Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



C1QC Gene

protein-coding   GIFtS: 62
GCID: GC01P022970

Complement Component 1, Q Subcomponent, C Chain

(Previous names: complement component 1, q subcomponent, gamma polypeptide)
(Previous symbol: C1QG)
  See C1QC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Complement Component 1, Q Subcomponent, C Chain1 2
C1QG1 2 3 5
Complement Component 1, Q Subcomponent, Gamma Polypeptide1 2
C1Q-C2
Complement C1q Subcomponent Subunit C2

External Ids:    HGNC: 12451   Entrez Gene: 7142   Ensembl: ENSG000001591897   OMIM: 1205755   UniProtKB: P027473   

Export aliases for C1QC gene to outside databases

Previous GC identifers: GC01P022842 GC01P021214


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for C1QC Gene:
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in
order to yield the first component of the serum complement system. A deficiency in C1q has been associated with
lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains,
and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal
globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the
C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode
the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for C1QC Gene:
C1QC (complement component 1, q subcomponent, C chain) is a protein-coding gene. Diseases associated with C1QC include c1q deficiency, and sulfite oxidase deficiency. An important paralog of this gene is C1QTNF6.

UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747
Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement
system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and
efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or
IgM antibody present in immune complexes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the C1QC gene promoter:
         AhR   AML1a   NRSF form 1   NRSF form 2   Arnt   HEN1   POU2F1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC1QC promoter sequence
   Search Chromatin IP Primers for C1QC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1QC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.11

C1QC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1QC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022970:  view genomic region     (about GC identifiers)

Start:
22,970,118 bp from pter      End:
22,974,603 bp from pter
Size:
4,486 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747 (See protein sequence)
Recommended Name: Complement C1q subcomponent subunit C precursor  
Size: 245 amino acids; 25774 Da
Subunit: C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q
subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and
three of which are disulfide-linked dimers of the C chain
5 PDB 3D structures from and Proteopedia for C1QC:
1PK6 (3D)        2JG8 (3D)        2JG9 (3D)        2WNU (3D)        2WNV (3D)    
Secondary accessions: Q7Z502 Q96DL2 Q96H05

Explore the universe of human proteins at neXtProt for C1QC: NX_P02747

Explore proteomics data for C1QC at MOPED

Post-translational modifications: 

  • O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl
    groups1
  • Glycosylation2 at Lys75
  • Modification sites at PhosphoSitePlus

  • See C1QC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107573.1  NP_758957.2  

    ENSEMBL proteins: 
     ENSP00000363771   ENSP00000363770   ENSP00000363768  
    Reactome Protein details: P02747

    C1QC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for C1QC
    OriGene Protein Over-expression Lysate for C1QC
    OriGene MassSpec for C1QC
    OriGene Custom Protein Services for C1QC
    GenScript Custom Purified and Recombinant Proteins Services for C1QC
    Novus Biologicals C1QC Protein
    Novus Biologicals C1QC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for C1QC 

    C1QC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for C1QC (Complement Component C1qC)
    OriGene Antibodies for C1QC
    OriGene Custom Antibody Services for C1QC
    Novus Biologicals C1QC Antibodies
    Abcam antibodies for C1QC (P02745, P02747, P02746)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for C1QC
    LSBio Antibodies in human, mouse, rat for C1QC

    C1QC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for C1QC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for C1QC
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for C1QC 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    complement: Complement system

    3 InterPro protein domains:
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR008160 Collagen
     IPR001073 C1q

    Graphical View of Domain Structure for InterPro Entry P02747

    ProtoNet protein and cluster: P02747

    3 Blocks protein domains:
    IPB001073 Complement C1q protein
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747
    Similarity: Contains 1 C1q domain
    Similarity: Contains 1 collagen-like domain


    Find genes that share domains with C1QC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C1QC_HUMAN, P02747
    Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement
    system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and
    efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or
    IgM antibody present in immune complexes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with C1QC           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1QC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C1QC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C1QC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C1QC

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat C1QC using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate C1QC:
    hsa-miR-4254 hsa-miR-765 hsa-miR-3175
    SwitchGear 3'UTR luciferase reporter plasmidC1QC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for C1QC
    Predesigned siRNA for gene silencing in human, mouse, rat C1QC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for C1QC

    Clone
    Products:
         
    OriGene clones in human, mouse for C1QC (see all 13)
    OriGene ORF clones in mouse, rat for C1QC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): C1QC (NM_001114101)
    Sino Biological Human cDNA Clone for C1QC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1QC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for C1QC
    Browse ESI BIO Cell Lines and PureStem Progenitors for C1QC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    C1QC_HUMAN, P02747: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--
    GO:0005615extracellular space IDA--
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with C1QC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for C1QC About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement Activation, Classical Pathway0.00
    Complement and Coagulation Cascades0.71
    2Creation of C4 and C2 activators
    Creation of C4 and C2 activators0.85
    Classical antibody-mediated complement activation0.82
    Initial triggering of complement0.85
    Complement cascade0.68
    3Complement Pathway
    Immune response Classic complement pathway0.56
    4RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40
    5Toll-like receptor signaling pathway
    Chagas disease (American trypanosomiasis)0.32


    Find genes that share SuperPaths with C1QC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for C1QC
        Classical Complement Pathway
    Complement Pathway

    1 GeneGo (Thomson Reuters) Pathway for C1QC
        Immune response Classical complement pathway

    2 BioSystems Pathways for C1QC
        Complement Activation, Classical Pathway
    Complement and Coagulation Cascades


    2 Reactome Pathways for C1QC
        Classical antibody-mediated complement activation
    Initial triggering of complement


    Selected Kegg Pathways  (Kegg details for C1QC) (see all 6):
        Complement and coagulation cascades
    Prion diseases
    Pertussis
    Chagas disease (American trypanosomiasis)
    Staphylococcus aureus infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C1QC
    Interactions:

        Search GeneGlobe Interaction Network for C1QC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for C1QC (P027472, 3 ENSP000003637684) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1QBP027462, 3, ENSP000003139674MINT-8040663 I2D: score=1 STRING: ENSP00000313967
    C1QAP027452, 3, ENSP000003637734MINT-8040663 I2D: score=1 STRING: ENSP00000363773
    FKBP2P268853, ENSP000003109354I2D: score=1 STRING: ENSP00000310935
    PTX3P260223, ENSP000002959274I2D: score=2 STRING: ENSP00000295927
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS9777412
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0030853negative regulation of granulocyte differentiation IDA10961870
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with C1QC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C1QC

    1 HMDB Compound for C1QC    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected DrugBank Compounds for C1QC (see all 18)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Abciximab7E3 (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Alefacept-- 222535-22-0target--17139284 17016423
    Alemtuzumab-- 216503-57-0target--17016423 17139284
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284
    BevacizumabantiVEGF (see all 3)216974-75-3target--17139284 17016423
    CetuximabAnti EGFR (see all 2)205923-56-4target--17139284 17016423
    DaclizumabAnti-IL-2 (see all 3)152923-56-3target--17139284 17016423
    Efalizumabanti alphaL integrin (see all 4)214745-43-4target--17139284 17016423
    EtanerceptCD120b (see all 7)185243-69-0target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for C1QC gene (2 alternative transcripts): 
    NM_001114101.1  NM_172369.3  

    Unigene Cluster for C1QC:

    Complement component 1, q subcomponent, C chain
    Hs.467753  [show with all ESTs]
    Unigene Representative Sequence: BQ711804
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374640(uc001bgc.4) ENST00000374639(uc001bga.4) ENST00000374637

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C1QC using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate C1QC:
    hsa-miR-4254 hsa-miR-765 hsa-miR-3175
    SwitchGear 3'UTR luciferase reporter plasmidC1QC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C1QC
    Predesigned siRNA for gene silencing in human, mouse, rat C1QC
    Clone
    Products:
         
    OriGene clones in human, mouse for C1QC (see all 13)
    OriGene ORF clones in mouse, rat for C1QC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): C1QC (NM_001114101)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1QC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for C1QC
    OriGene qSTAR qPCR primer pairs in human, mouse for C1QC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C1QC
      QuantiTect SYBR Green Assays in human, mouse, rat C1QC
      QuantiFast Probe-based Assays in human, mouse, rat C1QC

    Additional mRNA sequence: 

    AF087892.1 AK057792.1 AK130613.1 BC009016.1 

    15 DOTS entries:

    DT.95272435  DT.100833269  DT.92431893  DT.100839328  DT.100038193  DT.101982245  DT.121388766  DT.100038191 
    DT.100828744  DT.100828749  DT.95272436  DT.100828743  DT.121388793  DT.100828747  DT.100697109 

    Selected AceView cDNA sequences (see all 507):

    AI335628 BM713106 BQ712171 AI741805 R17629 BX337443 BX111339 BI769845 
    BI523824 AI749854 CR597625 BI835225 BU730331 BI835236 CD368327 AK130613 
    CR613096 AI792359 CR617126 CD108412 CR591547 BI521328 CR610701 BI824570 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for C1QC    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b
    SP1:                    -     -                           
    SP2:                    -     -     -     -               
    SP3:                                                      
    SP4:                          -                           
    SP5:                                                      


    ECgene alternative splicing isoforms for C1QC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    C1QC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCAATAC
    C1QC Expression
    About this image


    C1QC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    C1QC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C1QC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467753
        Custom PCR Arrays for C1QC
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for C1QC
    OriGene qSTAR qPCR primer pairs in human, mouse for C1QC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C1QC
    QuantiTect SYBR Green Assays in human, mouse, rat C1QC
    QuantiFast Probe-based Assays in human, mouse, rat C1QC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for C1QC gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C1qc1 , 5 complement component 1, q subcomponent, C chain1, 5 78.88(n)1
    74.66(a)1
      4 (69.05 cM)5
    122621  NM_007574.21  NP_031600.21 
     1368898045 
    chicken
    (Gallus gallus)
    Aves C1QC1 complement component 1, q subcomponent, C chain 64.49(n)
    61.68(a)
      419503  XM_417653.3  XP_417653.1 
    zebrafish
    (Danio rerio)
    Actinopterygii c1qc1 complement component 1, q subcomponent, C chain 54.63(n)
    52.2(a)
      449803  NM_001005976.1  NP_001005976.1 


    ENSEMBL Gene Tree for C1QC (if available)
    TreeFam Gene Tree for C1QC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for C1QC gene
    C1QTNF62  C1QB2  COL10A12  C1QTNF12  C1QTNF9B2  C1QA2  C1QTNF42  COL8A22  
    C1QTNF92  C1QTNF52  COL8A12  OTOL12  C1QTNF82  C1QTNF72  C1QTNF22  ADIPOQ2  
    11 SIMAP similar genes for C1QC using alignment to 1 protein entry:     C1QC_HUMAN:
    C1QB    COL4A5    ADIPOQ    C1QA    C1QTNF5    C1QL4
    C1QTNF2    C1QTNF9    C1QTNF9B    OTOL1    C1QL2

    Find genes that share paralogs with C1QC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for C1QC (see all 197)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0085424
    Complement component C1q deficiency (C1QD)4--see VAR_0085422 G R mis40--------
    rs1389729861,2
    C--21214232(+) TTTAT-/ACAC  
            
    ACACA
    2 -- us2k10--------
    rs1470105261,2
    C--21215156(+) GCTTG-/CCTTGC 2 -- int10--------
    rs716602541,2
    C--22969874(+) TTTAT-/ACACACA 2 -- us2k11Minor allele frequency- AC:0.50CSA 2
    rs106011441,2
    C--22974534(+) CATTC-/T/TT  
            
    TTTTT
    4 -- ut310--------
    rs710204411,2
    C--22974534(+) CATTC-/T/T   
       T
    /TTT
    TTTTT
    6 -- ut311NA 2
    rs2941801,2
    C,F,O,A,H--22974794(-) GGACCT/GCTGGC 2 -- ds500125Minor allele frequency- G:0.40MN NA NS EA WA CSA 1528
    rs740605491,2
    C,F--22974867(+) AAGCCC/TACAGG 2 -- ds50012Minor allele frequency- T:0.04WA 120
    rs2941791,2
    C,F,O,A,H--22974928(-) CCCATG/AGTAAA 2 -- ds500126Minor allele frequency- A:0.31MN NS EA NA WA CSA 2670
    rs1156911271,2
    F--22974946(+) TGGGCT/CTGGGT 2 -- ds50011Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for C1QC (22970118 - 22974603 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C1QC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871044CNV Loss21882294
    esv34161CNV Loss18971310

    Human Gene Mutation Database (HGMD): C1QC
    Locus Specific Mutation Databases (LSDB): C1QC

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C1QC
    DNA2.0 Custom Variant and Variant Library Synthesis for C1QC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 120575   
    OMIM disorders: 613652  
    UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747
  • Complement component C1q deficiency (C1QD) [MIM:613652]: A disorder caused by impaired activation of the
    complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus
    erythematosus and glomerulonephritis. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 7 diseases for C1QC:    
    About MalaCards
    c1q deficiency    sulfite oxidase deficiency    glomerulonephritis    complement component 4, partial deficiency of
    prion disease    trypanosomiasis    duchenne muscular dystrophy


    Find genes that share disorders with C1QC           About GenesLikeMe

    Genetic Association Database (GAD): C1QC
    Human Genome Epidemiology (HuGE) Navigator: C1QC (14 documents)

    Export disorders for C1QC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for C1QC gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with C1QC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q. (PubMed id 1706597)1, 2, 3 Sellar G.C.... Reid K.B.M. (Biochem. J. 1991)
    2. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    4. Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus. (PubMed id 20528885)1, 4 Rafiq S....Eggleton P. (Clin. Exp. Immunol. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (Br. J. Haematol. 2009)
    7. Complement C1Q polymorphisms modulate onset in familial amyloidotic polyneuropathy TTR Val30Met. (PubMed id 19493541)1, 4 Dardiotis E....Kyriakides T. (J. Neurol. Sci. 2009)
    8. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4 Miyagawa H....Horiuchi T. (Rheumatology (Oxford) 2008)
    9. PCR-RFLP genotyping of C1q mutations and single nucleotide polymorphisms in Malaysian patients with systemic lupus erythematosus. (PubMed id 18505047)1, 4 Chew C.H....Tan S.Y. (Hum. Biol. 2008)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 714 HGNC: 1245 AceView: C1QAandC1QG Ensembl:ENSG00000159189 euGenes: HUgn714
    ECgene: C1QC Kegg: 714 H-InvDB: C1QC

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for C1QC Pharmacogenomics, SNPs, Pathways
    C1QGbasehttp://bioinf.uta.fi/C1QGbase/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for C1QC gene:
    Search GeneIP for patents involving C1QC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for C1QC (Complement Component C1qC)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for C1QC   OriGene RNAi products in human, mouse, rat for C1QC  
     OriGene qPCR primer pairs and template standards for C1QC   OriGene Protein Over-expression Lysate for C1QC  
     OriGene MassSpec something-or-other for C1QC   OriGene clones in human, mouse for C1QC  
     OriGene qSTAR qPCR primer pairs in human, mouse for C1QC   OriGene Purified Protein for C1QC  
     OriGene ORF clones in mouse, rat for C1QC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for C1QC   OriGene Custom Protein Services for C1QC  

     
     
     Block miRNA regulation of human, mouse, rat C1QC using miScript Target Protectors SeqTarget long-range PCR primers for resequencing C1QC
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C1QC Predesigned siRNA for gene silencing in human, mouse, rat C1QC
     QuantiFast Probe-based Assays in human, mouse, rat C1QC QuantiTect SYBR Green Assays in human, mouse, rat C1QC
     Custom PCR Arrays for C1QC Search Chromatin IP Primers for C1QC
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C1QC  Search GeneGlobe Interaction Network for C1QC
     Regulatory tfbs in C1QC promoter
     GenScript Custom Purified and Recombinant Proteins Services for C1QC GenScript cDNA clones with any tag delivered in your preferred vector for C1QC
     GenScript Custom Assay Services for C1QC GenScript Custom overexpressing Cell Line Services for C1QC
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for C1QC
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for C1QC
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     C1QC antibodies
     C1QC proteins
     C1QC lysates
     Antibodies for C1QC
     See all of Abcam's Antibodies, Kits and Proteins for C1QC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for C1QC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QC
     SwitchGear 3'UTR luciferase reporter plasmids for C1QC
     SwitchGear Promoter luciferase reporter plasmids for C1QC
     ThermoFisher Antibodies for C1QC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QC
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C1QC
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C1QC
     LSBio Antibodies in human, mouse, rat for C1QC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for C1QC
      Search eBioscience for proteins for C1QC
      Search eBioscience for elisas for C1QC
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      C1QC gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4