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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C1D Gene

protein-coding   GIFtS: 53
GCID: GC02M068180

C1D nuclear receptor corepressor

(Previous name: C1D nuclear receptor co-repressor )
 Explore 20 diseases affiliated with
C1D via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C1D    

Aliases
for C1D gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
C1D Nuclear Receptor Corepressor1 2     C1D DNA-Binding Protein2
SUNCOR1 2 5     Nuclear DNA-Binding Protein2
LRP11 2     Nuclear Nucleic Acid-Binding Protein C1D2
SUN-CoR1 2     Small Unique Nuclear Receptor Co-Repressor2
C1D Nuclear Receptor Co-Repressor1 2     Small Unique Nuclear Receptor Corepressor2
HC1D1     

External Ids:    HGNC: 299111   Entrez Gene: 104382   Ensembl: ENSG000001972237   OMIM: 6069975   UniProtKB: Q139013   

Export aliases for C1D gene to outside databases

Previous GC identifers: GC02M068402 GC02M068227 GC02M068243 GC02M068125 GC02M068006


Summaries
for C1D gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for C1D:
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is
also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought
to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode
the same protein. Multiple pseudogenes of this gene are found on chromosome 10.(provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: C1D_HUMAN, Q13901
Function: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of
the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also
in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN
complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity)

Gene Wiki entry for C1D


Genomic Views
for C1D gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1D gene promoter:
         STAT1   Bach2   STAT1beta   AP-4   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   LCR-F1   POU3F2   STAT1alpha   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C1D promoter sequence
   Search SABiosciences Chromatin IP Primers for C1D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C1D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13-p12   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p13-p12

C1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1D gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M068180:  view genomic region     (about GC identifiers)

Start:
 68,268,262 bp from pter      End:
 68,338,080 bp from pter
Size:
 69,819 bases      Orientation:
 minus strand

Proteins
for C1D gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: C1D_HUMAN, Q13901 (See protein sequence)
Recommended Name: Nuclear nucleic acid-binding protein C1D  
Size: 141 amino acids; 16019 Da
Subunit: Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2 (By similarity). Interacts with
EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric
form interacts with TSNAX following gamma-radiation. Interacts with RAC3
Subcellular location: Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization
Secondary accessions: A8K336 D6W5F8 Q05D64

Explore the universe of human proteins at neXtProt for C1D: NX_Q13901

Post-translational modifications:

  • Phosphorylated by PRKDC1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13901

    • C1D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001177192.1  NP_001177194.1  NP_006324.1  NP_775269.1  

    ENSEMBL proteins: 
     ENSP00000348107   ENSP00000384304   ENSP00000386468   ENSP00000386779  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): C1D
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    Novus Biologicals C1D Proteins
    Novus Biologicals C1D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for C1D

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000176nuclear exosome (RNase complex) TAS17412707
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0017053transcriptional repressor complex IEA--


    C1D for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for C1D

    Protein Domains /
    Families
    for C1D gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    C1D for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011082 Exosome-assoc_fac/DNA_repair
     IPR007146 Sas10/Utp3/C1D

    Graphical View of Domain Structure for InterPro Entry Q13901

    ProtoNet protein and cluster: Q13901

    UniProtKB/Swiss-Prot: C1D_HUMAN, Q13901
    Similarity: Belongs to the C1D family


    Function
    for C1D gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: C1D_HUMAN, Q13901
    Function: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of
    the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also
    in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN
    complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity)
    Induction: By gamma-radiation

    miRNA
    Products:            		miRTarBase miRNAs that target C1D:
    hsa-mir-30a (MIRT005157), hsa-mir-192 (MIRT004148)

    OriGene 3'-UTR Clone (see all 2): C1D
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C1D
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate C1D (see all 10):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-522 hsa-miR-3133 hsa-miR-548aa hsa-miR-224* hsa-miR-570 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: C1D 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1D (see all 7)
    OriGene shRNA RFP: C1D
    OriGene siRNA: C1D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1D

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for C1D

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C1D (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for C1D
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1D 

    Cell Line
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    Search LifeMap BioReagents cell lines for C1D

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0003723RNA binding IDA17412707
    GO:0005515protein binding IPI17412707
    GO:0016922ligand-dependent nuclear receptor binding IEA--


    C1D for ontologies           About GeneDecksing



    Pathways & Interactions
    for C1D gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deadenylation-dependent mRNA decay
    		RNA degradation0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for C1D):
        RNA degradation


    C1D for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for C1D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for C1D (Q139011, 3 ENSP000003481074) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC10Q017801, 3, ENSP000003661354EBI-3844053,EBI-358236 I2D: score=2 STRING: ENSP00000366135
    TSNAXQ995983, ENSP000003555994I2D: score=4 STRING: ENSP00000355599
    PRKDCP785273, ENSP000003134204I2D: score=3 STRING: ENSP00000313420
    THRBP108283, ENSP000003488274I2D: score=2 STRING: ENSP00000348827
    NCOR1O753763, ENSP000002687124I2D: score=1 STRING: ENSP00000268712
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000460maturation of 5.8S rRNA IMP17412707
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IEA--


    C1D for ontologies           About GeneDecksing



    Drugs & Compounds
    for C1D gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    C1D for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C1D
    6 Novoseek chemical compound relationships for C1D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 25 1 9081096 (1)
    serine 9.95 3 8206988 (1), 10867876 (1), 8647861 (1)
    proline 9.69 2 2233723 (1), 10867876 (1)
    arginine 5.4 3 9757574 (1), 8647861 (1), 8670298 (1)
    zinc 3.19 1 11076952 (1)
    steroid 0 1 11303722 (1)

    Search CenterWatch for drugs/clinical trials and news about C1D 

    Transcripts
    for C1D gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for C1D gene (4 alternative transcripts): 
    NM_001190263.1  NM_001190265.1  NM_006333.3  NM_173177.2  

    Unigene Cluster for C1D:

    C1D nuclear receptor corepressor
    Hs.602900  [show with all ESTs]
    Unigene Representative Sequence: NM_001190265
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355848(uc002sec.3 uc002seb.3) ENST00000407324(uc002sea.4 uc010fdc.3 uc021viu.1)
    ENST00000410067 ENST00000409302 ENST00000479484 ENST00000485709 ENST00000470189


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C1D
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate C1D (see all 10):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-522 hsa-miR-3133 hsa-miR-548aa hsa-miR-224* hsa-miR-570 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: C1D 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C1D (see all 7)
    OriGene shRNA RFP: C1D
    OriGene siRNA: C1D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C1D
    Clone
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    GenScript Custom all cDNA clones Services for C1D
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C1D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C1D 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C1D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C1D

    Additional cDNA sequence: 

    AK290451.1 BC005235.1 BC009584.1 BC009589.1 BC016284.2 X95592.1 

    14 DOTS entries:

    DT.100797251  DT.452941  DT.91770516  DT.121253086  DT.97764095  DT.91770502  DT.121253037  DT.91770509 
    DT.121253092  DT.100797247  DT.121253051  DT.121253132  DT.97858764  DT.95329394 

    24/430 AceView cDNA sequences (see all 430):

    BI093844 AA305785 AI476631 BC066657 BM714895 BC020271 AI375251 BC009589 
    AI285866 BE857571 NM_006333 BM142471 CK820229 AL834142 BP350152 AA019009 
    BM786368 BX109819 CR593156 BM354091 BU581314 BU688593 BC014022 BM263178 

    GeneLoc Exon Structure


    Expression
    for C1D gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C1D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGACTGTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See C1D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C1D

    SOURCE GeneReport for Unigene cluster: Hs.602900

    UniProtKB/Swiss-Prot: C1D_HUMAN, Q13901
    Tissue specificity: Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland,
    thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in
    skeletal muscle, appendix, heart, lung and colon

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    In Situ
    Assay Products:     
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    Orthologs
    for C1D gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C1D gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia C1d1 , 5 C1D nuclear receptor co-repressor1, 5 87.38(n)1
    90.71(a)1    		   11 (9.89 cM)5
    573161  NM_020558.31  NP_065583.21 
     172575795 
    chicken
    (Gallus gallus)    		 Aves C1D1 C1D nuclear receptor corepressor 77.13(n)
    76.64(a)    		   421267  NM_001031036.2  NP_001026207.2 
    lizard
    (Anolis carolinensis)    		 Reptilia C1D6
    		 --
    		 82(a)
    		 1 ↔ 1
    		 1(126524250-126530358)
    African clawed frog
    (Xenopus laevis)    		 Amphibia 480305082   -- 75.76(n)    48030508 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc33g022 Transcribed sequence with weak similarity to protein more 74.56(n)    BI673950.1 


    ENSEMBL Gene Tree for C1D (if available)
    TreeFam Gene Tree for C1D (if available) 

    Paralogs
    for C1D gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C1D gene

    C1D for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for C1D
    PGOHUM00000238558 PGOHUM00000238559 PGOHUM00000238560 PGOHUM00000242386


    Genomic Variants
    for C1D gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/383 NCBI SNPs in C1D are shown (see all 383)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1496328371,2
    		--68269094(+) GGACTC/TCTCAT 4 -- ds50010--------
    rs1863983181,2
    		--68269359(+) CTTTAC/TTGAGA 4 -- ut310--------
    rs1896839311,2
    		--68269456(+) GGACAC/TAGAGG 4 -- ut310--------
    rs1817294501,2
    		--68269564(+) GTATCC/TATACA 4 -- ut310--------
    rs1862731591,2
    		--68269609(+) CTTAAC/TATCAT 4 -- ut310--------
    rs2019233831,2
    		--68269776(+) GAAAT-/AAGAGTC 4 -- ut310--------
    rs39618031,2
    		A--68269843(+) AGTGCA/TAATCA 4 -- ut31 ese30--------
    rs1905985901,2
    		--68269847(+) CTAATC/GAATAA 4 -- ut310--------
    rs28617951,2
    		A--68269939(+) CCTTGC/TCCTGC 4 -- ut31 ese30--------
    rs29020521,2
    		A--68269957(+) TTATTC/TTgcgg 4 -- ut310--------

    HapMap Linkage Disequilibrium report for C1D (68268262 - 68338080 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C1D: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C1D
    DNA2.0 Custom Variant and Variant Library Synthesis for C1D

    Disorders / Diseases
    for C1D gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    C1D for disorders           About GeneDecksing

    OMIM gene information: 606997    OMIM disorders: --

    20 diseases for C1D:    About MalaCards
    disseminated intravascular coagulation    primary ciliary dyskinesia    cerebral amyloid angiopathy    ciliary dyskinesia
    thyroiditis    iron overload    botulism    polymyositis
    rheumatoid arthritis    scleroderma    vaccinia    hepatocellular carcinoma
    cerebritis    arthritis    meningioma    breast cancer
    ischemia    carcinoma    leukemia    sepsis

    1 disease from the University of Copenhagen DISEASES database for C1D:
    Primary ciliary dyskinesia

    1 Novoseek disease relationship for C1D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 6.82 1 19887013 (1)

    Human Genome Epidemiology (HuGE) Navigator: C1D (4 documents)

    Export disorders for C1D gene to outside databases

    Publications
    for C1D gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C1D gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with C1D)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. (PubMed id 17412707)1, 2, 3 Schilders G.... Pruijn G.J.M. (2007)
    2. DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). (PubMed id 11801738)1, 2, 3 Erdemir T.... Yavuzer U. (2002)
    3. cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity. (PubMed id 9469821)1, 2, 3 Nehls P.... Werner D. (1998)
    4. C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome. (PubMed id 17599775)1, 3 Schilders G....Pruijn G.J. (2007)
    5. Induction of apoptosis by overexpression of the DNA-binding and DNA- PK-activating protein C1D. (PubMed id 10362552)1, 2 Rothbarth K....Werner D. (1999)
    6. DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. (PubMed id 9679063)1, 2 Yavuzer U....Jackson S.P. (1998)
    7. Identification of a novel Rac3-interacting protein C1D. (PubMed id 9852280)1, 2 Haataja L.... Heisterkamp N. (1998)
    8. Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. (PubMed id 9405624)1, 3 Zamir I....Lazar M.A. (1997)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    External Searches for C1D gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    Genome Databases showing C1D gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10438 HGNC: 29911 AceView: PPP3R1andC1DandLOC116143 Ensembl:ENSG00000197223 euGenes: HUgn10438
    ECgene: C1D Kegg: 10438 H-InvDB: C1D

    Other Databases showing C1D gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C1D gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C1D Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C1D gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C1D gene:
    Search GeneIP for patents involving C1D

    GeneCards and IP:
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