C1QL4 Gene
protein-coding GIFtS: 39
GCID: GC12M049726
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|
complement component 1, q subcomponent-like 4
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Aliases
for C1QL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Complement Component 1, Q Subcomponent-Like 41 2 | | C1QTNF111 2 | | CTRP111 2 | | Complement C1q-Like Protein 42 |
Export aliases for C1QL4 gene to outside databasesPrevious GC identifers: GC12M048013 GC12M046756 |
Summaries
for C1QL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: C1QL4_HUMAN, Q86Z23Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect oninhibitory synapses (By similarity)
|
Genomic Views
for C1QL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C1QL4 gene promoter:
GR STAT1 GR-beta STAT1beta STAT1alpha S8 STAT2 STAT3 PPAR-gamma2 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for C1QL4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1QL4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12C1QL4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M049726: view genomic region
(about GC identifiers)
Start:
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49,726,200 bp from pter |
End:
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49,730,971 bp from pter |
Size:
|
4,772 bases |
Orientation:
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minus strand |
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Proteins
for C1QL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C1QL4_HUMAN, Q86Z23 (See
protein sequence)Recommended Name: Complement C1q-like protein 4 precursor Size: 238 amino acids; 24909 Da
Subunit: Interacts with BAI3 (By similarity)
Subcellular location: Secreted (Potential)Explore the universe of human proteins at neXtProt for C1QL4: NX_Q86Z23
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86Z23
C1QL4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001008224.1
ENSEMBL proteins: ENSP00000335285
Human Recombinant Protein Products for C1QL4:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005581 | collagen |
IEA | -- |
C1QL4 for ontologies About GeneDecksing
C1QL4 Antibody Products:
Assay Products for C1QL4: |
Protein
Domains /
Families
for C1QL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C1QL4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86Z23ProtoNet protein and cluster: Q86Z23 2 Blocks protein families: IPB001073 Complement C1q protein IPB008160 Collagen triple helix repeat
UniProtKB/Swiss-Prot: C1QL4_HUMAN, Q86Z23Similarity: Contains 1 C1q domainSimilarity: Contains 1 collagen-like domain |
Function
for C1QL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: C1QL4_HUMAN, Q86Z23Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect oninhibitory synapses (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
C1QL4 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for C1QL4:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1QL4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C1QL4 (NM_001008223) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1QL4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QL4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QL4 |
|
Pathways & Interactions
for C1QL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1QL4
|
Drugs & Compounds
for C1QL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C1QL4
Search CenterWatch for drugs/clinical trials and news about C1QL4
|
Transcripts
for C1QL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C1QL4 gene: NM_001008223.1 Unigene Cluster for C1QL4: Complement component 1, q subcomponent-like 4 Hs.380386 [show with all ESTs]Unigene Representative Sequence: BC1108121 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000334221(uc001rtz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1QL4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C1QL4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C1QL4 (NM_001008223) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C1QL4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QL4 |
Additional cDNA sequence: AF466366.1 BC110812.1 1 DOTS entry: DT.101977763 12 AceView cDNA sequences: AF466366 CR600274 BM762336 AL518440 AL561826 BE888168 BM847021 AL529898 BM844470 AL518439 AL529897 AL519829
GeneLoc Exon Structure
|
Expression
for C1QL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C1QL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAACGGAC
About this image
See C1QL4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.380386
SABiosciences Custom PCR Arrays for C1QL4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1QL4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C1QL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1QL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1QL4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QL4 |
Orthologs
for C1QL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C1QL4 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
C1QL46 |
-- |
79(a) |
1 ↔ 1 |
GL343198.1(2343762-2385448) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.129052 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.54(n) |
|
BJ092454.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5592881 |
complement C1q-like protein 4-like |
70.72(n)
77.39(a) |
|
559288 XM_682618.2 XP_687710.2 |
ENSEMBL Gene Tree for C1QL4 (if available)
TreeFam Gene Tree for C1QL4 (if available) |
Paralogs
for C1QL4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C1QL4 gene
- C1QL32 COL8A22 C1QL22 C1QTNF92 C1QTNF52 OTOL12 C1QB2 COL10A12
- C1QTNF32 C1QTNF9B2 C1QA2 COL8A12 C1QL12 C1QTNF72 C1QTNF22 C1QC2
- ADIPOQ2
10 SIMAP similar genes for C1QL4 using alignment to 1 protein entry: C1QL4_HUMAN:C1QL3 C1QL1 C1QL2 OTOL1 C1QC C1QTNF3
COL8A2 C1QB ADIPOQ COL8A1
C1QL4 for paralogs About GeneDecksing
|
Genomic Variants
for C1QL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C1QL4 (49726200 - 49730971 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C1QL4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1QL4 |
|
Disorders
/ Diseases
for C1QL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C1QL4 for disorders About GeneDecksing
1  disease for C1QL4: About MalaCardsneuronitis
Export disorders for C1QL4 gene to outside databases
|
Publications
for C1QL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C1QL4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C1QL4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for C1QL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C1QL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C1QL4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C1QL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C1QL4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C1QL4 gene:
Search GeneIP for patents involving C1QL4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C1QL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QL4 |
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