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Aliases for C1QTNF4 Gene

Aliases for C1QTNF4 Gene

  • C1q And TNF Related 4 2 3
  • C1q And Tumor Necrosis Factor Related Protein 4 2 3 5
  • Complement-C1q Tumor Necrosis Factor-Related Protein 4 2 3
  • CTRP4 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 4 3
  • ZACRP4 3

External Ids for C1QTNF4 Gene

Previous GeneCards Identifiers for C1QTNF4 Gene

  • GC11M049522
  • GC11M048488
  • GC11M047643
  • GC11M047575
  • GC11M047567
  • GC11M047611
  • GC11M047312
  • GC11M047838
  • GC11M047957
  • GC11M050805
  • GC11M051600
  • GC11M052262

Summaries for C1QTNF4 Gene

GeneCards Summary for C1QTNF4 Gene

C1QTNF4 (C1q And TNF Related 4) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is C1QTNF8.

UniProtKB/Swiss-Prot for C1QTNF4 Gene

  • May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF4 Gene

Genomics for C1QTNF4 Gene

Regulatory Elements for C1QTNF4 Gene

Enhancers for C1QTNF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G047506 1.9 FANTOM5 Ensembl ENCODE dbSUPER 43.7 +81.1 81078 14.4 HDGF PKNOX1 WRNIP1 ZFP64 SIN3A FEZF1 ZNF2 FOS JUNB REST FNBP4 NUP160 ENSG00000200090 C1QTNF4 SLC39A13 CELF1 ENSG00000270060 DDB2 NDUFS3 PTPMT1
GH11G047521 1.4 Ensembl ENCODE dbSUPER 43.1 +70.4 70444 4.8 HDGF PKNOX1 SIN3A FEZF1 YY1 FOS DEK ZNF263 JUNB ZNF579 C1QTNF4 PTPMT1 NDUFS3 CELF1 FAM180B ENSG00000231880 RNU5E-10P C11orf49 ENSG00000270072 RN7SL652P
GH11G047387 2 FANTOM5 Ensembl ENCODE dbSUPER 26.6 +202.5 202450 8.8 HDGF CREB3L1 AGO1 SIN3A FEZF1 ZNF766 ZNF143 ZNF207 FOS DEK SPI1 C1QTNF4 MYBPC3 FNBP4 CELF1 ENSG00000255197 PSMC3 LRP4 MADD GC11M053136
GH11G047424 1.4 ENCODE dbSUPER 37.1 +168.5 168468 3.7 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 C1QTNF4 C11orf49 KBTBD4 FNBP4 ACP2 PSMC3 ENSG00000255197 PTPRJ GC11M053511 GC11M054024
GH11G047550 1.7 FANTOM5 ENCODE dbSUPER 30.4 +42.5 42473 3.8 HDGF PKNOX1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 C1QTNF4 C11orf49 RNU5E-10P ENSG00000231880 KBTBD4 FNBP4 CELF1 PTPRJ NR1H3 SPI1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1QTNF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1QTNF4 Gene

47,589,664 bp from pter
47,594,659 bp from pter
4,996 bases
Minus strand

Genomic View for C1QTNF4 Gene

Genes around C1QTNF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF4 Gene

Proteins for C1QTNF4 Gene

  • Protein details for C1QTNF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8IV25

    Protein attributes for C1QTNF4 Gene

    329 amino acids
    Molecular mass:
    35256 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1QTNF4 Gene

Post-translational modifications for C1QTNF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QTNF4 Gene

Antibody Products

  • R&D Systems Antibodies for C1QTNF4 (CTRP4/C1qTNF4)
  • Abcam antibodies for C1QTNF4
  • Santa Cruz Biotechnology (SCBT) Antibodies for C1QTNF4

No data available for DME Specific Peptides for C1QTNF4 Gene

Domains & Families for C1QTNF4 Gene

Gene Families for C1QTNF4 Gene

Protein Domains for C1QTNF4 Gene

Suggested Antigen Peptide Sequences for C1QTNF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QTNF4: view

No data available for UniProtKB/Swiss-Prot for C1QTNF4 Gene

Function for C1QTNF4 Gene

Molecular function for C1QTNF4 Gene

UniProtKB/Swiss-Prot Function:
May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL6.

Gene Ontology (GO) - Molecular Function for C1QTNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with C1QTNF4: view

Phenotypes for C1QTNF4 Gene

GenomeRNAi human phenotypes for C1QTNF4:
genes like me logo Genes that share phenotypes with C1QTNF4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF4

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF4 Gene

Localization for C1QTNF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF4 gene
Compartment Confidence
extracellular 4
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C1QTNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C1QTNF4: view

Pathways & Interactions for C1QTNF4 Gene

SuperPathways for C1QTNF4 Gene

No Data Available

Interacting Proteins for C1QTNF4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000302274 Q9BXJ3-C1QT4_HUMAN for C1QTNF4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C1QTNF4 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1QTNF4 Gene

Drugs & Compounds for C1QTNF4 Gene

No Compound Related Data Available

Transcripts for C1QTNF4 Gene

mRNA/cDNA for C1QTNF4 Gene

Unigene Clusters for C1QTNF4 Gene

C1q and tumor necrosis factor related protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF4 Gene

No ASD Table

Relevant External Links for C1QTNF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1QTNF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QTNF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QTNF4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.4), Brain - Putamen (basal ganglia) (x6.7), and Brain - Caudate (basal ganglia) (x5.6).

Protein differential expression in normal tissues from HIPED for C1QTNF4 Gene

This gene is overexpressed in Serum (63.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF4 Gene

Protein tissue co-expression partners for C1QTNF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF4 Gene:


SOURCE GeneReport for Unigene cluster for C1QTNF4 Gene:


mRNA Expression by UniProt/SwissProt for C1QTNF4 Gene:

Tissue specificity: Widely expressed at low levels.

Evidence on tissue expression from TISSUES for C1QTNF4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with C1QTNF4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF4 Gene

Orthologs for C1QTNF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1QTNF4 34 35
  • 99.19 (n)
(Canis familiaris)
Mammalia C1QTNF4 34 35
  • 92.99 (n)
(Mus musculus)
Mammalia C1qtnf4 34 16 35
  • 90.52 (n)
(Rattus norvegicus)
Mammalia C1qtnf4 34
  • 87.65 (n)
(Ornithorhynchus anatinus)
Mammalia C1QTNF4 35
  • 72 (a)
(Bos Taurus)
Mammalia MGC137014 35
  • 24 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 23 (a)
(Gallus gallus)
Aves C1QTNF4 34 35
  • 64.56 (n)
(Anolis carolinensis)
Reptilia C1QTNF4 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf4 34
  • 64.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26293 34
(Danio rerio)
Actinopterygii c1qtnf4 34 35
  • 66.15 (n)
wufi33h02 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
Species where no ortholog for C1QTNF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF4 Gene

Gene Tree for C1QTNF4 (if available)
Gene Tree for C1QTNF4 (if available)

Paralogs for C1QTNF4 Gene

genes like me logo Genes that share paralogs with C1QTNF4: view

Variants for C1QTNF4 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000508382 -- 47,596,730(+) TGGCT(C/T)ACTGC upstream-variant-2KB
rs1000518136 -- 47,591,342(+) AAAGT(G/T)CTGGG intron-variant
rs1000560398 -- 47,596,445(+) TTAAA(A/T)TTTTT upstream-variant-2KB
rs1001120002 -- 47,589,324(+) CACGC(C/T)CTGCT downstream-variant-500B
rs1001178393 -- 47,596,963(+) TCCCC(A/G)TCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF4 Gene

Variant ID Type Subtype PubMed ID
esv3579504 CNV loss 25503493
nsv509405 CNV insertion 20534489
nsv825872 CNV gain 20364138
nsv825873 CNV gain 20364138
nsv832142 CNV loss 17160897

Variation tolerance for C1QTNF4 Gene

Gene Damage Index Score: 2.62; 45.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF4 Gene

Disorders for C1QTNF4 Gene

Relevant External Links for C1QTNF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C1QTNF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF4 Gene

Publications for C1QTNF4 Gene

  1. Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappaB pathways and promotes cell survival in human cancer cells. (PMID: 21658842) Li Q. … Wang L. (Cancer Lett. 2011) 3 4 64
  2. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PMID: 16094384) Tao W.A. … Aebersold R. (Nat. Methods 2005) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. (PMID: 24366864) Byerly M.S. … Wong G.W. (J. Biol. Chem. 2014) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C1QTNF4 Gene

Sources for C1QTNF4 Gene

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