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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C19orf44 Gene

protein-coding GIFtS: 40
GCID: GC19P016607

chromosome 19 open reading frame 44

Search for C19orf44
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 19 Open Reading Frame 44¹ ²
FLJ21742¹
Uncharacterized Protein C19orf44²

External Ids:	HGNC: 26141¹	Entrez Gene: 84167²	Ensembl: ENSG00000105072⁷	UniProtKB: Q9H6X5³

Export aliases for C19orf44 gene to outside databases

Previous GC identifers: GC19P016469 GC19P016175

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C19orf44 gene promoter:
MEF-2 CUTL1 E47 MEF-2A POU2F1 POU2F1a Hand1 aMEF-2 Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C19orf44

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf44

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11

C19orf44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C19orf44 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P016607: view genomic region (about GC identifiers)

Start:	16,607,205 bp from pter	End:	16,632,163 bp from pter
Size:	24,959 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CS044_HUMAN, Q9H6X5 (See protein sequence)

Recommended Name: Uncharacterized protein C19orf44

Size: 657 amino acids; 71343 Da

Secondary accessions: Q8N6Y7

Alternative splicing: 2 isoforms: Q9H6X5-1 Q9H6X5-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C19orf44: NX_Q9H6X5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H6X5

C19orf44 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115583.1

ENSEMBL proteins:

ENSP00000221671

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9H6X5

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C19orf44

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for C19orf44 (Q9H6X5^{2, 3} ENSP00000221671⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC37	Q16543²^,³, ENSP00000222005⁴	MINT-8250800 I2D: score=2 STRING: ENSP00000222005
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C19orf44
Search CenterWatch for drugs/clinical trials and news about C19orf44 / CS044

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for C19orf44 gene:

NM_032207.2

Unigene Cluster for C19orf44:

Chromosome 19 open reading frame 44

Hs.631627 [show with all ESTs]

Unigene Representative Sequence: NM_032207

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000221671(uc002nef.1 uc002neg.3 uc002neh.1 uc010eai.1)

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Additional cDNA sequence:

AK025395.1 AK026145.1 AK225118.1 AK225678.1 AK297781.1 AK311324.1 BC027869.1

13 DOTS entries:

DT.410544 DT.95154495 DT.86855037 DT.97846751 DT.121500563 DT.318015 DT.95090896 DT.97804090

DT.100781339 DT.102832361 DT.121500662 DT.95089315 DT.91991483

24/55 AceView cDNA sequences (see all 55):

BC027869 BP376932 BX356390 AA769416 BF530070 BM799214 BU622506 BP343413

AK025395 NM_032207 BM547844 AI668904 BG337777 AI138550 BG339227 BM835742

AA045397 BX485865 BI769643 BX356389 BX105957 AA437057 BX507597 BM699609

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for C19orf44 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10
SP1:
SP2:
SP3:																					-
SP4:			-						-
SP5:

ECgene alternative splicing isoforms for C19orf44

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C19orf44 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGGATGG

About this image

C19orf44 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C19orf44 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C19orf44

SOURCE GeneReport for Unigene cluster: Hs.631627

SABiosciences Custom PCR Arrays for C19orf44

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C19orf44 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	1700030K09Rik^{1 , 5}	RIKEN cDNA 1700030K09 gene^{1, 5}	66.23(n)¹ 54.35(a)¹		8 (35.08 cM)⁵ 72254¹ NM_028170.2¹ NP_082446.2¹ 72443880⁵
chicken (Gallus gallus)	Aves	C28H19orf44¹	chromosome 28 open reading frame, human C19orf44	41.6(n) 30.83(a)		420145 XM_418261.3 XP_418261.3
lizard (Anolis carolinensis)	Reptilia	C19orf44⁶	--	33(a)	1 ↔ 1	AAWZ02036422(2221-5057)
zebrafish (Danio rerio)	Actinopterygii	LOC796836¹	uncharacterized protein C19orf44-like	46.48(n) 37.87(a)		796836 XM_001337197.4 XP_001337233.2

ENSEMBL Gene Tree for C19orf44 (if available)
TreeFam Gene Tree for C19orf44 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8103427^1,2	C,F,	--	16605386(+)	`cagacT/Cggttt`	2	--	us2k¹ int¹		1		WA	118
rs186153894^1,2		--	16605396(+)	`TTGAAC/TTCCTG`	2	--	int¹ us2k¹		0	--	--	--	--
rs191875741^1,2		--	16605404(+)	`CTGACC/TTCATG`	2	--	int¹ us2k¹		0	--	--	--	--
rs150757735^1,2		--	16605461(+)	`GCCACC/TGCGCC`	2	--	us2k¹ int¹		0	--	--	--	--
rs79686954^1,2		--	16605812(+)	`AGGCCT/GAGGCA`	2	--	us2k¹ int¹		1		NA	2
rs185806882^1,2		--	16605954(+)	`ATCACC/TTGAAC`	2	--	int¹ us2k¹		0	--	--	--	--
rs138266746^1,2		--	16605969(+)	`GAGACA/GGAGGT`	2	--	us2k¹ int¹		0	--	--	--	--
rs190661591^1,2		--	16606015(+)	`CTAGGC/TGACAG`	2	--	int¹ us2k¹		0	--	--	--	--
rs10409518^1,2	C,F,A,H,	--	16606070(+)	`ATCTTC/TGGCAA`	2	--	us2k¹ int¹		22		NS EA NA WA	2346
rs182519072^1,2		--	16606212(+)	`TAAAAA/GTACAA`	2	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C19orf44 (16607205 - 16632163 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C19orf44: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C19orf44 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C19orf44)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)¹ Matsumoto M....Nakayama K.I. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84167	HGNC: 26141	AceView: FLJ21742	Ensembl:ENSG00000105072	euGenes: HUgn84167
ECgene: C19orf44	H-InvDB: C19orf44

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C19orf44	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C19orf44 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C19orf44 gene:
Search GeneIP for patents involving C19orf44

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf44

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C19orf44 gene at Home site.

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C19orf44 Gene

chromosome 19 open reading frame 44

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C19orf44 Gene

chromosome 19 open reading frame 44

Aliasesfor C19orf44 gene

Summariesfor C19orf44 gene

Genomic Viewsfor C19orf44 gene

Proteinsfor C19orf44 gene

Protein Domains /Familiesfor C19orf44 gene

Functionfor C19orf44 gene

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Drugs & Compoundsfor C19orf44 gene

Transcriptsfor C19orf44 gene

Expression for C19orf44 gene

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Genome Databases showing C19orf44 gene

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Specialized Databases showing C19orf44 gene

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Aliases
for C19orf44 gene

Summaries
for C19orf44 gene

Genomic Views
for C19orf44 gene

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for C19orf44 gene

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Families
for C19orf44 gene

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for C19orf44 gene

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for C19orf44 gene

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for C19orf44 gene

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for C19orf44 gene

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for C19orf44 gene

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for C19orf44 gene

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for C19orf44 gene

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for C19orf44 gene

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for C19orf44 gene