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Aliases for C1QL3 Gene

Aliases for C1QL3 Gene

  • Complement Component 1, Q Subcomponent-Like 3 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 13 3 4
  • C1q/TNF-Related Protein 13 3 4
  • CTRP13 3 4
  • C1QTNF13 3
  • C1ql 3
  • K100 3

External Ids for C1QL3 Gene

Previous GeneCards Identifiers for C1QL3 Gene

  • GC10M016558
  • GC10M016594

Summaries for C1QL3 Gene

GeneCards Summary for C1QL3 Gene

C1QL3 (Complement Component 1, Q Subcomponent-Like 3) is a Protein Coding gene. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for C1QL3 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL3 Gene

Genomics for C1QL3 Gene

Regulatory Elements for C1QL3 Gene

Genomic Location for C1QL3 Gene

Chromosome:
10
Start:
16,513,743 bp from pter
End:
16,522,005 bp from pter
Size:
8,263 bases
Orientation:
Minus strand

Genomic View for C1QL3 Gene

Genes around C1QL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL3 Gene

Proteins for C1QL3 Gene

  • Protein details for C1QL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWW1-C1QL3_HUMAN
    Recommended name:
    Complement C1q-like protein 3
    Protein Accession:
    Q5VWW1
    Secondary Accessions:
    • A0PJY4
    • A0PJY5

    Protein attributes for C1QL3 Gene

    Size:
    255 amino acids
    Molecular mass:
    26719 Da
    Quaternary structure:
    • Forms homooligomers. Interacts with ADGRB3. Interacts with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

    Alternative splice isoforms for C1QL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QL3 Gene

Proteomics data for C1QL3 Gene at MOPED

Post-translational modifications for C1QL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL3 Gene

Domains & Families for C1QL3 Gene

Protein Domains for C1QL3 Gene

Suggested Antigen Peptide Sequences for C1QL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VWW1

UniProtKB/Swiss-Prot:

C1QL3_HUMAN :
  • Contains 1 C1q domain.
Domain:
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QL3: view

No data available for Gene Families for C1QL3 Gene

Function for C1QL3 Gene

Molecular function for C1QL3 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).

Phenotypes for C1QL3 Gene

genes like me logo Genes that share phenotypes with C1QL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL3

miRNA for C1QL3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1QL3 Gene

Localization for C1QL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1QL3 Gene COMPARTMENTS Subcellular localization image for C1QL3 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for C1QL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QL3: view

Pathways & Interactions for C1QL3 Gene

SuperPathways for C1QL3 Gene

No Data Available

Interacting Proteins for C1QL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298943%0d%0a9606.ENSP00000350894%0d%0a
Selected Interacting proteins: Q5VWW1-C1QL3_HUMAN ENSP00000298943 for C1QL3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for C1QL3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1QL3 Gene

Drugs & Compounds for C1QL3 Gene

No Compound Related Data Available

Transcripts for C1QL3 Gene

mRNA/cDNA for C1QL3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL3 Gene

Complement component 1, q subcomponent-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL3 Gene

No ASD Table

Relevant External Links for C1QL3 Gene

GeneLoc Exon Structure for
C1QL3
ECgene alternative splicing isoforms for
C1QL3

Expression for C1QL3 Gene

mRNA expression in normal human tissues for C1QL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QL3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x13.9), Brain - Frontal Cortex (BA9) (x9.7), and Brain - Cortex (x5.3).

Protein differential expression in normal tissues from HIPED for C1QL3 Gene

This gene is overexpressed in Adipocyte (35.1) and Frontal cortex (33.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QL3 Gene



SOURCE GeneReport for Unigene cluster for C1QL3 Gene Hs.676792

mRNA Expression by UniProt/SwissProt for C1QL3 Gene

Q5VWW1-C1QL3_HUMAN
Tissue specificity: Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney.
genes like me logo Genes that share expression patterns with C1QL3: view

Protein tissue co-expression partners for C1QL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for C1QL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1QL3 35
  • 95.29 (n)
  • 99.61 (a)
C1QL3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1QL3 35
  • 95.29 (n)
  • 99.61 (a)
mouse
(Mus musculus)
Mammalia C1ql3 35
  • 93.2 (n)
  • 99.61 (a)
C1ql3 16
C1ql3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1QL3 35
  • 99.74 (n)
  • 100 (a)
C1QL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C1ql3 35
  • 92.55 (n)
  • 99.61 (a)
oppossum
(Monodelphis domestica)
Mammalia C1QL3 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1QL3 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1QL3 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1ql3 35
  • 81.74 (n)
  • 94.61 (a)
zebrafish
(Danio rerio)
Actinopterygii c1ql3a 35
  • 77.68 (n)
  • 89.96 (a)
c1ql3a 36
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Capr 36
  • 5 (a)
OneToMany
Species with no ortholog for C1QL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL3 Gene

ENSEMBL:
Gene Tree for C1QL3 (if available)
TreeFam:
Gene Tree for C1QL3 (if available)

Paralogs for C1QL3 Gene

(11) SIMAP similar genes for C1QL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QL3: view

Variants for C1QL3 Gene

Sequence variations from dbSNP and Humsavar for C1QL3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs613731 -- 16,520,999(-) ACTAC(A/G/T)AGATG reference, missense, stop-gained
rs690666 -- 16,516,459(+) AATGG(G/T)GAAAA intron-variant
rs692738 -- 16,516,426(+) TGACT(C/T)GTGTT intron-variant
rs703012 -- 16,516,633(+) AAGGT(A/G)TTGGA intron-variant
rs703013 -- 16,516,676(+) ACACA(A/C)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QL3 Gene

Variant ID Type Subtype PubMed ID
nsv894907 CNV Gain 21882294
nsv831797 CNV Loss 17160897
nsv25020 CNV Loss 16902084

Variation tolerance for C1QL3 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QL3 Gene

HapMap Linkage Disequilibrium report
C1QL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL3 Gene

Disorders for C1QL3 Gene

Relevant External Links for C1QL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QL3

No disorders were found for C1QL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QL3 Gene

Publications for C1QL3 Gene

  1. Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. (PMID: 21378161) Wei Z. … Wong G.W. (J. Biol. Chem. 2011) 2 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47. (PMID: 10862616) Koide T. … Nagata K. (J. Biol. Chem. 2000) 3

Products for C1QL3 Gene

Sources for C1QL3 Gene

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