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Aliases for C19orf45 Gene

Aliases for C19orf45 Gene

  • Chromosome 19 Open Reading Frame 45 2 3 5

External Ids for C19orf45 Gene

Previous GeneCards Identifiers for C19orf45 Gene

  • GC19P007233

Summaries for C19orf45 Gene

GeneCards Summary for C19orf45 Gene

C19orf45 (Chromosome 19 Open Reading Frame 45) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf45 Gene

Genomics for C19orf45 Gene

Regulatory Elements for C19orf45 Gene

Enhancers for C19orf45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F007498 0.3 FANTOM5 79.7 +5.8 5849 0.1 C19orf45 PCP2 PNPLA6 EVI5L PEX11G ENSG00000267952
GH19F007424 0.4 ENCODE 17.5 -66.9 -66949 3.3 ELF3 ATF1 CREB3L1 SREBF2 RARA ZNF121 FOS CREM EGR2 SP3 ARHGEF18 C19orf45 PEX11G CAMSAP3 GC19P007434 ENSG00000267852
GH19F007427 0.2 ENCODE 12.4 -64.4 -64367 1.7 ELF3 DRAP1 ESRRA CBX3 SREBF2 BACH1 DMAP1 ZNF384 ZNF48 YY1 ARHGEF18 C19orf45 PEX11G CAMSAP3 GC19P007434 ENSG00000267852
GH19F007440 1 ENCODE 11.8 -52.3 -52291 0.9 HDAC1 CREB3L1 SIN3A ZNF335 GLIS2 ZNF766 GATA2 KLF13 MIER1 ZBTB11 PEX11G ARHGEF18 C19orf45 GC19M007438 GC19P007442
GH19F007410 0.2 ENCODE 11.4 -82.8 -82753 0.3 PKNOX1 IKZF1 TCF7 SPI1 C19orf45 PEX11G ENSG00000267852 GC19P007434
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C19orf45 on UCSC Golden Path with GeneCards custom track

Genomic Location for C19orf45 Gene

Chromosome:
19
Start:
7,492,976 bp from pter
End:
7,515,233 bp from pter
Size:
22,258 bases
Orientation:
Plus strand

Genomic View for C19orf45 Gene

Genes around C19orf45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf45 Gene

Proteins for C19orf45 Gene

  • Protein details for C19orf45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA69-CS045_HUMAN
    Recommended name:
    Uncharacterized protein C19orf45
    Protein Accession:
    Q8NA69
    Secondary Accessions:
    • Q8N115

    Protein attributes for C19orf45 Gene

    Size:
    505 amino acids
    Molecular mass:
    57331 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29824.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH34779.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C19orf45 Gene

Post-translational modifications for C19orf45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf45 Gene

No data available for DME Specific Peptides for C19orf45 Gene

Domains & Families for C19orf45 Gene

Protein Domains for C19orf45 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C19orf45: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C19orf45 Gene

Function for C19orf45 Gene

genes like me logo Genes that share phenotypes with C19orf45: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf45 Gene

Localization for C19orf45 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C19orf45 Gene COMPARTMENTS Subcellular localization image for C19orf45 gene
Compartment Confidence
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C19orf45 Gene

Pathways & Interactions for C19orf45 Gene

SuperPathways for C19orf45 Gene

No Data Available

Interacting Proteins for C19orf45 Gene

Gene Ontology (GO) - Biological Process for C19orf45 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C19orf45 Gene

Transcripts for C19orf45 Gene

Unigene Clusters for C19orf45 Gene

Chromosome 19 open reading frame 45:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf45 Gene

No ASD Table

Relevant External Links for C19orf45 Gene

GeneLoc Exon Structure for
C19orf45
ECgene alternative splicing isoforms for
C19orf45

Expression for C19orf45 Gene

mRNA expression in normal human tissues for C19orf45 Gene

mRNA differential expression in normal tissues according to GTEx for C19orf45 Gene

This gene is overexpressed in Testis (x31.1).

NURSA nuclear receptor signaling pathways regulating expression of C19orf45 Gene:

C19orf45

SOURCE GeneReport for Unigene cluster for C19orf45 Gene:

Hs.631862
genes like me logo Genes that share expression patterns with C19orf45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C19orf45 Gene

Orthologs for C19orf45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf45 34
  • 99.21 (n)
C19orf45 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf45 34
  • 79 (n)
C19orf45 35
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700019B03Rik 34 16 35
  • 69.38 (n)
rat
(Rattus norvegicus)
Mammalia RGD1563425 34
  • 69.05 (n)
dog
(Canis familiaris)
Mammalia C19orf45 35
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C19orf45 35
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf45 35
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves C28H19orf45 34
  • 48.56 (n)
C19orf45 35
  • 30 (a)
OneToOne
Species where no ortholog for C19orf45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C19orf45 Gene

ENSEMBL:
Gene Tree for C19orf45 (if available)
TreeFam:
Gene Tree for C19orf45 (if available)

Paralogs for C19orf45 Gene

No data available for Paralogs for C19orf45 Gene

Variants for C19orf45 Gene

Sequence variations from dbSNP and Humsavar for C19orf45 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403773 -- 7,498,362(+) catac(C/T)accat intron-variant, upstream-variant-2KB
rs10407177 -- 7,506,429(+) AATCC(A/C)GCCCC intron-variant
rs10412363 -- 7,500,477(+) TTTTT(A/T)AAAAT intron-variant
rs10592168 -- 7,496,811(+) AAATA(-/AATA)GCGAA upstream-variant-2KB
rs111327568 -- 7,504,591(+) ATCCC(A/G)GTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf45 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
esv3367657 CNV insertion 20981092
esv3643587 CNV loss 21293372
nsv1060887 CNV gain 25217958
nsv2400 CNV insertion 18451855
nsv828416 CNV loss 20364138

Variation tolerance for C19orf45 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.57; 98.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf45 Gene

Human Gene Mutation Database (HGMD)
C19orf45
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf45 Gene

Disorders for C19orf45 Gene

Relevant External Links for C19orf45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C19orf45

No disorders were found for C19orf45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf45 Gene

Publications for C19orf45 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for C19orf45 Gene

Sources for C19orf45 Gene

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