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C19orf70 Gene

protein-coding   GIFtS: 43
GCID: GC19M005678

Chromosome 19 Open Reading Frame 70

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 19 Open Reading Frame 701 2
P1172
QIL12
Protein QIL12
Protein P1173

External Ids:    HGNC: 337021   Entrez Gene: 1259882   Ensembl: ENSG000001749177   UniProtKB: Q5XKP03   
ORGUL members:         

Export aliases for C19orf70 gene to outside databases

Previous GC identifers: GC19M005634 GC19M005439


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C19orf70 Gene:
C19orf70 (chromosome 19 open reading frame 70) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the C19orf70 gene promoter:
         STAT5B   Sox5   AML1a   HOXA3   NRSF form 1   p300   NRSF form 2   HNF-4alpha1   ZIC2/Zic2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC19orf70 promoter sequence
   Search Chromatin IP Primers for C19orf70

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C19orf70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

C19orf70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C19orf70 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005678:  view genomic region     (about GC identifiers)

Start:
5,678,432 bp from pter      End:
5,680,911 bp from pter
Size:
2,480 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: QIL1_HUMAN, Q5XKP0 (See protein sequence)
Recommended Name: Protein QIL1  
Size: 118 amino acids; 13087 Da
Secondary accessions: Q86YE5

Explore the universe of human proteins at neXtProt for C19orf70: NX_Q5XKP0

Explore proteomics data for C19orf70 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C19orf70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_991330.1  
    ENSEMBL proteins: 
     ENSP00000468723   ENSP00000309561   ENSP00000465739   ENSP00000464857  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026769 QIL1

    Graphical View of Domain Structure for InterPro Entry Q5XKP0

    ProtoNet protein and cluster: Q5XKP0

    UniProtKB/Swiss-Prot: QIL1_HUMAN, Q5XKP0
    Similarity: Belongs to the UPF0433 family


    Find genes that share domains with C19orf70           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C19orf70
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    hsa-miR-22 hsa-miR-558 hsa-miR-4290
    SwitchGear 3'UTR luciferase reporter plasmidC19orf70 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with C19orf70           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C19orf70
    Interactions:

        Search GeneGlobe Interaction Network for C19orf70

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for C19orf70 (Q5XKP01, 3 ENSP000003095614) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PELOQ9BRX21, 3, ENSP000002743114EBI-1053887,EBI-1043580 I2D: score=1 STRING: ENSP00000274311
    ENSG00000206505P304573, ENSP000003731144I2D: score=1 STRING: ENSP00000373114
    HLA-AP304573I2D: score=1 
    TNFRSF14Q929563, ENSP000003479484I2D: score=1 STRING: ENSP00000347948
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C19orf70 (QIL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C19orf70 gene: 
    NM_205767.1  

    Unigene Cluster for C19orf70:

    Chromosome 19 open reading frame 70
    Hs.356626  [show with all ESTs]
    Unigene Representative Sequence: BM563199
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585605 ENST00000587950 ENST00000309324(uc002mch.1) ENST00000590389
    ENST00000587589 ENST00000590075
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate C19orf70:
    hsa-miR-22 hsa-miR-558 hsa-miR-4290
    SwitchGear 3'UTR luciferase reporter plasmidC19orf70 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat C19orf70
      QuantiFast Probe-based Assays in human, mouse, rat C19orf70

    Additional mRNA sequence: 

    BC009557.1 BC042386.1 BC052640.1 BC126939.1 

    8 DOTS entries:

    DT.446569  DT.92036786  DT.100767003  DT.100806447  DT.121494815  DT.92008870  DT.91798820  DT.92424090 

    Selected AceView cDNA sequences (see all 188):

    AA327326 AI817835 BM987212 CR615232 BU784535 AA369484 AI359175 NM_205767 
    BM701946 BF725056 BE393365 BQ083074 AA319963 CR596153 AI376399 AW444735 
    BE906305 BF526895 BF940054 BU728756 AI244359 BC009557 BM822922 CK823673 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C19orf70 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGGTGATGT
    C19orf70 Expression
    About this image

    C19orf70 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C19orf70 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356626
        Custom PCR Arrays for C19orf70
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf70

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C19orf70 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2410015M20Rik1 , 5 RIKEN cDNA 2410015M20 gene1, 5 84.75(n)1
    87.29(a)1
      17 (29.42 cM)5
    2249041  NM_153152.31  NP_694792.11 
     566074525 
    chicken
    (Gallus gallus)
    Aves LOC1008580911 protein QIL1-like 66.04(n)
    53.27(a)
      100858091  XM_003642843.2  XP_003642891.2 
    lizard
    (Anolis carolinensis)
    Reptilia C19orf706
    chromosome 19 open reading frame 70
    47(a)
    1 ↔ 1
    GL343717.1(87705-88732)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004895211 chromosome unknown open reading frame, human C19orf7 more 57.37(n)
    46.15(a)
      100489521  XM_002936324.2  XP_002936370.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-78l4.141 si:dkey-78l4.14 51.05(n)
    42.34(a)
      558738  NM_001044873.1  NP_001038338.1 


    ENSEMBL Gene Tree for C19orf70 (if available)
    TreeFam Gene Tree for C19orf70 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C19orf70 gene
    1 SIMAP similar gene for C19orf70 using alignment to 2 protein entries:     K7EIR2_HUMAN (see all proteins):
    QIL1

    Find genes that share paralogs with C19orf70           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for C19orf70
    PGOHUM00000237191


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C19orf70 (see all 20)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1499110391,2
    --5677955(+) CACCTA/GGATTT 1 -- int10--------
    rs1172252271,2
    C,F--5678016(+) GAGGGT/CGGAGT 1 -- int11Minor allele frequency- C:0.02EA 120
    rs24365271,2
    C,F,A,H--5678133(+) CTTCTG/ATCCAC 1 -- int126Minor allele frequency- A:0.25NS EA NA WA CSA 2355
    rs744583111,2
    F--5678221(+) ACTTTC/TCTGGC 1 -- int11Minor allele frequency- T:0.01WA 118
    rs790155011,2
    F--5678347(+) AGCCAT/CCAGGA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1919261791,2
    --5678479(+) GCCCTC/TGGAGT 1 -- ut310--------
    rs1169096851,2
    C,F--5678497(+) CAGTCC/TGGAGT 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs85841,2
    C,F--5678526(+) CCTGCC/TCGTTC 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs1439427731,2
    C--5678549(+) GCGGCC/TCCTGC 1 -- ut310--------
    rs2005187591,2
    --5678612(+) CTCGCC/GGGCCT 2 R G mis10--------

    HapMap Linkage Disequilibrium report for C19orf70 (5678432 - 5680911 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for C19orf70:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3694n71CNV Loss21882294
    nsv910894CNV Loss21882294
    dgv3695n71CNV Loss21882294
    dgv3693n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for C19orf70

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C19orf70 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C19orf70)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1, 3 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 125988 HGNC: 33702 AceView: QIL1 Ensembl:ENSG00000174917 euGenes: HUgn125988
    ECgene: C19orf70 H-InvDB: C19orf70

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C19orf70 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C19orf70 gene:
    Search GeneIP for patents involving C19orf70

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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