Aliases for C1D Gene
External Ids for C1D Gene
Previous GeneCards Identifiers for C1D Gene
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
GeneCards Summary for C1D Gene
C1D (C1D Nuclear Receptor Corepressor) is a Protein Coding gene. Diseases associated with C1D include Primary Ciliary Dyskinesia. Among its related pathways are rRNA processing in the nucleus and cytosol and Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and ligand-dependent nuclear receptor binding.
UniProtKB/Swiss-Prot for C1D Gene
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3-5 end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).