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Aliases for C1QTNF3 Gene

Aliases for C1QTNF3 Gene

  • C1q And Tumor Necrosis Factor Related Protein 3 2 3 5
  • Collagenous Repeat-Containing Sequence 26 KDa Protein 3 4
  • Secretory Protein CORS26 3 4
  • Cartonectin 2 3
  • CORS26 3 4
  • CTRP3 3 4
  • Collagenous Repeat-Containing Sequence Of 26-KDa 3
  • C1ATNF3 3
  • CORS-26 3
  • CORCS 3
  • CORS 3

External Ids for C1QTNF3 Gene

Previous GeneCards Identifiers for C1QTNF3 Gene

  • GC05M033966
  • GC05M034479
  • GC05M034065
  • GC05M034053
  • GC05M033987

Summaries for C1QTNF3 Gene

GeneCards Summary for C1QTNF3 Gene

C1QTNF3 (C1q And Tumor Necrosis Factor Related Protein 3) is a Protein Coding gene. Diseases associated with C1QTNF3 include pyosalpinx and anal canal squamous cell carcinoma. An important paralog of this gene is C1QL4.

Gene Wiki entry for C1QTNF3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF3 Gene

Genomics for C1QTNF3 Gene

Regulatory Elements for C1QTNF3 Gene

Genomic Location for C1QTNF3 Gene

34,017,858 bp from pter
34,043,832 bp from pter
25,975 bases
Minus strand

Genomic View for C1QTNF3 Gene

Genes around C1QTNF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF3 Gene

Proteins for C1QTNF3 Gene

  • Protein details for C1QTNF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 3
    Protein Accession:
    Secondary Accessions:
    • Q0VAN4
    • Q542Y2
    • Q6MZN1
    • Q96KY1

    Protein attributes for C1QTNF3 Gene

    246 amino acids
    Molecular mass:
    26994 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF3 Gene


neXtProt entry for C1QTNF3 Gene

Proteomics data for C1QTNF3 Gene at MOPED

Post-translational modifications for C1QTNF3 Gene

Other Protein References for C1QTNF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C1QTNF3 (C1qTNF3/CORS26)

No data available for DME Specific Peptides for C1QTNF3 Gene

Domains & Families for C1QTNF3 Gene

Protein Domains for C1QTNF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C1q domain.
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QTNF3: view

No data available for Gene Families for C1QTNF3 Gene

Function for C1QTNF3 Gene

genes like me logo Genes that share phenotypes with C1QTNF3: view

Animal Models for C1QTNF3 Gene

MGI Knock Outs for C1QTNF3:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1QTNF3 Gene

Localization for C1QTNF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF3 Gene


Subcellular locations from

Jensen Localization Image for C1QTNF3 Gene COMPARTMENTS Subcellular localization image for C1QTNF3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IDA 20739398
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with C1QTNF3: view

Pathways & Interactions for C1QTNF3 Gene

SuperPathways for C1QTNF3 Gene

No Data Available

Interacting Proteins for C1QTNF3 Gene

Gene Ontology (GO) - Biological Process for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042347 negative regulation of NF-kappaB import into nucleus IDA 16213490
GO:0045444 fat cell differentiation IEP 20739398
GO:0050728 negative regulation of inflammatory response IDA 16213490
GO:0070165 positive regulation of adiponectin secretion IDA 18421280
GO:0070206 protein trimerization IDA 16213490
genes like me logo Genes that share ontologies with C1QTNF3: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF3 Gene

Drugs & Compounds for C1QTNF3 Gene

No Compound Related Data Available

Transcripts for C1QTNF3 Gene

Unigene Clusters for C1QTNF3 Gene

C1q and tumor necrosis factor related protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - -
SP7: - -
SP8: - -

Relevant External Links for C1QTNF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1QTNF3 Gene

mRNA expression in normal human tissues for C1QTNF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1QTNF3 Gene

This gene is overexpressed in Fetal gut (25.9), Breast (13.2), Bone marrow mesenchymal stem cell (10.3), and Vitreous humor (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF3 Gene

SOURCE GeneReport for Unigene cluster for C1QTNF3 Gene Hs.171929

mRNA Expression by UniProt/SwissProt for C1QTNF3 Gene

Tissue specificity: Expressed in colon and small intestine.
genes like me logo Genes that share expression patterns with C1QTNF3: view

Protein tissue co-expression partners for C1QTNF3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for C1QTNF3 Gene

Orthologs for C1QTNF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C1QTNF3 35
  • 92.44 (n)
  • 97.17 (a)
C1QTNF3 36
  • 98 (a)
(Canis familiaris)
Mammalia C1QTNF3 35
  • 93.21 (n)
  • 97.49 (a)
-- 36
  • 97 (a)
(Mus musculus)
Mammalia C1qtnf3 35
  • 90.91 (n)
  • 93.1 (a)
C1qtnf3 16
C1qtnf3 36
  • 93 (a)
(Pan troglodytes)
Mammalia C1QTNF3 35
  • 99.9 (n)
  • 99.69 (a)
-- 36
  • 78 (a)
(Rattus norvegicus)
Mammalia C1qtnf3 35
  • 90.49 (n)
  • 94.67 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
(Gallus gallus)
Aves C1QTNF3 35
  • 78.7 (n)
  • 78.91 (a)
-- 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf3 35
  • 71.02 (n)
  • 69.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for C1QTNF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1QTNF3 Gene

Gene Tree for C1QTNF3 (if available)
Gene Tree for C1QTNF3 (if available)

Paralogs for C1QTNF3 Gene

(4) SIMAP similar genes for C1QTNF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QTNF3: view

Variants for C1QTNF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF3 Gene

Variant ID Type Subtype PubMed ID
nsv522715 CNV Gain 19592680
nsv830255 CNV Loss 17160897
nsv519240 CNV Gain 19592680
nsv507243 CNV Insertion 20534489
nsv880910 CNV Loss 21882294

Variation tolerance for C1QTNF3 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C1QTNF3 Gene

Disorders for C1QTNF3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for C1QTNF3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • pyosalpingitis
anal canal squamous cell carcinoma
  • squamous cell carcinoma of anal canal
branch retinal artery occlusion
  • arterial retinal branch occlusion
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C1QTNF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C1QTNF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QTNF3 Gene

Publications for C1QTNF3 Gene

  1. Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein). (PMID: 14654242) Schaffler A. … Muller-Ladner U. (Biochim. Biophys. Acta 2003) 3 4 23 67
  2. Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines. (PMID: 18421280) WAPlfing B. … SchAoffler A. (Obesity (Silver Spring) 2008) 2 3 23
  3. Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. (PMID: 17311679) Wurm S. … Buechler C. (Cardiovasc Diabetol 2007) 3 23
  4. The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells. (PMID: 16213490) Weigert J. … Buechler C. (FEBS Lett. 2005) 3 23
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3

Products for C1QTNF3 Gene

Sources for C1QTNF3 Gene

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