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C19orf40 Gene

protein-coding   GIFtS: 48
GCID: GC19P033463

Chromosome 19 Open Reading Frame 40

  See C19orf40-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 19 Open Reading Frame 401 2
FAAP242 5
24kDa1
Fanconi Anemia-Associated Protein1
Fanconi Anemia-Associated Protein Of 24 KDa2
Fanconi Anemia-Associated Protein, 24 KDa2

External Ids:    HGNC: 284671   Entrez Gene: 914422   Ensembl: ENSG000001319447   OMIM: 6108845   UniProtKB: Q9BTP73   

Export aliases for C19orf40 gene to outside databases

Previous GC identifers: GC19P038156 GC19P029965


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C19orf40 Gene:
FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA
damage response (Ciccia et al., 2007 (PubMed 17289582)).(supplied by OMIM, Mar 2008)

GeneCards Summary for C19orf40 Gene:
C19orf40 (chromosome 19 open reading frame 40) is a protein-coding gene. Diseases associated with C19orf40 include fanconi's anemia, and aplastic anemia. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot: FAP24_HUMAN, Q9BTP7
Function: Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2
monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA
cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand
DNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C19orf40 gene promoter:
         ISGF-3   FOXD1   YY1   CREB   CBF-B   CBF-A   HSF2   deltaCREB   Ik-1   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C19orf40

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C19orf40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

C19orf40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C19orf40 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P033463:  view genomic region     (about GC identifiers)

Start:
33,463,115 bp from pter      End:
33,469,128 bp from pter
Size:
6,014 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FAP24_HUMAN, Q9BTP7 (See protein sequence)
Recommended Name: Fanconi anemia-associated protein of 24 kDa  
Size: 215 amino acids; 23897 Da
Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9,
FANCM and FAAP24. Interacts with FANCM
5 PDB 3D structures from and Proteopedia for C19orf40:
2LYH (3D)        2M9M (3D)        2M9N (3D)        4BXO (3D)        4M6W (3D)    
Secondary accessions: B3KY46 Q8WUJ7 Q96FX6

Explore the universe of human proteins at neXtProt for C19orf40: NX_Q9BTP7

Explore proteomics data for C19orf40 at MOPED


See C19orf40 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689479.1  
ENSEMBL proteins: 
 ENSP00000254262   ENSP00000465569   ENSP00000466121   ENSP00000465728   ENSP00000468475  
Reactome Protein details: Q9BTP7

C19orf40 Human Recombinant Protein Products:

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Novus Biologicals C19orf40 Lysate
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Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
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C19orf40 Antibody Products:

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C19orf40 Assay Products:

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Search eBioscience for ELISAs for C19orf40 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR026985 FAAP24
 IPR010994 RuvA_2-like

Graphical View of Domain Structure for InterPro Entry Q9BTP7

ProtoNet protein and cluster: Q9BTP7

UniProtKB/Swiss-Prot: FAP24_HUMAN, Q9BTP7
Domain: The C-terminal region is distantly related to RuvA domain 2, a DNA-binding domain


Find genes that share domains with C19orf40           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FAP24_HUMAN, Q9BTP7
Function: Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2
monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA
cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand
DNA

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003682chromatin binding IDA--
GO:0005515protein binding IPI--
     
Find genes that share ontologies with C19orf40           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for C19orf40:
 Increased S DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C19orf40
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C19orf40
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miRNA
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Gene Editing
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GenScript: all cDNA clones in your preferred vector: C19orf40 (NM_152266)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for C19orf40
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf40

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FAP24_HUMAN, Q9BTP7: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol3

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005654nucleoplasm TAS--
GO:0005730NOT nucleolus IDA--
GO:0043231intracellular membrane-bounded organelle IDA--
GO:0043240Fanconi anaemia nuclear complex IDA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for C19orf40 About    
See pathways by source

SuperPathContained pathways About
1DNA Repair
DNA Repair0.45
2Fanconi Anemia pathway (REACTOME)
Fanconi Anemia pathway
3Fanconi anemia pathway (KEGG)
Fanconi anemia pathway


Find genes that share SuperPaths with C19orf40           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for C19orf40
    Fanconi Anemia pathway


1 Kegg Pathway  (Kegg details for C19orf40):
    Fanconi anemia pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C19orf40
Interactions:

    GeneGlobe Interaction Network for C19orf40

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for C19orf40 (Q9BTP73 ENSP000002542624) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
InteractantInteraction Details
GeneCardExternal ID(s)
FANCAO153603, ENSP000003739524I2D: score=1 STRING: ENSP00000373952
FANCBQ8NB913, ENSP000003268194I2D: score=1 STRING: ENSP00000326819
FANCGO152873, ENSP000003679104I2D: score=1 STRING: ENSP00000367910
FANCMQ8IYD83, ENSP000002674304I2D: score=2 STRING: ENSP00000267430
ATRQ135353, ENSP000003437414I2D: score=1 STRING: ENSP00000343741
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006281DNA repair TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C19orf40 (FAP24)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C19orf40 gene: 
NM_152266.3  

Unigene Cluster for C19orf40:

Chromosome 19 open reading frame 40
Hs.579899  [show with all ESTs]
Unigene Representative Sequence: AK128668
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000254262(uc002nud.4) ENST00000589646 ENST00000588258 ENST00000590179
ENST00000590281 ENST00000591791
miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat C19orf40
Clone
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat C19orf40

Additional mRNA sequence: 

AK128668.1 AK309396.1 BC003535.1 BC010170.2 BC020247.1 

5 DOTS entries:

DT.91715187  DT.91715190  DT.40188534  DT.91715195  DT.101966949 

Selected AceView cDNA sequences (see all 54):

BF793189 BE396092 BF036840 BM679170 BE793971 BG773468 BC010170 BM761534 
AK128668 BE790609 BE394126 BI829252 BX376697 BX382115 BG418961 BC003535 
BE563642 BM990829 CA419774 BX390218 BC020247 BG708918 CA307247 BG164300 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for C19orf40    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1:                          -                                       
SP2:                                                                  
SP3:                    -                                             
SP4:                    -     -     -                                 


ECgene alternative splicing isoforms for C19orf40

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C19orf40 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGACAGGTG
C19orf40 Expression
About this image

C19orf40 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C19orf40 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.579899
    Custom PCR Arrays for C19orf40
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QuantiFast Probe-based Assays in human, mouse, rat C19orf40
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf40

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for C19orf40 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia C230052I12Rik1 , 5 RIKEN cDNA C230052I12 gene1, 5 81.78(n)1
81.78(a)1
  7 (21.37 cM)5
1018311  NM_178643.51  NP_848758.11 
 353922755 
chicken
(Gallus gallus)
Aves C11H19ORF401 chromosome 11 open reading frame, human C19orf40 66.83(n)
62.8(a)
  415770  NM_001277595.1  NP_001264524.1 
lizard
(Anolis carolinensis)
Reptilia C19orf406
chromosome 19 open reading frame 40
61(a)
1 ↔ 1
GL343483.1(65931-70795)
tropical clawed frog
(Xenopus tropicalis)
Amphibia c19orf401 chromosome 19 open reading frame 40 62.8(n)
58.94(a)
  548876  NM_001016122.2  NP_001016122.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:1622671 zgc:162267 61.31(n)
61.66(a)
  559470  NM_001089523.1  NP_001082992.1 


ENSEMBL Gene Tree for C19orf40 (if available)
TreeFam Gene Tree for C19orf40 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for C19orf40 gene
1 SIMAP similar gene for C19orf40 using alignment to 1 protein entry:     K7EKQ4_HUMAN:
FAAP24

Find genes that share paralogs with C19orf40           About GenesLikeMe


1 Pseudogenes.org Pseudogene for C19orf40
PGOHUM00000239652


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C19orf40 (see all 120)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1826501341,2
C--33464914(+) CTTAAC/TCTGAA 1 -- int10--------
rs1418251191,2
C--33464916(+) TAACCC/TGAAAA 1 -- int10--------
rs786282561,2
C,F--33465006(+) AACCCA/G/TGATGA 3 Q R L mis12WA NA 4668
rs1872944471,2
C--33465032(+) CAGCCA/CTACAG 2 I L mis10--------
rs1468298491,2
C,F--33465034(+) GCCCTA/GCAGAA 2 L syn11Minor allele frequency- G:0.00NA 4552
rs1489515791,2
F--33465052(+) GTGCTG/AGACCT 2 /L syn11Minor allele frequency- A:0.00NA 4552
rs1428239841,2
C--33465097(+) GAAGCA/GTCCTG 2 A syn11Minor allele frequency- G:0.00NA 4552
rs360174551,2
C,F--33465099(-) GGCAGG/AATGCT 2 /S /F mis15Minor allele frequency- A:0.00NA EU 5956
rs2002311391,2
--33465106(+) TGCCTC/TGTCAT 2 L syn10--------
rs1846714951,2
--33465125(+) TGAGTA/GCCGAT 1 -- int10--------

HapMap Linkage Disequilibrium report for C19orf40 (33463115 - 33469128 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for C19orf40:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833807CNV Loss17160897
nsv820055CNV Gain19587683

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing C19orf40
DNA2.0 Custom Variant and Variant Library Synthesis for C19orf40

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610884    OMIM disorders: --

2 diseases for C19orf40:    
About MalaCards
fanconi's anemia    aplastic anemia

1 disease from the University of Copenhagen DISEASES database for C19orf40:
Aplastic anemia

Find genes that share disorders with C19orf40           About GenesLikeMe


Export disorders for C19orf40 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C19orf40 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with C19orf40)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. (PubMed id 17289582)1, 2, 3 Ciccia A....West S.C. (Mol. Cell 2007)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity. (PubMed id 23741361)1 Wang W....Zhou Y. (PLoS ONE 2013)
  4. Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. (PubMed id 24003026)1 Yang H....Ding J. (Nucleic Acids Res. 2013)
  5. Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex. (PubMed id 23932590)1 Coulthard R....McDonald N.Q. (Structure 2013)
  6. FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. (PubMed id 23333308)1 Wang Y....Li L. (Mol. Cell 2013)
  7. A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. (PubMed id 22705371)1 Yan Z.... Wang W. (Mol. Cell 2012)
  8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  9. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. (PubMed id 20670894)1 Huang M....D'Andrea A.D. (Mol. Cell 2010)
  10. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. (PubMed id 20347428)1 Yan Z....Wang W. (Mol. Cell 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 91442 HGNC: 28467 AceView: MGC32020 Ensembl:ENSG00000131944 euGenes: HUgn91442
ECgene: C19orf40 Kegg: 91442 H-InvDB: C19orf40

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C19orf40 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C19orf40 gene:
Search GeneIP for patents involving C19orf40

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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