Aliases for C19orf57 Gene
Aliases for C19orf57 Gene
External Ids for C19orf57 Gene
- HGNC: 28153
- Entrez Gene: 79173
- Ensembl: ENSG00000132016
- UniProtKB: Q0VDD7
Previous GeneCards Identifiers for C19orf57 Gene
- GC19M013855
- GC19M013856
- GC19M013993
- GC19M013564
- GC19M013883
- GC19M013884
- GC19M013894
Summaries for C19orf57 Gene
GeneCards Summary for C19orf57 Gene
C19orf57 (Chromosome 19 Open Reading Frame 57) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf57 Gene
Genomics for C19orf57 Gene
Regulatory Elements for C19orf57 Gene
Enhancers for C19orf57 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19G013884 | 1.4 | FANTOM5 Ensembl ENCODE | 13.1 | +20.1 | 20144 | 3.3 | BCOR PKNOX1 KLF1 ZMYM3 KLF17 BMI1 ZIC2 ZNF48 ZNF121 ZFHX2 | CC2D1A C19orf57 PALM3 EEF1DP1 MISP3 IL27RA CCDC130 DCAF15 GC19P013876 |
| GH19G013879 | 1.4 | Ensembl ENCODE | 13.1 | +25.0 | 24973 | 3.5 | HDGF PKNOX1 MLX AGO1 ARID4B SIN3A ZNF2 ZBTB7B YY1 CBX5 | CC2D1A C19orf57 PALM3 EEF1DP1 MISP3 ZNF333 TRMT1 GC19P013876 |
| GH19G014078 | 0.7 | FANTOM5 Ensembl | 11.6 | -172.2 | -172249 | 1.0 | ZNF146 | NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 ADGRE5 RFX1 |
| GH19G013883 | 0.6 | ENCODE | 13.1 | +22.6 | 22600 | 0.1 | CTCF ZNF687 ZSCAN4 REST NFIC IKZF1 GLIS1 HSF1 ZNF652 | CC2D1A C19orf57 PALM3 MISP3 EEF1DP1 GC19P013876 |
| GH19G013864 | 1.4 | FANTOM5 ENCODE dbSUPER | 2.9 | +41.6 | 41631 | 1.5 | HDGF KLF17 ZNF2 THRB ZNF48 GLIS2 KLF7 EGR2 ZEB2 ZFP69B | ADGRL1 CACNA1A C19orf57 CC2D1A NANOS3 MIR181C |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C19orf57 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C19orf57 gene promoter:
Regulatory Element Products
Genomic Location for C19orf57 Gene
- Chromosome:
- 19
- Start:
- 13,882,348 bp from pter
- End:
- 13,906,452 bp from pter
- Size:
- 24,105 bases
- Orientation:
- Minus strand
Genomic View for C19orf57 Gene
Genes around C19orf57 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.12 by Ensembl
- 19p13.12 by Entrez Gene
- 19p13.12 by HGNC
C19orf57 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C19orf57 Gene
Proteins for C19orf57 Gene
-
Protein details for C19orf57 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q0VDD7-CS057_HUMAN
- Recommended name:
- Uncharacterized protein C19orf57
- Protein Accession:
- Q0VDD7
- Q13411
- Q8N825
- Q96D63
- Q9BU49
Protein attributes for C19orf57 Gene
- Size:
- 668 amino acids
- Molecular mass:
- 69556 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB02340.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
Protein Expression for C19orf57 Gene
Post-translational modifications for C19orf57 Gene
Other Protein References for C19orf57 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for C19orf57
- Novus Biologicals Antibodies for C19orf57
-
Abcam antibodies for C19orf57
- Invitrogen Antibodies for C19orf57
- Search GeneTex for Antibodies for C19orf57
Protein Products
-
OriGene Purified Proteins for C19orf57
- Search Origene for MassSpec and Protein Over-expression Lysates for C19orf57
- Origene Custom Protein Services for C19orf57
- Search GeneTex for Proteins for C19orf57
Assay Products
No data available for DME Specific Peptides for C19orf57 Gene
Domains & Families for C19orf57 Gene
Suggested Antigen Peptide Sequences for C19orf57 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for C19orf57 Gene
Function for C19orf57 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for C19orf57 Gene
- GenomeRNAi human phenotypes for C19orf57:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
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-
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- Search ViGene Biosciences for C19orf57
CRISPR Products
-
OriGene CRISPR knockouts for C19orf57
-
Santa Cruz Biotechnology (SCBT) CRISPR for C19orf57
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miRNA Products
- Search ViGene Biosciences for C19orf57
Inhibitory RNA Products
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- Browse OriGene Inhibitory RNA Products For C19orf57
-
ViGene Biosciences ready-to-package AAV shRNAs for C19orf57 gene
Clone Products
-
OriGene ORF clones in human for C19orf57
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- VectorBuilder custom plasmid, inducible vectors for C19orf57
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C19orf57
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C19orf57
-
ViGene Biosciences adenoviral particle packaged cDNA for C19orf57 gene
-
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-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf57 Gene
Localization for C19orf57 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for C19orf57 Gene
Pathways & Interactions for C19orf57 Gene
No Data Available
Interacting Proteins for C19orf57 Gene
Selected Interacting proteins:
Q0VDD7-CS057_HUMAN
ENSP00000254336
for C19orf57 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | NAS | 8228263 |
No data available for Pathways by source and SIGNOR curated interactions for C19orf57 Gene
Transcripts for C19orf57 Gene
mRNA/cDNA for C19orf57 Gene
- (11) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (35) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C19orf57 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C19orf57
-
Santa Cruz Biotechnology (SCBT) CRISPR for C19orf57
- GenScript: Design CRISPR guide RNA sequences for C19orf57
miRNA Products
- Search ViGene Biosciences for C19orf57
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C19orf57
- Browse OriGene Inhibitory RNA Products For C19orf57
-
ViGene Biosciences ready-to-package AAV shRNAs for C19orf57 gene
Clone Products
-
OriGene ORF clones in human for C19orf57
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for C19orf57
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C19orf57
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C19orf57
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: |
Expression for C19orf57 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- XX Germ Cells Ovigerous Cord
- Ovigerous Cord
-
Gonad
- XX Germ Cells Ovigerous Cord
- Lower Urinary Tract (Urinary System)
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for C19orf57 Gene
This gene is overexpressed in Testis (x8.1).
This gene is overexpressed in Liver (45.0) and Kidney (14.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C19orf57 Gene
NURSA nuclear receptor signaling pathways regulating expression of C19orf57 Gene:
C19orf57SOURCE GeneReport for Unigene cluster for C19orf57 Gene:
Hs.143288Evidence on tissue expression from TISSUES for C19orf57 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for C19orf57
-
OriGene qPCR primer pairs for C19orf57
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf57 Gene
Orthologs for C19orf57 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C19H19orf57 34 |
|
||
| C19orf57 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C20H19orf57 34 |
|
||
| C19orf57 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C7H19orf57 34 |
|
||
| C19orf57 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | 4930432K21Rik 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1306072 34 |
|
- Species where no ortholog for C19orf57 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C19orf57 Gene
No data available for Paralogs for C19orf57 Gene
Variants for C19orf57 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000018074 | -- | 13,902,990(+) | CATGC(C/T)GTTCT | intron-variant | |
| rs1000199459 | -- | 13,883,530(+) | TTCAC(A/G)ACAGA | intron-variant | |
| rs1000317030 | -- | 13,903,302(+) | TATGC(A/G)TGGTA | intron-variant | |
| rs1000453134 | -- | 13,887,149(+) | GTGTG(A/G)CCACA | intron-variant | |
| rs1000484174 | -- | 13,891,949(+) | GCACC(C/T)GTAGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2668513 | CNV | deletion | 23128226 |
| esv3643730 | CNV | loss | 21293372 |
| esv3643731 | CNV | loss | 21293372 |
| nsv833757 | CNV | loss | 17160897 |
| nsv833760 | CNV | loss | 17160897 |
| nsv953979 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.78;
91.65% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C19orf57 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C19orf57
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf57 Gene
Disorders for C19orf57 Gene
Relevant External Links for C19orf57
No disorders were found for C19orf57 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf57 Gene
Publications for C19orf57 Gene
- Identification of human pre-T/NK cell-associated genes. (PMID: 8228263) Ranes-Goldberg M.G. … Spits H. (J. Immunol. 1993) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
Products for C19orf57 Gene
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- Custom Antibody ServicesOriGene Antibodies for C19orf57
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- OriGene qPCR primer pairs and template standards for C19orf57
- OriGene qPCR primer pairs for C19orf57
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- Novus Biologicals Antibodies for C19orf57
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- Horizon Cell Lines for C19orf57
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- VectorBuilder custom plasmid, inducible vectors for C19orf57
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C19orf57
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C19orf57 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer