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C1QTNF4 Gene

protein-coding   GIFtS: 47
GCID: GC11M047611

C1q And Tumor Necrosis Factor Related Protein 4

  Search for C1QTNF4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C1q And Tumor Necrosis Factor Related Protein 41 2
CTRP42 3 5
Complement-C1q Tumor Necrosis Factor-Related Protein 41 2
ZACRP42
Complement C1q Tumor Necrosis Factor-Related Protein 42

External Ids:    HGNC: 143461   Entrez Gene: 1149002   Ensembl: ENSG000001722477   OMIM: 6149115   UniProtKB: Q9BXJ33   

Export aliases for C1QTNF4 gene to outside databases

Previous GC identifers: GC11M049522 GC11M048488 GC11M047643 GC11M047575 GC11M047567 GC11M047312


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C1QTNF4 Gene:
C1QTNF4 (C1q and tumor necrosis factor related protein 4) is a protein-coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is C1QTNF6.

UniProtKB/Swiss-Prot: C1QT4_HUMAN, Q9BXJ3
Function: May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and
up-regulates IL6 production




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1QTNF4 gene promoter:
         YY1   CREB   RORalpha1   deltaCREB   Zic1   ZID   AP-2alpha   Pax-4a   AP-2alphaA   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC1QTNF4 promoter sequence
   Search Chromatin IP Primers for C1QTNF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1QTNF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11q11

C1QTNF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1QTNF4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M047611:  view genomic region     (about GC identifiers)

Start:
47,611,216 bp from pter      End:
47,616,211 bp from pter
Size:
4,996 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: C1QT4_HUMAN, Q9BXJ3 (See protein sequence)
Recommended Name: Complement C1q tumor necrosis factor-related protein 4 precursor  
Size: 329 amino acids; 35256 Da
Secondary accessions: Q8IV25

Explore the universe of human proteins at neXtProt for C1QTNF4: NX_Q9BXJ3

Explore proteomics data for C1QTNF4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C1QTNF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114115.2  
    ENSEMBL proteins: 
     ENSP00000302274   ENSP00000434548  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR001073 C1q

    Graphical View of Domain Structure for InterPro Entry Q9BXJ3

    ProtoNet protein and cluster: Q9BXJ3

    1 Blocks protein domain: IPB001073 Complement C1q protein

    UniProtKB/Swiss-Prot: C1QT4_HUMAN, Q9BXJ3
    Similarity: Contains 2 C1q domains


    Find genes that share domains with C1QTNF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C1QT4_HUMAN, Q9BXJ3
    Function: May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and
    up-regulates IL6 production
    Induction: Up-regulated by IL6

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with C1QTNF4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1QTNF4
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C1QT4_HUMAN, Q9BXJ3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with C1QTNF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1QTNF4
    Interactions:

        Search GeneGlobe Interaction Network for C1QTNF4

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1QTNF4 (C1QT4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C1QTNF4 gene: 
    NM_031909.2  

    Unigene Cluster for C1QTNF4:

    C1q and tumor necrosis factor related protein 4
    Hs.662633  [show with all ESTs]
    Unigene Representative Sequence: BQ068291
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302514(uc001ngc.2) ENST00000530097
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat C1QTNF4
      QuantiFast Probe-based Assays in human, mouse, rat C1QTNF4

    Additional mRNA sequence: 

    AF329838.1 BC035628.1 

    2 DOTS entries:

    DT.97840210  DT.92047789 

    Selected AceView cDNA sequences (see all 32):

    CR614754 BC035628 BE857943 BI756346 CD107260 NM_031909 BF115527 BG716758 
    AF329838 CK823465 BM967211 AW163266 BM716779 AI209086 BI757600 AI878893 
    AI652297 BX459970 BX324410 BM543573 BM926070 AW204677 BF967925 BF967202 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C1QTNF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGCCGGG
    C1QTNF4 Expression
    About this image


    C1QTNF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    C1QTNF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1QTNF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.662633

    UniProtKB/Swiss-Prot: C1QT4_HUMAN, Q9BXJ3
    Tissue specificity: Widely expressed at low levels

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C1QTNF4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C1qtnf41 , 5 C1q and tumor necrosis factor related protein 41, 5 90.52(n)1
    94.89(a)1
      2 (50.43 cM)5
    674451  NM_026161.31  NP_080437.21 
     908858605 
    chicken
    (Gallus gallus)
    Aves C1QTNF41 C1q and tumor necrosis factor related protein 4 64.56(n)
    64.33(a)
      428863  XM_426420.4  XP_426420.4 
    lizard
    (Anolis carolinensis)
    Reptilia C1QTNF46
    C1q and tumor necrosis factor related protein 4
    63(a)
    1 ↔ 1
    1(44312831-44314233)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.262932 Xenopus laevis transcribed sequence with weak similarity more 74.52(n)    CD325653.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi33h022 Transcribed sequence with weak similarity to protein more 77.72(n)    BI845426.1 


    ENSEMBL Gene Tree for C1QTNF4 (if available)
    TreeFam Gene Tree for C1QTNF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C1QTNF4 gene
    C1QTNF62  C1QB2  COL10A12  C1QTNF12  C1QTNF9B2  C1QA2  COL8A22  C1QTNF92  
    C1QTNF52  COL8A12  OTOL12  C1QTNF82  C1QTNF72  C1QC2  C1QTNF22  ADIPOQ2  

    Find genes that share paralogs with C1QTNF4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for C1QTNF4
    PGOHUM00000257808


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C1QTNF4 (see all 120)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107692791,2
    C--47611316(+) GCCTCG/CGGCCC 1 -- ut31 ese38Minor allele frequency- C:0.02NA CSA WA EA 367
    rs1865467621,2
    C--47611477(+) GTAGGC/TGCCGT 2 T A mis10--------
    rs2001896351,2
    --47611502(+) TGGCTA/GAGCAG 2 L syn10--------
    rs2021566831,2
    --47611523(+) TCGCCG/TCGCCG 2 R syn10--------
    rs1452229421,2
    C--47611580(+) GCGCCG/ATCGTC 2 /D syn11Minor allele frequency- A:0.00NA 3672
    rs2006357761,2
    --47611583(+) CCGTCA/GTCGTA 2 D syn10--------
    rs1996886531,2
    --47611647(+) TACGCA/GGCAGC 2 P L mis10--------
    rs1422548451,2
    C--47611672(+) GGAGAA/CGAAGT 2 V F mis11Minor allele frequency- C:0.00NA 2662
    rs2003741271,2
    C--47611720(+) CGCGTC/TGAAGT 2 N D mis10--------
    rs79422721,2
    C--47611727(+) AAGTCG/TCCGCC 2 G syn11Minor allele frequency- T:0.00EU 289

    HapMap Linkage Disequilibrium report for C1QTNF4 (47611216 - 47616211 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for C1QTNF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509405CNV Insertion20534489
    nsv832142CNV Loss17160897
    nsv825872CNV Gain20364138
    nsv825873CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614911    OMIM disorders: --


    Find genes that share disorders with C1QTNF4           About GenesLikeMe


    Export disorders for C1QTNF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C1QTNF4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C1QTNF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappaB pathways and promotes cell survival in human cancer cells. (PubMed id 21658842)1, 2 Li Q.... Wang L. (Cancer Lett. 2011)
    2. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1, 3 Tao W.A....Aebersold R. (Nat. Methods 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114900 HGNC: 14346 AceView: C1QTNF4 Ensembl:ENSG00000172247 euGenes: HUgn114900
    ECgene: C1QTNF4 H-InvDB: C1QTNF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C1QTNF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for C1QTNF4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C1QTNF4 gene:
    Search GeneIP for patents involving C1QTNF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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