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Aliases for C1QL3 Gene

Aliases for C1QL3 Gene

  • Complement Component 1, Q Subcomponent-Like 3 2 3
  • CTRP13 3 4 6
  • C1q And Tumor Necrosis Factor-Related Protein 13 3 4
  • C1q/TNF-Related Protein 13 3 4
  • K100 3 6
  • Complement C1q-Like Protein 3 3
  • C1QTNF13 3
  • C1ql 3

External Ids for C1QL3 Gene

Previous GeneCards Identifiers for C1QL3 Gene

  • GC10M016558
  • GC10M016594

Summaries for C1QL3 Gene

GeneCards Summary for C1QL3 Gene

C1QL3 (Complement Component 1, Q Subcomponent-Like 3) is a Protein Coding gene. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for C1QL3 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL3 Gene

Genomics for C1QL3 Gene

Regulatory Elements for C1QL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C1QL3 Gene

Start:
16,513,743 bp from pter
End:
16,522,005 bp from pter
Size:
8,263 bases
Orientation:
Minus strand

Genomic View for C1QL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1QL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL3 Gene

Proteins for C1QL3 Gene

  • Protein details for C1QL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWW1-C1QL3_HUMAN
    Recommended name:
    Complement C1q-like protein 3
    Protein Accession:
    Q5VWW1
    Secondary Accessions:
    • A0PJY4
    • A0PJY5

    Protein attributes for C1QL3 Gene

    Size:
    255 amino acids
    Molecular mass:
    26719 Da
    Quaternary structure:
    • Forms homooligomers. Interacts with BAI3. Interacts with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

    Alternative splice isoforms for C1QL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QL3 Gene

Proteomics data for C1QL3 Gene at MOPED

Post-translational modifications for C1QL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL3 Gene

Domains for C1QL3 Gene

Protein Domains for C1QL3 Gene

Suggested Antigen Peptide Sequences for C1QL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VWW1

UniProtKB/Swiss-Prot:

C1QL3_HUMAN :
  • Q5VWW1
Domain:
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QL3: view

No data available for Gene Families for C1QL3 Gene

Function for C1QL3 Gene

Molecular function for C1QL3 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).

Gene Ontology (GO) - Molecular Function for C1QL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with C1QL3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C1QL3 Gene

Localization for C1QL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1QL3 Gene COMPARTMENTS Subcellular localization image for C1QL3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for C1QL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QL3: view

Pathways for C1QL3 Gene

SuperPathways for C1QL3 Gene

No Data Available

Interacting Proteins for C1QL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298943%0d%0a9606.ENSP00000350894%0d%0a
Selected Interacting proteins: ENSP00000298943 Q5VWW1-C1QL3_HUMAN for C1QL3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C1QL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050807 regulation of synapse organization IEA --
genes like me logo Genes that share ontologies with C1QL3: view

No data available for Pathways by source for C1QL3 Gene

Transcripts for C1QL3 Gene

mRNA/cDNA for C1QL3 Gene

(24) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL3 Gene

Complement component 1, q subcomponent-like 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1QL3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL3 Gene

No ASD Table

Relevant External Links for C1QL3 Gene

GeneLoc Exon Structure for
C1QL3
ECgene alternative splicing isoforms for
C1QL3

Expression for C1QL3 Gene

mRNA expression in normal human tissues for C1QL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QL3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (13.9), Brain - Frontal Cortex (BA9) (9.7), and Brain - Cortex (5.3).

Protein differential expression in normal tissues for C1QL3 Gene

This gene is overexpressed in Adipocyte (35.1) and Frontal cortex (33.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C1QL3 Gene

SOURCE GeneReport for Unigene cluster for C1QL3 Gene Hs.676792

mRNA Expression by UniProt/SwissProt for C1QL3 Gene

Q5VWW1-C1QL3_HUMAN
Tissue specificity: Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney.
genes like me logo Genes that share expressions with C1QL3: view

Expression partners for C1QL3 Gene

In Situ Assay Products

Orthologs for C1QL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1QL3 35
  • 95.29 (n)
  • 99.61 (a)
C1QL3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1QL3 35
  • 95.29 (n)
  • 99.61 (a)
mouse
(Mus musculus)
Mammalia C1ql3 35
  • 93.2 (n)
  • 99.61 (a)
C1ql3 16
C1ql3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1QL3 35
  • 99.74 (n)
  • 100 (a)
C1QL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C1ql3 35
  • 92.55 (n)
  • 99.61 (a)
oppossum
(Monodelphis domestica)
Mammalia C1QL3 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1QL3 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1QL3 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1ql3 35
  • 81.74 (n)
  • 94.61 (a)
zebrafish
(Danio rerio)
Actinopterygii c1ql3a 35
  • 77.68 (n)
  • 89.96 (a)
c1ql3a 36
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Capr 36
  • 5 (a)
OneToMany
Species with no ortholog for C1QL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL3 Gene

ENSEMBL:
Gene Tree for C1QL3 (if available)
TreeFam:
Gene Tree for C1QL3 (if available)

Paralogs for C1QL3 Gene

Selected SIMAP similar genes for C1QL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QL3: view

Variants for C1QL3 Gene

Sequence variations from dbSNP and Humsavar for C1QL3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs590303 -- 16,516,295(+) ACGCA(C/G)TTTGA intron-variant
rs591658 -- 16,516,591(+) CATGT(G/T)CTATG intron-variant
rs613731 -- 16,520,999(-) ACTAC(G/T)AGATG reference, stop-gained
rs690666 -- 16,516,459(+) AATGG(G/T)GAAAA intron-variant
rs692738 -- 16,516,426(+) TGACT(C/T)GTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QL3 Gene

Variant ID Type Subtype PubMed ID
nsv894907 CNV Gain 21882294
nsv831797 CNV Loss 17160897
nsv25020 CNV Loss 16902084

Relevant External Links for C1QL3 Gene

HapMap Linkage Disequilibrium report
C1QL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL3 Gene

Disorders for C1QL3 Gene

No disorders were found for C1QL3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for C1QL3 Gene

Publications for C1QL3 Gene

  1. Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. (PMID: 21378161) Wei Z. … Wong G.W. (J. Biol. Chem. 2011) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47. (PMID: 10862616) Koide T. … Nagata K. (J. Biol. Chem. 2000) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C1QL3 Gene

Sources for C1QL3 Gene

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