Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C1QC Gene

protein-coding GIFtS: 61
GCID: GC01P022970

Complement Component 1, Q Subcomponent, C Chain

(Previous names: complement component 1, q subcomponent, gamma polypeptide)
(Previous symbol: C1QG)

17 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Complement Component 1, Q Subcomponent, C Chain¹ ²
C1QG¹ ² ³ ⁵
Complement Component 1, Q Subcomponent, Gamma Polypeptide¹ ²
C1Q-C²
Complement C1q Subcomponent Subunit C²

External Ids:	HGNC: 1245¹	Entrez Gene: 714²	Ensembl: ENSG00000159189⁷	OMIM: 120575⁵	UniProtKB: P02747³

Export aliases for C1QC gene to outside databases

Previous GC identifers: GC01P022842 GC01P021214

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C1QC Gene:

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in

order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus

erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six

C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region.

The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of

human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been

found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for C1QC Gene:

C1QC (complement component 1, q subcomponent, C chain) is a protein-coding gene. Diseases associated with C1QC include chronic wasting disease, and glomerulonephritis, and among its related super-pathways are Complement and Coagulation Cascades and Immune response Lectin induced complement pathway. An important paralog of this gene is C1QTNF6.

UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747

Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement

system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and

efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM

antibody present in immune complexes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_004610.19 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C1QC gene promoter:
AhR AML1a NRSF form 1 NRSF form 2 Arnt HEN1 POU2F1 POU2F1a POU2F1b POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C1QC promoter sequence

Search SABiosciences Chromatin IP Primers for C1QC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1QC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.11

C1QC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1QC gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P022970: view genomic region (about GC identifiers)

Start:	22,970,118 bp from pter	End:	22,974,603 bp from pter
Size:	4,486 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747 (See protein sequence)

Recommended Name: Complement C1q subcomponent subunit C precursor

Size: 245 amino acids; 25774 Da

Subunit: C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent

is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are

disulfide-linked dimers of the C chain

Subcellular location: Secreted

5 PDB 3D structures from and Proteopedia for C1QC:

1PK6 (3D)

2JG8 (3D)

2JG9 (3D)

2WNU (3D)

2WNV (3D)

Secondary accessions: Q7Z502 Q96DL2 Q96H05

Explore the universe of human proteins at neXtProt for C1QC: NX_P02747

Explore proteomics data for C1QC at MOPED

Post-translational modifications:

UniProtKB: O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl

groups

View neXtProt modification sites for NX_P02747

C1QC Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001107573.1 NP_758957.2

ENSEMBL proteins:

ENSP00000363771 ENSP00000363770 ENSP00000363768

Reactome Protein details: P02747
Human Recombinant Protein Products for C1QC:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for C1QC OriGene Protein Over-expression Lysate for C1QC OriGene MassSpec for C1QC OriGene Custom Protein Services for C1QC
	GenScript Custom Purified and Recombinant Proteins Services for C1QC
	Novus Biologicals C1QC Protein Novus Biologicals C1QC Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005581	collagen	IEA	--

C1QC for ontologies About GeneDecksing

C1QC Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for C1QC (Complement Component C1qC)
	OriGene Antibodies for C1QC OriGene Custom Antibody Services for C1QC
	GenScript Custom Superior Antibodies Services for C1QC
	Novus Biologicals C1QC Antibodies
	Abcam antibodies for C1QC
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for C1QC
	LSBio Antibodies in human, mouse, rat for C1QC

Assay Products for C1QC:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for C1QC
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for C1QC
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

complement: Complement system

3 InterPro protein domains:

IPR008983 Tumour_necrosis_fac-like_dom

IPR008160 Collagen

IPR001073 C1q

Graphical View of Domain Structure for InterPro Entry P02747

ProtoNet protein and cluster: P02747

3 Blocks protein domains:

IPB001073 Complement C1q protein

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747

Similarity: Contains 1 C1q domain

Similarity: Contains 1 collagen-like domain

C1QC for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: C1QC_HUMAN, P02747

Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement

system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and

efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM

antibody present in immune complexes

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

C1QC for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for C1QC

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C1QC

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C1QC
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate C1QC:
		hsa-miR-4254 hsa-miR-765 hsa-miR-3175
		SwitchGear 3'UTR luciferase reporter plasmid: C1QC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for C1QC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1QC
		Sirion Biotech Custom design and validation of potent shRNA sequences against C1QC

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for C1QC
			Sirion Biotech Customized adenovirus for overexpression of C1QC Customized adenovirus for potent knockdown of C1QC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for C1QC (see all 14) OriGene ORF clones in mouse, rat for C1QC OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): C1QC (NM_001114101)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1QC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for C1QC
		Search LifeMap BioReagents cell lines for C1QC
		Sirion Biotech Customized stable knockdown cell line services for C1QC Customized inducible knockdown cell line services for C1QC Customized stable overexpressing cell line services for C1QC Customized inducible overexpressing cell line services for C1QC

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QC

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for C1QC About (see all 10)

See pathways by source

SuperPath

Contained pathways About

Complement and coagulation cascades

Complement and Coagulation Cascades

0.71

Complement and coagulation cascades

0.71

Immune response Lectin induced complement pathway

Immune response Classic complement pathway

0.53

Immune response Classical complement pathway

0.52

Classical antibody-mediated complement activation

	Classical antibody-mediated complement activation	0.88			Initial triggering of complement	0.86
	Creation of C4 and C2 activators	0.88			Complement cascade	0.76

Immune System

Immune System

0.56

Innate Immune System

0.50

Classical Complement Pathway

Complement Activation, Classical Pathway

0.68

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for C1QC

Immune response Classic complement pathway

1 GeneGo (Thomson Reuters) Pathway for C1QC

Immune response Classical complement pathway

2 BioSystems Pathways for C1QC

	Complement Activation, Classical Pathway
	Complement and Coagulation Cascades

5/6 Reactome Pathways for C1QC (see all 6)

	Classical antibody-mediated complement activation
	Creation of C4 and C2 activators
	Complement cascade
	Immune System
	Initial triggering of complement

5/6 Kegg Pathways (Kegg details for C1QC) (see all 6):

	Complement and coagulation cascades
	Prion diseases
	Pertussis
	Chagas disease (American trypanosomiasis)
	Staphylococcus aureus infection

C1QC for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C1QC

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/18 Interacting proteins for C1QC (P02747^{2, 3} ENSP00000363768⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C1QB	P02746²^,³, ENSP00000313967⁴	MINT-8040663 I2D: score=1 STRING: ENSP00000313967
C1QA	P02745²^,³, ENSP00000363773⁴	MINT-8040663 I2D: score=1 STRING: ENSP00000363773
FKBP2	P26885³, ENSP00000310935⁴	I2D: score=1 STRING: ENSP00000310935
PTX3	P26022³, ENSP00000295927⁴	I2D: score=2 STRING: ENSP00000295927
APOA1	P02647³, ENSP00000236850⁴	I2D: score=1 STRING: ENSP00000236850

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	NAS	9777412
GO:0006956	complement activation	TAS	--
GO:0006958	complement activation, classical pathway	TAS	--
GO:0030853	negative regulation of granulocyte differentiation	IDA	10961870
GO:0045087	innate immune response	TAS	--

C1QC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C1QC

1 HMDB Compound for C1QC About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

10/18 DrugBank Compounds for C1QC (see all 18) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Abciximab	7E3 (see all 4)	143653-53-6	target	--	17016423 17139284
Adalimumab	--	331731-18-1	target	--	17016423 17139284
Alefacept	--	222535-22-0	target	--	17139284 17016423
Alemtuzumab	--	216503-57-0	target	--	17016423 17139284
Basiliximab	chimeric mouse-human antiCD25 (see all 2)	152923-56-3	target	--	17016423 17139284
Bevacizumab	antiVEGF (see all 3)	216974-75-3	target	--	17139284 17016423
Cetuximab	Anti EGFR (see all 2)	205923-56-4	target	--	17139284 17016423
Daclizumab	Anti-IL-2 (see all 3)	152923-56-3	target	--	17139284 17016423
Efalizumab	anti alphaL integrin (see all 4)	214745-43-4	target	--	17139284 17016423
Etanercept	CD120b (see all 7)	185243-69-0	target	--	17139284 17016423

Search CenterWatch for drugs/clinical trials and news about C1QC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C1QC gene (2 alternative transcripts):

NM_001114101.1 NM_172369.3

Unigene Cluster for C1QC:

Complement component 1, q subcomponent, C chain

Hs.467753 [show with all ESTs]

Unigene Representative Sequence: BQ711804

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374640(uc001bgc.4) ENST00000374639(uc001bga.4) ENST00000374637

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C1QC
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate C1QC:
		hsa-miR-4254 hsa-miR-765 hsa-miR-3175
		SwitchGear 3'UTR luciferase reporter plasmid: C1QC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for C1QC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1QC
		Sirion Biotech Custom design and validation of potent shRNA sequences against C1QC

Clone Products:		OriGene clones in human, mouse for C1QC (see all 14) OriGene ORF clones in mouse, rat for C1QC OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): C1QC (NM_001114101)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1QC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QC

Primer Products:		OriGene qPCR primer pairs and template standards for C1QC OriGene qSTAR qPCR primer pairs in human, mouse for C1QC
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat C1QC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1QC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1QC

Additional mRNA sequence:

AF087892.1 AK057792.1 AK130613.1 BC009016.1

15 DOTS entries:

DT.95272435 DT.100833269 DT.92431893 DT.100839328 DT.100038193 DT.101982245 DT.121388766 DT.100038191

DT.100828744 DT.100828749 DT.95272436 DT.100828743 DT.121388793 DT.100828747 DT.100697109

24/507 AceView cDNA sequences (see all 507):

CA406370 R17629 BX337443 BX111339 BQ712171 BM717026 CR623532 CD367233

AA025953 CR604785 BM713106 BI764061 CD108412 BI835225 CD368327 BU730331

BU732984 BM694149 BI835236 BI824570 CD742606 BC071986 BI838362 CR613096

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for C1QC About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b
SP1:							-		-
SP2:							-		-		-		-
SP3:
SP4:									-
SP5:

ECgene alternative splicing isoforms for C1QC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C1QC expression in normal human tissues (normalized intensities) C1QC embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAATCAATAC

About this image

C1QC expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/3 selected tissues (see all 3) fully expand


Kidney (Urinary System)
Metanephric Mesenchyme Cells Metanephric Mesenchyme

Eye (Sensory Organs)
Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

Spleen (NULL)

See C1QC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1QC

SOURCE GeneReport for Unigene cluster: Hs.467753

SABiosciences Custom PCR Arrays for C1QC

Primer Products:		OriGene qPCR primer pairs and template standards for C1QC OriGene qSTAR qPCR primer pairs in human, mouse for C1QC
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat C1QC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1QC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1QC

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C1QC gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	C1qc^{1 , 5}	complement component 1, q subcomponent, C chain^{1, 5}	77.96(n)¹ 74.29(a)¹	4 (69.05 cM)⁵ 12262¹ NM_007574.2¹ NP_031600.2¹ 136889804⁵
chicken (Gallus gallus)	Aves	C1QC¹	complement component 1, q subcomponent, C chain	62.99(n) 59.32(a)	419503 XM_417653.2 XP_417653.1
zebrafish (Danio rerio)	Actinopterygii	c1qc¹	complement component 1, q subcomponent, C chain	53.53(n) 50.48(a)	449803 NM_001005976.1 NP_001005976.1

ENSEMBL Gene Tree for C1QC (if available)
TreeFam Gene Tree for C1QC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for C1QC gene

C1QTNF6² COL10A1² C1QB² C1QTNF1² C1QTNF9B² C1QA² C1QTNF4² COL8A2²

C1QTNF9² C1QTNF5² COL8A1² OTOL1² C1QTNF8² C1QTNF7² C1QTNF2² ADIPOQ²

11 SIMAP similar genes for C1QC using alignment to 1 protein entry: C1QC_HUMAN:

C1QB COL4A5 ADIPOQ C1QA C1QTNF5 C1QL4

C1QTNF2 C1QTNF9 C1QTNF9B OTOL1 C1QL2

C1QC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_008542⁴		Complement component C1q deficiency (C1QD)⁴	--	see VAR_008542	2	G R	mis⁴		0	--	--	--	--
rs138972986^1,2	C	--	21214232(+)	`TTTAT-/ACAC ACACA`	2	--	us2k¹		0	--	--	--	--
rs147010526^1,2	C	--	21215156(+)	`GCTTG-/CCTTGC`	2	--	int¹		0	--	--	--	--
rs71660254^1,2	C	--	22969874(+)	`TTTAT-/ACACACA`	2	--	us2k¹		1		CSA	2
rs10601144^1,2	C	--	22974534(+)	`CATTC-/T/TT TTTTT`	4	--	ut3¹		0	--	--	--	--
rs71020441^1,2	C	--	22974534(+)	`CATTC-/T/T T/TTTTTTTT`	6	--	ut3¹		1		NA	2
rs294180^1,2	C,F,O,A,H	--	22974794(-)	`GGACCT/GCTGGC`	2	--	ds500¹		25		MN NA NS EA WA CSA	1528
rs74060549^1,2	C,F	--	22974867(+)	`AAGCCC/TACAGG`	2	--	ds500¹		2		WA	120
rs294179^1,2	C,F,O,A,H	--	22974928(-)	`CCCATG/AGTAAA`	2	--	ds500¹		26		MN NS EA NA WA CSA	2670
rs115691127^1,2	F	--	22974946(+)	`TGGGCT/CTGGGT`	2	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for C1QC (22970118 - 22974603 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for C1QC: About this table

Variant ID	Type	Subtype	PubMed ID
nsv871044	CNV	Loss	21882294
esv34161	CNV	Loss	18971310

Human Gene Mutation Database (HGMD): C1QC

Locus Specific Mutation Databases (LSDB): C1QC

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1QC

DNA2.0 Custom Variant and Variant Library Synthesis for C1QC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C1QC for disorders About GeneDecksing

OMIM gene information: 120575 OMIM disorders: --

UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747

Complement component C1q deficiency (C1QD) [MIM:613652]: A disorder caused by impaired activation of the

complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus

erythematosus and glomerulonephritis. Note=The disease is caused by mutations affecting the gene represented in this

entry

17 diseases for C1QC: About MalaCards

chronic wasting disease glomerulonephritis trypanosomiasis duchenne muscular dystrophy

prion disease chagas disease lupus erythematosus pertussis

polyneuropathy systemic lupus erythematosus non-hodgkin lymphoma hodgkin's lymphoma

muscular dystrophy meningioma hepatitis b hepatitis

leukemia

Genetic Association Database (GAD): C1QC
Human Genome Epidemiology (HuGE) Navigator: C1QC (14 documents)

Export disorders for C1QC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C1QC gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with C1QC)

Utopia: connect your pdf to the dynamic
world of online information

Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q. (PubMed id 1706597)^{1, 2, 3} Sellar G.C.... Reid K.B.M. (1991)
Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (2010)
Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (2010)
Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus. (PubMed id 20528885)^{1, 4} Rafiq S....Eggleton P. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)^{1, 4} Cerhan J.R....Slager S.L. (2009)
Complement C1Q polymorphisms modulate onset in famili al amyloidotic polyneuropathy TTR Val30Met. (PubMed id 19493541)^{1, 4} Dardiotis E....Kyriakides T. (2009)
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)^{1, 4} Miyagawa H....Horiuchi T. (2008)
PCR-RFLP genotyping of C1q mutations and single nucleotide polymorphisms in Malaysian patients with systemic lupus erythematosus. (PubMed id 18505047)^{1, 4} Chew C.H....Tan S.Y. (2008)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 714	HGNC: 1245	AceView: C1QAandC1QG	Ensembl:ENSG00000159189	euGenes: HUgn714
ECgene: C1QC	Kegg: 714	H-InvDB: C1QC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C1QC	Pharmacogenomics, SNPs, Pathways
C1QGbase	http://bioinf.uta.fi/C1QGbase/

Intellectual Property for C1QC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C1QC gene:
Search GeneIP for patents involving C1QC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for C1QC (Complement Component C1qC)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for C1QC		OriGene RNAi products in human, mouse, rat for C1QC
	OriGene qPCR primer pairs and template standards for C1QC		OriGene Protein Over-expression Lysate for C1QC
	OriGene MassSpec something-or-other for C1QC		OriGene clones in human, mouse for C1QC
	OriGene qSTAR qPCR primer pairs in human, mouse for C1QC		OriGene Purified Protein for C1QC
	OriGene ORF clones in mouse, rat for C1QC		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for C1QC		OriGene Custom Protein Services for C1QC

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C1QC
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1QC
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1QC
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1QC
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1QC
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1QC

	GenScript Custom Purified and Recombinant Proteins Services for C1QC		GenScript cDNA clones with any tag delivered in your preferred vector for C1QC
	GenScript Custom Assay Services for C1QC		GenScript Custom Superior Antibodies Services for C1QC
	GenScript Custom overexpressing Cell Line Services for C1QC		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in C1QC promoter
	Search Chromatin IP Primers for C1QC
	RT² qPCR Primer Assay in human, mouse, rat C1QC
	Search GNC Networks for C1QC
	SABiosciences Custom PCR Arrays for C1QC

Search Tocris compounds for C1QC

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	C1QC antibodies
	C1QC proteins
	C1QC lysates

	Antibodies for C1QC
	See all of Abcam's Antibodies, Kits and Proteins for C1QC
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Search LifeMap BioReagents cell lines for C1QC

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QC

	SwitchGear 3'UTR luciferase reporter plasmids for C1QC
	SwitchGear Promoter luciferase reporter plasmids for C1QC

ThermoFisher Antibodies for C1QC

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1QC

	inGenious Targeting Laboratory - Custom generated mouse model solutions for C1QC
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C1QC

Customized:

	stable knockdown cell line services for C1QC
	inducible knockdown cell line services for C1QC
	design and validation of potent shRNA sequences against C1QC
	adenovirus for potent knockdown of C1QC
	stable overexpressing cell line services for C1QC
	inducible overexpressing cell line services for C1QC
	adenovirus for overexpression of C1QC

LSBio Antibodies in human, mouse, rat for C1QC

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C1QC gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

C1QC Gene

Complement Component 1, Q Subcomponent, C Chain

Aliases
for C1QC gene

Summaries
for C1QC gene

Genomic Views
for C1QC gene

Proteins
for C1QC gene

Protein Domains /
Families
for C1QC gene

Function
for C1QC gene

Pathways & Interactions
for C1QC gene

Drugs & Compounds
for C1QC gene

Transcripts
for C1QC gene

Expression
for C1QC gene

Orthologs
for C1QC gene

Paralogs
for C1QC gene

Genomic Variants
for C1QC gene

Disorders / Diseases
for C1QC gene

Publications
for C1QC gene

External Searches for C1QC gene

Genome Databases showing C1QC gene

Other Databases showing C1QC gene

Specialized Databases showing C1QC gene

Intellectual Property
for C1QC gene

Products
for C1QC gene

View Random Gene

Advanced Search

Export list of displayed genes

C1QC Gene

Complement Component 1, Q Subcomponent, C Chain

Aliasesfor C1QC gene

Summariesfor C1QC gene

Genomic Viewsfor C1QC gene

Proteinsfor C1QC gene

Protein Domains /Familiesfor C1QC gene

Functionfor C1QC gene

Pathways & Interactionsfor C1QC gene

Drugs & Compoundsfor C1QC gene

Transcriptsfor C1QC gene

Expression for C1QC gene

Orthologsfor C1QC gene

Paralogsfor C1QC gene

Genomic Variantsfor C1QC gene

Disorders / Diseasesfor C1QC gene

Publicationsfor C1QC gene

External Searches for C1QC gene

Genome Databases showing C1QC gene

Other Databases showing C1QC gene

Specialized Databases showing C1QC gene

Intellectual Propertyfor C1QC gene

Productsfor C1QC gene

View Random Gene

Aliases
for C1QC gene

Summaries
for C1QC gene

Genomic Views
for C1QC gene

Proteins
for C1QC gene

Protein Domains /
Families
for C1QC gene

Function
for C1QC gene

Pathways & Interactions
for C1QC gene

Drugs & Compounds
for C1QC gene

Transcripts
for C1QC gene

Expression
for C1QC gene

Orthologs
for C1QC gene

Paralogs
for C1QC gene

Genomic Variants
for C1QC gene

Disorders / Diseases
for C1QC gene

Publications
for C1QC gene

Intellectual Property
for C1QC gene

Products
for C1QC gene