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Aliases for C19orf68 Gene

Aliases for C19orf68 Gene

  • Chromosome 19 Open Reading Frame 68 2 3 5

External Ids for C19orf68 Gene

Previous GeneCards Identifiers for C19orf68 Gene

  • GC19P053366
  • GC19P048673
  • GC19P045057

Summaries for C19orf68 Gene

GeneCards Summary for C19orf68 Gene

C19orf68 (Chromosome 19 Open Reading Frame 68) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf68 Gene

Genomics for C19orf68 Gene

Regulatory Elements for C19orf68 Gene

Enhancers for C19orf68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G047239 2 FANTOM5 Ensembl ENCODE dbSUPER 22.1 -930.1 -930103 3.1 CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZC3H4 BICRA NOP53-AS1 ENSG00000268810 PPP5D1 C19orf68 CCDC9 SLC8A2 SLC1A5 ENSG00000268746
GH19G049154 1.6 Ensembl ENCODE dbSUPER 22.1 +986.1 986102 5.1 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 CA11 SEC1P C19orf68 TRPM4 PRR12 GRWD1 RPS11 NTN5 SNORD35A PIH1D1
GH19G047741 1.4 ENCODE dbSUPER 22.1 -426.7 -426741 5.0 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZC3H4 SELENOW BICRA CA11 C19orf68 NOP53 SNORD23 NTN5 GRWD1 NOP53-AS1
GH19G048958 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +793.4 793368 10.2 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PPP1R15A PRR12 NUP62 IZUMO1 RUVBL2 CA11 SEC1P SNORD35B C19orf68 ALDH16A1
GH19G048328 1.7 FANTOM5 ENCODE dbSUPER 12.8 +161.0 161004 5.8 CREB3L1 AGO1 FEZF1 YBX1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TMEM143 BICRA GRWD1 CA11 C19orf68 SYNGR4 NOP53-AS1 EMP3 RASIP1 SLC8A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C19orf68 on UCSC Golden Path with GeneCards custom track

Promoters for C19orf68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110666 -362 1801 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for C19orf68 Gene

Chromosome:
19
Start:
48,170,662 bp from pter
End:
48,197,621 bp from pter
Size:
26,960 bases
Orientation:
Plus strand

Genomic View for C19orf68 Gene

Genes around C19orf68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf68 Gene

Proteins for C19orf68 Gene

  • Protein details for C19orf68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XI8-CS068_HUMAN
    Recommended name:
    Uncharacterized protein C19orf68
    Protein Accession:
    Q86XI8

    Protein attributes for C19orf68 Gene

    Size:
    627 amino acids
    Molecular mass:
    70073 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH43386.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C19orf68 Gene

Post-translational modifications for C19orf68 Gene

  • Ubiquitination at Lys286
  • Modification sites at PhosphoSitePlus

Other Protein References for C19orf68 Gene

No data available for DME Specific Peptides for C19orf68 Gene

Domains & Families for C19orf68 Gene

Protein Domains for C19orf68 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C19orf68: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C19orf68 Gene

Function for C19orf68 Gene

Gene Ontology (GO) - Molecular Function for C19orf68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with C19orf68: view
genes like me logo Genes that share phenotypes with C19orf68: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C19orf68 Gene

Localization for C19orf68 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf68 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for C19orf68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with C19orf68: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C19orf68 Gene

Pathways & Interactions for C19orf68 Gene

SuperPathways for C19orf68 Gene

No Data Available

Interacting Proteins for C19orf68 Gene

Gene Ontology (GO) - Biological Process for C19orf68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with C19orf68: view

No data available for Pathways by source and SIGNOR curated interactions for C19orf68 Gene

Drugs & Compounds for C19orf68 Gene

No Compound Related Data Available

Transcripts for C19orf68 Gene

mRNA/cDNA for C19orf68 Gene

Unigene Clusters for C19orf68 Gene

Chromosome 19 open reading frame 68:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf68 Gene

No ASD Table

Relevant External Links for C19orf68 Gene

GeneLoc Exon Structure for
C19orf68
ECgene alternative splicing isoforms for
C19orf68

Expression for C19orf68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C19orf68 Gene

Protein differential expression in normal tissues from HIPED for C19orf68 Gene

This gene is overexpressed in Testis (23.0), Liver, secretome (22.0), and Peripheral blood mononuclear cells (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C19orf68 Gene



Protein tissue co-expression partners for C19orf68 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C19orf68 Gene:

C19orf68

SOURCE GeneReport for Unigene cluster for C19orf68 Gene:

Hs.664054

Evidence on tissue expression from TISSUES for C19orf68 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with C19orf68: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf68 Gene

Orthologs for C19orf68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf68 34
  • 97.96 (n)
C19orf68 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C19orf68 35
  • 89 (a)
OneToOne
C18H19orf68 34
  • 86.4 (n)
dog
(Canis familiaris)
Mammalia C1H19orf68 34
  • 86.9 (n)
C19orf68 35
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 6330408A02Rik 34 16 35
  • 76.95 (n)
rat
(Rattus norvegicus)
Mammalia RGD1310257 34
  • 76 (n)
oppossum
(Monodelphis domestica)
Mammalia C19orf68 35
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf68 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf68 35
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia 6330408a02rik 34
  • 50.07 (n)
Species where no ortholog for C19orf68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C19orf68 Gene

ENSEMBL:
Gene Tree for C19orf68 (if available)
TreeFam:
Gene Tree for C19orf68 (if available)

Paralogs for C19orf68 Gene

No data available for Paralogs for C19orf68 Gene

Variants for C19orf68 Gene

Sequence variations from dbSNP and Humsavar for C19orf68 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000004962 -- 48,182,503(+) AGCCC(A/G)CTGCG reference, synonymous-codon
rs1000013643 -- 48,183,367(+) TGTGA(C/T)CCGCC intron-variant
rs1000025107 -- 48,179,140(+) TCTGA(-/T)TTTTT intron-variant, upstream-variant-2KB
rs1000048604 -- 48,171,696(+) TAGAG(G/T)CACCA intron-variant, upstream-variant-2KB
rs1000071585 -- 48,183,489(+) GCAGA(C/G)GTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf68 Gene

Variant ID Type Subtype PubMed ID
esv1261804 CNV insertion 17803354
esv34181 CNV loss 18971310
nsv525109 CNV loss 19592680
nsv833853 CNV loss 17160897
nsv953597 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for C19orf68 Gene

Gene Damage Index Score: 0.82; 17.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf68 Gene

Disorders for C19orf68 Gene

Relevant External Links for C19orf68

Human Genome Epidemiology (HuGE) Navigator
C19orf68
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C19orf68

No disorders were found for C19orf68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf68 Gene

Publications for C19orf68 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PMID: 20195357) Miyamoto-Sato E. … Yanagawa H. (PLoS ONE 2010) 3 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 64

Products for C19orf68 Gene

Sources for C19orf68 Gene

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