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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C1QB Gene

protein-coding GIFtS: 65
GCID: GC01P022979

complement component 1, q subcomponent, B chain

(Previous names: complement component 1, q subcomponent, beta polypeptide...)

Explore 24 diseases affiliated with
C1QB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Complement Component 1, Q Subcomponent, B Chain¹ ²
Complement Component 1, Q Subcomponent, Beta Polypeptide¹ ²
Complement C1q Subcomponent Subunit B²
Complement Component C1q, B Chain²
Complement Subcomponent C1q Chain B²

External Ids:	HGNC: 1242¹	Entrez Gene: 713²	Ensembl: ENSG00000173369⁷	OMIM: 120570⁵	UniProtKB: P02746³

Export aliases for C1QB gene to outside databases

Previous GC identifers: GC01P022555 GC01P022014 GC01P022125 GC01P022449 GC01P022455 GC01P022725 GC01P022852 GC01P021227

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C1QB:

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in

order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus

erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six

C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The

A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of

human complement subcomponent C1q (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: C1QB_HUMAN, P02746

Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement

system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and

efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM

antibody present in immune complexes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C1QB gene promoter:
AhR Pax-5 AML1a E47 c-Ets-1 C/EBPalpha Arnt HEN1 AREB6 IRF-7A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C1QB promoter sequence

Search SABiosciences Chromatin IP Primers for C1QB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1QB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.3-p34.1

C1QB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1QB gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P022979: view genomic region (about GC identifiers)

Start:	22,979,255 bp from pter	End:	22,988,031 bp from pter
Size:	8,777 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: C1QB_HUMAN, P02746 (See protein sequence)

Recommended Name: Complement C1q subcomponent subunit B precursor

Size: 253 amino acids; 26722 Da

Subunit: C1 is a calcium-dependent trimolecular complex of C1q, c1r and C1s in the molar ration of 1:2:2. C1q

subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three

of which are disulfide-linked dimers of the C chain

Subcellular location: Secreted

5 PDB 3D structures from and Proteopedia for C1QB:

1PK6 (3D)

2JG8 (3D)

2JG9 (3D)

2WNU (3D)

2WNV (3D)

Secondary accessions: Q5T959 Q96H17

Explore the universe of human proteins at neXtProt for C1QB: NX_P02746

Post-translational modifications:

Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Human C1Q contains up to

68.3 hydroxylysine-galactosylglucose residues and up to 2.5 hydroxylysine-galactose per molecule. Total percentage

hydroxylysine residues glycosylated is 86.4%¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02746

C1QB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000482.3

ENSEMBL proteins:

ENSP00000426317 ENSP00000423689 ENSP00000404606 ENSP00000313967

Reactome Protein details: P02746
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	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005581	collagen	IEA	--
GO:0005602	complement component C1 complex	TAS	1706597

C1QB for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C1QB for domains About GeneDecksing

3 InterPro domains/families:

IPR008983 Tumour_necrosis_fac-like_dom

IPR008160 Collagen

IPR001073 C1q

Graphical View of Domain Structure for InterPro Entry P02746

ProtoNet protein and cluster: P02746

3 Blocks protein families:

IPB001073 Complement C1q protein

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: C1QB_HUMAN, P02746

Similarity: Contains 1 C1q domain

Similarity: Contains 2 collagen-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: C1QB_HUMAN, P02746

Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement

system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and

efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM

antibody present in immune complexes

Genatlas biochemistry entry for C1QB:

complement component 1,q subcomponent,beta polypeptide (2.5kb),classical pathway of C3 activation,see C1Q@

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QB

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12960167
GO:0042803	protein homodimerization activity	IEA	--

C1QB for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cleavage of Alpha-1-Microglobulin

	Classical antibody-mediated complement activation	0.74			Initial triggering of complement	0.60
	Creation of C4 and C2 activators	0.70			Complement cascade	0.47

Classical Complement Pathway

	Classical Complement Pathway	1.00			Complement Activation, Classical Pathway	0.65
	Complement Pathway	0.75

Immune response_Classical complement pathway

Immune response_Classical complement pathway

1.00

Immune response Classic complement pathway

0.98

Immune System

Immune System

1.00

Innate Immune System

0.46

Complement and coagulation cascades

Complement and coagulation cascades

1.00

Complement and Coagulation Cascades

0.72

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for C1QB

Immune response Classic complement pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for C1QB

	Classical Complement Pathway
	Complement Pathway

1 GeneGo (Thomson Reuters) Pathway for C1QB

Immune response Classical complement pathway

2 BioSystems Pathways for C1QB

	Complement Activation, Classical Pathway
	Complement and Coagulation Cascades

5/6 Reactome Pathways for C1QB (see all 6)

	Classical antibody-mediated complement activation
	Creation of C4 and C2 activators
	Complement cascade
	Immune System
	Initial triggering of complement

5/6 Kegg Pathways (Kegg details for C1QB) (see all 6):

	Complement and coagulation cascades
	Prion diseases
	Pertussis
	Chagas disease (American trypanosomiasis)
	Staphylococcus aureus infection

C1QB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for C1QB

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/22 Interacting proteins for C1QB (P02746^{1, 2, 3} ENSP00000313967⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C1QA	P02745¹^,²^,³, ENSP00000363773⁴	EBI-2813376,EBI-1220209 MINT-8040663 I2D: score=1 STRING: ENSP00000363773
DEFA1	P59665³, ENSP00000372126⁴	I2D: score=1 STRING: ENSP00000372126
C1QC	P02747²^,³, ENSP00000363768⁴	MINT-8040663 I2D: score=1 STRING: ENSP00000363768
HRG	P04196³, ENSP00000232003⁴	I2D: score=2 STRING: ENSP00000232003
C1R	P00736³, ENSP00000290575⁴	I2D: score=1 STRING: ENSP00000290575

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006956	complement activation	TAS	--
GO:0006958	complement activation, classical pathway	TAS	--
GO:0007420	brain development	--	--
GO:0007568	aging	--	--
GO:0010033	response to organic substance	--	--

C1QB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C1QB

1 HMDB Compound for C1QB About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

10/18 DrugBank Compounds for C1QB (see all 18) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Abciximab	7E3 antibody (see all 4)	143653-53-6	target	--	17016423 17139284
Adalimumab	--	331731-18-1	target	--	17016423 17139284
Alefacept	--	222535-22-0	target	--	17139284 17016423
Alemtuzumab	--	216503-57-0	target	--	17016423 17139284
Basiliximab	chimeric mouse-human antiCD25 (see all 2)	152923-56-3	target	--	17016423 17139284
Bevacizumab	antiVEGF (see all 3)	216974-75-3	target	--	17139284 17016423
Cetuximab	Anti EGFR (see all 2)	205923-56-4	target	--	17139284 17016423
Daclizumab	Anti-IL-2 (see all 3)	152923-56-3	target	--	17139284 17016423
Efalizumab	anti alphaL integrin (see all 4)	214745-43-4	target	--	17139284 17016423
Etanercept	CD120b (see all 7)	185243-69-0	target	--	17139284 17016423

Search CenterWatch for drugs/clinical trials and news about C1QB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C1QB gene:

NM_000491.3

Unigene Cluster for C1QB:

Complement component 1, q subcomponent, B chain

Hs.8986 [show with all ESTs]

Unigene Representative Sequence: BQ881988

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000510260 ENST00000509305 ENST00000432749 ENST00000314933(uc001bgd.3)

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Additional cDNA sequence:

BC008983.1 X03084.1

6 DOTS entries:

DT.100810190 DT.95150289 DT.100802966 DT.92424223 DT.95150295 DT.100646233

24/258 AceView cDNA sequences (see all 258):

BM769734 BM773507 AV707811 BI824711 BI835876 AV703148 CR595684 BM069799

BI836949 AL080021 BI834172 BF437726 BM820258 CA393597 BQ706375 BI836616

BX344158 CR603615 AW951361 BM705339 AA369611 BM826724 CA397917 BQ709429

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for C1QB About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5
SP1:
SP2:					-
SP3:													-

ECgene alternative splicing isoforms for C1QB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C1QB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGGTGCCA

About this image

C1QB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Limb

Forelimb Myotome

Limb Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C1QB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C1QB

SOURCE GeneReport for Unigene cluster: Hs.8986

SABiosciences Custom PCR Arrays for C1QB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C1QB Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C1QB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C1QB gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	C1QB¹	complement component 1, q subcomponent, B chain	63.88(n) 56.9(a)		428197 XM_425756.3 XP_425756.2
African clawed frog (Xenopus laevis)	Amphibia	Xl.24421²	Xenopus laevis transcribed sequence with weak similarity more	71.06(n)		CB197048.2

ENSEMBL Gene Tree for C1QB (if available)
TreeFam Gene Tree for C1QB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for C1QB gene

C1QL3² COL8A2² C1QTNF9² C1QL2² C1QTNF5² OTOL1² COL10A1² C1QTNF3²

C1QTNF9B² C1QA² COL8A1² C1QL1² C1QTNF7² C1QC² C1QTNF2² ADIPOQ²

C1QL4²

18/19 SIMAP similar genes for C1QB using alignment to 5 protein entries: C1QB_HUMAN (see all proteins) (see all similar genes):

C1QC C1QA ADIPOQ COL1A1 COL4A6 C1QTNF2

COL13A1 COL10A1 C1QL2 C1QTNF7 COL8A2 C1QTNF9

OTOL1 C1QL4 C1QL3 C1QTNF5 C1QTNF9B COL21A1

C1QB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34964610^1,2	C,	--	21222166(+)	`AGTCCG/ATGCTC`	1	--	us2k¹		2		NA	122
rs11583021^1,2	C,F,H,	--	21222178(+)	`TAACCC/GACCTC`	1	--	us2k¹		8		NS EA NA WA	662
rs55764616^1,2	C,	--	21222399(+)	`CTACTT/AAAAAA`	1	--	us2k¹		2		WA CSA	3
rs17433222^1,2	C,F,H,	--	21222985(+)	`GCATCG/AGCCCC`	1	--	us2k¹		32		NA EA NS MN CSA WA	3367
rs112845075^1,2		--	21223002(+)	`CACGTC/TTTTCT`	1	--	us2k¹		1		CSA	2
rs72651392^1,2	C,	--	21223139(+)	`TGCACA/GTGGAA`	1	--	us2k¹		0	--	--	--	--
rs79006175^1,2		--	21223540(+)	`TCCTCC/TCCCAT`	1	--	us2k¹		1		EA	120
rs59746943^1,2	C,	--	21223610(+)	`TTATGG/ATCCCA`	1	--	us2k¹		1		WA	2
rs115261584^1,2	C,F,	--	21224226(+)	`ACCTGC/TCTCGG`	1	--	int¹		1		WA	118
rs6696518^1,2	C,F,H,	--	21225209(+)	`CCTCTC/TTCCCC`	1	--	int¹ trp³		5		NS EA WA	522

HapMap Linkage Disequilibrium report for C1QB (22979255 - 22988031 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C1QB
1 CNV: 47887
Human Gene Mutation Database (HGMD): C1QB

Locus Specific Mutation Databases (LSDB): C1QB

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C1QB for disorders About GeneDecksing

OMIM gene information: 120570 OMIM disorders: --

UniProtKB/Swiss-Prot: C1QB_HUMAN, P02746

Defects in C1QB are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect

resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads

to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis

20/24 diseases for C1QB (see all 24): About MalaCards

lupus erythematosus glomerulonephritis duchenne muscular dystrophy non-hodgkin lymphoma

cervical adenitis amyotrophic lateral sclerosis muscular dystrophy lateral sclerosis

systemic lupus erythematosus hodgkin's lymphoma prion disease chagas disease

polyneuropathy trypanosomiasis hepatitis b pertussis

neurodegeneration meningioma hepatitis cervicitis

Genatlas disease: C1QB

glomerulonephritis,lupus systemic syndrome

Human Genome Epidemiology (HuGE) Navigator: C1QB (13 documents)

Export disorders for C1QB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C1QB gene, integrated from 9 sources (see all 65):
(articles sorted by number of sources associating them with C1QB)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties. (PubMed id 12960167)^{1, 2} Gaboriaud C.... Arlaud G.J. (2003)
Molecular basis of hereditary C1q deficiency. (PubMed id 9777412)^{1, 2} Petry F. (1998)
Localization of the gene cluster encoding the A, B, and C chains of human C1q to 1p34.1-1p36.3. (PubMed id 1537612)^{1, 3} Sellar G.C....Reid K.B. (1992)
Molecular cloning and characterization of the complementary DNA and gene coding for the B-chain of subcomponent C1q of the human complement system. (PubMed id 3000358)^{1, 2} Reid K.B.M. (1985)
Cloning and characterization of the complementary DNA for the B chain of normal human serum C1q. (PubMed id 6208566)^{1, 2} Reid K.B.M.... Wood K.J. (1984)
Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement. (PubMed id 6981411)^{1, 2} Reid K.B.M.... Frampton J. (1982)
Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement. (PubMed id 486087)^{1, 2} Reid K.B.M. (1979)
Amino acid sequence of the N-terminal 108 amino acid residues of the B chain of subcomponent C1q of the first component of human complement. (PubMed id 708376)^{1, 2} Reid K.B.M. and Thompson E.O.P. (1978)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 713	HGNC: 1242	AceView: C1QB	Ensembl:ENSG00000173369	euGenes: HUgn713
ECgene: C1QB	Kegg: 713	H-InvDB: C1QB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C1QB	Pharmacogenomics, SNPs, Pathways
C1QBbase	http://bioinf.uta.fi/C1QBbase/

Intellectual Property for C1QB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for C1QB gene:
Search GeneIP for patents involving C1QB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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C1QB Gene

complement component 1, q subcomponent, B chain

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complement component 1, q subcomponent, B chain

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