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Aliases for C1QTNF1 Gene

Aliases for C1QTNF1 Gene

  • C1q And TNF Related 1 2 3
  • C1q And Tumor Necrosis Factor Related Protein 1 2 3 5
  • G Protein Coupled Receptor Interacting Protein 2 3
  • G Protein-Coupled Receptor-Interacting Protein 3 4
  • CTRP1 3 4
  • GIP 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 1 3
  • ZSIG37 3

External Ids for C1QTNF1 Gene

Previous GeneCards Identifiers for C1QTNF1 Gene

  • GC17U990301
  • GC17M080159
  • GC17P077481
  • GC17P077627
  • GC17P077617
  • GC17P074531
  • GC17P077020
  • GC17P072443

Summaries for C1QTNF1 Gene

GeneCards Summary for C1QTNF1 Gene

C1QTNF1 (C1q And TNF Related 1) is a Protein Coding gene. GO annotations related to this gene include collagen binding. An important paralog of this gene is C1QTNF6.

Gene Wiki entry for C1QTNF1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF1 Gene

Genomics for C1QTNF1 Gene

Regulatory Elements for C1QTNF1 Gene

Enhancers for C1QTNF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G079036 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.4 +15.1 15094 3.7 TBP CTCF TAF1 JUN MAX SIN3A CEBPG RAD21 ZIC2 RELA C1QTNF1 ENGASE CANT1 BIRC5 CYTH1 USP36 C1QTNF1-AS1
GH17G079022 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +2.7 2705 6.5 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS PAF1 ZNF263 C1QTNF1 CANT1 ENGASE C1QTNF1-AS1
GH17G079072 1.1 ENCODE 21.5 +51.6 51632 3.6 HDGF PKNOX1 CREB3L1 ARNT SIN3A YBX1 YY1 ZNF766 ZNF207 KLF13 C1QTNF1 ENGASE CANT1 PIR37581
GH17G079045 1.1 ENCODE dbSUPER 20.9 +23.2 23220 0.2 CTCF TFAP4 RB1 SUZ12 ARID4B MAX RAD21 TEAD3 GLIS2 SCRT2 C1QTNF1 C1QTNF1-AS1 ENGASE
GH17G078932 2 FANTOM5 Ensembl ENCODE dbSUPER 10 -88.1 -88129 4.5 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF143 FOS C1QTNF1 ENSG00000267491 CEP295NL CANT1 TIMP2 GC17P078963
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1QTNF1 on UCSC Golden Path with GeneCards custom track

Promoters for C1QTNF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099023 1586 801 ZSCAN4 INSM2 KLF17 SIN3A FEZF1 ZNF2 ZNF48 GLIS2 ZNF366 SCRT2

Transcription factor binding sites by QIAGEN in the C1QTNF1 gene promoter:

Genomic Location for C1QTNF1 Gene

Chromosome:
17
Start:
79,022,814 bp from pter
End:
79,049,788 bp from pter
Size:
26,975 bases
Orientation:
Plus strand

Genomic View for C1QTNF1 Gene

Genes around C1QTNF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF1 Gene

Proteins for C1QTNF1 Gene

  • Protein details for C1QTNF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ1-C1QT1_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 1
    Protein Accession:
    Q9BXJ1
    Secondary Accessions:
    • Q6ZMH6
    • Q96NF2
    • Q9GZR4

    Protein attributes for C1QTNF1 Gene

    Size:
    281 amino acids
    Molecular mass:
    31743 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG44303.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC20425.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C1QTNF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QTNF1 Gene

Post-translational modifications for C1QTNF1 Gene

  • Glycosylation at posLast=9393
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for C1QTNF1 (CTRP1/C1qTNF1)
  • Cloud-Clone Corp. Antibodies for C1QTNF1
  • Santa Cruz Biotechnology (SCBT) Antibodies for C1QTNF1

No data available for DME Specific Peptides for C1QTNF1 Gene

Domains & Families for C1QTNF1 Gene

Gene Families for C1QTNF1 Gene

Suggested Antigen Peptide Sequences for C1QTNF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QTNF1: view

No data available for UniProtKB/Swiss-Prot for C1QTNF1 Gene

Function for C1QTNF1 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12409230
GO:0005518 collagen binding IDA 16195328
genes like me logo Genes that share ontologies with C1QTNF1: view
genes like me logo Genes that share phenotypes with C1QTNF1: view

Animal Models for C1QTNF1 Gene

MGI Knock Outs for C1QTNF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF1

CRISPR Products

miRNA for C1QTNF1 Gene

miRTarBase miRNAs that target C1QTNF1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1QTNF1 Gene

Localization for C1QTNF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 4
cytosol 4
lysosome 1

Gene Ontology (GO) - Cellular Components for C1QTNF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IDA 18171693
GO:0005634 nucleus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C1QTNF1: view

Pathways & Interactions for C1QTNF1 Gene

SuperPathways for C1QTNF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1QTNF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 18171693
GO:0010544 negative regulation of platelet activation IDA 16195328
GO:0010628 positive regulation of gene expression IDA 18171693
GO:0010906 regulation of glucose metabolic process IEA --
GO:0043410 positive regulation of MAPK cascade IEA --
genes like me logo Genes that share ontologies with C1QTNF1: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF1 Gene

Drugs & Compounds for C1QTNF1 Gene

No Compound Related Data Available

Transcripts for C1QTNF1 Gene

Unigene Clusters for C1QTNF1 Gene

C1q and tumor necrosis factor related protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
SP1: - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - - -
SP6: -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10:

Relevant External Links for C1QTNF1 Gene

GeneLoc Exon Structure for
C1QTNF1
ECgene alternative splicing isoforms for
C1QTNF1

Expression for C1QTNF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QTNF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QTNF1 Gene

This gene is overexpressed in Artery - Coronary (x6.2), Artery - Tibial (x5.5), Heart - Atrial Appendage (x4.7), and Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for C1QTNF1 Gene

This gene is overexpressed in Milk (57.1) and Placenta (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C1QTNF1 Gene



Protein tissue co-expression partners for C1QTNF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF1 Gene:

C1QTNF1

SOURCE GeneReport for Unigene cluster for C1QTNF1 Gene:

Hs.201398

Evidence on tissue expression from TISSUES for C1QTNF1 Gene

  • Intestine(4.2)
  • Skin(4.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with C1QTNF1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF1 Gene

Orthologs for C1QTNF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF1 34 35
  • 90.74 (n)
dog
(Canis familiaris)
Mammalia C1QTNF1 34 35
  • 86.81 (n)
cow
(Bos Taurus)
Mammalia C1QTNF1 34 35
  • 86.26 (n)
rat
(Rattus norvegicus)
Mammalia C1qtnf1 34
  • 82.8 (n)
mouse
(Mus musculus)
Mammalia C1qtnf1 34 16 35
  • 81.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1QTNF1 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1QTNF1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1QTNF1 34
  • 77.17 (n)
-- 35
  • 54 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia C1QTNF1 35
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100538079 34
  • 71.77 (n)
c1qtnf1 35 35
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
OneToMany
Species where no ortholog for C1QTNF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF1 Gene

ENSEMBL:
Gene Tree for C1QTNF1 (if available)
TreeFam:
Gene Tree for C1QTNF1 (if available)

Paralogs for C1QTNF1 Gene

(4) SIMAP similar genes for C1QTNF1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QTNF1: view

Variants for C1QTNF1 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000052875 -- 79,029,233(+) GGGAA(C/T)GGTCG intron-variant, upstream-variant-2KB
rs1000147926 -- 79,034,630(+) TTTTG(A/T)CCCAA intron-variant
rs1000263656 -- 79,033,762(+) AGGAA(C/G)AGCCT intron-variant, upstream-variant-2KB
rs1000310947 -- 79,040,173(+) GACAA(C/T)AGGAA intron-variant
rs1000356766 -- 79,049,130(+) GTTGG(A/C)AGCAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF1 Gene

Variant ID Type Subtype PubMed ID
dgv1825e59 CNV duplication 20981092
esv3641342 CNV loss 21293372
esv3641343 CNV loss 21293372
nsv1057193 CNV gain 25217958
nsv2156 CNV deletion 18451855
nsv470610 CNV loss 18288195
nsv470611 CNV gain 18288195
nsv521186 CNV loss 19592680
nsv523650 CNV loss 19592680
nsv833556 CNV loss 17160897

Variation tolerance for C1QTNF1 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QTNF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF1 Gene

Disorders for C1QTNF1 Gene

Relevant External Links for C1QTNF1

Genetic Association Database (GAD)
C1QTNF1
Human Genome Epidemiology (HuGE) Navigator
C1QTNF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QTNF1

No disorders were found for C1QTNF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF1 Gene

Publications for C1QTNF1 Gene

  1. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PMID: 18842294) Ennis S. … Lotery A. (Lancet 2008) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. GIP, a G-protein-coupled receptor interacting protein. (PMID: 12409230) Innamorati G. … Birnbaumer M. (Regul. Pept. 2002) 2 3 64

Products for C1QTNF1 Gene

Sources for C1QTNF1 Gene

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