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Aliases for C19orf57 Gene

Aliases for C19orf57 Gene

  • Chromosome 19 Open Reading Frame 57 2 3 5
  • Pre-T/NK Cell-Associated Protein 3B3 4

External Ids for C19orf57 Gene

Previous GeneCards Identifiers for C19orf57 Gene

  • GC19M013855
  • GC19M013856
  • GC19M013993
  • GC19M013564
  • GC19M013883
  • GC19M013884
  • GC19M013894

Summaries for C19orf57 Gene

GeneCards Summary for C19orf57 Gene

C19orf57 (Chromosome 19 Open Reading Frame 57) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf57 Gene

Genomics for C19orf57 Gene

Regulatory Elements for C19orf57 Gene

Enhancers for C19orf57 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G013884 1.4 FANTOM5 Ensembl ENCODE 13.1 +20.1 20144 3.3 BCOR PKNOX1 KLF1 ZMYM3 KLF17 BMI1 ZIC2 ZNF48 ZNF121 ZFHX2 CC2D1A C19orf57 PALM3 EEF1DP1 MISP3 IL27RA CCDC130 DCAF15 GC19P013876
GH19G013879 1.4 Ensembl ENCODE 13.1 +25.0 24973 3.5 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A ZNF2 ZBTB7B YY1 CBX5 CC2D1A C19orf57 PALM3 EEF1DP1 MISP3 ZNF333 TRMT1 GC19P013876
GH19G014078 0.7 FANTOM5 Ensembl 11.6 -172.2 -172249 1.0 ZNF146 NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 ADGRE5 RFX1
GH19G013883 0.6 ENCODE 13.1 +22.6 22600 0.1 CTCF ZNF687 ZSCAN4 REST NFIC IKZF1 GLIS1 HSF1 ZNF652 C19orf57 CC2D1A PALM3 MISP3 EEF1DP1 GC19P013876
GH19G013864 1.4 FANTOM5 ENCODE dbSUPER 2.9 +41.6 41631 1.5 HDGF KLF17 ZNF2 THRB ZNF48 GLIS2 KLF7 EGR2 ZEB2 ZFP69B ADGRL1 CACNA1A C19orf57 CC2D1A NANOS3 MIR181C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C19orf57 on UCSC Golden Path with GeneCards custom track

Promoters for C19orf57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107457 152 1001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143

Genomic Location for C19orf57 Gene

Chromosome:
19
Start:
13,882,348 bp from pter
End:
13,906,452 bp from pter
Size:
24,105 bases
Orientation:
Minus strand

Genomic View for C19orf57 Gene

Genes around C19orf57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf57 Gene

Proteins for C19orf57 Gene

  • Protein details for C19orf57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VDD7-CS057_HUMAN
    Recommended name:
    Uncharacterized protein C19orf57
    Protein Accession:
    Q0VDD7
    Secondary Accessions:
    • Q13411
    • Q8N825
    • Q96D63
    • Q9BU49

    Protein attributes for C19orf57 Gene

    Size:
    668 amino acids
    Molecular mass:
    69556 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB02340.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for C19orf57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C19orf57 Gene

Post-translational modifications for C19orf57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C19orf57 Gene

Domains & Families for C19orf57 Gene

Protein Domains for C19orf57 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C19orf57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C19orf57: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C19orf57 Gene

Function for C19orf57 Gene

Gene Ontology (GO) - Molecular Function for C19orf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C19orf57: view
genes like me logo Genes that share phenotypes with C19orf57: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf57 Gene

Localization for C19orf57 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf57 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for C19orf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C19orf57: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C19orf57 Gene

Pathways & Interactions for C19orf57 Gene

SuperPathways for C19orf57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C19orf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development NAS 8228263
genes like me logo Genes that share ontologies with C19orf57: view

No data available for Pathways by source and SIGNOR curated interactions for C19orf57 Gene

Drugs & Compounds for C19orf57 Gene

No Compound Related Data Available

Transcripts for C19orf57 Gene

Unigene Clusters for C19orf57 Gene

Chromosome 19 open reading frame 57:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf57 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for C19orf57 Gene

GeneLoc Exon Structure for
C19orf57
ECgene alternative splicing isoforms for
C19orf57

Expression for C19orf57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C19orf57 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C19orf57 Gene

This gene is overexpressed in Testis (x8.1).

Protein differential expression in normal tissues from HIPED for C19orf57 Gene

This gene is overexpressed in Liver (45.0) and Kidney (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C19orf57 Gene



NURSA nuclear receptor signaling pathways regulating expression of C19orf57 Gene:

C19orf57

SOURCE GeneReport for Unigene cluster for C19orf57 Gene:

Hs.143288

Evidence on tissue expression from TISSUES for C19orf57 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with C19orf57: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf57 Gene

Orthologs for C19orf57 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C19orf57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf57 34
  • 99.06 (n)
C19orf57 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf57 34
  • 70.81 (n)
C19orf57 35
  • 55 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf57 34
  • 70.11 (n)
C19orf57 35
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930432K21Rik 34 16 35
  • 62.89 (n)
rat
(Rattus norvegicus)
Mammalia RGD1306072 34
  • 62.3 (n)
Species where no ortholog for C19orf57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C19orf57 Gene

ENSEMBL:
Gene Tree for C19orf57 (if available)
TreeFam:
Gene Tree for C19orf57 (if available)

Paralogs for C19orf57 Gene

No data available for Paralogs for C19orf57 Gene

Variants for C19orf57 Gene

Sequence variations from dbSNP and Humsavar for C19orf57 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000018074 -- 13,902,990(+) CATGC(C/T)GTTCT intron-variant
rs1000199459 -- 13,883,530(+) TTCAC(A/G)ACAGA intron-variant
rs1000317030 -- 13,903,302(+) TATGC(A/G)TGGTA intron-variant
rs1000453134 -- 13,887,149(+) GTGTG(A/G)CCACA intron-variant
rs1000484174 -- 13,891,949(+) GCACC(C/T)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf57 Gene

Variant ID Type Subtype PubMed ID
esv2668513 CNV deletion 23128226
esv3643730 CNV loss 21293372
esv3643731 CNV loss 21293372
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Variation tolerance for C19orf57 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf57 Gene

Disorders for C19orf57 Gene

Relevant External Links for C19orf57

Genetic Association Database (GAD)
C19orf57
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C19orf57

No disorders were found for C19orf57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf57 Gene

Publications for C19orf57 Gene

  1. Identification of human pre-T/NK cell-associated genes. (PMID: 8228263) Ranes-Goldberg M.G. … Spits H. (J. Immunol. 1993) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for C19orf57 Gene

Sources for C19orf57 Gene

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