C19orf53 Gene
protein-coding GIFtS: 43
GCID: GC19P013885
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chromosome 19 open reading frame 53
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Aliases
for C19orf53 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 19 Open Reading Frame 531 2 | | LYDG101 2 | | HSPC0231 | | Leydig Cell Tumor 10 KDa Protein Homolog2 |
Export aliases for C19orf53 gene to outside databasesPrevious GC identifers: GC19P013747 GC19P013456 |
Summaries
for C19orf53 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: L10K_HUMAN, Q9UNZ5Function: May have a potential role in hypercalcemia of malignancy (By similarity)
|
Genomic Views
for C19orf53 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C19orf53 gene promoter:
AhR RFX1 RP58 AML1a Arnt AREB6 E2F E2F-1 Zic3 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for C19orf53
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf53 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2C19orf53 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P013885: view genomic region
(about GC identifiers)
Start:
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13,884,982 bp from pter |
End:
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13,889,587 bp from pter |
Size:
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4,606 bases |
Orientation:
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plus strand |
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Proteins
for C19orf53 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: L10K_HUMAN, Q9UNZ5 (See
protein sequence)Recommended Name: Leydig cell tumor 10 kDa protein homolog Size: 99 amino acids; 10577 Da
Secondary accessions: B2R4J9Explore the universe of human proteins at neXtProt for C19orf53: NX_Q9UNZ5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UNZ5
C19orf53 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054766.1
ENSEMBL proteins: ENSP00000465432 ENSP00000221576 ENSP00000466736 ENSP00000464785 ENSP00000464891 ENSP00000468676
Human Recombinant Protein Products for C19orf53:
C19orf53 Antibody Products:
Assay Products for C19orf53: |
Protein
Domains /
Families
for C19orf53 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C19orf53 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UNZ5ProtoNet protein and cluster: Q9UNZ5 UniProtKB/Swiss-Prot: L10K_HUMAN, Q9UNZ5Similarity: Belongs to the UPF0390 family |
Function
for C19orf53 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: L10K_HUMAN, Q9UNZ5Function: May have a potential role in hypercalcemia of malignancy (By similarity)Phenotypes:
3 GenomeRNAi human phenotypes for C19orf53:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf53 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf53
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for C19orf53 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf53 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf53 |
|
Pathways & Interactions
for C19orf53 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C19orf53
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for C19orf53 (Q9UNZ53 ENSP000002215764) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C19orf53 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C19orf53
Search CenterWatch for drugs/clinical trials and news about C19orf53 / L10K
|
Transcripts
for C19orf53 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C19orf53 gene: NM_014047.2 Unigene Cluster for C19orf53: Chromosome 19 open reading frame 53 Hs.231616 [show with all ESTs]Unigene Representative Sequence: BU1858946 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000588234 ENST00000221576(uc002mxg.3) ENST00000588858 ENST00000588841
ENST00000592760 ENST00000593274
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf53 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf53
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C19orf53 (NM_014047) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C19orf53 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf53 |
Additional cDNA sequence: AF078852.1 AF086483.1 AK311855.1 BC015465.2 11 DOTS entries: DT.447837 DT.100059302 DT.91946836 DT.95357547 DT.95357559 DT.91790505 DT.97856461 DT.100662988 DT.121471238 DT.121471256 DT.91767303 24/318 AceView cDNA sequences (see all 318): AA953343 BM853057 BM702712 F31995 AW849320 AI371483 AV708499 AI351238 AW849640 CB125868 AI422733 BM991551 AI471074 BG575700 F32324 AA953149 CB110566 BQ021795 BU179217 AI094807 CA950633 CB126428 AW849529 BG113978
GeneLoc Exon Structure
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Expression
for C19orf53 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C19orf53 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGTGGTGAT
About this image
See C19orf53 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C19orf53
SOURCE GeneReport for Unigene cluster: Hs.231616
SABiosciences Custom PCR Arrays for C19orf53
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C19orf53
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C19orf53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C19orf53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C19orf53 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf53 |
Orthologs
for C19orf53 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C19orf53 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for C19orf53 (if available)
TreeFam Gene Tree for C19orf53 (if available) |
Paralogs
for C19orf53 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C19orf53 gene
C19orf53 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for C19orf53
PGOHUM00000238922
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Genomic Variants
for C19orf53 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C19orf53 (13884982 - 13889587 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C19orf53
1 CNV: 5088 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C19orf53 |
|
Disorders
/ Diseases
for C19orf53 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C19orf53 for disorders About GeneDecksing
2  diseases for C19orf53: About MalaCardsleydig cell tumor hypercalcemia
Human Genome Epidemiology (HuGE) Navigator: C19orf53 (1 document)
Export disorders for C19orf53 gene to outside databases
|
Publications
for C19orf53 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C19orf53 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C19orf53) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (2005)
- Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S....Mann M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for C19orf53 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C19orf53 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C19orf53 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C19orf53 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C19orf53 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C19orf53 gene:
Search GeneIP for patents involving C19orf53
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C19orf53 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C19orf53 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C19orf53 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C19orf53 | | | OriGene Protein Over-expression Lysate for C19orf53 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C19orf53 | | OriGene 3'-UTR Clone for C19orf53 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf53 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf53 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C19orf53 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C19orf53 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C19orf53 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf53 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C19orf53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C19orf53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C19orf53 |
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 | | | C19orf53 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf53 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for C19orf53 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf53 |
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