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Aliases for C1QTNF6 Gene

Aliases for C1QTNF6 Gene

  • C1q And Tumor Necrosis Factor Related Protein 6 2 3 5
  • CTRP6 3 4
  • Complement-C1q Tumor Necrosis Factor-Related Protein 6 3
  • ZACRP6 3
  • CTFP6 3

External Ids for C1QTNF6 Gene

Previous GeneCards Identifiers for C1QTNF6 Gene

  • GC22M034190
  • GC22M035819
  • GC22M035900
  • GC22M037576
  • GC22M020541

Summaries for C1QTNF6 Gene

GeneCards Summary for C1QTNF6 Gene

C1QTNF6 (C1q And Tumor Necrosis Factor Related Protein 6) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is COL8A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF6 Gene

Genomics for C1QTNF6 Gene

Regulatory Elements for C1QTNF6 Gene

Enhancers for C1QTNF6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C1QTNF6 on UCSC Golden Path with GeneCards custom track

Promoters for C1QTNF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1QTNF6 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1QTNF6 Gene

37,180,166 bp from pter
37,199,385 bp from pter
19,220 bases
Minus strand

Genomic View for C1QTNF6 Gene

Genes around C1QTNF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF6 Gene

Proteins for C1QTNF6 Gene

  • Protein details for C1QTNF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5H9G8
    • Q6ZRM7

    Protein attributes for C1QTNF6 Gene

    259 amino acids
    Molecular mass:
    28669 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF6 Gene


neXtProt entry for C1QTNF6 Gene

Proteomics data for C1QTNF6 Gene at MOPED

Post-translational modifications for C1QTNF6 Gene

  • Glycosylation at Asn 72
  • Modification sites at PhosphoSitePlus

Other Protein References for C1QTNF6 Gene

Antibody Products

  • Abcam antibodies for CTRP6

No data available for DME Specific Peptides for C1QTNF6 Gene

Domains & Families for C1QTNF6 Gene

Suggested Antigen Peptide Sequences for C1QTNF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C1q domain.
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QTNF6: view

No data available for Gene Families for C1QTNF6 Gene

Function for C1QTNF6 Gene

genes like me logo Genes that share phenotypes with C1QTNF6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF6

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1QTNF6 Gene

Localization for C1QTNF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF6 Gene


Subcellular locations from

Jensen Localization Image for C1QTNF6 Gene COMPARTMENTS Subcellular localization image for C1QTNF6 gene
Compartment Confidence
extracellular 3
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C1QTNF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1QTNF6: view

Pathways & Interactions for C1QTNF6 Gene

SuperPathways for C1QTNF6 Gene

No Data Available

Interacting Proteins for C1QTNF6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000338812 Q9BXI9-C1QT6_HUMAN for C1QTNF6 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for C1QTNF6 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1QTNF6 Gene

Drugs & Compounds for C1QTNF6 Gene

No Compound Related Data Available

Transcripts for C1QTNF6 Gene

Unigene Clusters for C1QTNF6 Gene

C1q and tumor necrosis factor related protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6
SP1: - - -
SP2: -
SP3: - - - -
SP5: - - -

Relevant External Links for C1QTNF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1QTNF6 Gene

mRNA expression in normal human tissues for C1QTNF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1QTNF6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C1QTNF6 Gene

SOURCE GeneReport for Unigene cluster for C1QTNF6 Gene Hs.22011

genes like me logo Genes that share expression patterns with C1QTNF6: view

Protein tissue co-expression partners for C1QTNF6 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C1QTNF6 Gene

Orthologs for C1QTNF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C1QTNF6 35
  • 81.93 (n)
  • 72.69 (a)
C1QTNF6 36
  • 69 (a)
(Canis familiaris)
Mammalia C1QTNF6 35
  • 82.7 (n)
  • 76.37 (a)
C1QTNF6 36
  • 70 (a)
(Mus musculus)
Mammalia C1qtnf6 35
  • 75.8 (n)
  • 69.5 (a)
C1qtnf6 16
C1qtnf6 36
  • 67 (a)
(Pan troglodytes)
Mammalia C1QTNF6 35
  • 99.04 (n)
  • 99.64 (a)
C1QTNF6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia C1qtnf6 35
  • 76.49 (n)
  • 70.93 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
(Gallus gallus)
Aves C1QTNF6 35
  • 63.99 (n)
  • 58.63 (a)
-- 36
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
(Danio rerio)
Actinopterygii c1qtnf6a 35
  • 64.36 (n)
  • 58.99 (a)
c1qtnf6a 36
  • 51 (a)
CABZ01084570.1 36
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
Species with no ortholog for C1QTNF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF6 Gene

Gene Tree for C1QTNF6 (if available)
Gene Tree for C1QTNF6 (if available)

Paralogs for C1QTNF6 Gene

(5) SIMAP similar genes for C1QTNF6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QTNF6: view

Variants for C1QTNF6 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs229527 - 37,185,445(-) CATGG(G/T)GACAG reference, missense
rs229526 - 37,185,382(-) GATCC(A/C/G)TATGG reference, missense
rs7290488 - 37,185,343(+) GGCAG(C/T)CGCTG reference, missense
rs17812699 - 37,182,612(+) GGCAC(A/G)GGGCG reference, missense
rs17812681 - 37,182,348(+) TGCTG(C/T)GCTCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF6 Gene

Variant ID Type Subtype PubMed ID
esv34015 CNV Loss 18971310
nsv829203 CNV Loss 20364138
nsv915018 CNV Loss 21882294
nsv915019 CNV Loss 21882294
nsv915020 CNV Loss 21882294

Variation tolerance for C1QTNF6 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.72; 97.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C1QTNF6 Gene

Disorders for C1QTNF6 Gene

Relevant External Links for C1QTNF6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C1QTNF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF6 Gene

Publications for C1QTNF6 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation. (PMID: 25962701) Lei H. … Wu L.L. (Basic Res. Cardiol. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J. … Thomson W. (Pharmacogenomics J. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for C1QTNF6 Gene

Sources for C1QTNF6 Gene