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Aliases for C19orf57 Gene

Aliases for C19orf57 Gene

  • Chromosome 19 Open Reading Frame 57 2 3 5
  • Pre-T/NK Cell-Associated Protein 3B3 4

External Ids for C19orf57 Gene

Previous GeneCards Identifiers for C19orf57 Gene

  • GC19M013855
  • GC19M013856
  • GC19M013993
  • GC19M013564

Summaries for C19orf57 Gene

GeneCards Summary for C19orf57 Gene

C19orf57 (Chromosome 19 Open Reading Frame 57) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf57 Gene

Genomics for C19orf57 Gene

Regulatory Elements for C19orf57 Gene

Enhancers for C19orf57 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C19orf57 on UCSC Golden Path with GeneCards custom track

Promoters for C19orf57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C19orf57 on UCSC Golden Path with GeneCards custom track

Genomic Location for C19orf57 Gene

13,882,348 bp from pter
13,906,452 bp from pter
24,105 bases
Minus strand

Genomic View for C19orf57 Gene

Genes around C19orf57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf57 Gene

Proteins for C19orf57 Gene

  • Protein details for C19orf57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C19orf57
    Protein Accession:
    Secondary Accessions:
    • Q13411
    • Q8N825
    • Q96D63
    • Q9BU49

    Protein attributes for C19orf57 Gene

    668 amino acids
    Molecular mass:
    69556 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB02340.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for C19orf57 Gene


neXtProt entry for C19orf57 Gene

Proteomics data for C19orf57 Gene at MOPED

Post-translational modifications for C19orf57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf57 Gene

No data available for DME Specific Peptides for C19orf57 Gene

Domains & Families for C19orf57 Gene

Protein Domains for C19orf57 Gene


Suggested Antigen Peptide Sequences for C19orf57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C19orf57: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C19orf57 Gene

Function for C19orf57 Gene

genes like me logo Genes that share phenotypes with C19orf57: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf57 Gene

Localization for C19orf57 Gene

Subcellular locations from

Jensen Localization Image for C19orf57 Gene COMPARTMENTS Subcellular localization image for C19orf57 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C19orf57 Gene

Pathways & Interactions for C19orf57 Gene

SuperPathways for C19orf57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C19orf57 Gene


No data available for Pathways by source and SIGNOR curated interactions for C19orf57 Gene

Drugs & Compounds for C19orf57 Gene

No Compound Related Data Available

Transcripts for C19orf57 Gene

Unigene Clusters for C19orf57 Gene

Chromosome 19 open reading frame 57:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf57 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for C19orf57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C19orf57 Gene

mRNA expression in normal human tissues for C19orf57 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C19orf57 Gene

This gene is overexpressed in Testis (x8.1).

Protein differential expression in normal tissues from HIPED for C19orf57 Gene

This gene is overexpressed in Liver (45.0) and Kidney (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C19orf57 Gene

SOURCE GeneReport for Unigene cluster for C19orf57 Gene Hs.143288

genes like me logo Genes that share expression patterns with C19orf57: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C19orf57 Gene

Orthologs for C19orf57 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C19orf57 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C7H19orf57 35
  • 70.11 (n)
  • 51.69 (a)
C19orf57 36
  • 50 (a)
(Canis familiaris)
Mammalia C20H19orf57 35
  • 70.81 (n)
  • 52.58 (a)
C19orf57 36
  • 55 (a)
(Mus musculus)
Mammalia 4930432K21Rik 35
  • 62.89 (n)
  • 46.44 (a)
4930432K21Rik 16
4930432K21Rik 36
  • 38 (a)
(Pan troglodytes)
Mammalia C19H19orf57 35
  • 99.06 (n)
  • 98.43 (a)
C19orf57 36
  • 94 (a)
(Rattus norvegicus)
Mammalia RGD1306072 35
  • 62.3 (n)
  • 45.66 (a)
Species with no ortholog for C19orf57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C19orf57 Gene

Gene Tree for C19orf57 (if available)
Gene Tree for C19orf57 (if available)

Paralogs for C19orf57 Gene

No data available for Paralogs for C19orf57 Gene

Variants for C19orf57 Gene

Sequence variations from dbSNP and Humsavar for C19orf57 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2305775 - 13,890,057(-) TGCCT(A/G)GAGGG reference, missense
rs3803892 - 13,889,357(-) TCAGC(A/G)GGGCA reference, missense
rs7256820 -- 13,901,097(+) tctcc(C/T)aagta intron-variant
rs7257933 -- 13,896,035(+) gaggc(C/T)gaggc intron-variant
rs7258085 -- 13,898,054(+) agatg(C/G)cgcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf57 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV Loss 17160897
nsv911098 CNV Loss 21882294
dgv3738n71 CNV Loss 21882294
nsv911102 CNV Loss 21882294
dgv3739n71 CNV Loss 21882294
nsv833760 CNV Loss 17160897
esv2668513 CNV Deletion 23128226
dgv3740n71 CNV Loss 21882294
dgv3741n71 CNV Loss 21882294

Variation tolerance for C19orf57 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C19orf57 Gene

Disorders for C19orf57 Gene

Relevant External Links for C19orf57

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C19orf57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf57 Gene

Publications for C19orf57 Gene

  1. Identification of human pre-T/NK cell-associated genes. (PMID: 8228263) Ranes-Goldberg M.G. … Spits H. (J. Immunol. 1993) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for C19orf57 Gene

Sources for C19orf57 Gene