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Aliases for C1QL2 Gene

Aliases for C1QL2 Gene

  • Complement C1q Like 2 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 10 3 4
  • Complement Component 1, Q Subcomponent-Like 2 2 3
  • C1q/TNF-Related Protein 10 3 4
  • CTRP10 3 4
  • C1q And Tumor Necrosis Factor Related Protein 10 2
  • C1q-Domain Containing Protein 3
  • Complement C1q-Like Protein 2 3
  • C1QTNF10 3

External Ids for C1QL2 Gene

Previous GeneCards Identifiers for C1QL2 Gene

  • GC02M120009
  • GC02M119630
  • GC02M119914
  • GC02M112238

Summaries for C1QL2 Gene

GeneCards Summary for C1QL2 Gene

C1QL2 (Complement C1q Like 2) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is C1QL3.

UniProtKB/Swiss-Prot for C1QL2 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL2 Gene

Genomics for C1QL2 Gene

Regulatory Elements for C1QL2 Gene

Enhancers for C1QL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G119485 2.1 VISTA Ensembl ENCODE dbSUPER 4.6 -330.2 -330245 7.6 HNRNPUL1 FOXA2 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 YY1 FOS ZNF263 ENSG00000231013 SCTR C1QL2
GH02G119111 0.6 ENCODE 12.1 +47.1 47068 0.1 ZNF579 JUND FOXA2 JUN FOS FOXA1 C1QL2 LOC105373580
GH02G119126 0.6 ENCODE 11.8 +32.1 32076 0.2 CTCF REST ZIC2 RAD21 ZNF560 GLIS2 GLIS1 ZNF512 ZNF143 CREM C1QL2 LOC105373580
GH02G119112 0.4 ENCODE 12.1 +45.8 45796 1.0 CTBP2 C1QL2 TMEM177 LOC105373580
GH02G119437 0.9 dbSUPER 5.3 -279.2 -279237 2.0 ELF3 HNRNPUL1 MLX ARID4B DMAP1 RAD21 ZNF48 RARA YY1 GATA4 ENSG00000231013 SCTR C1QL2 TMEM37
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C1QL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1QL2 Gene

119,156,243 bp from pter
119,158,895 bp from pter
2,653 bases
Minus strand

Genomic View for C1QL2 Gene

Genes around C1QL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL2 Gene

Proteins for C1QL2 Gene

  • Protein details for C1QL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1q-like protein 2
    Protein Accession:

    Protein attributes for C1QL2 Gene

    287 amino acids
    Molecular mass:
    29468 Da
    Quaternary structure:
    • Forms homotrimers which can further assemble to form higher-order oligomeric complexes. Interacts with ADGRB3. May interact with ERFE. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

neXtProt entry for C1QL2 Gene

Post-translational modifications for C1QL2 Gene

No Post-translational modifications

Other Protein References for C1QL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL2 Gene

Domains & Families for C1QL2 Gene

Gene Families for C1QL2 Gene

Suggested Antigen Peptide Sequences for C1QL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QL2: view

No data available for UniProtKB/Swiss-Prot for C1QL2 Gene

Function for C1QL2 Gene

Molecular function for C1QL2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

Gene Ontology (GO) - Molecular Function for C1QL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QL2: view

Phenotypes for C1QL2 Gene

genes like me logo Genes that share phenotypes with C1QL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL2

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QL2 Gene

Localization for C1QL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QL2 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for C1QL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QL2: view

Pathways & Interactions for C1QL2 Gene

SuperPathways for C1QL2 Gene

No Data Available

Interacting Proteins for C1QL2 Gene

Gene Ontology (GO) - Biological Process for C1QL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051259 protein oligomerization IEA --
genes like me logo Genes that share ontologies with C1QL2: view

No data available for Pathways by source and SIGNOR curated interactions for C1QL2 Gene

Drugs & Compounds for C1QL2 Gene

No Compound Related Data Available

Transcripts for C1QL2 Gene

mRNA/cDNA for C1QL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL2 Gene

Complement component 1, q subcomponent-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL2 Gene

No ASD Table

Relevant External Links for C1QL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1QL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QL2 Gene

This gene is overexpressed in Brain - Hippocampus (x8.2), Brain - Amygdala (x6.9), Brain - Cortex (x5.8), Brain - Frontal Cortex (BA9) (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.4), and Brain - Hypothalamus (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of C1QL2 Gene:


SOURCE GeneReport for Unigene cluster for C1QL2 Gene:

genes like me logo Genes that share expression patterns with C1QL2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QL2 Gene

Orthologs for C1QL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1QL2 34 35
  • 99.39 (n)
(Canis familiaris)
Mammalia C1QL2 34 35
  • 90.82 (n)
(Monodelphis domestica)
Mammalia C1QL2 35
  • 89 (a)
(Bos Taurus)
Mammalia C1QL2 34 35
  • 88.85 (n)
(Mus musculus)
Mammalia C1ql2 34 16 35
  • 86.53 (n)
(Rattus norvegicus)
Mammalia C1ql2 34
  • 85.6 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 1 (a)
(Anolis carolinensis)
Reptilia C1QL2 35
  • 96 (a)
(Danio rerio)
Actinopterygii c1ql2 34 35
  • 73.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta Capr 35
  • 5 (a)
Species where no ortholog for C1QL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL2 Gene

Gene Tree for C1QL2 (if available)
Gene Tree for C1QL2 (if available)

Paralogs for C1QL2 Gene

(7) SIMAP similar genes for C1QL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QL2: view

Variants for C1QL2 Gene

Sequence variations from dbSNP and Humsavar for C1QL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000183501 -- 119,160,012(+) GAATA(C/G)TCTAT upstream-variant-2KB
rs1001447505 -- 119,157,588(+) GACCT(C/G)CCCGT reference, missense
rs1002465342 -- 119,156,344(+) TGTGG(A/G)TGGGG utr-variant-3-prime
rs1003084855 -- 119,160,228(+) TGTCC(G/T)GGGGG upstream-variant-2KB
rs1003423066 -- 119,157,437(+) GCATC(A/G)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QL2 Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV gain 19166990
nsv582783 CNV gain 21841781
nsv582784 CNV gain 21841781
nsv829637 CNV gain 20364138
nsv954802 CNV deletion 24416366

Variation tolerance for C1QL2 Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1QL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL2 Gene

Disorders for C1QL2 Gene

Relevant External Links for C1QL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C1QL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QL2 Gene

Publications for C1QL2 Gene

  1. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. (PMID: 18783346) Wong G.W. … Lodish H.F. (Biochem. J. 2008) 2 3 64
  2. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3 64
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C1QL2 Gene

Sources for C1QL2 Gene

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