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Aliases for C1D Gene

Aliases for C1D Gene

  • C1D Nuclear Receptor Corepressor 2 3 5
  • Small Unique Nuclear Receptor Co-Repressor 2 3
  • C1D Nuclear Receptor Co-Repressor 2 3
  • HC1D 3 4
  • Small Unique Nuclear Receptor Corepressor 3
  • Nuclear DNA-Binding Protein 3
  • C1D DNA-Binding Protein 3
  • SUN-CoR 3
  • SUNCOR 3
  • Rrp47 3
  • LRP1 3

External Ids for C1D Gene

Previous GeneCards Identifiers for C1D Gene

  • GC02M068402
  • GC02M068227
  • GC02M068243
  • GC02M068180
  • GC02M068125
  • GC02M068006

Summaries for C1D Gene

Entrez Gene Summary for C1D Gene

  • The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

GeneCards Summary for C1D Gene

C1D (C1D Nuclear Receptor Corepressor) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include RNA binding and ligand-dependent nuclear receptor binding.

UniProtKB/Swiss-Prot for C1D Gene

  • Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3-5 end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).

Gene Wiki entry for C1D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1D Gene

Genomics for C1D Gene

Genomic Location for C1D Gene

Chromosome:
2
Start:
68,041,130 bp from pter
End:
68,110,948 bp from pter
Size:
69,819 bases
Orientation:
Minus strand

Genomic View for C1D Gene

Genes around C1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1D Gene

Proteins for C1D Gene

  • Protein details for C1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13901-C1D_HUMAN
    Recommended name:
    Nuclear nucleic acid-binding protein C1D
    Protein Accession:
    Q13901
    Secondary Accessions:
    • A8K336
    • D6W5F8
    • Q05D64

    Protein attributes for C1D Gene

    Size:
    141 amino acids
    Molecular mass:
    16019 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2 (By similarity). Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3.

neXtProt entry for C1D Gene

Proteomics data for C1D Gene at MOPED

Post-translational modifications for C1D Gene

Other Protein References for C1D Gene

Antibody Products

No data available for DME Specific Peptides for C1D Gene

Domains & Families for C1D Gene

Protein Domains for C1D Gene

Suggested Antigen Peptide Sequences for C1D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13901

UniProtKB/Swiss-Prot:

C1D_HUMAN :
  • Belongs to the C1D family.
Family:
  • Belongs to the C1D family.
genes like me logo Genes that share domains with C1D: view

No data available for Gene Families for C1D Gene

Function for C1D Gene

Molecular function for C1D Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3-5 end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
UniProtKB/Swiss-Prot Induction:
By gamma-radiation.

Gene Ontology (GO) - Molecular Function for C1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 17412707
genes like me logo Genes that share ontologies with C1D: view
genes like me logo Genes that share phenotypes with C1D: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1D Gene

Localization for C1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1D Gene

Nucleus. Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization (PubMed:17412707). Colocalizes with TSNAX in the nucleus (PubMed:11801738). {ECO:0000269 PubMed:11801738, ECO:0000269 PubMed:17412707}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1D Gene COMPARTMENTS Subcellular localization image for C1D gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for C1D Gene

Pathways & Interactions for C1D Gene

genes like me logo Genes that share pathways with C1D: view

Gene Ontology (GO) - Biological Process for C1D Gene

None

No data available for SIGNOR curated interactions for C1D Gene

Drugs & Compounds for C1D Gene

(4) Drugs for C1D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for C1D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with C1D: view

Transcripts for C1D Gene

Unigene Clusters for C1D Gene

C1D nuclear receptor corepressor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C1D Gene

No ASD Table

Relevant External Links for C1D Gene

GeneLoc Exon Structure for
C1D
ECgene alternative splicing isoforms for
C1D

Expression for C1D Gene

mRNA expression in normal human tissues for C1D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1D Gene

This gene is overexpressed in Lung (38.7) and Pancreas (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C1D Gene



SOURCE GeneReport for Unigene cluster for C1D Gene Hs.602900

mRNA Expression by UniProt/SwissProt for C1D Gene

Q13901-C1D_HUMAN
Tissue specificity: Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon.
genes like me logo Genes that share expression patterns with C1D: view

Protein tissue co-expression partners for C1D Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for C1D Gene

Orthologs for C1D Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1D 35
  • 93.14 (n)
  • 97.16 (a)
C1D 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1D 35
  • 94.09 (n)
  • 95.74 (a)
C1D 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C1d 35
  • 87.38 (n)
  • 90.71 (a)
C1d 16
C1d 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1D 35
  • 99.53 (n)
  • 99.29 (a)
C1D 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1D 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1D 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1D 35
  • 79.79 (n)
  • 81.1 (a)
C1D 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1D 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1d 35
  • 71.67 (n)
  • 71.43 (a)
Str.6344 35
zebrafish
(Danio rerio)
Actinopterygii c1d 35
  • 65.22 (n)
  • 61.59 (a)
wufc33g02 35
c1d 36
  • 57 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for C1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1D Gene

ENSEMBL:
Gene Tree for C1D (if available)
TreeFam:
Gene Tree for C1D (if available)

Paralogs for C1D Gene

Pseudogenes.org Pseudogenes for C1D Gene

genes like me logo Genes that share paralogs with C1D: view

No data available for Paralogs for C1D Gene

Variants for C1D Gene

Sequence variations from dbSNP and Humsavar for C1D Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10444 - 68,042,936(-) CAAAA(C/T)CGAAA reference, missense
rs1343913 -- 68,046,064(-) TATTC(C/T)ATGAA intron-variant
rs2141779 -- 68,064,888(+) tggac(A/G)gagaa upstream-variant-2KB
rs3755168 -- 68,046,428(+) AAAGA(C/G)AGAGG intron-variant
rs2902052 -- 68,042,825(+) TTATT(C/T)Tgcgg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C1D Gene

Variant ID Type Subtype PubMed ID
nsv834251 CNV Loss 17160897
nsv525802 CNV Loss 19592680

Variation tolerance for C1D Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1D Gene

HapMap Linkage Disequilibrium report
C1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1D Gene

Disorders for C1D Gene

Relevant External Links for C1D

Genetic Association Database (GAD)
C1D
Human Genome Epidemiology (HuGE) Navigator
C1D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1D

No disorders were found for C1D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1D Gene

Publications for C1D Gene

  1. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. (PMID: 17412707) Schilders G. … Pruijn G.J.M. (Nucleic Acids Res. 2007) 2 3 4 67
  2. C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome. (PMID: 17599775) Schilders G. … Pruijn G.J. (Arthritis Rheum. 2007) 2 3
  3. DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). (PMID: 11801738) Erdemir T. … Yavuzer U. (J. Cell Sci. 2002) 2 3
  4. cDNA cloning, recombinant expression and characterization of polypeptides with exceptional DNA affinity. (PMID: 9469821) Nehls P. … Werner D. (Nucleic Acids Res. 1998) 2 3
  5. Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. (PMID: 9405624) Zamir I. … Lazar M.A. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3

Products for C1D Gene

Sources for C1D Gene

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