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Aliases for C1QTNF3 Gene

Aliases for C1QTNF3 Gene

  • C1q And TNF Related 3 2 3
  • C1q And Tumor Necrosis Factor Related Protein 3 2 3 5
  • Collagenous Repeat-Containing Sequence 26 KDa Protein 3 4
  • Secretory Protein CORS26 3 4
  • Cartonectin 2 3
  • CORS26 3 4
  • CTRP3 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 3 3
  • Collagenous Repeat-Containing Sequence Of 26-KDa 3
  • C1ATNF3 3
  • CORS-26 3
  • CORCS 3
  • CORS 3

External Ids for C1QTNF3 Gene

Previous GeneCards Identifiers for C1QTNF3 Gene

  • GC05M033966
  • GC05M034479
  • GC05M034065
  • GC05M034053
  • GC05M033987

Summaries for C1QTNF3 Gene

GeneCards Summary for C1QTNF3 Gene

C1QTNF3 (C1q And TNF Related 3) is a Protein Coding gene. Diseases associated with C1QTNF3 include Pyosalpinx and Anal Canal Squamous Cell Carcinoma. An important paralog of this gene is C1QTNF3-AMACR.

Gene Wiki entry for C1QTNF3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF3 Gene

Genomics for C1QTNF3 Gene

Regulatory Elements for C1QTNF3 Gene

Enhancers for C1QTNF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G034006 1.7 FANTOM5 ENCODE dbSUPER 2.7 +35.2 35176 4.5 HNRNPUL1 FOXA2 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 AMACR ENSG00000249572 BRIX1 C1QTNF3
GH05G034042 0.7 Ensembl ENCODE 0.7 +0.1 82 2.9 MAX REST NR2F2 AMACR C1QTNF3
GH05G034033 1.1 ENCODE dbSUPER 0.4 +9.2 9217 2.2 ELF3 FOXA2 ATF1 THRB RAD21 YY1 RARA GATA4 CREM MIXL1 AMACR C1QTNF3
GH05G034052 0.8 Ensembl ENCODE 0.4 -9.7 -9722 2.4 JUND SMARCA4 ZBTB40 EZH2 AMACR GC05P034055 C1QTNF3
GH05G034021 1 Ensembl ENCODE dbSUPER 0.3 +21.5 21457 0.9 FOSL1 EED SUPT20H AMACR C1QTNF3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1QTNF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1QTNF3 Gene

Chromosome:
5
Start:
34,017,858 bp from pter
End:
34,043,832 bp from pter
Size:
25,975 bases
Orientation:
Minus strand

Genomic View for C1QTNF3 Gene

Genes around C1QTNF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF3 Gene

Proteins for C1QTNF3 Gene

  • Protein details for C1QTNF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ4-C1QT3_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 3
    Protein Accession:
    Q9BXJ4
    Secondary Accessions:
    • Q0VAN4
    • Q542Y2
    • Q6MZN1
    • Q96KY1

    Protein attributes for C1QTNF3 Gene

    Size:
    246 amino acids
    Molecular mass:
    26994 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QTNF3 Gene

Post-translational modifications for C1QTNF3 Gene

Other Protein References for C1QTNF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C1QTNF3 (CTRP3/C1qTNF3/CORS26)
  • Abcam antibodies for C1QTNF3

Assay Products

  • Cloud-Clone Corp. Assay Kits for C1QTNF3

No data available for DME Specific Peptides for C1QTNF3 Gene

Domains & Families for C1QTNF3 Gene

No data available for UniProtKB/Swiss-Prot for C1QTNF3 Gene

Function for C1QTNF3 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C1QTNF3: view
genes like me logo Genes that share phenotypes with C1QTNF3: view

Animal Models for C1QTNF3 Gene

MGI Knock Outs for C1QTNF3:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for C1QTNF3 (CTRP3/C1qTNF3/CORS26)

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1QTNF3 Gene

Localization for C1QTNF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space ISS --
GO:0005623 cell IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with C1QTNF3: view

Pathways & Interactions for C1QTNF3 Gene

SuperPathways for C1QTNF3 Gene

No Data Available

Interacting Proteins for C1QTNF3 Gene

Gene Ontology (GO) - Biological Process for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035356 cellular triglyceride homeostasis IDA 20739398
GO:0042347 negative regulation of NF-kappaB import into nucleus IDA 16213490
GO:0045444 fat cell differentiation IEP 20739398
GO:0045721 negative regulation of gluconeogenesis IDA 20952387
GO:0050715 positive regulation of cytokine secretion IDA 18421280
genes like me logo Genes that share ontologies with C1QTNF3: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF3 Gene

Drugs & Compounds for C1QTNF3 Gene

No Compound Related Data Available

Transcripts for C1QTNF3 Gene

Unigene Clusters for C1QTNF3 Gene

C1q and tumor necrosis factor related protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for C1QTNF3 (CTRP3/C1qTNF3/CORS26)

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: - - - -
SP3:
SP4: -
SP5: - - - - -
SP6: - - - - - -
SP7: - -
SP8: - -

Relevant External Links for C1QTNF3 Gene

GeneLoc Exon Structure for
C1QTNF3
ECgene alternative splicing isoforms for
C1QTNF3

Expression for C1QTNF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QTNF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1QTNF3 Gene

This gene is overexpressed in Fetal gut (25.9), Breast (13.2), Bone marrow mesenchymal stem cell (10.3), and Vitreous humor (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF3 Gene



Protein tissue co-expression partners for C1QTNF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF3 Gene:

C1QTNF3

SOURCE GeneReport for Unigene cluster for C1QTNF3 Gene:

Hs.171929

mRNA Expression by UniProt/SwissProt for C1QTNF3 Gene:

Q9BXJ4-C1QT3_HUMAN
Tissue specificity: Expressed in colon and small intestine.

Evidence on tissue expression from TISSUES for C1QTNF3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with C1QTNF3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF3 Gene

Orthologs for C1QTNF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF3 34
  • 99.9 (n)
-- 35
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
C1QTNF3 34
  • 93.21 (n)
cow
(Bos Taurus)
Mammalia C1QTNF3 34 35
  • 92.44 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia C1qtnf3 34 16 35
  • 90.91 (n)
rat
(Rattus norvegicus)
Mammalia C1qtnf3 34
  • 90.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 87 (a)
OneToMany
C1QTNF3 34
  • 78.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf3 34
  • 71.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for C1QTNF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C1QTNF3 Gene

ENSEMBL:
Gene Tree for C1QTNF3 (if available)
TreeFam:
Gene Tree for C1QTNF3 (if available)

Paralogs for C1QTNF3 Gene

(4) SIMAP similar genes for C1QTNF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QTNF3: view

Variants for C1QTNF3 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000206472 -- 34,040,331(+) ACTGA(C/G)CTCTA intron-variant
rs1000441180 -- 34,030,567(+) AAGAC(-/AG)GGTTG intron-variant
rs1000480135 -- 34,032,630(+) CGTCT(C/G)TATTA intron-variant
rs1000536419 -- 34,019,204(+) TACTG(C/T)TTCCT intron-variant, utr-variant-3-prime
rs1000658048 -- 34,038,266(+) CGAAG(A/G)TAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF3 Gene

Variant ID Type Subtype PubMed ID
nsv507243 OTHER sequence alteration 20534489
nsv519240 CNV gain 19592680
nsv522715 CNV gain 19592680
nsv830255 CNV loss 17160897

Variation tolerance for C1QTNF3 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF3 Gene

Disorders for C1QTNF3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for C1QTNF3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pyosalpinx
  • pyosalpingitis
anal canal squamous cell carcinoma
  • squamous cell carcinoma of anal canal
branch retinal artery occlusion
  • arterial retinal branch occlusion
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C1QTNF3

Genetic Association Database (GAD)
C1QTNF3
Human Genome Epidemiology (HuGE) Navigator
C1QTNF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QTNF3
genes like me logo Genes that share disorders with C1QTNF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QTNF3 Gene

Publications for C1QTNF3 Gene

  1. Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines. (PMID: 18421280) WAPlfing B. … SchAoffler A. (Obesity (Silver Spring) 2008) 2 3 22 64
  2. Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein). (PMID: 14654242) Schaffler A. … Muller-Ladner U. (Biochim. Biophys. Acta 2003) 3 4 22 64
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  4. C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. (PMID: 20952387) Peterson J.M. … Wong G.W. (J. Biol. Chem. 2010) 3 4 64
  5. Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. (PMID: 17311679) Wurm S. … Buechler C. (Cardiovasc Diabetol 2007) 3 22 64

Products for C1QTNF3 Gene

Sources for C1QTNF3 Gene

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