Aliases for C19orf40 Gene
External Ids for C19orf40 Gene
Previous GeneCards Identifiers for C19orf40 Gene
FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
GeneCards Summary for C19orf40 Gene
C19orf40 (Chromosome 19 Open Reading Frame 40) is a Protein Coding gene. Diseases associated with C19orf40 include aplastic anemia. Among its related pathways are DNA Repair and Fanconi anemia pathway (KEGG). GO annotations related to this gene include chromatin binding.
UniProtKB/Swiss-Prot for C19orf40 Gene
Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.