Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C19orf66 Gene

Aliases for C19orf66 Gene

  • Chromosome 19 Open Reading Frame 66 2 3 5
  • Repressor Of Yield Of Dengue Virus 2 3
  • RyDEN 3 4
  • Repressor Of Yield Of DENV 3
  • UPF0515 Protein C19orf66 3

External Ids for C19orf66 Gene

Previous GeneCards Identifiers for C19orf66 Gene

  • GC19P010196
  • GC19P009777

Summaries for C19orf66 Gene

GeneCards Summary for C19orf66 Gene

C19orf66 (Chromosome 19 Open Reading Frame 66) is a Protein Coding gene. Diseases associated with C19orf66 include west nile virus.

UniProtKB/Swiss-Prot for C19orf66 Gene

  • Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf66 Gene

Genomics for C19orf66 Gene

Regulatory Elements for C19orf66 Gene

Promoters for C19orf66 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C19orf66 on UCSC Golden Path with GeneCards custom track

Genomic Location for C19orf66 Gene

Chromosome:
19
Start:
10,086,119 bp from pter
End:
10,093,252 bp from pter
Size:
7,134 bases
Orientation:
Plus strand

Genomic View for C19orf66 Gene

Genes around C19orf66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf66 Gene

Proteins for C19orf66 Gene

  • Protein details for C19orf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUL5-RYDEN_HUMAN
    Recommended name:
    Repressor of yield of DENV protein
    Protein Accession:
    Q9NUL5
    Secondary Accessions:
    • A8MQT9
    • Q4G188
    • Q8IYH6
    • Q8N8V1

    Protein attributes for C19orf66 Gene

    Size:
    291 amino acids
    Molecular mass:
    33110 Da
    Quaternary structure:
    • Interacts with PABPC1 (PubMed:26735137). Found in a complex with PABPC1 and LARP1 (PubMed:26735137).

    Alternative splice isoforms for C19orf66 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C19orf66 Gene

Proteomics data for C19orf66 Gene at MOPED

Post-translational modifications for C19orf66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf66 Gene

No data available for DME Specific Peptides for C19orf66 Gene

Domains & Families for C19orf66 Gene

Protein Domains for C19orf66 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C19orf66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUL5

UniProtKB/Swiss-Prot:

RYDEN_HUMAN :
  • Belongs to the RyDEN family.
Family:
  • Belongs to the RyDEN family.
genes like me logo Genes that share domains with C19orf66: view

No data available for Gene Families for C19orf66 Gene

Function for C19orf66 Gene

Molecular function for C19orf66 Gene

UniProtKB/Swiss-Prot Function:
Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137).
UniProtKB/Swiss-Prot Induction:
Up-regulated by interferon (IFN) treatment.
genes like me logo Genes that share phenotypes with C19orf66: view

Animal Model Products

CRISPR Products

miRNA for C19orf66 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C19orf66 Gene

Localization for C19orf66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C19orf66 Gene

Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. {ECO:0000269 PubMed:26735137}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C19orf66 Gene COMPARTMENTS Subcellular localization image for C19orf66 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for C19orf66 Gene

Pathways & Interactions for C19orf66 Gene

SuperPathways for C19orf66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C19orf66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034342 response to type III interferon IDA 26735137
GO:0045071 negative regulation of viral genome replication IMP 26735137
genes like me logo Genes that share ontologies with C19orf66: view

No data available for Pathways by source and SIGNOR curated interactions for C19orf66 Gene

Drugs & Compounds for C19orf66 Gene

No Compound Related Data Available

Transcripts for C19orf66 Gene

Unigene Clusters for C19orf66 Gene

Chromosome 19 open reading frame 66:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf66 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10
SP1: -
SP2: - - -
SP3: -
SP4: -
SP5: - - -
SP6:
SP7: -
SP8:

Relevant External Links for C19orf66 Gene

GeneLoc Exon Structure for
C19orf66
ECgene alternative splicing isoforms for
C19orf66

Expression for C19orf66 Gene

mRNA expression in normal human tissues for C19orf66 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C19orf66 Gene

This gene is overexpressed in Liver (x6.7).

Protein differential expression in normal tissues from HIPED for C19orf66 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C19orf66 Gene



SOURCE GeneReport for Unigene cluster for C19orf66 Gene Hs.655613

genes like me logo Genes that share expression patterns with C19orf66: view

Protein tissue co-expression partners for C19orf66 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for C19orf66 Gene

Orthologs for C19orf66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf66 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C7H19orf66 35
  • 91.21 (n)
  • 96.34 (a)
C7H19orf66 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf66 35
  • 90.96 (n)
  • 96.34 (a)
C19orf66 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A230050P20Rik 35
  • 84.94 (n)
  • 93.79 (a)
A230050P20Rik 16
A230050P20Rik 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf66 35
  • 97.14 (n)
  • 96.9 (a)
C19ORF66 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC500956 35
  • 85.28 (n)
  • 96.32 (a)
oppossum
(Monodelphis domestica)
Mammalia C19orf66 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf66 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf66 35
  • 61.22 (n)
  • 58.94 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:171711 35
  • 58.24 (n)
  • 54.72 (a)
C3H19orf66 36
  • 46 (a)
OneToOne
Species with no ortholog for C19orf66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C19orf66 Gene

ENSEMBL:
Gene Tree for C19orf66 (if available)
TreeFam:
Gene Tree for C19orf66 (if available)

Paralogs for C19orf66 Gene

No data available for Paralogs for C19orf66 Gene

Variants for C19orf66 Gene

Sequence variations from dbSNP and Humsavar for C19orf66 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1979262 -- 10,087,765(+) AGGCT(A/G)GGATG intron-variant
rs2227286 -- 10,087,083(+) GGTGC(G/T)GGGAC intron-variant
rs2232063 -- 10,085,674(+) ACCGG(A/G)CTACT upstream-variant-2KB
rs2232064 -- 10,089,726(+) TGGGG(C/G)AGTTG intron-variant, downstream-variant-500B
rs2232065 -- 10,089,781(+) GAGGG(C/G)AGATA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C19orf66 Gene

Variant ID Type Subtype PubMed ID
dgv3724n71 CNV Gain 21882294
nsv458355 CNV Loss 19166990
nsv2414 CNV Insertion 18451855
nsv833743 CNV Loss 17160897

Variation tolerance for C19orf66 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf66 Gene

HapMap Linkage Disequilibrium report
C19orf66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf66 Gene

Disorders for C19orf66 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C19orf66 Gene - From: GeneCards

Disorder Aliases PubMed IDs
west nile virus
  • west nile virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C19orf66

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C19orf66
genes like me logo Genes that share disorders with C19orf66: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C19orf66 Gene

Publications for C19orf66 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for C19orf66 Gene

Sources for C19orf66 Gene

Back to Top

Content