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Aliases for C1QTNF2 Gene

Aliases for C1QTNF2 Gene

  • C1q And Tumor Necrosis Factor Related Protein 2 2 3 5
  • CTRP2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 2 3
  • Complement-C1q Tumor Necrosis Factor-Related Protein 2 3
  • Zacrp2 3

External Ids for C1QTNF2 Gene

Previous GeneCards Identifiers for C1QTNF2 Gene

  • GC05M159893
  • GC05M159710
  • GC05M159755
  • GC05M159707
  • GC05M154868

Summaries for C1QTNF2 Gene

GeneCards Summary for C1QTNF2 Gene

C1QTNF2 (C1q And Tumor Necrosis Factor Related Protein 2) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is C1QTNF7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF2 Gene

Genomics for C1QTNF2 Gene

Regulatory Elements for C1QTNF2 Gene

Enhancers for C1QTNF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F160008 1.2 ENCODE 25.5 +361.1 361133 2.3 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZBED8 PWWP2A C1QTNF2 LOC101927740 RNF145 ENSG00000254199 LINC01845 ENSG00000223908 TTC1 FABP6
GH05F160361 1 Ensembl ENCODE 25.3 +7.3 7258 4.4 ZNF146 CBX3 MAX E2F6 CREM STAT1 L3MBTL2 RNF2 BHLHE40 USF2 C1QTNF2 CCNJL
GH05F160344 1.1 Ensembl ENCODE 17.7 +25.3 25267 0.9 CTCF PKNOX1 ZNF792 WRNIP1 ARID4B RAD21 RFX5 ZNF664 ZNF335 ZNF366 C1QTNF2 CCNJL GC05P160327
GH05F160356 0.7 Ensembl ENCODE 26.6 +13.0 13012 2.9 FOSL1 ESRRA GATA2 C1QTNF2 ZBED8 CCNJL
GH05F160163 1.6 FANTOM5 Ensembl ENCODE 11 +204.3 204269 4.8 PKNOX1 ATF1 SIN3A DMAP1 ZNF48 GLIS2 ELK1 FOS ZNF548 SP3 C1QTNF2 FABP6 TTC1 PWWP2A GC05P160140
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1QTNF2 on UCSC Golden Path with GeneCards custom track

Promoters for C1QTNF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001295479 252 1201 SUZ12 ZMYM3 MAX NFXL1 ZIC2 E2F1 ZNF664 ZFHX2 PATZ1 ZNF600

Genomic Location for C1QTNF2 Gene

Chromosome:
5
Start:
160,347,751 bp from pter
End:
160,370,652 bp from pter
Size:
22,902 bases
Orientation:
Minus strand

Genomic View for C1QTNF2 Gene

Genes around C1QTNF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF2 Gene

Proteins for C1QTNF2 Gene

  • Protein details for C1QTNF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ5-C1QT2_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 2
    Protein Accession:
    Q9BXJ5

    Protein attributes for C1QTNF2 Gene

    Size:
    285 amino acids
    Molecular mass:
    29952 Da
    Quaternary structure:
    • May interact with ERFE.
    SequenceCaution:
    • Sequence=AAH11699.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH54506.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C1QTNF2 Gene

Post-translational modifications for C1QTNF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QTNF2 Gene

Antibody Products

  • Abcam antibodies for C1QTNF2

No data available for DME Specific Peptides for C1QTNF2 Gene

Domains & Families for C1QTNF2 Gene

Gene Families for C1QTNF2 Gene

Suggested Antigen Peptide Sequences for C1QTNF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXJ5

UniProtKB/Swiss-Prot:

C1QT2_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QTNF2: view

Function for C1QTNF2 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QTNF2: view

Phenotypes for C1QTNF2 Gene

genes like me logo Genes that share phenotypes with C1QTNF2: view

Animal Models for C1QTNF2 Gene

MGI Knock Outs for C1QTNF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF2

miRNA for C1QTNF2 Gene

miRTarBase miRNAs that target C1QTNF2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1QTNF2 Gene

Localization for C1QTNF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF2 gene
Compartment Confidence
extracellular 3
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for C1QTNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C1QTNF2: view

Pathways & Interactions for C1QTNF2 Gene

SuperPathways for C1QTNF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1QTNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0045725 positive regulation of glycogen biosynthetic process IEA --
GO:0046321 positive regulation of fatty acid oxidation IEA --
GO:0046326 positive regulation of glucose import IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with C1QTNF2: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF2 Gene

Transcripts for C1QTNF2 Gene

mRNA/cDNA for C1QTNF2 Gene

Unigene Clusters for C1QTNF2 Gene

C1q and tumor necrosis factor related protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF2 Gene

No ASD Table

Relevant External Links for C1QTNF2 Gene

GeneLoc Exon Structure for
C1QTNF2
ECgene alternative splicing isoforms for
C1QTNF2

Expression for C1QTNF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1QTNF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QTNF2 Gene

This gene is overexpressed in Artery - Aorta (x6.9), Artery - Coronary (x4.3), and Artery - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for C1QTNF2 Gene

This gene is overexpressed in Tlymphocyte (39.2), Monocytes (14.6), and Blymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF2 Gene



Protein tissue co-expression partners for C1QTNF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF2 Gene:

C1QTNF2

SOURCE GeneReport for Unigene cluster for C1QTNF2 Gene:

Hs.110062
genes like me logo Genes that share expression patterns with C1QTNF2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for C1QTNF2 Gene

Orthologs for C1QTNF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF2 34 35
  • 98.99 (n)
dog
(Canis familiaris)
Mammalia C1QTNF2 34 35
  • 90.76 (n)
cow
(Bos Taurus)
Mammalia C1QTNF2 34 35
  • 89.47 (n)
mouse
(Mus musculus)
Mammalia C1qtnf2 34 16 35
  • 88 (n)
rat
(Rattus norvegicus)
Mammalia C1qtnf2 34
  • 86.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1QTNF2 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1QTNF2 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1QTNF2 34 35
  • 72.65 (n)
lizard
(Anolis carolinensis)
Reptilia C1QTNF2 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490036 34
  • 66.07 (n)
zebrafish
(Danio rerio)
Actinopterygii c1qtnf2 34 35
  • 63.47 (n)
Species where no ortholog for C1QTNF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF2 Gene

ENSEMBL:
Gene Tree for C1QTNF2 (if available)
TreeFam:
Gene Tree for C1QTNF2 (if available)

Paralogs for C1QTNF2 Gene

(9) SIMAP similar genes for C1QTNF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QTNF2: view

Variants for C1QTNF2 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10044293 -- 160,368,798(+) GACAG(C/G/T)GGGGA intron-variant
rs10053189 -- 160,349,630(+) TCCCC(C/T)TTCTT intron-variant, reference, synonymous-codon
rs10056839 -- 160,347,905(+) CAGGC(A/G)CCCAA utr-variant-3-prime
rs10463079 -- 160,358,846(+) cgtga(C/T)ctcgg intron-variant
rs1105787 -- 160,364,132(+) TATTA(A/C)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF2 Gene

Variant ID Type Subtype PubMed ID
nsv473554 CNV novel sequence insertion 20440878
nsv1015634 CNV gain 25217958
esv3607370 CNV gain 21293372
esv3607367 CNV gain 21293372
esv2730977 CNV deletion 23290073

Variation tolerance for C1QTNF2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF2 Gene

Disorders for C1QTNF2 Gene

Relevant External Links for C1QTNF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QTNF2

No disorders were found for C1QTNF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF2 Gene

Publications for C1QTNF2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Weight loss after gastric bypass is associated with a variant at 15q26.1. (PMID: 23643386) Hatoum I.J. … Kaplan L.M. (Am. J. Hum. Genet. 2013) 3 64

Products for C1QTNF2 Gene

Sources for C1QTNF2 Gene

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