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Aliases for C1QTNF3 Gene

Aliases for C1QTNF3 Gene

  • C1q And Tumor Necrosis Factor Related Protein 3 2 3
  • CORS26 3 4 6
  • CTRP3 3 4 6
  • Collagenous Repeat-Containing Sequence 26 KDa Protein 3 4
  • Secretory Protein CORS26 3 4
  • Cartonectin 2 3
  • C1ATNF3 3 6
  • Complement C1q Tumor Necrosis Factor-Related Protein 3 3
  • Collagenous Repeat-Containing Sequence Of 26-KDa 3
  • CORS-26 3
  • CORCS 3
  • CORS 3

External Ids for C1QTNF3 Gene

Previous GeneCards Identifiers for C1QTNF3 Gene

  • GC05M033966
  • GC05M034479
  • GC05M034065
  • GC05M034053
  • GC05M033987

Summaries for C1QTNF3 Gene

GeneCards Summary for C1QTNF3 Gene

C1QTNF3 (C1q And Tumor Necrosis Factor Related Protein 3) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include identical protein binding. An important paralog of this gene is C1QL4.

Gene Wiki entry for C1QTNF3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF3 Gene

Genomics for C1QTNF3 Gene

Regulatory Elements for C1QTNF3 Gene

Genomic Location for C1QTNF3 Gene

Start:
34,017,858 bp from pter
End:
34,043,832 bp from pter
Size:
25,975 bases
Orientation:
Minus strand

Genomic View for C1QTNF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1QTNF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF3 Gene

Proteins for C1QTNF3 Gene

  • Protein details for C1QTNF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ4-C1QT3_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 3
    Protein Accession:
    Q9BXJ4
    Secondary Accessions:
    • Q0VAN4
    • Q542Y2
    • Q6MZN1
    • Q96KY1

    Protein attributes for C1QTNF3 Gene

    Size:
    246 amino acids
    Molecular mass:
    26994 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QTNF3 Gene

Proteomics data for C1QTNF3 Gene at MOPED

Post-translational modifications for C1QTNF3 Gene

Other Protein References for C1QTNF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C1QTNF3 (C1qTNF3/CORS26)

No data available for DME Specific Peptides for C1QTNF3 Gene

Domains for C1QTNF3 Gene

Protein Domains for C1QTNF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXJ4

UniProtKB/Swiss-Prot:

C1QT3_HUMAN :
  • Q9BXJ4
Domain:
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QTNF3: view

No data available for Gene Families for C1QTNF3 Gene

Function for C1QTNF3 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 20952387
genes like me logo Genes that share ontologies with C1QTNF3: view

Phenotypes for C1QTNF3 Gene

GenomeRNAi human phenotypes for C1QTNF3:
genes like me logo Genes that share phenotypes with C1QTNF3: view

Animal Model Products

CRISPR Products

miRNA for C1QTNF3 Gene

miRTarBase miRNAs that target C1QTNF3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C1QTNF3 Gene

Localization for C1QTNF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1QTNF3 Gene COMPARTMENTS Subcellular localization image for C1QTNF3 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space ISS --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with C1QTNF3: view

Pathways for C1QTNF3 Gene

genes like me logo Genes that share pathways with C1QTNF3: view

Interacting Proteins for C1QTNF3 Gene

Gene Ontology (GO) - Biological Process for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 20952387
GO:0035356 cellular triglyceride homeostasis IDA 20739398
GO:0042347 negative regulation of NF-kappaB import into nucleus IDA 16213490
GO:0045444 fat cell differentiation IEP 20739398
GO:0045721 negative regulation of gluconeogenesis IDA 20952387
genes like me logo Genes that share ontologies with C1QTNF3: view

Transcripts for C1QTNF3 Gene

Unigene Clusters for C1QTNF3 Gene

C1q and tumor necrosis factor related protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1QTNF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: - - - -
SP3:
SP4: -
SP5: - - - - -
SP6: - - - - - -
SP7: - -
SP8: - -

Relevant External Links for C1QTNF3 Gene

GeneLoc Exon Structure for
C1QTNF3
ECgene alternative splicing isoforms for
C1QTNF3

Expression for C1QTNF3 Gene

mRNA expression in normal human tissues for C1QTNF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C1QTNF3 Gene

SOURCE GeneReport for Unigene cluster for C1QTNF3 Gene Hs.171929

mRNA Expression by UniProt/SwissProt for C1QTNF3 Gene

Q9BXJ4-C1QT3_HUMAN
Tissue specificity: Expressed in colon and small intestine.
genes like me logo Genes that share expressions with C1QTNF3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for C1QTNF3 Gene

Orthologs for C1QTNF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 78 (a)
OneToMany
C1QTNF3 35
  • 99.9 (n)
  • 99.69 (a)
cow
(Bos Taurus)
Mammalia C1QTNF3 35
  • 92.44 (n)
  • 97.17 (a)
C1QTNF3 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
OneToMany
C1QTNF3 35
  • 93.21 (n)
  • 97.49 (a)
mouse
(Mus musculus)
Mammalia C1qtnf3 35
  • 90.91 (n)
  • 93.1 (a)
C1qtnf3 16
C1qtnf3 36
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia C1qtnf3 35
  • 90.49 (n)
  • 94.67 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
OneToMany
C1QTNF3 35
  • 78.7 (n)
  • 78.91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf3 35
  • 71.02 (n)
  • 69.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for C1QTNF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1QTNF3 Gene

ENSEMBL:
Gene Tree for C1QTNF3 (if available)
TreeFam:
Gene Tree for C1QTNF3 (if available)

Paralogs for C1QTNF3 Gene

Selected SIMAP similar genes for C1QTNF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QTNF3: view

Variants for C1QTNF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF3 Gene

Variant ID Type Subtype PubMed ID
nsv522715 CNV Gain 19592680
nsv830255 CNV Loss 17160897
nsv519240 CNV Gain 19592680
nsv507243 CNV Insertion 20534489
nsv880910 CNV Loss 21882294

Relevant External Links for C1QTNF3 Gene

HapMap Linkage Disequilibrium report
C1QTNF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C1QTNF3 Gene

Disorders for C1QTNF3 Gene

(1) University of Copenhagen DISEASES for C1QTNF3 Gene

Relevant External Links for C1QTNF3

Genetic Association Database (GAD)
C1QTNF3
Human Genome Epidemiology (HuGE) Navigator
C1QTNF3
genes like me logo Genes that share disorders with C1QTNF3: view

No data available for UniProtKB/Swiss-Prot for C1QTNF3 Gene

Publications for C1QTNF3 Gene

  1. Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein). (PMID: 14654242) Schaffler A. … Muller-Ladner U. (Biochim. Biophys. Acta 2003) 3 4 23
  2. Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines. (PMID: 18421280) WAPlfing B. … SchAoffler A. (Obesity (Silver Spring) 2008) 2 3 23
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  4. The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells. (PMID: 16213490) Weigert J. … Buechler C. (FEBS Lett. 2005) 3 23
  5. Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. (PMID: 17311679) Wurm S. … Buechler C. (Cardiovasc Diabetol 2007) 3 23

Products for C1QTNF3 Gene

Sources for C1QTNF3 Gene

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