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Aliases for C1D Gene

Aliases for C1D Gene

  • C1D Nuclear Receptor Corepressor 2 3
  • Small Unique Nuclear Receptor Co-Repressor 2 3
  • C1D Nuclear Receptor Co-Repressor 2 3
  • SUNCOR 3 6
  • HC1D 3 4
  • Small Unique Nuclear Receptor Corepressor 3
  • Nuclear Nucleic Acid-Binding Protein C1D 3
  • Nuclear DNA-Binding Protein 3
  • C1D DNA-Binding Protein 3
  • SUN-CoR 3
  • Rrp47 3
  • LRP1 3

External Ids for C1D Gene

Previous GeneCards Identifiers for C1D Gene

  • GC02M068402
  • GC02M068227
  • GC02M068243
  • GC02M068180
  • GC02M068125
  • GC02M068006

Summaries for C1D Gene

Entrez Gene Summary for C1D Gene

  • The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

GeneCards Summary for C1D Gene

C1D (C1D Nuclear Receptor Corepressor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include RNA binding and ligand-dependent nuclear receptor binding.

UniProtKB/Swiss-Prot for C1D Gene

  • Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3-5 end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).

Gene Wiki entry for C1D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1D Gene

Genomics for C1D Gene

Genomic Location for C1D Gene

Start:
68,041,130 bp from pter
End:
68,110,948 bp from pter
Size:
69,819 bases
Orientation:
Minus strand

Genomic View for C1D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1D Gene

Proteins for C1D Gene

  • Protein details for C1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13901-C1D_HUMAN
    Recommended name:
    Nuclear nucleic acid-binding protein C1D
    Protein Accession:
    Q13901
    Secondary Accessions:
    • A8K336
    • D6W5F8
    • Q05D64

    Protein attributes for C1D Gene

    Size:
    141 amino acids
    Molecular mass:
    16019 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2 (By similarity). Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3.

neXtProt entry for C1D Gene

Proteomics data for C1D Gene at MOPED

Post-translational modifications for C1D Gene

Other Protein References for C1D Gene

No data available for DME Specific Peptides for C1D Gene

Domains for C1D Gene

Protein Domains for C1D Gene

Suggested Antigen Peptide Sequences for C1D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13901

UniProtKB/Swiss-Prot:

C1D_HUMAN :
  • Q13901
Family:
  • Belongs to the C1D family.
genes like me logo Genes that share domains with C1D: view

No data available for Gene Families for C1D Gene

Function for C1D Gene

Molecular function for C1D Gene

UniProtKB/Swiss-Prot Function: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3-5 end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
UniProtKB/Swiss-Prot Induction: By gamma-radiation.

Gene Ontology (GO) - Molecular Function for C1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0003723 RNA binding IDA 17412707
GO:0005515 protein binding IPI 17412707
GO:0016922 ligand-dependent nuclear receptor binding IEA --
genes like me logo Genes that share ontologies with C1D: view

Animal Model Products

CRISPR Products

miRNA for C1D Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C1D Gene

Localization for C1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1D Gene

Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1D Gene COMPARTMENTS Subcellular localization image for C1D gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for C1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 nuclear exosome (RNase complex) TAS 17412707
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0017053 transcriptional repressor complex IEA --
genes like me logo Genes that share ontologies with C1D: view

Pathways for C1D Gene

genes like me logo Genes that share pathways with C1D: view

Pathways by source for C1D Gene

Gene Ontology (GO) - Biological Process for C1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IMP 17412707
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with C1D: view

Compounds for C1D Gene

(6) Novoseek inferred chemical compound relationships for C1D Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 25 1
serine 9.95 3
proline 9.69 2
arginine 5.4 3
zinc 3.19 1
genes like me logo Genes that share compounds with C1D: view

Transcripts for C1D Gene

Unigene Clusters for C1D Gene

C1D nuclear receptor corepressor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C1D

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1D Gene

No ASD Table

Relevant External Links for C1D Gene

GeneLoc Exon Structure for
C1D
ECgene alternative splicing isoforms for
C1D

Expression for C1D Gene

mRNA expression in normal human tissues for C1D Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C1D Gene

SOURCE GeneReport for Unigene cluster for C1D Gene Hs.602900

mRNA Expression by UniProt/SwissProt for C1D Gene

Q13901-C1D_HUMAN
Tissue specificity: Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon.
genes like me logo Genes that share expressions with C1D: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for C1D Gene

Orthologs for C1D Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1D 35
  • 99.53 (n)
  • 99.29 (a)
C1D 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1D 35
  • 93.14 (n)
  • 97.16 (a)
C1D 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1D 35
  • 94.09 (n)
  • 95.74 (a)
C1D 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C1d 35
  • 87.38 (n)
  • 90.71 (a)
C1d 16
C1d 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1D 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1D 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1D 35
  • 79.79 (n)
  • 81.1 (a)
C1D 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1D 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1d 35
  • 71.67 (n)
  • 71.43 (a)
Str.6344 35
zebrafish
(Danio rerio)
Actinopterygii c1d 35
  • 65.22 (n)
  • 61.59 (a)
c1d 36
  • 57 (a)
OneToOne
wufc33g02 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for C1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1D Gene

ENSEMBL:
Gene Tree for C1D (if available)
TreeFam:
Gene Tree for C1D (if available)

Paralogs for C1D Gene

Pseudogenes.org Pseudogenes for C1D Gene

genes like me logo Genes that share paralogs with C1D: view

No data available for Paralogs for C1D Gene

Variants for C1D Gene

Sequence variations from dbSNP and Humsavar for C1D Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10444 - 68,042,936(-) CAAAA(C/T)CGAAA missense, reference
rs1343913 -- 68,046,064(-) TATTC(C/T)ATGAA intron-variant
rs2141779 -- 68,064,888(+) tggac(A/G)gagaa upstream-variant-2KB
rs2861795 -- 68,042,807(+) CCTTG(C/T)CCTGC utr-variant-3-prime
rs2861796 -- 68,061,320(+) AGTCC(C/T)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1D Gene

Variant ID Type Subtype PubMed ID
nsv834251 CNV Loss 17160897
nsv525802 CNV Loss 19592680

Relevant External Links for C1D Gene

HapMap Linkage Disequilibrium report
C1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1D Gene

Disorders for C1D Gene

(1) University of Copenhagen DISEASES for C1D Gene

(1) Novoseek inferred disease relationships for C1D Gene

Disease -log(P) Hits PubMed IDs
inflammation 6.82 1

Relevant External Links for C1D

Genetic Association Database (GAD)
C1D
Human Genome Epidemiology (HuGE) Navigator
C1D
genes like me logo Genes that share disorders with C1D: view

No data available for UniProtKB/Swiss-Prot for C1D Gene

Publications for C1D Gene

  1. cDNA cloning, recombinant expression and characterization of polypeptides with exceptional DNA affinity. (PMID: 9469821) Nehls P. … Werner D. (Nucleic Acids Res. 1998) 2 3 4
  2. DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). (PMID: 11801738) Erdemir T. … Yavuzer U. (J. Cell Sci. 2002) 2 3 4
  3. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. (PMID: 17412707) Schilders G. … Pruijn G.J.M. (Nucleic Acids Res. 2007) 2 3 4
  4. C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome. (PMID: 17599775) Schilders G. … Pruijn G.J. (Arthritis Rheum. 2007) 2 3
  5. Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. (PMID: 9405624) Zamir I. … Lazar M.A. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3

Products for C1D Gene

Sources for C1D Gene

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