Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C1QL2 Gene

Aliases for C1QL2 Gene

  • Complement Component 1, Q Subcomponent-Like 2 2 3
  • CTRP10 3 4 6
  • C1q And Tumor Necrosis Factor Related Protein 10 2 3
  • C1q And Tumor Necrosis Factor-Related Protein 10 3 4
  • C1q/TNF-Related Protein 10 3 4
  • C1QTNF10 3 6
  • C1q-Domain Containing Protein 3
  • Complement C1q-Like Protein 2 3

External Ids for C1QL2 Gene

Previous GeneCards Identifiers for C1QL2 Gene

  • GC02M120009
  • GC02M119630
  • GC02M119914
  • GC02M112238

Summaries for C1QL2 Gene

GeneCards Summary for C1QL2 Gene

C1QL2 (Complement Component 1, Q Subcomponent-Like 2) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for C1QL2 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL2 Gene

Genomics for C1QL2 Gene

Regulatory Elements for C1QL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C1QL2 Gene

119,156,243 bp from pter
119,158,895 bp from pter
2,653 bases
Minus strand

Genomic View for C1QL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1QL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL2 Gene

Proteins for C1QL2 Gene

  • Protein details for C1QL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1q-like protein 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for C1QL2 Gene

    287 amino acids
    Molecular mass:
    29468 Da
    Quaternary structure:
    • Forms homotrimers which can further assemble to form higher-order oligomeric complexes. Interacts with BAI3. May interact with FAM132B. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

neXtProt entry for C1QL2 Gene

Proteomics data for C1QL2 Gene at MOPED

Post-translational modifications for C1QL2 Gene

No Post-translational modifications

Other Protein References for C1QL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C1QL2 (C1qTNF10/C1qL2)

No data available for DME Specific Peptides for C1QL2 Gene

Domains for C1QL2 Gene

Protein Domains for C1QL2 Gene

Suggested Antigen Peptide Sequences for C1QL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C1q domain.
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with C1QL2: view

No data available for Gene Families for C1QL2 Gene

Function for C1QL2 Gene

Molecular function for C1QL2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

Gene Ontology (GO) - Molecular Function for C1QL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QL2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QL2 Gene

Localization for C1QL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL2 Gene


Subcellular locations from

Jensen Localization Image for C1QL2 Gene COMPARTMENTS Subcellular localization image for C1QL2 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for C1QL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QL2: view

Pathways for C1QL2 Gene

SuperPathways for C1QL2 Gene

No Data Available

Interacting Proteins for C1QL2 Gene

Gene Ontology (GO) - Biological Process for C1QL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051259 protein oligomerization IEA --
genes like me logo Genes that share ontologies with C1QL2: view

No data available for Pathways by source for C1QL2 Gene

Transcripts for C1QL2 Gene

mRNA/cDNA for C1QL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL2 Gene

Complement component 1, q subcomponent-like 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1QL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL2 Gene

No ASD Table

Relevant External Links for C1QL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1QL2 Gene

mRNA expression in normal human tissues for C1QL2 Gene

mRNA differential expression in normal tissues according to GTEx for C1QL2 Gene

This gene is overexpressed in Brain - Hippocampus (8.2), Brain - Amygdala (6.9), Brain - Cortex (5.8), Brain - Frontal Cortex (BA9) (5.8), Brain - Anterior cingulate cortex (BA24) (5.4), and Brain - Hypothalamus (5.2).

SOURCE GeneReport for Unigene cluster for C1QL2 Gene Hs.433493

genes like me logo Genes that share expressions with C1QL2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for C1QL2 Gene

Orthologs for C1QL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C1QL2 35
  • 88.85 (n)
  • 95.82 (a)
C1QL2 36
  • 96 (a)
(Canis familiaris)
Mammalia C1QL2 35
  • 90.82 (n)
  • 95.47 (a)
C1QL2 36
  • 95 (a)
(Mus musculus)
Mammalia C1ql2 35
  • 86.53 (n)
  • 94.08 (a)
C1ql2 16
C1ql2 36
  • 94 (a)
(Pan troglodytes)
Mammalia C1QL2 35
  • 99.39 (n)
  • 99.63 (a)
C1QL2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia C1ql2 35
  • 85.6 (n)
  • 94.43 (a)
(Monodelphis domestica)
Mammalia C1QL2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 1 (a)
(Anolis carolinensis)
Reptilia C1QL2 36
  • 96 (a)
(Danio rerio)
Actinopterygii c1ql2 35
  • 73.79 (n)
  • 82.66 (a)
c1ql2 36
  • 79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Capr 36
  • 5 (a)
Species with no ortholog for C1QL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL2 Gene

Gene Tree for C1QL2 (if available)
Gene Tree for C1QL2 (if available)

Paralogs for C1QL2 Gene

(7) SIMAP similar genes for C1QL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QL2: view

Variants for C1QL2 Gene

Sequence variations from dbSNP and Humsavar for C1QL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1317848 -- 119,157,933(+) GGGCC(G/T)CCCCG synonymous-codon, reference
rs1446129 -- 119,160,062(-) CACAC(C/T)GGCGG upstream-variant-2KB
rs1446130 -- 119,159,810(-) AGTGC(C/T)GGCAT upstream-variant-2KB
rs2121217 -- 119,158,737(+) CCGGC(A/T)CCGCG utr-variant-5-prime, upstream-variant-2KB
rs3980308 -- 119,157,870(-) GTGGC(C/G)CGCGG frameshift-variant, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1QL2 Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
nsv874957 CNV Loss 21882294
nsv874958 CNV Gain 21882294
nsv829637 CNV Gain 20364138

Relevant External Links for C1QL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL2 Gene

Disorders for C1QL2 Gene

Relevant External Links for C1QL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for C1QL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for C1QL2 Gene

Publications for C1QL2 Gene

  1. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. (PMID: 18783346) Wong G.W. … Lodish H.F. (Biochem. J. 2008) 2 3
  2. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C1QL2 Gene

Sources for C1QL2 Gene

Back to Top