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Aliases for C1QTNF12 Gene

Aliases for C1QTNF12 Gene

  • C1q And TNF Related 12 2 3 5
  • Adipose-Derived Insulin-Sensitizing Factor 2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 12 3 4
  • C1q And Tumor Necrosis Factor Related Protein 12 2 3
  • Family With Sequence Similarity 132 Member A 2 3
  • C1q And TNF Related Protein 12 3 4
  • C1q Domain Containing 2 2 3
  • Adipolin 2 3
  • FAM132A 3 4
  • C1QDC2 3 4
  • CTRP12 3 4
  • Family With Sequence Similarity 132, Member A 2
  • C1q/TNF-Related Protein 12 3
  • Protein FAM132A 3

External Ids for C1QTNF12 Gene

Previous HGNC Symbols for C1QTNF12 Gene

  • C1QDC2
  • FAM132A

Summaries for C1QTNF12 Gene

GeneCards Summary for C1QTNF12 Gene

C1QTNF12 (C1q And TNF Related 12) is a Protein Coding gene. An important paralog of this gene is ERFE.

UniProtKB/Swiss-Prot for C1QTNF12 Gene

  • Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.

Additional gene information for C1QTNF12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF12 Gene

Genomics for C1QTNF12 Gene

Regulatory Elements for C1QTNF12 Gene

Enhancers for C1QTNF12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H001127 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +118.0 117977 4 FOXA2 ARID4B DMAP1 RAD21 YY1 CREM EGR2 THAP11 KLF11 MCM3 SDF4 TTLL10 MXRA8 TTLL10-AS1 ENSG00000230092 B3GALT6 C1QTNF12 UBE2J2 LOC100288379 CDK11A
GH01H001131 1.4 Ensembl ENCODE dbSUPER 11.9 +112.1 112138 6.5 ELF3 PKNOX1 NFRKB BMI1 RAD21 EGR1 SCRT2 ATF7 RUNX3 CREM TTLL10 TTLL10-AS1 B3GALT6 SDF4 C1QTNF12 UBE2J2 C1orf159 LINC01342 GC01M001125
GH01H001189 0.4 FANTOM5 12 +57.8 57827 0.3 SDF4 B3GALT6 MIR200A MIR200B MIR429 LINC01786 UBE2J2 C1QTNF12 TNFRSF18 HES4
GH01H001249 1.1 Ensembl ENCODE 0.7 -3.4 -3367 1.6 HDGF CTCF PKNOX1 ATF1 MAX EBF1 CC2D1A POLR2A PATZ1 ZNF143 B3GALT6 ANKRD65 ATAD3B C1QTNF12 ENSG00000260179
GH01H001235 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +7.7 7658 7.9 PKNOX1 FOXA2 MLX ARID4B DMAP1 GLIS2 FOS KLF7 DEK SP5 B3GALT6 ANKRD65 ATAD3B SDF4 AURKAIP1 ENSG00000237094 CPTP CDK11B PLEKHN1 PIR44892
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1QTNF12 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C1QTNF12 Gene

Genomic Locations for C1QTNF12 Gene
chr1:1,242,446-1,247,218
(GRCh38/hg38)
Size:
4,773 bases
Orientation:
Minus strand
chr1:1,177,826-1,182,102
(GRCh37/hg19)

Genomic View for C1QTNF12 Gene

Genes around C1QTNF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF12 Gene

Proteins for C1QTNF12 Gene

  • Protein details for C1QTNF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7M4-ADIPL_HUMAN
    Recommended name:
    Adipolin
    Protein Accession:
    Q5T7M4
    Secondary Accessions:
    • Q5EBL5

    Protein attributes for C1QTNF12 Gene

    Size:
    302 amino acids
    Molecular mass:
    32416 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked. May interact with ERFE (By similarity).

neXtProt entry for C1QTNF12 Gene

Post-translational modifications for C1QTNF12 Gene

  • Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN. Insulin enhances endogenous C1QTNF12 cleavage.

Other Protein References for C1QTNF12 Gene

No data available for DME Specific Peptides for C1QTNF12 Gene

Domains & Families for C1QTNF12 Gene

Gene Families for C1QTNF12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C1QTNF12 Gene

Suggested Antigen Peptide Sequences for C1QTNF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7M4

UniProtKB/Swiss-Prot:

ADIPL_HUMAN :
  • Belongs to the adipolin/erythroferrone family.
Family:
  • Belongs to the adipolin/erythroferrone family.
genes like me logo Genes that share domains with C1QTNF12: view

Function for C1QTNF12 Gene

Molecular function for C1QTNF12 Gene

UniProtKB/Swiss-Prot Function:
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.
UniProtKB/Swiss-Prot Induction:
By insulin in subcutaneous adipose tissue.

Gene Ontology (GO) - Molecular Function for C1QTNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity ISS --
genes like me logo Genes that share ontologies with C1QTNF12: view

Phenotypes for C1QTNF12 Gene

genes like me logo Genes that share phenotypes with C1QTNF12: view

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for C1QTNF12 (Adipolin/FAM132A)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF12 Gene

Localization for C1QTNF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF12 Gene

Adipolin fC1QTNF12: Secreted.
Adipolin gC1QTNF12: Secreted. Note=In sera is the predominant form. {ECO:0000269 PubMed:22275362}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF12 gene
Compartment Confidence
extracellular 5
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C1QTNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C1QTNF12: view

Pathways & Interactions for C1QTNF12 Gene

SuperPathways for C1QTNF12 Gene

No Data Available

Interacting Proteins for C1QTNF12 Gene

Gene Ontology (GO) - Biological Process for C1QTNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010906 regulation of glucose metabolic process IEA --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0045721 negative regulation of gluconeogenesis IEA --
GO:0046324 regulation of glucose import ISS,IEA --
GO:0046326 positive regulation of glucose import IEA --
genes like me logo Genes that share ontologies with C1QTNF12: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF12 Gene

Drugs & Compounds for C1QTNF12 Gene

No Compound Related Data Available

Transcripts for C1QTNF12 Gene

mRNA/cDNA for C1QTNF12 Gene

Clone Products

  • R&D Systems cDNA Clones for C1QTNF12 (Adipolin/FAM132A)

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF12 Gene

No ASD Table

Relevant External Links for C1QTNF12 Gene

GeneLoc Exon Structure for
C1QTNF12
ECgene alternative splicing isoforms for
C1QTNF12

Expression for C1QTNF12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF12 Gene:

C1QTNF12

mRNA Expression by UniProt/SwissProt for C1QTNF12 Gene:

Q5T7M4-ADIPL_HUMAN
Tissue specificity: Predominantly expressed by adipose tissues.
genes like me logo Genes that share expression patterns with C1QTNF12: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF12 Gene

Orthologs for C1QTNF12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF12 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FAM132A 33 34
  • 79.07 (n)
cow
(Bos Taurus)
Mammalia FAM132A 33 34
  • 76.11 (n)
rat
(Rattus norvegicus)
Mammalia Fam132a 33
  • 75 (n)
mouse
(Mus musculus)
Mammalia Fam132a 33 34
  • 74.55 (n)
C1qtnf12 16
platypus
(Ornithorhynchus anatinus)
Mammalia FAM132A 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM132A 33 34
  • 62.21 (n)
lizard
(Anolis carolinensis)
Reptilia FAM132A 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam132a 33
  • 58.19 (n)
Str.12517 33
zebrafish
(Danio rerio)
Actinopterygii fam132a 33 34
  • 58.7 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12580 33
Species where no ortholog for C1QTNF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF12 Gene

ENSEMBL:
Gene Tree for C1QTNF12 (if available)
TreeFam:
Gene Tree for C1QTNF12 (if available)

Paralogs for C1QTNF12 Gene

Paralogs for C1QTNF12 Gene

genes like me logo Genes that share paralogs with C1QTNF12: view

Variants for C1QTNF12 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000190648 -- 1,242,027(+) CACGC(A/G)GTCCC downstream-variant-500B
rs1000299631 -- 1,246,338(+) CTTCC(C/T)AGAGG intron-variant
rs1000399684 -- 1,246,105(+) GAGTC(A/C)TGGGG intron-variant
rs1000680997 -- 1,244,586(+) CAGAA(C/T)CAGGG intron-variant
rs1000950429 -- 1,244,576(+) GCACT(C/G)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF12 Gene

Variant ID Type Subtype PubMed ID
nsv950452 CNV deletion 24416366
nsv544965 CNV loss 21841781
nsv544964 CNV loss 21841781
nsv544947 CNV loss 21841781
nsv517709 CNV gain+loss 19592680
nsv482937 CNV loss 15286789
nsv470680 CNV loss 18288195
nsv469848 CNV gain 16826518
nsv455661 CNV loss 19166990
nsv1160772 CNV duplication 26073780
nsv1074016 CNV deletion 25765185
nsv10161 CNV gain+loss 18304495
nsv1003578 CNV gain 25217958
esv3584991 CNV gain 21293372
dgv2n67 CNV gain 20364138
dgv10n106 CNV deletion 24896259

Variation tolerance for C1QTNF12 Gene

Gene Damage Index Score: 8.31; 85.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF12 Gene

Disorders for C1QTNF12 Gene

Relevant External Links for C1QTNF12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QTNF12

No disorders were found for C1QTNF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF12 Gene

Publications for C1QTNF12 Gene

  1. Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex vivo effects. (PMID: 24492466) Tan BK … Randeva HS (The Journal of endocrinology 2014) 3 4 60
  2. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. (PMID: 21849507) Enomoto T … Ouchi N (The Journal of biological chemistry 2011) 2 3 60
  3. Circulating C1q complement/TNF-related protein (CTRP) 1, CTRP9, CTRP12 and CTRP13 concentrations in Type 2 diabetes mellitus: In vivo regulation by glucose. (PMID: 28207876) Bai B … Chen J (PloS one 2017) 3 60
  4. The Effect of Coenzyme Q10 Supplementation on Circulating Levels of Novel Adipokine Adipolin/CTRP12 in Overweight and Obese Patients with Type 2 Diabetes. (PMID: 27657997) Mehrdadi P … Hosseinzadeh-Attar MJ (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2016) 3 60
  5. Circulatory changes of the novel adipokine adipolin/CTRP12 in response to metformin treatment and an oral glucose challenge in humans. (PMID: 24612181) Tan BK … Randeva HS (Clinical endocrinology 2014) 3 60

Products for C1QTNF12 Gene

Sources for C1QTNF12 Gene

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