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Aliases for C1QTNF8 Gene

Aliases for C1QTNF8 Gene

  • C1q And Tumor Necrosis Factor Related Protein 8 2 3 5
  • C1q/TNF-Related Protein 8 3 4
  • CTRP8 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 8 3
  • UNQ5829 3

External Ids for C1QTNF8 Gene

Previous GeneCards Identifiers for C1QTNF8 Gene

  • GC16M001078
  • GC16M001069
  • GC16M001138

Summaries for C1QTNF8 Gene

GeneCards Summary for C1QTNF8 Gene

C1QTNF8 (C1q And Tumor Necrosis Factor Related Protein 8) is a Protein Coding gene. Diseases associated with C1QTNF8 include Brain Cancer. An important paralog of this gene is C1QTNF6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF8 Gene

Genomics for C1QTNF8 Gene

Regulatory Elements for C1QTNF8 Gene

Enhancers for C1QTNF8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F001098 0.2 ENCODE 0.8 -2.5 -2471 0.1 SMARCA4 ZNF341 GLIS1 ZSCAN29 ZIC2 C1QTNF8 ENSG00000260702
GH16F001093 0.2 ENCODE 0.8 +2.7 2731 0.2 RING1 KLF1 ESRRA ARID4B DMAP1 HBP1 HIC1 ZFHX2 ADNP NR2F6 IFT140 LOC105371038 HN1L NME3 CCDC154 ENSG00000262528 ENSG00000268836 EME2 C1QTNF8 SSTR5-AS1
GH16F001100 0.3 FANTOM5 0.8 -3.9 -3927 0.4 KLF1 KLF17 ZIC2 HIC1 GLIS2 ZFHX2 GLIS1 SCRT2 EGR2 C1QTNF8 ENSG00000260702
GH16F001094 0.6 ENCODE 0.8 +2.1 2081 0.1 RNF2 SP2 REST ZNF600 KDM1A C1QTNF8 SSTR5-AS1
GH16F001095 0.2 ENCODE 0.8 +2.4 2391 0.2 RING1 TBP ZNF146 RNF2 NRF1 ARID4B DMAP1 HBP1 KDM6A ZHX1 IFT140 LOC105371038 HN1L NME3 CCDC154 ENSG00000262528 ENSG00000268836 EME2 C1QTNF8 SSTR5-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C1QTNF8 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1QTNF8 Gene

Chromosome:
16
Start:
1,088,226 bp from pter
End:
1,096,306 bp from pter
Size:
8,081 bases
Orientation:
Minus strand

Genomic View for C1QTNF8 Gene

Genes around C1QTNF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF8 Gene

Proteins for C1QTNF8 Gene

  • Protein details for C1QTNF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60827-C1QT8_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 8
    Protein Accession:
    P60827
    Secondary Accessions:
    • B7U178

    Protein attributes for C1QTNF8 Gene

    Size:
    252 amino acids
    Molecular mass:
    27685 Da
    Quaternary structure:
    • Homotrimer. Forms heteromeric complexes with C1QL1.
    SequenceCaution:
    • Sequence=AAQ89191.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which does not match the genome.; Evidence={ECO:0000305}; Sequence=ACJ46463.1; Type=Miscellaneous discrepancy; Note=Contains a 30 bp insertion which does not match the genome.; Evidence={ECO:0000305};

neXtProt entry for C1QTNF8 Gene

Post-translational modifications for C1QTNF8 Gene

Other Protein References for C1QTNF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QTNF8 Gene

Domains & Families for C1QTNF8 Gene

Gene Families for C1QTNF8 Gene

Suggested Antigen Peptide Sequences for C1QTNF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60827

UniProtKB/Swiss-Prot:

C1QT8_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QTNF8: view

Function for C1QTNF8 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19666007
genes like me logo Genes that share ontologies with C1QTNF8: view
genes like me logo Genes that share phenotypes with C1QTNF8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF8 Gene

Localization for C1QTNF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1QTNF8 Gene COMPARTMENTS Subcellular localization image for C1QTNF8 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C1QTNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QTNF8: view

Pathways & Interactions for C1QTNF8 Gene

SuperPathways for C1QTNF8 Gene

No Data Available

Interacting Proteins for C1QTNF8 Gene

Gene Ontology (GO) - Biological Process for C1QTNF8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF8 Gene

Transcripts for C1QTNF8 Gene

mRNA/cDNA for C1QTNF8 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QTNF8 Gene

C1q and tumor necrosis factor related protein 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF8 Gene

No ASD Table

Relevant External Links for C1QTNF8 Gene

GeneLoc Exon Structure for
C1QTNF8
ECgene alternative splicing isoforms for
C1QTNF8

Expression for C1QTNF8 Gene

mRNA expression in normal human tissues for C1QTNF8 Gene

mRNA differential expression in normal tissues according to GTEx for C1QTNF8 Gene

This gene is overexpressed in Artery - Aorta (x11.9), Pituitary (x11.1), and Fallopian Tube (x6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF8 Gene



Protein tissue co-expression partners for C1QTNF8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF8 Gene:

C1QTNF8

SOURCE GeneReport for Unigene cluster for C1QTNF8 Gene:

Hs.527853

mRNA Expression by UniProt/SwissProt for C1QTNF8 Gene:

P60827-C1QT8_HUMAN
Tissue specificity: Expressed predominantly in lung and testis.
genes like me logo Genes that share expression patterns with C1QTNF8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for C1QTNF8 Gene

Orthologs for C1QTNF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF8 34 35
  • 98.54 (n)
cow
(Bos Taurus)
Mammalia C1QTNF8 34 35
  • 85.78 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves C1QTNF8 34
  • 65.07 (n)
-- 35
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf1 34
  • 59.77 (n)
Str.8598 34
zebrafish
(Danio rerio)
Actinopterygii c1qtnf6a 35
  • 47 (a)
ManyToMany
CABZ01084570.1 35
  • 47 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
OneToMany
Species where no ortholog for C1QTNF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF8 Gene

ENSEMBL:
Gene Tree for C1QTNF8 (if available)
TreeFam:
Gene Tree for C1QTNF8 (if available)

Paralogs for C1QTNF8 Gene

(3) SIMAP similar genes for C1QTNF8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QTNF8: view

Variants for C1QTNF8 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111400035 -- 1,091,331(+) GCTCC(C/T)GCCCG intron-variant
rs111448848 -- 1,092,439(+) TCAAC(A/C)AATCA intron-variant
rs111465135 -- 1,093,191(+) GCGCT(-/CAAC)CAATC intron-variant
rs111493318 -- 1,093,299(+) GTCGG(C/T)GCTCA intron-variant
rs111525619 -- 1,092,697(+) AATCC(C/G)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF8 Gene

Variant ID Type Subtype PubMed ID
dgv2691n100 CNV gain 25217958
dgv2692n100 CNV gain 25217958
esv1360970 CNV insertion 17803354
esv2422427 CNV duplication 17116639
esv3364240 CNV duplication 20981092
esv3637603 CNV gain 21293372
nsv1046885 CNV gain 25217958
nsv1160327 CNV deletion 26073780
nsv428316 CNV gain+loss 18775914
nsv457315 CNV gain 19166990
nsv457323 CNV loss 19166990
nsv471066 CNV loss 18288195
nsv471067 CNV gain 18288195
nsv571046 CNV gain 21841781
nsv571092 CNV gain 21841781
nsv571100 CNV loss 21841781
nsv571101 CNV gain 21841781
nsv571102 CNV loss 21841781
nsv833116 CNV loss 17160897
nsv952898 CNV deletion 24416366

Variation tolerance for C1QTNF8 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF8 Gene

Disorders for C1QTNF8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1QTNF8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C1QTNF8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QTNF8
genes like me logo Genes that share disorders with C1QTNF8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QTNF8 Gene

Publications for C1QTNF8 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members. (PMID: 19666007) Peterson J.M. … Wong G.W. (Biochem. Biophys. Res. Commun. 2009) 3 4 64
  3. C1q-tumor necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. (PMID: 24014093) Glogowska A. … Klonisch T. (J. Pathol. 2013) 3 64
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64

Products for C1QTNF8 Gene

Sources for C1QTNF8 Gene

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