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Aliases for C1D Gene

Aliases for C1D Gene

  • C1D Nuclear Receptor Corepressor 2 3 5
  • Small Unique Nuclear Receptor Co-Repressor 2 3
  • C1D Nuclear Receptor Co-Repressor 2 3
  • HC1D 3 4
  • Small Unique Nuclear Receptor Corepressor 3
  • Nuclear Nucleic Acid-Binding Protein C1D 3
  • Nuclear DNA-Binding Protein 3
  • C1D DNA-Binding Protein 3
  • SUN-CoR 3
  • SUNCOR 3
  • Rrp47 3
  • LRP1 3

External Ids for C1D Gene

Previous GeneCards Identifiers for C1D Gene

  • GC02M068402
  • GC02M068227
  • GC02M068243
  • GC02M068180
  • GC02M068125
  • GC02M068006

Summaries for C1D Gene

Entrez Gene Summary for C1D Gene

  • The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

GeneCards Summary for C1D Gene

C1D (C1D Nuclear Receptor Corepressor) is a Protein Coding gene. Diseases associated with C1D include Primary Ciliary Dyskinesia. Among its related pathways are rRNA processing in the nucleus and cytosol and Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and ligand-dependent nuclear receptor binding.

UniProtKB/Swiss-Prot for C1D Gene

  • Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3-5 end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).

Gene Wiki entry for C1D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1D Gene

Genomics for C1D Gene

Regulatory Elements for C1D Gene

Enhancers for C1D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F068192 1.8 VISTA Ensembl ENCODE 10.9 -83.6 -83593 4.7 ATF1 PKNOX1 ARNT ZNF766 ZNF143 FOS JUNB REST TBX21 ZNF518A WDR92 PPP3R1 PNO1 C1D ENSG00000273275 LOC102724389
GH02F068059 0.4 ENCODE 7.1 +51.0 50953 0.9 ZNF639 ATF1 ZNF197 PKNOX1 NR2F1 ZBTB11 CEBPB RELA ARID1B ZNF766 C1D LOC402076
GH02F067879 0.9 Ensembl ENCODE 4.6 +230.5 230523 1.4 ZNF654 SP3 ZFP64 ZBTB11 ZNF140 SIN3A REST ZNF623 ZNF518A ZNF781 ETAA1 CNRIP1 WDR92 C1D LINC01812 LOC402076
GH02F068361 1.2 FANTOM5 ENCODE 2.8 -255.3 -255259 8.5 HDGF PKNOX1 ATF1 ARNT CREB3L1 WRNIP1 SIN3A ARID4B DMAP1 YY1 PLEK FBXO48 APLF ARHGAP25 C1D PPP3R1 LOC101927723
GH02F068375 1.6 FANTOM5 Ensembl ENCODE 2.3 -272.3 -272325 16.5 HDGF PKNOX1 WRNIP1 ZNF766 JUNB TBX21 CREB3 MEF2D SMARCA4 PBX2 PLEK FBXO48 APLF ARHGAP25 PPP3R1 C1D LOC101927723 LOC391383
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C1D on UCSC Golden Path with GeneCards custom track

Genomic Location for C1D Gene

Chromosome:
2
Start:
68,041,130 bp from pter
End:
68,110,948 bp from pter
Size:
69,819 bases
Orientation:
Minus strand

Genomic View for C1D Gene

Genes around C1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1D Gene

Proteins for C1D Gene

  • Protein details for C1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13901-C1D_HUMAN
    Recommended name:
    Nuclear nucleic acid-binding protein C1D
    Protein Accession:
    Q13901
    Secondary Accessions:
    • A8K336
    • D6W5F8
    • Q05D64

    Protein attributes for C1D Gene

    Size:
    141 amino acids
    Molecular mass:
    16019 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2 (By similarity). Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3.

neXtProt entry for C1D Gene

Post-translational modifications for C1D Gene

Other Protein References for C1D Gene

No data available for DME Specific Peptides for C1D Gene

Domains & Families for C1D Gene

Protein Domains for C1D Gene

Suggested Antigen Peptide Sequences for C1D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13901

UniProtKB/Swiss-Prot:

C1D_HUMAN :
  • Belongs to the C1D family.
Family:
  • Belongs to the C1D family.
genes like me logo Genes that share domains with C1D: view

No data available for Gene Families for C1D Gene

Function for C1D Gene

Molecular function for C1D Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3-5 end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
UniProtKB/Swiss-Prot Induction:
By gamma-radiation.

Gene Ontology (GO) - Molecular Function for C1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0003714 transcription corepressor activity IEA --
GO:0003723 RNA binding IEA,IDA 17412707
GO:0005515 protein binding IPI 17412707
GO:0016922 ligand-dependent nuclear receptor binding IEA --
genes like me logo Genes that share ontologies with C1D: view
genes like me logo Genes that share phenotypes with C1D: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1D Gene

Localization for C1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1D Gene

Nucleus. Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization (PubMed:17412707). Colocalizes with TSNAX in the nucleus (PubMed:11801738). {ECO:0000269 PubMed:11801738, ECO:0000269 PubMed:17412707}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C1D Gene COMPARTMENTS Subcellular localization image for C1D gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for C1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 nuclear exosome (RNase complex) TAS 17412707
GO:0005634 nucleus IDA,TAS --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with C1D: view

Pathways & Interactions for C1D Gene

genes like me logo Genes that share pathways with C1D: view

Pathways by source for C1D Gene

Gene Ontology (GO) - Biological Process for C1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IMP 17412707
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006364 rRNA processing TAS --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with C1D: view

No data available for SIGNOR curated interactions for C1D Gene

Drugs & Compounds for C1D Gene

(4) Drugs for C1D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for C1D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with C1D: view

Transcripts for C1D Gene

Unigene Clusters for C1D Gene

C1D nuclear receptor corepressor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1D Gene

No ASD Table

Relevant External Links for C1D Gene

GeneLoc Exon Structure for
C1D
ECgene alternative splicing isoforms for
C1D

Expression for C1D Gene

mRNA expression in normal human tissues for C1D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1D Gene

This gene is overexpressed in Lung (38.7) and Pancreas (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C1D Gene



Protein tissue co-expression partners for C1D Gene

NURSA nuclear receptor signaling pathways regulating expression of C1D Gene:

C1D

SOURCE GeneReport for Unigene cluster for C1D Gene:

Hs.602900

mRNA Expression by UniProt/SwissProt for C1D Gene:

Q13901-C1D_HUMAN
Tissue specificity: Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon.
genes like me logo Genes that share expression patterns with C1D: view

Primer Products

No data available for mRNA differential expression in normal tissues for C1D Gene

Orthologs for C1D Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1D 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia C1D 34 35
  • 94.09 (n)
cow
(Bos Taurus)
Mammalia C1D 34 35
  • 93.14 (n)
mouse
(Mus musculus)
Mammalia C1d 34 16 35
  • 87.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1D 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1D 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1D 34 35
  • 79.79 (n)
lizard
(Anolis carolinensis)
Reptilia C1D 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1d 34
  • 71.67 (n)
Str.6344 34
zebrafish
(Danio rerio)
Actinopterygii c1d 34 35
  • 65.22 (n)
wufc33g02 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for C1D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1D Gene

ENSEMBL:
Gene Tree for C1D (if available)
TreeFam:
Gene Tree for C1D (if available)

Paralogs for C1D Gene

Pseudogenes.org Pseudogenes for C1D Gene

genes like me logo Genes that share paralogs with C1D: view

No data available for Paralogs for C1D Gene

Variants for C1D Gene

Sequence variations from dbSNP and Humsavar for C1D Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10179069 -- 68,064,710(+) aaaaa(G/T)aaaag upstream-variant-2KB
rs10187476 -- 68,063,060(+) TGATC(C/T)CACGC upstream-variant-2KB
rs10203061 -- 68,054,627(+) tgact(A/G)aatat intron-variant
rs10207196 -- 68,043,126(+) GTACA(C/T)CTTGG intron-variant
rs10444 -- 68,042,936(-) CAAAA(C/T)CGAAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for C1D Gene

Variant ID Type Subtype PubMed ID
nsv525802 CNV loss 19592680
nsv834251 CNV loss 17160897

Variation tolerance for C1D Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1D Gene

Disorders for C1D Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1D Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary ciliary dyskinesia
  • ciliary motility disorder
- elite association - COSMIC cancer census association via MalaCards
Search C1D in MalaCards View complete list of genes associated with diseases

Relevant External Links for C1D

Genetic Association Database (GAD)
C1D
Human Genome Epidemiology (HuGE) Navigator
C1D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C1D
genes like me logo Genes that share disorders with C1D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1D Gene

Publications for C1D Gene

  1. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. (PMID: 17412707) Schilders G. … Pruijn G.J.M. (Nucleic Acids Res. 2007) 2 3 4 64
  2. DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). (PMID: 11801738) Erdemir T. … Yavuzer U. (J. Cell Sci. 2002) 2 3 4 64
  3. cDNA cloning, recombinant expression and characterization of polypeptides with exceptional DNA affinity. (PMID: 9469821) Nehls P. … Werner D. (Nucleic Acids Res. 1998) 2 3 4 64
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64

Products for C1D Gene

Sources for C1D Gene

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