C19orf80 Gene
protein-coding GIFtS: 36
GCID: GC19P011349
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chromosome 19 open reading frame 80
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Aliases
for C19orf80 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 19 Open Reading Frame 801 2 | | PVPA5992 | | ANGPTL81 2 | | Hepatocellular Carcinoma-Associated Gene TD262 | | RIFL1 2 | | Hepatocellular Carcinoma-Associated Protein TD262 | | TD261 2 | | Lipasin1 | | PRO11852 | | |
Export aliases for C19orf80 gene to outside databases |
Summaries
for C19orf80 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C19orf80 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for C19orf80
Other transcription factors
Search SABiosciences Chromatin IP Primers for C19orf80
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf80 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2C19orf80 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P011349: view genomic region
(about GC identifiers)
Start:
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11,348,178 bp from pter |
End:
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11,352,619 bp from pter |
Size:
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4,442 bases |
Orientation:
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plus strand |
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Proteins
for C19orf80 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TD26_HUMAN, Q6UXH0 (See
protein sequence)Recommended Name: Hepatocellular carcinoma-associated protein TD26 precursor Size: 198 amino acids; 22105 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=AAF76204.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=EAW84186.1; Type=Erroneous gene model prediction;
Secondary accessions: Q9NQZ1Explore the universe of human proteins at neXtProt for C19orf80: NX_Q6UXH0
C19orf80 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061157.3
ENSEMBL proteins: ENSP00000464941 ENSP00000252453 ENSP00000465378
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
C19orf80 for ontologies About GeneDecksing
C19orf80 Antibody Products:
Assay Products for C19orf80: |
Protein
Domains /
Families
for C19orf80 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C19orf80 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6UXH0ProtoNet protein and cluster: Q6UXH0 |
Function
for C19orf80 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf80 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf80
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for C19orf80 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C19orf80 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf80 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf80 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
C19orf80 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Gm6484tm1Lex for C19orf80
1 MGI phenotypic allele  for Gm6484 (no phenotypes)
C19orf80 for phenotypes About GeneDecksing
|
Pathways & Interactions
for C19orf80 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C19orf80
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for C19orf80 (Q6UXH01 ENSP000002524534) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C19orf80 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C19orf80
Search CenterWatch for drugs/clinical trials and news about C19orf80 / TD26
|
Transcripts
for C19orf80 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C19orf80 gene: NM_018687.6 Unigene Cluster for C19orf80: Chromosome 19 open reading frame 80 Hs.534467 [show with all ESTs]Unigene Representative Sequence: AF2713503 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000591200 ENST00000252453(uc010dxw.3 uc021upg.1) ENST00000587543
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf80 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf80
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for C19orf80 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C19orf80 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf80 |
Additional cDNA sequence: AF271350.2 AY358356.1 BC113823.1 5 DOTS entries: DT.91652802 DT.454372 DT.40281916 DT.97766754 DT.97773588 15 AceView cDNA sequences: AV718605 AV719284 AV656411 NM_018687 AV655891 AV654765 AV656119 BQ002776 AY358356 AA923549 AV697855 BI832620 AF271350 AI950351 BF511595
GeneLoc Exon Structure
|
Expression
for C19orf80 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C19orf80 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTACACACC
About this image
See C19orf80 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C19orf80
SOURCE GeneReport for Unigene cluster: Hs.534467
SABiosciences Custom PCR Arrays for C19orf80
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C19orf80
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat C19orf80 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C19orf80 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C19orf80 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf80 |
Orthologs
for C19orf80 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for C19orf80 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for C19orf80 (if available)
TreeFam Gene Tree for C19orf80 (if available) |
Paralogs
for C19orf80 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C19orf80 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C19orf80 (11348178 - 11352619 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C19orf80: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C19orf80 |
|
Disorders
/ Diseases
for C19orf80 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C19orf80 for disorders About GeneDecksing
2  diseases for C19orf80: About MalaCardshepatocellular carcinoma carcinoma
Export disorders for C19orf80 gene to outside databases
|
Publications
for C19orf80 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C19orf80 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C19orf80) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Atypical angiopoietin-like protein that regulates ANGP TL3. (PubMed id 23150577)1, 3 Quagliarini F....Hobbs H.H. (2012)
- Lipasin, a novel nutritionally-regulated liver-enriche d factor that regulates serum triglyceride levels. (PubMed id 22809513)1, 3 Zhang R. (2012)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. (PubMed id 23261442)1 Fu Z....Zhang R. (2013)
- Identification of RIFL, a novel adipocyte-enriched ins ulin target gene with a role in lipid metabolism. (PubMed id 22569073)1 Ren G....Smas C.M. (2012)
- Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for C19orf80 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C19orf80 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C19orf80 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C19orf80 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for C19orf80 gene:
Search GeneIP for patents involving C19orf80
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C19orf80 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C19orf80 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C19orf80 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C19orf80 | | | OriGene Protein Over-expression Lysate for C19orf80 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C19orf80 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf80 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf80 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C19orf80 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C19orf80 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf80 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C19orf80 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C19orf80 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C19orf80 |
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 | | | C19orf80 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf80 |
|  |  |  | | | | Search ThermoFisher Antibodies for C19orf80 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf80 |
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