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Aliases for C19orf53 Gene

Aliases for C19orf53 Gene

  • Chromosome 19 Open Reading Frame 53 2 3 5
  • Leydig Cell Tumor 10 KDa Protein Homolog 2 3
  • HSPC023 3
  • LYDG10 3

External Ids for C19orf53 Gene

Previous GeneCards Identifiers for C19orf53 Gene

  • GC19P013885
  • GC19P013456

Summaries for C19orf53 Gene

GeneCards Summary for C19orf53 Gene

C19orf53 (Chromosome 19 Open Reading Frame 53) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C19orf53 Gene

  • May have a potential role in hypercalcemia of malignancy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf53 Gene

Genomics for C19orf53 Gene

Regulatory Elements for C19orf53 Gene

Enhancers for C19orf53 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F013773 1.2 ENCODE 16.8 +0.5 505 2.7 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 MRI1 ZNF333 C19orf53 ENSG00000267735 MIR181C CCDC130 SYCE2 ITGB1P1 NANOS3 TRMT1
GH19F013833 1.6 FANTOM5 ENCODE 11.7 +70.4 70405 23.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CCDC130 MRI1 TRMT1 ENSG00000267735 DCAF15 MIR181C RFX1 MIR24-2 ZSWIM4 SYCE2
GH19F013780 1 Ensembl ENCODE 17.4 +7.7 7679 2.3 BCOR KLF1 SIN3A KLF17 ZMYM3 ZNF2 HIC1 ZNF121 ZNF664 ZFHX2 C19orf53 MIR1199 ENSG00000280221
GH19F013793 1.2 ENCODE 13.2 +21.7 21680 5.5 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MIR24-2 C19orf53 MRI1 MIR23A MIR27A ITGB1P1 FARSA ENSG00000267582 ZSWIM4
GH19F013787 0.9 ENCODE 16 +14.9 14893 4.0 FEZF1 ZNF48 ZNF121 SCRT2 SP5 CEBPB PPARG NR2F2 ZSCAN16 ETV4 C19orf53 MIR23A MIR24-2 MIR27A MRI1 MIR1199 ENSG00000280221
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C19orf53 on UCSC Golden Path with GeneCards custom track

Promoters for C19orf53 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C19orf53 Gene

13,774,168 bp from pter
13,778,773 bp from pter
4,606 bases
Plus strand

Genomic View for C19orf53 Gene

Genes around C19orf53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf53 Gene

Proteins for C19orf53 Gene

  • Protein details for C19orf53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leydig cell tumor 10 kDa protein homolog
    Protein Accession:
    Secondary Accessions:
    • B2R4J9

    Protein attributes for C19orf53 Gene

    99 amino acids
    Molecular mass:
    10577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C19orf53 Gene

Post-translational modifications for C19orf53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf53 Gene

No data available for DME Specific Peptides for C19orf53 Gene

Domains & Families for C19orf53 Gene

Protein Domains for C19orf53 Gene


Suggested Antigen Peptide Sequences for C19orf53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0390 family.
  • Belongs to the UPF0390 family.
genes like me logo Genes that share domains with C19orf53: view

No data available for Gene Families for C19orf53 Gene

Function for C19orf53 Gene

Molecular function for C19orf53 Gene

UniProtKB/Swiss-Prot Function:
May have a potential role in hypercalcemia of malignancy.
genes like me logo Genes that share phenotypes with C19orf53: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C19orf53 Gene

Localization for C19orf53 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf53 gene
Compartment Confidence
nucleus 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C19orf53 Gene

Pathways & Interactions for C19orf53 Gene

SuperPathways for C19orf53 Gene

No Data Available

Interacting Proteins for C19orf53 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9UNZ5-L10K_HUMAN ENSP00000465432 for C19orf53 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C19orf53 Gene


No data available for Pathways by source and SIGNOR curated interactions for C19orf53 Gene

Transcripts for C19orf53 Gene

Unigene Clusters for C19orf53 Gene

Chromosome 19 open reading frame 53:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf53 Gene

No ASD Table

Relevant External Links for C19orf53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C19orf53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C19orf53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C19orf53 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C19orf53 Gene

Protein tissue co-expression partners for C19orf53 Gene

NURSA nuclear receptor signaling pathways regulating expression of C19orf53 Gene:


SOURCE GeneReport for Unigene cluster for C19orf53 Gene:

genes like me logo Genes that share expression patterns with C19orf53: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C19orf53 Gene

Orthologs for C19orf53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf53 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C19orf53 35
  • 100 (a)
C19H19orf53 34
  • 99.66 (n)
(Canis familiaris)
Mammalia C20H19orf53 34
  • 83.33 (n)
C19orf53 35
  • 81 (a)
(Bos Taurus)
Mammalia C7H19orf53 34 35 35
  • 82.08 (n)
(Mus musculus)
Mammalia D8Ertd738e 34 16 35
  • 80.09 (n)
(Rattus norvegicus)
Mammalia LOC288913 34
  • 75.27 (n)
(Monodelphis domestica)
Mammalia C19orf53 35
  • 67 (a)
(Anolis carolinensis)
Reptilia C19orf53 35
  • 66 (a)
(Danio rerio)
Actinopterygii C1H19orf53 35
  • 59 (a)
Species where no ortholog for C19orf53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C19orf53 Gene

Gene Tree for C19orf53 (if available)
Gene Tree for C19orf53 (if available)

Paralogs for C19orf53 Gene Pseudogenes for C19orf53 Gene

genes like me logo Genes that share paralogs with C19orf53: view

No data available for Paralogs for C19orf53 Gene

Variants for C19orf53 Gene

Sequence variations from dbSNP and Humsavar for C19orf53 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10104 -- 13,774,670(-) CCTTC(C/T)TGGGA downstream-variant-500B, reference, missense
rs10401231 -- 13,777,366(+) GAGAC(A/G)AGAGG intron-variant
rs10409198 -- 13,777,533(+) TCGGA(A/G)CTCAG intron-variant
rs10416625 -- 13,778,575(+) TGCCC(A/G)GGGGA utr-variant-3-prime
rs10416998 -- 13,778,697(+) ACCAG(A/C)GTCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C19orf53 Gene

Variant ID Type Subtype PubMed ID
esv3893166 CNV gain 25118596
nsv833757 CNV loss 17160897

Variation tolerance for C19orf53 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.11; 93.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf53 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf53 Gene

Disorders for C19orf53 Gene

Relevant External Links for C19orf53

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C19orf53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf53 Gene

Publications for C19orf53 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G. … Cagney G. (Sci. Rep. 2015) 3 64

Products for C19orf53 Gene

Sources for C19orf53 Gene

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