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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C19orf66 Gene

protein-coding   GIFtS: 43
GCID: GC19P010196

chromosome 19 open reading frame 66
  Search for C19orf66
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C19orf66    

Aliases
for C19orf66 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 19 Open Reading Frame 661 2
FLJ112861
UPF0515 Protein C19orf662

External Ids:    HGNC: 256491   Entrez Gene: 553372   Ensembl: ENSG000001308137   UniProtKB: Q9NUL53   

Export aliases for C19orf66 gene to outside databases

Previous GC identifers: GC19P010053 GC19P009777


Summaries
for C19orf66 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C19orf66 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C19orf66 gene promoter:
         AML1a   Pax-5   Pax-2   LCR-F1   Arnt   Egr-2   HOXA5   Zic1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): C19orf66 promoter sequence
   Search SABiosciences Chromatin IP Primers for C19orf66

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf66


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

C19orf66 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C19orf66 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010196:  view genomic region     (about GC identifiers)

Start:
 10,196,798 bp from pter      End:
 10,203,928 bp from pter
Size:
 7,131 bases      Orientation:
 plus strand

Proteins
for C19orf66 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CS066_HUMAN, Q9NUL5 (See protein sequence)
Recommended Name: UPF0515 protein C19orf66  
Size: 291 amino acids; 33110 Da
Secondary accessions: A8MQT9 Q4G188 Q8IYH6 Q8N8V1
Alternative splicing: 4 isoforms:  Q9NUL5-1   Q9NUL5-2   Q9NUL5-3   Q9NUL5-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C19orf66: NX_Q9NUL5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NUL5

    • C19orf66 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060851.2  
    ENSEMBL proteins: 
     ENSP00000253110   ENSP00000467182   ENSP00000466633   ENSP00000466550   ENSP00000380978  
     ENSP00000466217   ENSP00000467167  

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    Uscn Proteins for C19orf66


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    Uscn ELISAs and CLIAs for C19orf66

    Protein Domains /
    Families
    for C19orf66 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    C19orf66 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026795 UPF0515

    Graphical View of Domain Structure for InterPro Entry Q9NUL5

    ProtoNet protein and cluster: Q9NUL5

    UniProtKB/Swiss-Prot: CS066_HUMAN, Q9NUL5
    Similarity: Belongs to the UPF0515 family


    Function
    for C19orf66 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone: C19orf66
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    hsa-miR-214 hsa-miR-3150b-3p hsa-miR-3119 hsa-miR-4299 hsa-miR-3153 hsa-miR-761 hsa-miR-3670
    SwitchGear 3'UTR luciferase reporter plasmid: C19orf66 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    1 GenomeRNAi human phenotype for C19orf66:
     Decreased viability of wild-ty 


    Pathways & Interactions
    for C19orf66 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C19orf66

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for C19orf66 (Q9NUL52 ENSP000002531104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TERF1ENSP000002766034STRING: ENSP00000276603
    --Q9WMX22MINT-7047515
    About this table

    Drugs & Compounds
    for C19orf66 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C19orf66
    Search CenterWatch for drugs/clinical trials and news about C19orf66 / CS066 

    Transcripts
    for C19orf66 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for C19orf66 gene: 
    NM_018381.2  

    Unigene Cluster for C19orf66:

    Chromosome 19 open reading frame 66
    Hs.655613  [show with all ESTs]
    Unigene Representative Sequence: AK096142
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592551 ENST00000253110(uc002mmt.2 uc002mmu.4 uc002mmv.4)
    ENST00000585919 ENST00000591813 ENST00000587710 ENST00000590378 ENST00000397881(uc002mmw.4)
    ENST00000586889 ENST00000587609 ENST00000593131 ENST00000586730

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate C19orf66:
    hsa-miR-214 hsa-miR-3150b-3p hsa-miR-3119 hsa-miR-4299 hsa-miR-3153 hsa-miR-761 hsa-miR-3670
    SwitchGear 3'UTR luciferase reporter plasmid: C19orf66 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C19orf66 (see all 4)
    OriGene shRNA RFP: C19orf66
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    Clone
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    Additional cDNA sequence: 

    AK002148.1 AK096142.1 AL137694.1 BC035817.2 

    16 DOTS entries:

    DT.100789430  DT.100789431  DT.100026728  DT.100026730  DT.91720084  DT.100758593  DT.70102779  DT.100026733 
    DT.121500956  DT.86846457  DT.95076395  DT.95298239  DT.314781  DT.91871672  DT.97803572  DT.99955688 

    24/145 AceView cDNA sequences (see all 145):

    AA299583 CR594187 BU727550 AA827880 BU073055 AL137694 AI692205 AA806770 
    AK098062 CB157650 AU138927 BX402447 BM703026 AA643901 CR592012 BU165842 
    BQ679152 AA588811 AA703179 AA649144 BI062912 BM828891 AL556827 AA456589 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for C19orf66 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10
    SP1:                                                  -                                                         
    SP2:                                      -     -     -                                                         
    SP3:                                                  -                                                         
    SP4:                                                  -                                                         
    SP5:        -     -     -                                                                                       


    ECgene alternative splicing isoforms for C19orf66

    Expression
    for C19orf66 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C19orf66 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCTCTCACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C19orf66 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C19orf66 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C19orf66

    SOURCE GeneReport for Unigene cluster: Hs.655613
        SABiosciences Custom PCR Arrays for C19orf66
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    In Situ
    Assay Products:     
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    Orthologs
    for C19orf66 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C19orf66 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia A230050P20Rik1 , 5 RIKEN cDNA A230050P20 gene1, 5 86.09(n)1
    95.86(a)1    		   9 (7.65 cM)5
    3192781  NM_175687.21  NP_783618.11 
     208686425 
    lizard
    (Anolis carolinensis)    		 Reptilia C19orf666
    		 --
    		 59(a)
    		 1 ↔ 1
    		 GL343414.1(495058-506372)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1717111 zgc:171711 58.15(n)
    53.96(a)    		   797287  NM_001105527.1  NP_001098997.1 


    ENSEMBL Gene Tree for C19orf66 (if available)
    TreeFam Gene Tree for C19orf66 (if available) 

    Paralogs
    for C19orf66 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C19orf66 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/123 NCBI SNPs in C19orf66 are shown (see all 123)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1912839201,2
    		--10194825(+) GTACAC/TGCTCT 1 -- us2k10--------
    rs1830920001,2
    		--10194844(+) GCCACA/GGTGAT 1 -- us2k10--------
    rs72550321,2
    		C,F,A,H,--10194884(+) TTCTGT/CGCTAA 1 -- us2k1 tfbs332Minor allele frequency- C:0.07NS EA NA WA CSA 2918
    rs72551431,2
    		C--10194900(+) AAAATC/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs116723971,2
    		H--10194906(+) AAAAAA/CCAAAA 1 -- us2k10--------
    rs116681901,2
    		C,F,H--10194907(+) AAAAAC/AAAAAA 1 -- us2k17Minor allele frequency- A:0.01EA NS NA 794
    rs1859085031,2
    		--10194952(+) AGACTC/TTTACC 1 -- us2k10--------
    rs1907979981,2
    		--10194986(+) ATCTCC/GGCCAG 1 -- us2k10--------
    rs1420167881,2
    		--10195161(+) GCCACA/GAGGAA 1 -- us2k10--------
    rs791683131,2
    		F,--10195324(+) TTTTCC/TTTTTC 1 -- us2k12Minor allele frequency- T:0.14WA EA 238

    HapMap Linkage Disequilibrium report for C19orf66 (10196798 - 10203928 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for C19orf66
         2 CNVs: 89089 5085

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for C19orf66 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C19orf66 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C19orf66 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C19orf66)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for C19orf66 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C19orf66 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55337 HGNC: 25649 AceView: FLJ11286 Ensembl:ENSG00000130813 euGenes: HUgn55337
    ECgene: C19orf66 H-InvDB: C19orf66

    Other Databases showing C19orf66 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C19orf66 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C19orf66 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C19orf66 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C19orf66 gene:
    Search GeneIP for patents involving C19orf66

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C19orf66 gene

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    In Situ Hybridization Assays from
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     Browse OriGene Antibodies   OriGene shRNA RFP for C19orf66  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C19orf66
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     C19orf66 Proteins, Antibodies, CLIAs, and ELISAs
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     SwitchGear 3'UTR luciferase reporter plasmids for C19orf66
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     Search ThermoFisher Antibodies for C19orf66
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf66
           
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