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Aliases for C1QTNF7 Gene

Aliases for C1QTNF7 Gene

  • C1q And Tumor Necrosis Factor Related Protein 7 2 3 5
  • CTRP7 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 7 3
  • Complement-C1q Tumor Necrosis Factor-Related Protein 7 3
  • ZACRP7 3

External Ids for C1QTNF7 Gene

Previous GeneCards Identifiers for C1QTNF7 Gene

  • GC04P015156
  • GC04P015029
  • GC04P015092
  • GC04P015017
  • GC04P014691

Summaries for C1QTNF7 Gene

GeneCards Summary for C1QTNF7 Gene

C1QTNF7 (C1q And Tumor Necrosis Factor Related Protein 7) is a Protein Coding gene. An important paralog of this gene is C1QTNF2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF7 Gene

Genomics for C1QTNF7 Gene

Regulatory Elements for C1QTNF7 Gene

Enhancers for C1QTNF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C1QTNF7 on UCSC Golden Path with GeneCards custom track

Promoters for C1QTNF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C1QTNF7 Gene

Chromosome:
4
Start:
15,339,818 bp from pter
End:
15,446,169 bp from pter
Size:
106,352 bases
Orientation:
Plus strand

Genomic View for C1QTNF7 Gene

Genes around C1QTNF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF7 Gene

Proteins for C1QTNF7 Gene

  • Protein details for C1QTNF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ2-C1QT7_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 7
    Protein Accession:
    Q9BXJ2
    Secondary Accessions:
    • B2RBT3
    • J3KPW3

    Protein attributes for C1QTNF7 Gene

    Size:
    289 amino acids
    Molecular mass:
    30683 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QTNF7 Gene

Post-translational modifications for C1QTNF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QTNF7 Gene

No data available for DME Specific Peptides for C1QTNF7 Gene

Domains & Families for C1QTNF7 Gene

Protein Domains for C1QTNF7 Gene

Suggested Antigen Peptide Sequences for C1QTNF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXJ2

UniProtKB/Swiss-Prot:

C1QT7_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QTNF7: view

No data available for Gene Families for C1QTNF7 Gene

Function for C1QTNF7 Gene

genes like me logo Genes that share phenotypes with C1QTNF7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF7

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF7 Gene

Localization for C1QTNF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1QTNF7 Gene COMPARTMENTS Subcellular localization image for C1QTNF7 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C1QTNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QTNF7: view

Pathways & Interactions for C1QTNF7 Gene

SuperPathways for C1QTNF7 Gene

No Data Available

Interacting Proteins for C1QTNF7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295297%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000295297 Q9BXJ2-C1QT7_HUMAN for C1QTNF7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C1QTNF7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF7 Gene

Drugs & Compounds for C1QTNF7 Gene

No Compound Related Data Available

Transcripts for C1QTNF7 Gene

Unigene Clusters for C1QTNF7 Gene

C1q and tumor necrosis factor related protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5:
SP6:

Relevant External Links for C1QTNF7 Gene

GeneLoc Exon Structure for
C1QTNF7
ECgene alternative splicing isoforms for
C1QTNF7

Expression for C1QTNF7 Gene

mRNA expression in normal human tissues for C1QTNF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QTNF7 Gene

This gene is overexpressed in Artery - Tibial (x5.6).

Protein differential expression in normal tissues from HIPED for C1QTNF7 Gene

This gene is overexpressed in Pancreas (35.6), Prostate (15.8), Gallbladder (7.1), and Urinary Bladder (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C1QTNF7 Gene



NURSA nuclear receptor signaling pathways regulating expression of C1QTNF7 Gene:

C1QTNF7

SOURCE GeneReport for Unigene cluster for C1QTNF7 Gene:

Hs.153714
genes like me logo Genes that share expression patterns with C1QTNF7: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C1QTNF7 Gene

Orthologs for C1QTNF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1QTNF7 34
  • 91.93 (n)
  • 97.23 (a)
C1QTNF7 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1QTNF7 34
  • 92.45 (n)
  • 95.95 (a)
C1QTNF7 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C1qtnf7 34
  • 87.95 (n)
  • 95.95 (a)
C1qtnf7 16
C1qtnf7 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF7 34
  • 99.77 (n)
  • 100 (a)
C1QTNF7 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C1qtnf7 34
  • 89.39 (n)
  • 96.89 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia C1QTNF7 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1QTNF7 34
  • 80.16 (n)
  • 86.85 (a)
C1QTNF7 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1QTNF7 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf7 34
  • 73.08 (n)
  • 79.02 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC564609 34
  • 64.79 (n)
  • 66.9 (a)
CABZ01048675.1 35
  • 67 (a)
OneToOne
Species where no ortholog for C1QTNF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF7 Gene

ENSEMBL:
Gene Tree for C1QTNF7 (if available)
TreeFam:
Gene Tree for C1QTNF7 (if available)

Paralogs for C1QTNF7 Gene

(8) SIMAP similar genes for C1QTNF7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QTNF7: view

Variants for C1QTNF7 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1029972 -- 15,437,158(+) TAACA(C/T)CAGGA intron-variant
rs1029973 -- 15,437,227(+) acaaa(C/T)aaaca intron-variant
rs768031 -- 15,443,409(-) CACTA(G/T)CCCAT utr-variant-3-prime
rs768032 -- 15,443,448(-) CTGCT(C/T)ATCAC utr-variant-3-prime
rs768033 -- 15,443,285(-) AATAA(C/T)AAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF7 Gene

Variant ID Type Subtype PubMed ID
esv2623009 CNV insertion 19546169
esv2759227 CNV gain+loss 17122850
esv3599738 CNV loss 21293372

Variation tolerance for C1QTNF7 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF7 Gene

Disorders for C1QTNF7 Gene

Relevant External Links for C1QTNF7

Genetic Association Database (GAD)
C1QTNF7
Human Genome Epidemiology (HuGE) Navigator
C1QTNF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QTNF7

No disorders were found for C1QTNF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF7 Gene

Publications for C1QTNF7 Gene

  1. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick D.M. … Bierut L. (Mol. Psychiatry 2011) 3 46 65
  2. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PMID: 19344414) Cerhan J.R. … Slager S.L. (Br. J. Haematol. 2009) 3 46 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3 65
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3 65

Products for C1QTNF7 Gene

Sources for C1QTNF7 Gene

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