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Aliases for C1QL4 Gene

Aliases for C1QL4 Gene

  • Complement C1q Like 4 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 11 3 4
  • Complement Component 1, Q Subcomponent Like 4 2 3
  • C1q/TNF-Related Protein 11 3 4
  • CTRP11 3 4
  • Complement C1q-Like Protein 4 3
  • C1QTNF11 3

External Ids for C1QL4 Gene

Previous GeneCards Identifiers for C1QL4 Gene

  • GC12M048013
  • GC12M049726
  • GC12M046756

Summaries for C1QL4 Gene

GeneCards Summary for C1QL4 Gene

C1QL4 (Complement C1q Like 4) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is C1QL1.

UniProtKB/Swiss-Prot for C1QL4 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL4 Gene

Genomics for C1QL4 Gene

Regulatory Elements for C1QL4 Gene

Enhancers for C1QL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F049321 0.5 ENCODE 20.1 +14.1 14129 2.4 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 C1QL4 RPL35AP28 LALBA OR5BS1P OR11M1P ENSG00000258273 H1FNT ENSG00000257253 LOC283332 DNAJC22
GH12F049263 0.2 ENCODE 18.4 +70.7 70660 6.6 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 MEF2D CCNT1 DDX23 KANSL2 LOC390314 PRKAG1 C1QL4 BCDIN3D CACNB3 CERS5 PRPH
GH12F049284 0.4 FANTOM5 11.7 +52.5 52505 0.1 GLIS1 PRDM1 C1QL4 PRPH GC12M049291 ENSG00000258232
GH12F049358 1 Ensembl ENCODE 11.3 -21.7 -21714 1.0 CTCF MXI1 CBX3 ARID4B ZNF384 ZNF2 RAD21 RFX5 GATA3 ZFHX2 KCNH3 C1QL4 MCRS1 CCNT1 SPATS2 DNAJC22
GH12F049514 1.1 Ensembl ENCODE 11.1 -178.2 -178176 1.2 ZNF263 MAZ JUN BHLHE40 ZFP37 ZHX2 ZIC2 ZNF335 FOSL1 JUND SPATS2 KCNH3 C1QL4 MCRS1 PRPH FMNL3 TMBIM6 ENSG00000257464
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C1QL4 on UCSC Golden Path with GeneCards custom track

Promoters for C1QL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243915 -112 601 ATF1 PKNOX1 SIN3A FEZF1 ZNF48 ZNF2 ZNF766 GLIS2 ZNF143 KLF7

Genomic Location for C1QL4 Gene

Chromosome:
12
Start:
49,332,411 bp from pter
End:
49,337,188 bp from pter
Size:
4,778 bases
Orientation:
Minus strand

Genomic View for C1QL4 Gene

Genes around C1QL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL4 Gene

Proteins for C1QL4 Gene

  • Protein details for C1QL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Z23-C1QL4_HUMAN
    Recommended name:
    Complement C1q-like protein 4
    Protein Accession:
    Q86Z23

    Protein attributes for C1QL4 Gene

    Size:
    238 amino acids
    Molecular mass:
    24909 Da
    Quaternary structure:
    • Forms homooligomers, predominantly dimers or trimers. Forms heterooligomers with C1QL1, C1QL2 and C1QL3, when proteins are coexpressed; this interaction does not occur after secretion. Interacts with ADGRB3.

neXtProt entry for C1QL4 Gene

Post-translational modifications for C1QL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL4 Gene

Domains & Families for C1QL4 Gene

Gene Families for C1QL4 Gene

Protein Domains for C1QL4 Gene

Suggested Antigen Peptide Sequences for C1QL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Z23

UniProtKB/Swiss-Prot:

C1QL4_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QL4: view

Function for C1QL4 Gene

Molecular function for C1QL4 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).

Gene Ontology (GO) - Molecular Function for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QL4: view
genes like me logo Genes that share phenotypes with C1QL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QL4 Gene

Localization for C1QL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1QL4 Gene COMPARTMENTS Subcellular localization image for C1QL4 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C1QL4: view

Pathways & Interactions for C1QL4 Gene

SuperPathways for C1QL4 Gene

No Data Available

Interacting Proteins for C1QL4 Gene

Gene Ontology (GO) - Biological Process for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045599 negative regulation of fat cell differentiation IEA --
GO:0048147 negative regulation of fibroblast proliferation IEA --
GO:0070373 negative regulation of ERK1 and ERK2 cascade IEA --
genes like me logo Genes that share ontologies with C1QL4: view

No data available for Pathways by source and SIGNOR curated interactions for C1QL4 Gene

Transcripts for C1QL4 Gene

mRNA/cDNA for C1QL4 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL4 Gene

Complement component 1, q subcomponent-like 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL4 Gene

No ASD Table

Relevant External Links for C1QL4 Gene

GeneLoc Exon Structure for
C1QL4
ECgene alternative splicing isoforms for
C1QL4

Expression for C1QL4 Gene

mRNA expression in normal human tissues for C1QL4 Gene

mRNA differential expression in normal tissues according to GTEx for C1QL4 Gene

This gene is overexpressed in Testis (x16.8), Brain - Hypothalamus (x6.1), and Vagina (x5.0).

Protein differential expression in normal tissues from HIPED for C1QL4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QL4 Gene



Protein tissue co-expression partners for C1QL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1QL4 Gene:

C1QL4

SOURCE GeneReport for Unigene cluster for C1QL4 Gene:

Hs.380386

mRNA Expression by UniProt/SwissProt for C1QL4 Gene:

Q86Z23-C1QL4_HUMAN
Tissue specificity: Highest expression levels in testis and adipose tissue, lower levels in skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with C1QL4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C1QL4 Gene

Orthologs for C1QL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QL4 34 35
  • 99.86 (n)
oppossum
(Monodelphis domestica)
Mammalia C1QL4 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1QL4 34 35
  • 92.3 (n)
mouse
(Mus musculus)
Mammalia C1ql4 34 16 35
  • 87.85 (n)
rat
(Rattus norvegicus)
Mammalia C1ql4 34
  • 86.07 (n)
cow
(Bos Taurus)
Mammalia C1QL4 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1QL4 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1ql4 34
  • 69.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12905 34
zebrafish
(Danio rerio)
Actinopterygii C1QL4 (1 of 2) 35
  • 74 (a)
OneToMany
C1QL4 (2 of 2) 35
  • 74 (a)
OneToMany
LOC567540 34
  • 67.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta Capr 35
  • 4 (a)
OneToMany
Species where no ortholog for C1QL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL4 Gene

ENSEMBL:
Gene Tree for C1QL4 (if available)
TreeFam:
Gene Tree for C1QL4 (if available)

Paralogs for C1QL4 Gene

(7) SIMAP similar genes for C1QL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QL4: view

Variants for C1QL4 Gene

Sequence variations from dbSNP and Humsavar for C1QL4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10400435 -- 49,332,335(+) GGAGC(C/T)CTTTA downstream-variant-500B
rs10400567 -- 49,331,937(+) AGCCT(C/T)CCACT downstream-variant-500B
rs10650135 -- 49,332,871(+) CCTCC(-/CTCC)TCTTC utr-variant-3-prime
rs111504645 -- 49,337,943(+) CCAGA(C/G)GGGGA upstream-variant-2KB
rs111645880 -- 49,334,337(+) GGTGC(A/G)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QL4 Gene

Variant ID Type Subtype PubMed ID
dgv1497n100 CNV gain 25217958
nsv1134226 CNV deletion 24896259
nsv826368 CNV gain 20364138
nsv832405 CNV gain 17160897
nsv952175 CNV deletion 24416366

Variation tolerance for C1QL4 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL4 Gene

Disorders for C1QL4 Gene

Relevant External Links for C1QL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QL4

No disorders were found for C1QL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QL4 Gene

Publications for C1QL4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. (PMID: 23449976) Wei Z. … Wong G.W. (J. Biol. Chem. 2013) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C1QL4 Gene

Sources for C1QL4 Gene

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