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Aliases for C1QL3 Gene

Aliases for C1QL3 Gene

  • Complement C1q Like 3 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 13 3 4
  • Complement Component 1, Q Subcomponent-Like 3 2 3
  • C1q/TNF-Related Protein 13 3 4
  • CTRP13 3 4
  • Complement C1q-Like Protein 3 3
  • C1QTNF13 3
  • C1ql 3
  • K100 3

External Ids for C1QL3 Gene

Previous GeneCards Identifiers for C1QL3 Gene

  • GC10M016558
  • GC10M016594

Summaries for C1QL3 Gene

GeneCards Summary for C1QL3 Gene

C1QL3 (Complement C1q Like 3) is a Protein Coding gene. An important paralog of this gene is C1QL1.

UniProtKB/Swiss-Prot for C1QL3 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).

Additional gene information for C1QL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL3 Gene

Genomics for C1QL3 Gene

Regulatory Elements for C1QL3 Gene

Enhancers for C1QL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H016439 1.3 FANTOM5 Ensembl ENCODE 10.7 +81.6 81605 2 HDAC1 ZNF687 SOX6 SMAD5 CEBPB ZNF76 JUNB BATF YY1 FOSL1 PTER C1QL3 RNU2-18P
GH10H016470 0.6 ENCODE 10.9 +51.1 51079 1 TCF12 PKNOX1 EGR1 ZSCAN29 DPF2 TRIM24 ETV6 PTER C1QL3 RNU2-18P
GH10H016612 0.6 ENCODE 9.5 -90.4 -90432 0 ZNF511 CEBPB MIER2 REST ZNF644 ZSCAN9 ZNF766 RFX3 ZNF143 HOMEZ ENSG00000225213 C1QL3 MINDY3 GC10P016625 GC10M016562
GH10H016852 0.8 Ensembl ENCODE 4.6 -331.2 -331187 0 CTCF ZNF654 ZNF316 SMC3 REST RCOR1 RAD21 VIM VIM-AS1 ENSG00000234961 C1QL3 GC10P016843 CUBN
GH10H016515 0.3 FANTOM5 0.4 +6.7 6712 0 GC10M016512 C1QL3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1QL3 on UCSC Golden Path with GeneCards custom track

Promoters for C1QL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025008 605 401 CTCF SUZ12 ZNF10 FEZF1 ZBTB8A ZNF398 HIC1 GLIS2 GLIS1 MLLT1

Genomic Location for C1QL3 Gene

Chromosome:
10
Start:
16,513,743 bp from pter
End:
16,522,005 bp from pter
Size:
8,263 bases
Orientation:
Minus strand

Genomic View for C1QL3 Gene

Genes around C1QL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL3 Gene

Proteins for C1QL3 Gene

  • Protein details for C1QL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWW1-C1QL3_HUMAN
    Recommended name:
    Complement C1q-like protein 3
    Protein Accession:
    Q5VWW1
    Secondary Accessions:
    • A0PJY4
    • A0PJY5

    Protein attributes for C1QL3 Gene

    Size:
    255 amino acids
    Molecular mass:
    26719 Da
    Quaternary structure:
    • Forms homooligomers. Interacts with ADGRB3. Interacts with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

    Alternative splice isoforms for C1QL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QL3 Gene

Post-translational modifications for C1QL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL3 Gene

Domains & Families for C1QL3 Gene

Gene Families for C1QL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for C1QL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QL3: view

No data available for UniProtKB/Swiss-Prot for C1QL3 Gene

Function for C1QL3 Gene

Molecular function for C1QL3 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).

Phenotypes for C1QL3 Gene

genes like me logo Genes that share phenotypes with C1QL3: view

Animal Models for C1QL3 Gene

MGI Knock Outs for C1QL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL3

CRISPR Products

miRNA for C1QL3 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1QL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1QL3 Gene

Localization for C1QL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QL3 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for C1QL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QL3 Gene

Pathways & Interactions for C1QL3 Gene

SuperPathways for C1QL3 Gene

No Data Available

Interacting Proteins for C1QL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298943%0d%0a9606.ENSP00000350894%0d%0a
Selected Interacting proteins: Q5VWW1-C1QL3_HUMAN ENSP00000298943 for C1QL3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C1QL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050807 regulation of synapse organization IEA --
genes like me logo Genes that share ontologies with C1QL3: view

No data available for Pathways by source and SIGNOR curated interactions for C1QL3 Gene

Drugs & Compounds for C1QL3 Gene

No Compound Related Data Available

Transcripts for C1QL3 Gene

mRNA/cDNA for C1QL3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL3 Gene

Complement component 1, q subcomponent-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C1QL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL3 Gene

No ASD Table

Relevant External Links for C1QL3 Gene

GeneLoc Exon Structure for
C1QL3
ECgene alternative splicing isoforms for
C1QL3

Expression for C1QL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QL3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x13.9), Brain - Frontal Cortex (BA9) (x9.7), and Brain - Cortex (x5.3).

Protein differential expression in normal tissues from HIPED for C1QL3 Gene

This gene is overexpressed in Adipocyte (35.1) and Frontal cortex (33.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QL3 Gene



Protein tissue co-expression partners for C1QL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1QL3 Gene:

C1QL3

SOURCE GeneReport for Unigene cluster for C1QL3 Gene:

Hs.676792

mRNA Expression by UniProt/SwissProt for C1QL3 Gene:

Q5VWW1-C1QL3_HUMAN
Tissue specificity: Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney.

Evidence on tissue expression from TISSUES for C1QL3 Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Intestine(4.3)
  • Skin(4.3)
  • Eye(4.2)
  • Blood(3.7)
  • Liver(3.6)
  • Kidney(3.4)
  • Pancreas(3.2)
  • Heart(2.5)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with C1QL3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QL3 Gene

Orthologs for C1QL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL3 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia C1QL3 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1QL3 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1QL3 33 34
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia C1QL3 33 34
  • 95.29 (n)
dog
(Canis familiaris)
Mammalia C1QL3 33
  • 95.29 (n)
mouse
(Mus musculus)
Mammalia C1ql3 33 16 34
  • 93.2 (n)
rat
(Rattus norvegicus)
Mammalia C1ql3 33
  • 92.55 (n)
lizard
(Anolis carolinensis)
Reptilia C1QL3 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1ql3 33
  • 81.74 (n)
zebrafish
(Danio rerio)
Actinopterygii c1ql3a 33 34
  • 77.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta Capr 34
  • 5 (a)
OneToMany
Species where no ortholog for C1QL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL3 Gene

ENSEMBL:
Gene Tree for C1QL3 (if available)
TreeFam:
Gene Tree for C1QL3 (if available)

Paralogs for C1QL3 Gene

(11) SIMAP similar genes for C1QL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QL3: view

Variants for C1QL3 Gene

Sequence variations from dbSNP and Humsavar for C1QL3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000060872 -- 16,516,467(+) AAAAA(A/G)TTAAA intron-variant
rs1000167046 -- 16,521,749(+) CGGTC(C/G)GCACG utr-variant-5-prime
rs1000545642 -- 16,518,082(+) GTTTT(A/T)TGAAA intron-variant, downstream-variant-500B
rs1000578398 -- 16,517,838(+) TTGTA(C/T)TTCTG intron-variant, nc-transcript-variant
rs1001263749 -- 16,515,359(+) CAGAG(A/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QL3 Gene

Variant ID Type Subtype PubMed ID
nsv1046833 CNV gain 25217958
nsv25020 CNV deletion 16902084
nsv831797 CNV loss 17160897

Variation tolerance for C1QL3 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL3 Gene

Disorders for C1QL3 Gene

Relevant External Links for C1QL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1QL3

No disorders were found for C1QL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QL3 Gene

Publications for C1QL3 Gene

  1. Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. (PMID: 21378161) Wei Z … Wong GW (The Journal of biological chemistry 2011) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  3. Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 Serum Levels with Coronary Artery Disease in Subjects with and without Type 2 Diabetes Mellitus. (PMID: 28033351) Fadaei R … Fallah S (PloS one 2016) 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for C1QL3 Gene

Sources for C1QL3 Gene

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