 8
    Hs.527853  [show with all ESTs]
    Unigene Representative Sequence: NM_207419
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328449(uc010uuw.1)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1QTNF8

    Additional mRNA sequence: 

    AY358832.1 FJ422561.1 

    2 DOTS entries:

    DT.99952480  DT.120661174 

    3 AceView cDNA sequences:

    AY358832 NM_207419 BG926615 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1QTNF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTTTATC
    C1QTNF8 Expression
    About this image


    See C1QTNF8 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.527853

    UniProtKB/Swiss-Prot: C1QT8_HUMAN, P60827
    Tissue specificity: Expressed predominantly in lung and testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QTNF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C1QTNF8 gene from 5/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    53(a)
    possible ortholog
    6(153661882-153677910)
    chicken
    (Gallus gallus)
    Aves C1QTNF81 C1q and tumor necrosis factor related protein 8 63.4(n)
    60(a)
      427666  XM_425240.2  XP_425240.1 
    lizard
    (Anolis carolinensis)
    Reptilia C1QTNF86
    C1QTNF66
    Uncharacterized protein
    60(a)
    46(a)
    possible ortholog
    many → 1
    GL343263.1(1797713-1803135)
    5(22810719-22820350)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.85982 Transcribed sequence with weak similarity to protein more 75.66(n)    CF377658.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01084570.16
    c1qtnf6a6
    C1q and tumor necrosis factor related protein 6a
    44(a)
    44(a)
    many ↔ many
    many ↔ many
    6(164068-167270)
    3(25322121-25323822)


    ENSEMBL Gene Tree for C1QTNF8 (if available)
    TreeFam Gene Tree for C1QTNF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C1QTNF8 gene
    C1QTNF62  C1QB2  COL10A12  C1QTNF12  C1QTNF9B2  C1QA2  C1QTNF42  COL8A22  
    C1QTNF92  C1QTNF52  COL8A12  OTOL12  C1QTNF72  C1QC2  C1QTNF22  ADIPOQ2  
    3 SIMAP similar genes for C1QTNF8 using alignment to 1 protein entry:     C1QT8_HUMAN:
    C1QTNF6    dJ151B14.4    C1QTNF1

    C1QTNF8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/406 SNPs in C1QTNF8 are shown (see all 406)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815060151,2
    --1137762(+) AGGACA/GGCTTG 1 -- ds50010--------
    rs1172610591,2
    C,F--1137936(+) CAGGTG/ATCCAT 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1864736881,2
    --1137945(+) ATCAAC/TAAACA 1 -- ds50010--------
    rs1912024171,2
    --1137995(+) TACTTG/TTGTGA 1 -- ds50010--------
    rs27295861,2
    C,F--1138075(-) TCCCCA/GTCCAC 1 -- ds50016Minor allele frequency- G:0.39NA WA CSA 245
    rs27451241,2
    C--1138076(+) TGGATG/AGGGAG 1 -- ds50013Minor allele frequency- A:0.23WA NA 240
    rs782345811,2
    F--1138130(+) GGAACC/TGTTTG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1819227881,2
    --1138265(+) TAAACA/GGATAA 1 -- ut310--------
    rs781994261,2
    F--1138349(+) CGCGTC/TCCCCA 1 -- ut310--------
    rs1471653731,2
    --1138368(+) CTGTGC/TGGTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for C1QTNF8 (1138226 - 1146244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for C1QTNF8 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    esv1360970CNV Insertion17803354
    dgv2510n71CNV Loss21882294
    nsv904932CNV Loss21882294
    nsv457323CNV Loss19166990
    nsv471066CNV Loss18288195
    dgv2520n71CNV Loss21882294
    dgv2514n71CNV Loss21882294
    dgv2505n71CNV Loss21882294
    dgv2504n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C1QTNF8 for disorders           About MalaCards
    OMIM gene information: 614147    OMIM disorders: --


    C1QTNF8 for disorders           About GeneDecksing


    Export disorders for C1QTNF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1QTNF8 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C1QTNF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. CTRP8 and CTRP9B are novel proteins that hetero-oligo merize with C1q/TNF family members. (PubMed id 19666007)1, 2 Peterson J.M....Wong G.W. (2009)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 390664 HGNC: 31374 AceView: C1QTNF8 Ensembl:ENSG00000184471 euGenes: HUgn390664
    ECgene: C1QTNF8 H-InvDB: C1QTNF8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1QTNF8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for C1QTNF8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C1QTNF8 gene:
    Search GeneIP for patents involving C1QTNF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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