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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1QC Gene

protein-coding   GIFtS: 57
GCID: GC01P022970

complement component 1, q subcomponent, C chain

(Previous names: complement component 1, q subcomponent, gamma polypeptide...)
(Previous symbol: C1QG)
 Explore 18 diseases affiliated with
C1QC via our new
 Human Malady Compendium 
Biological research products
for C1QC
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Complement Component 1, Q Subcomponent, C Chain1 2
C1QG1 2 3 5
Complement Component 1, Q Subcomponent, Gamma Polypeptide1 2
C1Q-C2
Complement C1q Subcomponent Subunit C2

External Ids:    HGNC: 12451   Entrez Gene: 7142   Ensembl: ENSG000001591897   OMIM: 1205755   UniProtKB: P027473   

Export aliases for C1QC gene to outside databases

Previous GC identifers: GC01P022842 GC01P021214


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C1QC:
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in
order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus
erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six
C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region.
The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of
human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been
found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747
Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement
system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and
efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM
antibody present in immune complexes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1QC gene promoter:
         AhR   AML1a   NRSF form 1   NRSF form 2   Arnt   HEN1   POU2F1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC1QC promoter sequence
   Search SABiosciences Chromatin IP Primers for C1QC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1QC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.11

C1QC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1QC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022970:  view genomic region     (about GC identifiers)

Start:
22,970,118 bp from pter      End:
22,974,603 bp from pter
Size:
4,486 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747 (See protein sequence)
Recommended Name: Complement C1q subcomponent subunit C precursor  
Size: 245 amino acids; 25774 Da
Subunit: C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent
is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are
disulfide-linked dimers of the C chain
Subcellular location: Secreted
5 PDB 3D structures from and Proteopedia for C1QC:
1PK6 (3D)        2JG8 (3D)        2JG9 (3D)        2WNU (3D)        2WNV (3D)    
Secondary accessions: Q7Z502 Q96DL2 Q96H05

Explore the universe of human proteins at neXtProt for C1QC: NX_P02747

Post-translational modifications:

  • O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl
  • groups1
  • View neXtProt modification sites for NX_P02747

  • C1QC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107573.1  NP_758957.2  

    ENSEMBL proteins: 
     ENSP00000363771   ENSP00000363770   ENSP00000363768  
    Reactome Protein details: P02747
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): C1QC
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    Novus Biologicals C1QC Protein
    Novus Biologicals C1QC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--


    C1QC for ontologies           About GeneDecksing



    C1QC Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    C1QC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR008160 Collagen
     IPR001073 C1q

    Graphical View of Domain Structure for InterPro Entry P02747

    ProtoNet protein and cluster: P02747

    3 Blocks protein families:
    IPB001073 Complement C1q protein
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747
    Similarity: Contains 1 C1q domain
    Similarity: Contains 1 collagen-like domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747
    Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement
    system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and
    efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM
    antibody present in immune complexes

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    SwitchGear 3'UTR luciferase reporter plasmidC1QC 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cleavage of Alpha-1-Microglobulin
    Classical antibody-mediated complement activation0.74
    Initial triggering of complement0.60
    Creation of C4 and C2 activators0.70
    Complement cascade0.47
    2Immune response_Classical complement pathway
    Immune response_Classical complement pathway1.00
    Immune response Classic complement pathway0.98
    3Immune System
    Immune System1.00
    Innate Immune System0.46
    4Complement and coagulation cascades
    Complement and coagulation cascades1.00
    Complement and Coagulation Cascades0.72
    5Systemic lupus erythematosus
    Systemic lupus erythematosus1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for C1QC
        Immune response Classic complement pathway


    1 GeneGo (Thomson Reuters) Pathway for C1QC
        Immune response Classical complement pathway

    2 BioSystems Pathways for C1QC 
        Complement Activation, Classical Pathway
    Complement and Coagulation Cascades

    5/6        Reactome Pathways for C1QC (see all 6)
        Classical antibody-mediated complement activation
    Creation of C4 and C2 activators
    Complement cascade
    Immune System
    Initial triggering of complement


    5/6         Kegg Pathways  (Kegg details for C1QC) (see all 6):
        Complement and coagulation cascades
    Prion diseases
    Pertussis
    Chagas disease (American trypanosomiasis)
    Staphylococcus aureus infection


    C1QC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1QC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/18 Interacting proteins for C1QC (P027472, 3 ENSP000003637684) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1QBP027462, 3, ENSP000003139674MINT-8040663 I2D: score=1 STRING: ENSP00000313967
    C1QAP027452, 3, ENSP000003637734MINT-8040663 I2D: score=1 STRING: ENSP00000363773
    FKBP2P268853, ENSP000003109354I2D: score=1 STRING: ENSP00000310935
    PTX3P260223, ENSP000002959274I2D: score=2 STRING: ENSP00000295927
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS9777412
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0030853negative regulation of granulocyte differentiation IDA10961870
    GO:0045087innate immune response TAS--


    C1QC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1QC

    1 HMDB Compound for C1QC    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/18 DrugBank Compounds for C1QC (see all 18)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Abciximab7E3 antibody (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Alefacept-- 222535-22-0target--17139284 17016423
    Alemtuzumab-- 216503-57-0target--17016423 17139284
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284
    BevacizumabantiVEGF (see all 3)216974-75-3target--17139284 17016423
    CetuximabAnti EGFR (see all 2)205923-56-4target--17139284 17016423
    DaclizumabAnti-IL-2 (see all 3)152923-56-3target--17139284 17016423
    Efalizumabanti alphaL integrin (see all 4)214745-43-4target--17139284 17016423
    EtanerceptCD120b (see all 7)185243-69-0target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about C1QC 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C1QC gene (2 alternative transcripts): 
    NM_001114101.1  NM_172369.3  

    Unigene Cluster for C1QC:

    Complement component 1, q subcomponent, C chain
    Hs.467753  [show with all ESTs]
    Unigene Representative Sequence: BQ711804
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374640(uc001bgc.4) ENST00000374639(uc001bga.4) ENST00000374637


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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate C1QC:
    hsa-miR-4254 hsa-miR-765 hsa-miR-3175
    SwitchGear 3'UTR luciferase reporter plasmidC1QC 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF087892.1 AK057792.1 AK130613.1 BC009016.1 

    15 DOTS entries:

    DT.95272435  DT.100833269  DT.92431893  DT.100839328  DT.100038193  DT.101982245  DT.121388766  DT.100038191 
    DT.100828744  DT.100828749  DT.95272436  DT.100828743  DT.121388793  DT.100828747  DT.100697109 

    24/507 AceView cDNA sequences (see all 507):

    CR600681 BI838362 BI761121 CD367233 CA941757 BM691745 CA406370 CD364998 
    CR623532 BI824570 CD108412 AA335122 CD370377 BU732984 BI821519 BI835225 
    CR610701 CR615645 CD671747 CA414800 BU730331 AA025953 CD671328 AI792359 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for C1QC    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b
    SP1:                    -     -                           
    SP2:                    -     -     -     -               
    SP3:                                                      
    SP4:                          -                           
    SP5:                                                      


    ECgene alternative splicing isoforms for C1QC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1QC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATCAATAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See C1QC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1QC

    SOURCE GeneReport for Unigene cluster: Hs.467753
        SABiosciences Custom PCR Arrays for C1QC
    Primer
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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for C1QC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C1QC gene from 2/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves C1QC1 complement component 1, q subcomponent, C chain 62.99(n)
    59.32(a)
      419503  XM_417653.2  XP_417653.1 
    zebrafish
    (Danio rerio)
    Actinopterygii c1qc1 complement component 1, q subcomponent, C chain 53.53(n)
    50.48(a)
      449803  NM_001005976.1  NP_001005976.1 


    ENSEMBL Gene Tree for C1QC (if available)
    TreeFam Gene Tree for C1QC (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C1QC gene
    C1QL32  COL8A22  C1QTNF92  C1QL22  C1QTNF52  OTOL12  C1QB2  COL10A12  
    C1QTNF32  C1QTNF9B2  C1QA2  COL8A12  C1QL12  C1QTNF72  C1QTNF22  ADIPOQ2  
    C1QL42  
    12 SIMAP similar genes for C1QC using alignment to 1 protein entry:     C1QC_HUMAN:
    C1QB    COL4A5    ADIPOQ    C1QA    C1QTNF5    C1QL4
    C1QTNF2    C1QTNF9    C1QTNF9B    OTOL1    C1QL2    C1QL1

    C1QC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/149 NCBI SNPs in C1QC are shown (see all 149    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs746622111,2
    F,--21212581(+) CCCCCA/C/GGCCTC 2 -- us2k12WA NA 238
    rs728771441,2
    C,--21213001(+) CGGAGC/TGGGGC 2 -- us2k12Minor allele frequency- T:0.05WA 120
    rs124045371,2
    C,F,H,--21213722(+) AAAGCC/TAAGGC 2 -- us2k124Minor allele frequency- T:0.10NS EA NA MN 2474
    rs66769971,2
    C,F,A,H,--21214298(+) TTCCTC/GATTTC 2 -- us2k112Minor allele frequency- G:0.10NS EA NA WA 1302
    rs118038651,2
    C,F,A,H--21214303(+) CATTTC/TGGACA 2 -- us2k15Minor allele frequency- T:0.01NS EA NA 418
    rs67005901,2
    C,F,A,H,--21214322(+) CGGTGG/CGGGGA 2 -- us2k18Minor allele frequency- C:0.07NS EA NA WA 432
    rs456110351,2
    F,--21214548(+) GGCCAG/TAAACC 2 -- ut511Minor allele frequency- T:0.02EA 120
    rs749091671,2
    F,--21214790(+) AGGACG/AGGCCC 2 -- int11Minor allele frequency- A:0.02NA 120
    rs159401,2
    C,F,--21215000(+) CTGCCA/C/G/
            
    GGGGC
    8 P syn13MN 556
    rs2018567681,2
    C--21215944(-) TTTCCA/CCNNNN 2 -- int10--------

    HapMap Linkage Disequilibrium report for C1QC (22970118 - 22974603 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for C1QC
         1 CNV: 47887
    Human Gene Mutation Database (HGMD): C1QC

    Locus Specific Mutation Databases (LSDB): C1QC

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1QC
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C1QC for disorders           About GeneDecksing

    OMIM gene information: 120575    OMIM disorders: --

    UniProtKB/Swiss-Prot: C1QC_HUMAN, P02747
  • Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect
  • resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads
    to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis

    18 diseases for C1QC:    About MalaCards
    lupus erythematosus    glomerulonephritis    duchenne muscular dystrophy    non-hodgkin lymphoma
    chronic wasting disease    muscular dystrophy    systemic lupus erythematosus    hodgkin's lymphoma
    prion disease    chagas disease    polyneuropathy    trypanosomiasis
    hepatitis b    pertussis    meningioma    hepatitis
    immunodeficiency    leukemia

    Human Genome Epidemiology (HuGE) Navigator: C1QC (14 documents)

    Export disorders for C1QC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1QC gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with C1QC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q. (PubMed id 1706597)1, 2, 3 Sellar G.C.... Reid K.B.M. (1991)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties. (PubMed id 12960167)1, 2 Gaboriaud C.... Arlaud G.J. (2003)
    6. Molecular basis of hereditary C1q deficiency. (PubMed id 9777412)1, 2 Petry F. (1998)
    7. Homozygous hereditary C1q deficiency and systemic lupus erythematosus. A new family and the molecular basis of C1q deficiency in three families. (PubMed id 8630118)1, 2 Slingsby J.H.... Walport M.J. (1996)
    8. Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement. (PubMed id 486087)1, 2 Reid K.B.M. (1979)
    9. Mesenchymal stromal cells derived from umbilical cord blood migrate in response to complement C1q. (PubMed id 22264191)1 Qiu Y....Janowska-Wieczorek A. (2012)
    10. Identification of a major linear C1q epitope allows de tection of systemic lupus erythematosus anti-C1q antibodies by a specific peptid e-based enzyme-linked immunosorbent assay. (PubMed id 22740328)1 Vanhecke D....Trendelenburg M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 714 HGNC: 1245 AceView: C1QAandC1QG Ensembl:ENSG00000159189 euGenes: HUgn714
    ECgene: C1QC Kegg: 714 H-InvDB: C1QC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1QC Pharmacogenomics, SNPs, Pathways
    C1QGbasehttp://bioinf.uta.fi/C1QGbase/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C1QC gene:
    Search GeneIP for patents involving C1QC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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