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Aliases for C1QL4 Gene

Aliases for C1QL4 Gene

  • Complement Component 1, Q Subcomponent-Like 4 2 3
  • CTRP11 3 4 6
  • C1q And Tumor Necrosis Factor-Related Protein 11 3 4
  • C1q/TNF-Related Protein 11 3 4
  • Complement C1q-Like Protein 4 3
  • C1QTNF11 3

External Ids for C1QL4 Gene

Previous GeneCards Identifiers for C1QL4 Gene

  • GC12M048013
  • GC12M049726
  • GC12M046756

Summaries for C1QL4 Gene

GeneCards Summary for C1QL4 Gene

C1QL4 (Complement Component 1, Q Subcomponent-Like 4) is a Protein Coding gene. An important paralog of this gene is CBLN3.

UniProtKB/Swiss-Prot for C1QL4 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL4 Gene

Genomics for C1QL4 Gene

Regulatory Elements for C1QL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C1QL4 Gene

Start:
49,332,411 bp from pter
End:
49,337,188 bp from pter
Size:
4,778 bases
Orientation:
Minus strand

Genomic View for C1QL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1QL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL4 Gene

Proteins for C1QL4 Gene

  • Protein details for C1QL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Z23-C1QL4_HUMAN
    Recommended name:
    Complement C1q-like protein 4
    Protein Accession:
    Q86Z23
    Secondary Accessions:

    Protein attributes for C1QL4 Gene

    Size:
    238 amino acids
    Molecular mass:
    24909 Da
    Quaternary structure:
    • Forms homooligomers, predominantly dimers or trimers. Forms heterooligomers with C1QL1, C1QL2 and C1QL3, when proteins are coexpressed; this interaction does not occur after secretion. Interacts with BAI3.

neXtProt entry for C1QL4 Gene

Proteomics data for C1QL4 Gene at MOPED

Post-translational modifications for C1QL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL4 Gene

Domains for C1QL4 Gene

Protein Domains for C1QL4 Gene

Suggested Antigen Peptide Sequences for C1QL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Z23

UniProtKB/Swiss-Prot:

C1QL4_HUMAN :
  • Q86Z23
Domain:
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QL4: view

No data available for Gene Families for C1QL4 Gene

Function for C1QL4 Gene

Molecular function for C1QL4 Gene

UniProtKB/Swiss-Prot Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).

Gene Ontology (GO) - Molecular Function for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QL4: view

Phenotypes for C1QL4 Gene

GenomeRNAi human phenotypes for C1QL4:
genes like me logo Genes that share phenotypes with C1QL4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C1QL4 Gene

Localization for C1QL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1QL4 Gene COMPARTMENTS Subcellular localization image for C1QL4 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C1QL4: view

Pathways for C1QL4 Gene

SuperPathways for C1QL4 Gene

No Data Available

Interacting Proteins for C1QL4 Gene

Gene Ontology (GO) - Biological Process for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045599 negative regulation of fat cell differentiation IEA --
GO:0048147 negative regulation of fibroblast proliferation IEA --
GO:0070373 negative regulation of ERK1 and ERK2 cascade IEA --
genes like me logo Genes that share ontologies with C1QL4: view

No data available for Pathways by source for C1QL4 Gene

Transcripts for C1QL4 Gene

mRNA/cDNA for C1QL4 Gene

(12) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL4 Gene

Complement component 1, q subcomponent-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1QL4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C1QL4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL4 Gene

No ASD Table

Relevant External Links for C1QL4 Gene

GeneLoc Exon Structure for
C1QL4
ECgene alternative splicing isoforms for
C1QL4

Expression for C1QL4 Gene

mRNA expression in normal human tissues for C1QL4 Gene

mRNA differential expression in normal tissues according to GTEx for C1QL4 Gene

This gene is overexpressed in Testis (16.8), Brain - Hypothalamus (6.1), and Vagina (5.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C1QL4 Gene

SOURCE GeneReport for Unigene cluster for C1QL4 Gene Hs.380386

mRNA Expression by UniProt/SwissProt for C1QL4 Gene

Q86Z23-C1QL4_HUMAN
Tissue specificity: Highest expression levels in testis and adipose tissue, lower levels in skeletal muscle and kidney.
genes like me logo Genes that share expressions with C1QL4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C1QL4 Gene

Orthologs for C1QL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QL4 35
  • 99.86 (n)
  • 100 (a)
C1QL4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1QL4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1QL4 35
  • 92.3 (n)
  • 99.58 (a)
C1QL4 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C1ql4 35
  • 87.85 (n)
  • 96.44 (a)
C1ql4 16
C1ql4 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1QL4 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C1ql4 35
  • 86.07 (n)
  • 96.44 (a)
lizard
(Anolis carolinensis)
Reptilia C1QL4 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12905 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c1ql4 35
  • 69.24 (n)
  • 77.27 (a)
zebrafish
(Danio rerio)
Actinopterygii C1QL4 (1 of 2) 36
  • 74 (a)
OneToMany
C1QL4 (2 of 2) 36
  • 74 (a)
OneToMany
LOC567540 35
  • 67.3 (n)
  • 75.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Capr 36
  • 4 (a)
OneToMany
Species with no ortholog for C1QL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL4 Gene

ENSEMBL:
Gene Tree for C1QL4 (if available)
TreeFam:
Gene Tree for C1QL4 (if available)

Paralogs for C1QL4 Gene

Selected SIMAP similar genes for C1QL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QL4: view

Variants for C1QL4 Gene

Sequence variations from dbSNP and Humsavar for C1QL4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7299812 -- 49,335,677(+) AGGTC(A/G)CAGCT intron-variant
rs7959732 -- 49,337,395(+) ACTTT(C/T)ACCCT upstream-variant-2KB
rs7972869 -- 49,337,384(+) GCTGT(A/G)TCTTT upstream-variant-2KB
rs10400435 -- 49,332,335(+) GGAGC(C/T)CTTTA downstream-variant-500B
rs10650135 -- 49,332,871(+) CCTCC(-/CTCC)TCTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C1QL4 Gene

Variant ID Type Subtype PubMed ID
dgv1423n71 CNV Loss 21882294
nsv832405 CNV Gain 17160897
nsv826368 CNV Gain 20364138

Relevant External Links for C1QL4 Gene

HapMap Linkage Disequilibrium report
C1QL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL4 Gene

Disorders for C1QL4 Gene

No disorders were found for C1QL4 Gene.

No data available for UniProtKB/Swiss-Prot for C1QL4 Gene

Publications for C1QL4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. (PMID: 23449976) Wei Z. … Wong G.W. (J. Biol. Chem. 2013) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C1QL4 Gene

Sources for C1QL4 Gene

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