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C1QTNF8 Gene

protein-coding   GIFtS: 38
GCID: GC16M001138

C1q And Tumor Necrosis Factor Related Protein 8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C1q And Tumor Necrosis Factor Related Protein 81 2
CTRP82 3 5
C1q/TNF-Related Protein 82 3
UNQ58292
Complement C1q Tumor Necrosis Factor-Related Protein 82

External Ids:    HGNC: 313741   Entrez Gene: 3906642   Ensembl: ENSG000001844717   OMIM: 6141475   UniProtKB: P608273   

Export aliases for C1QTNF8 gene to outside databases

Previous GC identifers: GC16M001078 GC16M001069


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1QTNF8 Gene:
C1QTNF8 (C1q and tumor necrosis factor related protein 8) is a protein-coding gene. An important paralog of this gene is C1QTNF6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1QTNF8 gene promoter:
         Bach2   Pax-2   CUTL1   Pax-2a   c-Ets-1   HSF2   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): C1QTNF8 promoter sequence
   Search Chromatin IP Primers for C1QTNF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1QTNF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

C1QTNF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1QTNF8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001138:  view genomic region     (about GC identifiers)

Start:
1,138,226 bp from pter      End:
1,146,244 bp from pter
Size:
8,019 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: C1QT8_HUMAN, P60827 (See protein sequence)
Recommended Name: Complement C1q tumor necrosis factor-related protein 8 precursor  
Size: 252 amino acids; 27685 Da
Subunit: Homotrimer. Forms heteromeric complexes with C1QL1
Sequence caution: Sequence=AAQ89191.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which does
not match the genome; Sequence=ACJ46463.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which
does not match the genome;
Secondary accessions: B7U178

Explore the universe of human proteins at neXtProt for C1QTNF8: NX_P60827

Explore proteomics data for C1QTNF8 at MOPED

Post-translational modifications: 

  • No N-glycosylation1
  • Modification sites at neXtProt

  • See C1QTNF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_997302.2  
    ENSEMBL proteins: 
     ENSP00000330426  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR008160 Collagen
     IPR001073 C1q

    Graphical View of Domain Structure for InterPro Entry P60827

    ProtoNet protein and cluster: P60827

    2 Blocks protein domains:
    IPB001073 Complement C1q protein
    IPB008160 Collagen triple helix repeat


    UniProtKB/Swiss-Prot: C1QT8_HUMAN, P60827
    Similarity: Contains 1 C1q domain
    Similarity: Contains 1 collagen-like domain


    Find genes that share domains with C1QTNF8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with C1QTNF8           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C1QT8_HUMAN, P60827: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005581collagen IEA--

    Find genes that share ontologies with C1QTNF8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1QTNF8
    Interactions:

        Search GeneGlobe Interaction Network for C1QTNF8

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1QTNF8 (C1QT8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C1QTNF8 gene: 
    NM_207419.3  

    Unigene Cluster for C1QTNF8:

    C1q and tumor necrosis factor related protein 8
    Hs.527853  [show with all ESTs]
    Unigene Representative Sequence: NM_207419
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328449(uc010uuw.1)
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      QuantiFast Probe-based Assays in human, mouse, rat C1QTNF8

    Additional mRNA sequence: 

    AY358832.1 FJ422561.1 

    2 DOTS entries:

    DT.99952480  DT.120661174 

    3 AceView cDNA sequences:

    NM_207419 AY358832 BG926615 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C1QTNF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTTTATC
    C1QTNF8 Expression
    About this image

    C1QTNF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1QTNF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.527853

    UniProtKB/Swiss-Prot: C1QT8_HUMAN, P60827
    Tissue specificity: Expressed predominantly in lung and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C1QTNF8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    48(a)
    1 → many
    8(91944216-91955964)
    chicken
    (Gallus gallus)
    Aves C1QTNF81 C1q and tumor necrosis factor related protein 8 65.07(n)
    61.57(a)
      427666  XM_425240.3  XP_425240.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    49(a)
    1 → many
    5(22810719-22820350)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.85982 Transcribed sequence with weak similarity to protein more 75.66(n)    CF377658.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01084570.16
    c1qtnf6a6
    C1q and tumor necrosis factor related protein 6a
    47(a)
    47(a)
    many ↔ many
    many ↔ many
    6(164068-167270) ENSDARG00000006544
    3(25318057-25323929) ENSDARG00000055175


    ENSEMBL Gene Tree for C1QTNF8 (if available)
    TreeFam Gene Tree for C1QTNF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C1QTNF8 gene
    C1QTNF62  C1QB2  COL10A12  C1QTNF12  C1QTNF9B2  C1QA2  C1QTNF42  COL8A22  
    C1QTNF92  C1QTNF52  COL8A12  OTOL12  C1QTNF72  C1QC2  C1QTNF22  ADIPOQ2  
    3 SIMAP similar genes for C1QTNF8 using alignment to 1 protein entry:     C1QT8_HUMAN:
    C1QTNF6    dJ151B14.4    C1QTNF1

    Find genes that share paralogs with C1QTNF8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C1QTNF8 (see all 406)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815060151,2
    --1137762(+) AGGACA/GGCTTG 1 -- ds50010--------
    rs1172610591,2
    C,F--1137936(+) CAGGTG/ATCCAT 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1864736881,2
    --1137945(+) ATCAAC/TAAACA 1 -- ds50010--------
    rs1912024171,2
    --1137995(+) TACTTG/TTGTGA 1 -- ds50010--------
    rs27295861,2
    C,F--1138075(-) TCCCCA/GTCCAC 1 -- ds50016Minor allele frequency- G:0.39NA WA CSA 245
    rs27451241,2
    C--1138076(+) TGGATG/AGGGAG 1 -- ds50013Minor allele frequency- A:0.23WA NA 240
    rs782345811,2
    F--1138130(+) GGAACC/TGTTTG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1819227881,2
    --1138265(+) TAAACA/GGATAA 1 -- ut310--------
    rs781994261,2
    F--1138349(+) CGCGTC/TCCCCA 1 -- ut310--------
    rs1471653731,2
    --1138368(+) CTGTGC/TGGTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for C1QTNF8 (1138226 - 1146244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for C1QTNF8 (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    esv1360970CNV Insertion17803354
    dgv2510n71CNV Loss21882294
    nsv904932CNV Loss21882294
    nsv457323CNV Loss19166990
    nsv471066CNV Loss18288195
    dgv2520n71CNV Loss21882294
    dgv2514n71CNV Loss21882294
    dgv2505n71CNV Loss21882294
    dgv2504n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614147    OMIM disorders: --


    Find genes that share disorders with C1QTNF8           About GenesLikeMe


    Export disorders for C1QTNF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C1QTNF8 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C1QTNF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members. (PubMed id 19666007)1, 2 Peterson J.M.... Wong G.W. (Biochem. Biophys. Res. Commun. 2009)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390664 HGNC: 31374 AceView: C1QTNF8 Ensembl:ENSG00000184471 euGenes: HUgn390664
    ECgene: C1QTNF8 H-InvDB: C1QTNF8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C1QTNF8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for C1QTNF8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C1QTNF8 gene:
    Search GeneIP for patents involving C1QTNF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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