Aliases for C19orf66 Gene
Aliases for C19orf66 Gene
External Ids for C19orf66 Gene
- HGNC: 25649
- Entrez Gene: 55337
- Ensembl: ENSG00000130813
- OMIM: 616808
- UniProtKB: Q9NUL5
Previous GeneCards Identifiers for C19orf66 Gene
- GC19P010196
- GC19P009777
Summaries for C19orf66 Gene
GeneCards Summary for C19orf66 Gene
C19orf66 (Chromosome 19 Open Reading Frame 66) is a Protein Coding gene. Diseases associated with C19orf66 include West Nile Virus.
UniProtKB/Swiss-Prot for C19orf66 Gene
-
Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf66 Gene
Genomics for C19orf66 Gene
Regulatory Elements for C19orf66 Gene
Enhancers for C19orf66 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C19orf66 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C19orf66 Gene
- Chromosome:
- 19
- Start:
- 10,086,119 bp from pter
- End:
- 10,093,252 bp from pter
- Size:
- 7,134 bases
- Orientation:
- Plus strand
Genomic View for C19orf66 Gene
Genes around C19orf66 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
C19orf66 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C19orf66 Gene
Proteins for C19orf66 Gene
-
Protein details for C19orf66 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NUL5-RYDEN_HUMAN
- Recommended name:
- Repressor of yield of DENV protein
- Protein Accession:
- Q9NUL5
- A8MQT9
- Q4G188
- Q8IYH6
- Q8N8V1
Protein attributes for C19orf66 Gene
- Size:
- 291 amino acids
- Molecular mass:
- 33110 Da
- Quaternary structure:
-
- Interacts with PABPC1 (PubMed:26735137). Found in a complex with PABPC1 and LARP1 (PubMed:26735137).
Protein Expression for C19orf66 Gene
Post-translational modifications for C19orf66 Gene
Other Protein References for C19orf66 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C19orf66
-
Abcam antibodies for C19orf66
- Search GeneTex for Antibodies for C19orf66
Protein Products
-
OriGene Purified Proteins for C19orf66
- Search Origene for MassSpec and Protein Over-expression Lysates for C19orf66
- Origene Custom Protein Services for C19orf66
- Search GeneTex for Proteins for C19orf66
Assay Products
No data available for DME Specific Peptides for C19orf66 Gene
Domains & Families for C19orf66 Gene
Suggested Antigen Peptide Sequences for C19orf66 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NUL5- Family:
-
- Belongs to the RyDEN family.
No data available for Gene Families for C19orf66 Gene
Function for C19orf66 Gene
Molecular function for C19orf66 Gene
- UniProtKB/Swiss-Prot Function:
- Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by interferon (IFN) treatment.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 26735137 |
| GO:0005515 | protein binding | IPI | 21044950 |
Phenotypes for C19orf66 Gene
- GenomeRNAi human phenotypes for C19orf66:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for C19orf66 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C19orf66 gene
- Search ViGene Biosciences for C19orf66
CRISPR Products
-
OriGene CRISPR knockouts for C19orf66
-
Santa Cruz Biotechnology (SCBT) CRISPR for C19orf66
- GenScript: Design CRISPR guide RNA sequences for C19orf66
miRNA for C19orf66 Gene
- miRTarBase miRNAs that target C19orf66
miRNA Products
- Search ViGene Biosciences for C19orf66
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C19orf66
- Browse OriGene Inhibitory RNA Products For C19orf66
-
ViGene Biosciences ready-to-package AAV shRNAs for C19orf66 gene
Clone Products
-
OriGene ORF clones in human for C19orf66
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- VectorBuilder custom plasmid, inducible vectors for C19orf66
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C19orf66
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C19orf66
-
ViGene Biosciences adenoviral particle packaged cDNA for C19orf66 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C19orf66 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C19orf66 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C19orf66 Gene
Localization for C19orf66 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C19orf66 Gene
- Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. {ECO:0000269 PubMed:26735137}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 26735137 |
| GO:0005737 | cytoplasm | IDA,IEA | 26735137 |
Pathways & Interactions for C19orf66 Gene
No Data Available
Interacting Proteins for C19orf66 Gene
Selected Interacting proteins:
Q9NUL5-RYDEN_HUMAN
ENSP00000253110
for C19orf66 Gene via
UniProtKB
IID
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0034340 | response to type I interferon | IDA | 26735137 |
| GO:0034341 | response to interferon-gamma | IDA | 26735137 |
| GO:0034342 | response to type III interferon | IDA | 26735137 |
| GO:0045071 | negative regulation of viral genome replication | IMP | 26735137 |
| GO:0051607 | defense response to virus | IDA,IEA | 26735137 |
No data available for Pathways by source and SIGNOR curated interactions for C19orf66 Gene
Transcripts for C19orf66 Gene
mRNA/cDNA for C19orf66 Gene
- (5) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (145) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C19orf66 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C19orf66
-
Santa Cruz Biotechnology (SCBT) CRISPR for C19orf66
- GenScript: Design CRISPR guide RNA sequences for C19orf66
miRNA Products
- Search ViGene Biosciences for C19orf66
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C19orf66
- Browse OriGene Inhibitory RNA Products For C19orf66
-
ViGene Biosciences ready-to-package AAV shRNAs for C19orf66 gene
Clone Products
-
OriGene ORF clones in human for C19orf66
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C19orf66
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C19orf66
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 |
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| SP8: |
Expression for C19orf66 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
mRNA differential expression in normal tissues according to GTEx for C19orf66 Gene
This gene is overexpressed in Liver (x6.7).
This gene is overexpressed in Peripheral blood mononuclear cells (14.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C19orf66 Gene
NURSA nuclear receptor signaling pathways regulating expression of C19orf66 Gene:
C19orf66SOURCE GeneReport for Unigene cluster for C19orf66 Gene:
Hs.655613Evidence on tissue expression from TISSUES for C19orf66 Gene
- Liver(4.5)
- Pancreas(4.1)
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for C19orf66
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf66 Gene
Orthologs for C19orf66 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C19ORF66 35 |
|
OneToOne | |
| C19H19orf66 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | C19orf66 35 |
|
OneToOne | |
| C20H19orf66 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | C7H19orf66 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC500956 34 |
|
||
| mouse (Mus musculus) |
Mammalia | A230050P20Rik 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C19orf66 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C19orf66 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | c19orf66 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:171711 34 |
|
||
| C3H19orf66 35 |
|
OneToOne |
- Species where no ortholog for C19orf66 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for C19orf66 Gene
No data available for Paralogs for C19orf66 Gene
Variants for C19orf66 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000367573 | -- | 10,089,145(+) | CAGCA(A/G)GCAGG | intron-variant, reference, missense, utr-variant-5-prime | |
| rs1000752628 | -- | 10,090,129(+) | TCTGA(C/G)CTAAG | intron-variant, downstream-variant-500B | |
| rs1000814936 | -- | 10,088,935(+) | AGAGC(A/G)AAACT | intron-variant | |
| rs1001175014 | -- | 10,090,977(+) | GCTTC(C/T)GAACC | intron-variant | |
| rs1001496709 | -- | 10,085,716(+) | CCGCT(C/T)CCCCC | upstream-variant-2KB |
Residual Variation Intolerance Score:
57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.52% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C19orf66 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C19orf66
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf66 Gene
Disorders for C19orf66 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| west nile virus |
|
|
Search C19orf66 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for C19orf66
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C19orf66
No data available for UniProtKB/Swiss-Prot and Genatlas for C19orf66 Gene
Publications for C19orf66 Gene
- Characterization of RyDEN (C19orf66) as an interferon-stimulated cellular inhibitor against dengue virus replication. (PMID: 26735137) Suzuki Y. … Yamamoto N. (PLoS Pathog. 2016) 2 3 4 64
- IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10. (PMID: 27974568) Balinsky C.A. … Zoon K.C. (J. Virol. 2017) 2 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
Products for C19orf66 Gene
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- Browse R&D Systems for biochemical assays
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- OriGene qPCR primer pairs for C19orf66
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- GenScript: Design CRISPR guide RNA sequences for C19orf66
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- Novus Biologicals Antibodies for C19orf66
- Novus Biologicals proteins and lysates for C19orf66
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for C19orf66 gene
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- Horizon Cell Lines for C19orf66
- Cyagen custom Knockout/knockin (KOKI) mouse models for C19orf66
- VectorBuilder custom plasmid, inducible vectors for C19orf66
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C19orf66
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C19orf66 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer