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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C19orf60 Gene

protein-coding   GIFtS: 39
GCID: GC19P018699

Chromosome 19 Open Reading Frame 60

  Search for C19orf60
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 19 Open Reading Frame 601 2
Uncharacterized Protein C19orf602

External Ids:    HGNC: 260981   Entrez Gene: 550492   Ensembl: ENSG000000060157   UniProtKB: Q96EN93   

Export aliases for C19orf60 gene to outside databases

Previous GC identifers: GC19P018561 GC19P018262


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C19orf60 Gene: 
C19orf60 (chromosome 19 open reading frame 60) is a protein-coding gene. GO annotations related to this gene include protein binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C19orf60 gene promoter:
         AhR   Lmo2   AP-4   HNF-4alpha2   AP-2gamma   Arnt   HNF-4alpha1   CREB   NF-kappaB1   MRF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C19orf60

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf60


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

C19orf60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C19orf60 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P018699:  view genomic region     (about GC identifiers)

Start:
18,699,495 bp from pter      End:
18,703,147 bp from pter
Size:
3,653 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CS060_HUMAN, Q96EN9 (See protein sequence)
Recommended Name: Uncharacterized protein C19orf60  
Size: 201 amino acids; 22599 Da
Sequence caution: Sequence=BAA91400.1; Type=Frameshift; Positions=107;
Secondary accessions: E9PAS0 Q8NAX4 Q9NWI0
Alternative splicing: 3 isoforms:  Q96EN9-1   Q96EN9-2   Q96EN9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C19orf60: NX_Q96EN9

Explore proteomics data for C19orf60 at MOPED 

C19orf60 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C19orf60 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001093888.1  NP_001093889.1  

ENSEMBL proteins: 
 ENSP00000351422   ENSP00000398467   ENSP00000471429   ENSP00000469859  

Human Recombinant Protein Products for C19orf60: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96EN9


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI16189514
     
C19orf60 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for C19orf60:
 Synthetic lethal with Ras 

Animal Models:
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miRNA
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Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C19orf60

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/7 Interacting proteins for C19orf60 (Q96EN91, 2, 3 ENSP000003514224) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
SMN1Q166372, 3MINT-8270904 I2D: score=2 
SMN2Q166372, 3MINT-8270904 I2D: score=2 
OSGEPQ9NPF42, 3MINT-8265098 I2D: score=2 
TK1P041832, 3MINT-8273026 I2D: score=2 
MDFIQ997501, 2, 3, ENSP000002303214EBI-745810,EBI-724076 MINT-66725 I2D: score=5 STRING: ENSP00000230321
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C19orf60 (CS060)

Search CenterWatch for drugs/clinical trials and news about C19orf60 / CS060

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C19orf60 gene (3 alternative transcripts): 
NM_017967.2  NM_001100418.1  NM_001100419.1  

Unigene Cluster for C19orf60:

Chromosome 19 open reading frame 60
Hs.655317  [show with all ESTs]
Unigene Representative Sequence: AK094710
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000598375 ENST00000358607(uc002nju.2 uc002njv.4) ENST00000450195(uc010ebs.3)
ENST00000600997 ENST00000601736 ENST00000597371 ENST00000595490 ENST00000595077

miRNA
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hsa-miR-1207-3p
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Inhib. RNA
Products:
     
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OriGene RNAi products in human, mouse, rat for C19orf60
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C19orf60
Clone
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OriGene ORF clones in mouse, rat for C19orf60
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GenScript: all cDNA clones in your preferred vector (see all 2): C19orf60 (NM_001100419)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for C19orf60
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf60
Sirion Biotech Customized lentivirus for stable overexpression of C19orf60 
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Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C19orf60

Additional mRNA sequence: 

AK000857.1 AK054670.1 AK091925.1 AK094710.1 BC012078.1 

16 DOTS entries:

DT.100845537  DT.86852028  DT.121499149  DT.95189254  DT.40111085  DT.100845535  DT.121499185  DT.102838526 
DT.75168885  DT.100026653  DT.100845538  DT.95189260  DT.95189261  DT.121499147  DT.100845534  DT.95293310 

24/173 AceView cDNA sequences (see all 173):

BF591405 CA422953 CB137039 BF939241 D20857 AI223191 AI380546 CK299281 
BU844497 AI433538 BC012078 AW075602 BM128521 CB155247 CB177427 CB047779 
CD673861 AV707942 CR625418 CR616719 BM725708 BM695241 BM919196 AI656998 

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C19orf60 (see all 7)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1:                                -                       -     -           -                     
SP2:                                -     -                 -     -           -                     
SP3:                                -     -     -     -     -     -           -                     
SP4:                                                                                                
SP5:                                                        -     -           -                     


ECgene alternative splicing isoforms for C19orf60

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C19orf60 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGGCGATCA
C19orf60 Expression
About this image


See C19orf60 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C19orf60

SOURCE GeneReport for Unigene cluster: Hs.655317
    SABiosciences Custom PCR Arrays for C19orf60
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C19orf60
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf60

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C19orf60 gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 2810428I15Rik1 , 5 RIKEN cDNA 2810428I15 gene1, 5 80.29(n)1
72.96(a)1
  8 (34.15 cM)5
664621  NM_025577.21  NP_079853.11 
 705042925 
chicken
(Gallus gallus)
Aves LOC1008575941 uncharacterized LOC100857594 63.87(n)
51.05(a)
  100857594  XM_003642885.1  XP_003642933.1 
zebrafish
(Danio rerio)
Actinopterygii si:ch211-87h14.31 si:ch211-87h14.3 49.88(n)
39.72(a)
  564601  XM_687931.5  XP_693023.3 


ENSEMBL Gene Tree for C19orf60 (if available)
TreeFam Gene Tree for C19orf60 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/154 SNPs in C19orf60 are shown (see all 154)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1907085661,2
--18697655(+) GGCTTA/CTTCCA 2 -- us2k10--------
rs48088221,2
C,F,A,H--18697778(+) actgcA/Tgatgg 2 -- us2k1 tfbs325Minor allele frequency- T:0.40NS EA NA WA 2530
rs1817828781,2
--18697840(+) CTGCCA/GGCCCA 2 -- us2k10--------
rs1396591221,2
--18697852(+) ACCCGA/GACGTT 2 -- us2k10--------
rs1858686721,2
--18697878(+) TCTCAC/TGAGGA 2 -- us2k10--------
rs48088231,2
C,F,A,H--18698019(+) TTTACC/TGGGCA 2 -- us2k123Minor allele frequency- T:0.40NS EA NA WA CSA 2320
rs124628901,2
C,H--18698165(+) cgaggT/Cgggcg 2 -- us2k13Minor allele frequency- C:0.17NA WA 6
rs104073221,2
C,F,H--18698221(+) aacccC/Tgcctc 2 -- us2k18Minor allele frequency- T:0.20NA WA CSA 15
rs72455371,2
C--18698418(+) aaaaaA/Caaaaa 2 -- us2k12Minor allele frequency- C:0.25NA 4
rs65122761,2
C,A--18698419(+) aaaacA/Caaaaa 2 -- us2k1 trp31Minor allele frequency- C:0.00NA 2

HapMap Linkage Disequilibrium report for C19orf60 (18699495 - 18703147 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for C19orf60:    About this table     
Variant IDTypeSubtypePubMed ID
dgv3785n71CNV Loss21882294
nsv833776CNV Loss17160897
nsv911290CNV Loss21882294
dgv3784n71CNV Loss21882294
nsv911282CNV Loss21882294
nsv911288CNV Loss21882294
nsv911281CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C19orf60 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with C19orf60)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  3. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
  4. A novel human protein is able to interact with hepati tis B virus core deletion mutant but not with the wild-type protein. (PubMed id 19770013)1 Razanskas R. and Sasnauskas K. (2009)
  5. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
  6. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
  7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 55049 HGNC: 26098 AceView: FLJ20850 Ensembl:ENSG00000006015 euGenes: HUgn55049
ECgene: C19orf60 H-InvDB: C19orf60

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C19orf60 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C19orf60 gene:
Search GeneIP for patents involving C19orf60

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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