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Aliases for C19orf53 Gene

Aliases for C19orf53 Gene

  • Chromosome 19 Open Reading Frame 53 2 3 5
  • Leydig Cell Tumor 10 KDa Protein Homolog 2
  • HSPC023 3
  • LYDG10 3

External Ids for C19orf53 Gene

Previous GeneCards Identifiers for C19orf53 Gene

  • GC19P013885
  • GC19P013456

Summaries for C19orf53 Gene

GeneCards Summary for C19orf53 Gene

C19orf53 (Chromosome 19 Open Reading Frame 53) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C19orf53 Gene

  • May have a potential role in hypercalcemia of malignancy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf53 Gene

Genomics for C19orf53 Gene

Regulatory Elements for C19orf53 Gene

Enhancers for C19orf53 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C19orf53 on UCSC Golden Path with GeneCards custom track

Promoters for C19orf53 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C19orf53 on UCSC Golden Path with GeneCards custom track

Genomic Location for C19orf53 Gene

Chromosome:
19
Start:
13,774,168 bp from pter
End:
13,778,773 bp from pter
Size:
4,606 bases
Orientation:
Plus strand

Genomic View for C19orf53 Gene

Genes around C19orf53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf53 Gene

Proteins for C19orf53 Gene

  • Protein details for C19orf53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNZ5-L10K_HUMAN
    Recommended name:
    Leydig cell tumor 10 kDa protein homolog
    Protein Accession:
    Q9UNZ5
    Secondary Accessions:
    • B2R4J9

    Protein attributes for C19orf53 Gene

    Size:
    99 amino acids
    Molecular mass:
    10577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C19orf53 Gene

Proteomics data for C19orf53 Gene at MOPED

Post-translational modifications for C19orf53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf53 Gene

No data available for DME Specific Peptides for C19orf53 Gene

Domains & Families for C19orf53 Gene

Protein Domains for C19orf53 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C19orf53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNZ5

UniProtKB/Swiss-Prot:

L10K_HUMAN :
  • Belongs to the UPF0390 family.
Family:
  • Belongs to the UPF0390 family.
genes like me logo Genes that share domains with C19orf53: view

No data available for Gene Families for C19orf53 Gene

Function for C19orf53 Gene

Molecular function for C19orf53 Gene

UniProtKB/Swiss-Prot Function:
May have a potential role in hypercalcemia of malignancy.
genes like me logo Genes that share phenotypes with C19orf53: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C19orf53 Gene

Localization for C19orf53 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C19orf53 Gene COMPARTMENTS Subcellular localization image for C19orf53 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C19orf53 Gene

Pathways & Interactions for C19orf53 Gene

SuperPathways for C19orf53 Gene

No Data Available

Interacting Proteins for C19orf53 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000465432%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000465432 Q9UNZ5-L10K_HUMAN for C19orf53 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C19orf53 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C19orf53 Gene

Drugs & Compounds for C19orf53 Gene

No Compound Related Data Available

Transcripts for C19orf53 Gene

Unigene Clusters for C19orf53 Gene

Chromosome 19 open reading frame 53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf53 Gene

No ASD Table

Relevant External Links for C19orf53 Gene

GeneLoc Exon Structure for
C19orf53
ECgene alternative splicing isoforms for
C19orf53

Expression for C19orf53 Gene

mRNA expression in normal human tissues for C19orf53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C19orf53 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C19orf53 Gene



SOURCE GeneReport for Unigene cluster for C19orf53 Gene Hs.231616

genes like me logo Genes that share expression patterns with C19orf53: view

Protein tissue co-expression partners for C19orf53 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C19orf53 Gene

Orthologs for C19orf53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf53 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C7H19orf53 35
  • 82.08 (n)
  • 84.95 (a)
C7H19orf53 36
  • 84 (a)
OneToMany
C7H19orf53 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C20H19orf53 35
  • 83.33 (n)
  • 84.69 (a)
C19orf53 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D8Ertd738e 35
  • 80.09 (n)
  • 87.01 (a)
D8Ertd738e 16
D8Ertd738e 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf53 35
  • 99.66 (n)
  • 100 (a)
C19orf53 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC288913 35
  • 75.27 (n)
  • 78.49 (a)
oppossum
(Monodelphis domestica)
Mammalia C19orf53 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf53 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C1H19orf53 36
  • 59 (a)
OneToOne
Species with no ortholog for C19orf53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C19orf53 Gene

ENSEMBL:
Gene Tree for C19orf53 (if available)
TreeFam:
Gene Tree for C19orf53 (if available)

Paralogs for C19orf53 Gene

Pseudogenes.org Pseudogenes for C19orf53 Gene

genes like me logo Genes that share paralogs with C19orf53: view

No data available for Paralogs for C19orf53 Gene

Variants for C19orf53 Gene

Sequence variations from dbSNP and Humsavar for C19orf53 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_053783 -
rs12979573 -- 13,776,952(+) ttttg(G/T)ttttt intron-variant
rs12985521 -- 13,776,951(+) ttttt(G/T)ttttt intron-variant
rs13345723 -- 13,775,409(+) cgagt(A/C)ggtag intron-variant
rs13346983 -- 13,774,995(+) CACAG(A/G)GATCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf53 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV Loss 17160897

Variation tolerance for C19orf53 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.11; 93.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf53 Gene

HapMap Linkage Disequilibrium report
C19orf53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf53 Gene

Disorders for C19orf53 Gene

Relevant External Links for C19orf53

Human Genome Epidemiology (HuGE) Navigator
C19orf53
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C19orf53

No disorders were found for C19orf53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf53 Gene

Publications for C19orf53 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for C19orf53 Gene

Sources for C19orf53 Gene

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