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Aliases for C1QTNF6 Gene

Aliases for C1QTNF6 Gene

  • C1q And TNF Related 6 2 3
  • C1q And Tumor Necrosis Factor Related Protein 6 2 3 5
  • CTRP6 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 6 3
  • Complement-C1q Tumor Necrosis Factor-Related Protein 6 3
  • ZACRP6 3
  • CTFP6 3

External Ids for C1QTNF6 Gene

Previous GeneCards Identifiers for C1QTNF6 Gene

  • GC22M034190
  • GC22M035819
  • GC22M035900
  • GC22M037576
  • GC22M020541

Summaries for C1QTNF6 Gene

GeneCards Summary for C1QTNF6 Gene

C1QTNF6 (C1q And TNF Related 6) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is C1QTNF8.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF6 Gene

Genomics for C1QTNF6 Gene

Regulatory Elements for C1QTNF6 Gene

Enhancers for C1QTNF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G037191 1.6 Ensembl ENCODE dbSUPER 27.5 +2.9 2908 9.5 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 C1QTNF6 IL2RB ENSG00000235237 TMPRSS6 ENSG00000231467 CYTH4 SSTR3 GC22M037168
GH22G037182 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +12.5 12523 8.6 PKNOX1 ZNF121 GLIS2 GATA2 FOS ZNF263 SP3 NFYC REST ZNF623 C1QTNF6 ENSG00000235237 TMPRSS6 ENSG00000231467 CYTH4 ENSG00000226233 ENSG00000229971 IL2RB GC22M037168
GH22G037211 1.6 Ensembl ENCODE dbSUPER 26.3 -13.0 -13032 1.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B C1QTNF6 IL2RB RPS15AP38 ENSG00000226233
GH22G037175 1.4 Ensembl ENCODE dbSUPER 21.3 +21.0 20982 6.0 HDAC1 ELF3 ATF1 NFIB CREB3L1 AGO1 RAD21 RARA YY1 ZNF121 C1QTNF6 TMPRSS6 ENSG00000231467 CYTH4 SSTR3 ENSG00000226233 IL2RB GC22M037168
GH22G037204 0.9 dbSUPER 20.9 -6.4 -6408 3.1 TBP FOXA2 PKNOX1 INSM2 ZNF48 YY1 ZEB1 ZNF121 SCRT2 THAP11 C1QTNF6 ENSG00000235237 IL2RB TMPRSS6 ENSG00000231467 TEX33 ENSG00000226233
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1QTNF6 on UCSC Golden Path with GeneCards custom track

Promoters for C1QTNF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000145956 185 1201 HDGF PKNOX1 MLX CREB3L1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for C1QTNF6 Gene

Chromosome:
22
Start:
37,180,166 bp from pter
End:
37,199,385 bp from pter
Size:
19,220 bases
Orientation:
Minus strand

Genomic View for C1QTNF6 Gene

Genes around C1QTNF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF6 Gene

Proteins for C1QTNF6 Gene

  • Protein details for C1QTNF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXI9-C1QT6_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 6
    Protein Accession:
    Q9BXI9
    Secondary Accessions:
    • Q5H9G8
    • Q6ZRM7

    Protein attributes for C1QTNF6 Gene

    Size:
    259 amino acids
    Molecular mass:
    28669 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QTNF6 Gene

Post-translational modifications for C1QTNF6 Gene

  • Glycosylation at posLast=7272
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C1QTNF6 Gene

Domains & Families for C1QTNF6 Gene

Gene Families for C1QTNF6 Gene

Suggested Antigen Peptide Sequences for C1QTNF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QTNF6: view

No data available for UniProtKB/Swiss-Prot for C1QTNF6 Gene

Function for C1QTNF6 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QTNF6: view
genes like me logo Genes that share phenotypes with C1QTNF6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF6

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1QTNF6 Gene

Localization for C1QTNF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF6 gene
Compartment Confidence
extracellular 3
plasma membrane 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for C1QTNF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1QTNF6: view

Pathways & Interactions for C1QTNF6 Gene

SuperPathways for C1QTNF6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1QTNF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051259 protein oligomerization IEA --
GO:0070208 protein heterotrimerization IEA --
genes like me logo Genes that share ontologies with C1QTNF6: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF6 Gene

Drugs & Compounds for C1QTNF6 Gene

No Compound Related Data Available

Transcripts for C1QTNF6 Gene

Unigene Clusters for C1QTNF6 Gene

C1q and tumor necrosis factor related protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6
SP1: - - -
SP2: -
SP3: - - - -
SP4:
SP5: - - -

Relevant External Links for C1QTNF6 Gene

GeneLoc Exon Structure for
C1QTNF6
ECgene alternative splicing isoforms for
C1QTNF6

Expression for C1QTNF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QTNF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1QTNF6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C1QTNF6 Gene



Protein tissue co-expression partners for C1QTNF6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF6 Gene:

C1QTNF6

SOURCE GeneReport for Unigene cluster for C1QTNF6 Gene:

Hs.22011
genes like me logo Genes that share expression patterns with C1QTNF6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF6 Gene

Orthologs for C1QTNF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF6 34 35
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia C1QTNF6 34 35
  • 82.7 (n)
cow
(Bos Taurus)
Mammalia C1QTNF6 34 35
  • 81.93 (n)
rat
(Rattus norvegicus)
Mammalia C1qtnf6 34
  • 76.49 (n)
mouse
(Mus musculus)
Mammalia C1qtnf6 34 16 35
  • 75.8 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves C1QTNF6 34
  • 63.99 (n)
-- 35
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii c1qtnf6a 34 35
  • 64.36 (n)
CABZ01084570.1 35
  • 49 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
OneToMany
Species where no ortholog for C1QTNF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF6 Gene

ENSEMBL:
Gene Tree for C1QTNF6 (if available)
TreeFam:
Gene Tree for C1QTNF6 (if available)

Paralogs for C1QTNF6 Gene

(5) SIMAP similar genes for C1QTNF6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QTNF6: view

Variants for C1QTNF6 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000110474 -- 37,188,348(+) AGAGC(C/T)GCTTC intron-variant, upstream-variant-2KB
rs1000167599 -- 37,195,061(+) AGAAG(A/C)AAGCT intron-variant
rs1000399092 -- 37,188,603(+) AGCTA(A/G)AGTGC intron-variant, upstream-variant-2KB
rs1000438586 -- 37,180,434(+) GTTTG(A/G)AAGGC utr-variant-3-prime
rs1000533829 -- 37,191,295(+) TAATG(A/T)CCATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF6 Gene

Variant ID Type Subtype PubMed ID
esv34015 CNV loss 18971310
nsv829203 CNV loss 20364138

Variation tolerance for C1QTNF6 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.72; 97.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF6 Gene

Disorders for C1QTNF6 Gene

Relevant External Links for C1QTNF6

Genetic Association Database (GAD)
C1QTNF6
Human Genome Epidemiology (HuGE) Navigator
C1QTNF6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QTNF6

No disorders were found for C1QTNF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF6 Gene

Publications for C1QTNF6 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N. … Do C.B. (PLoS ONE 2012) 3 46 64
  3. Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. (PMID: 20203524) Pierce B.L. … Ahsan H. (Hum. Hered. 2010) 3 46 64
  4. Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. (PMID: 20410501) Jin Y. … Spritz R.A. (N. Engl. J. Med. 2010) 3 46 64
  5. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PMID: 19430480) Barrett J.C. … Rich S.S. (Nat. Genet. 2009) 3 46 64

Products for C1QTNF6 Gene

Sources for C1QTNF6 Gene

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